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Volumn 51, Issue 1, 2017, Pages 63-69

Azathioprine and 6-Mercaptopurine-induced Liver Injury

Author keywords

6 mercaptopurine; azathioprine; drug induced liver injury; hepatotoxicity

Indexed keywords

6 MERCAPTOPURINE DERIVATIVE; 6 METHYL MERCAPTOPURINE; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ANTINUCLEAR ANTIBODY; ASPARTATE AMINOTRANSFERASE; AZATHIOPRINE; BILIRUBIN; CORTICOSTEROID; DRUG METABOLITE; MERCAPTOPURINE; UNCLASSIFIED DRUG;

EID: 85006365348     PISSN: 01920790     EISSN: 15392031     Source Type: Journal    
DOI: 10.1097/MCG.0000000000000568     Document Type: Article
Times cited : (66)

References (39)
  • 1
    • 32244441026 scopus 로고
    • Hepatitis in association with prolonged 6-mercaptopurine therapy
    • McIlvanie SK, MacCarthy JD. Hepatitis in association with prolonged 6-mercaptopurine therapy. Blood. 1959;14:80-90.
    • (1959) Blood , vol.14 , pp. 80-90
    • McIlvanie, S.K.1    MacCarthy, J.D.2
  • 2
    • 13444305261 scopus 로고
    • Toxic complications of treatment with 6-mercaptopurine: Two cases with hepatic necrosis and intestinal ulceration
    • Clark PA, Hsia YE, Huntsman RG. Toxic complications of treatment with 6-mercaptopurine: two cases with hepatic necrosis and intestinal ulceration. Br Med J. 1960;1:393-395.
    • (1960) Br Med J , vol.1 , pp. 393-395
    • Clark, P.A.1    Hsia, Y.E.2    Huntsman, R.G.3
  • 3
    • 0000378195 scopus 로고
    • Hepatotoxicity of mercaptopurine
    • Einhorn M, Davidsohn I. Hepatotoxicity of mercaptopurine. JAMA. 1964;188:802-806.
    • (1964) JAMA , vol.188 , pp. 802-806
    • Einhorn, M.1    Davidsohn, I.2
  • 4
    • 0014166872 scopus 로고
    • Mercaptopurine hepatotoxicity in a patient with chronic active hepatitis
    • Krawitt EL, Stein JH, Kirkendall WM, et al. Mercaptopurine hepatotoxicity in a patient with chronic active hepatitis. Arch Intern Med. 1967;120:729-734.
    • (1967) Arch Intern Med , vol.120 , pp. 729-734
    • Krawitt, E.L.1    Stein, J.H.2    Kirkendall, W.M.3
  • 6
    • 0014406759 scopus 로고
    • Portal hypertension in a case of acute leukemia treated with antimetabolites for 10 years
    • Lascari AD, Givier RL, Soper RT, et al. Portal hypertension in a case of acute leukemia treated with antimetabolites for 10 years. N Engl J Med. 1968;279:303-306.
    • (1968) N Engl J Med , vol.279 , pp. 303-306
    • Lascari, A.D.1    Givier, R.L.2    Soper, R.T.3
  • 7
  • 8
    • 0023008319 scopus 로고
    • Cholestasis and sinusoidal dilatation following treatment with azathioprine
    • Lemarchand P, Desrumeaux B, Bercoff E, et al. Cholestasis and sinusoidal dilatation following treatment with azathioprine. Gastroenterol Clin Biol. 1986;10:853-854.
    • (1986) Gastroenterol Clin Biol , vol.10 , pp. 853-854
    • Lemarchand, P.1    Desrumeaux, B.2    Bercoff, E.3
  • 9
    • 0024474913 scopus 로고
    • Probable azathioprine hepatotoxicity: A case report
    • Small P, Lichter M. Probable azathioprine hepatotoxicity: A case report. Ann Allergy. 1989;62:518-520.
    • (1989) Ann Allergy , vol.62 , pp. 518-520
    • Small, P.1    Lichter, M.2
  • 10
    • 0028793746 scopus 로고
    • Azathioprinehypersensitivity-like reactions-a case report and a review of the literature
    • Knowles SR, Gupta AK, Shear NH, et al. Azathioprinehypersensitivity-like reactions-a case report and a review of the literature. Clin Exp Dermatol. 1995;20:353-356.
    • (1995) Clin Exp Dermatol , vol.20 , pp. 353-356
    • Knowles, S.R.1    Gupta, A.K.2    Shear, N.H.3
  • 11
    • 0024510347 scopus 로고
    • Hepatotoxicity of azathioprine in renal transplant recipients
    • Ramalho HJ, Terra EG, Cartapatti E, et al. Hepatotoxicity of azathioprine in renal transplant recipients. Transplant Proc. 1989;21(pt 2):1716-1717.
    • (1989) Transplant Proc , vol.21 , pp. 1716-1717
    • Ramalho, H.J.1    Terra, E.G.2    Cartapatti, E.3
  • 12
    • 0025757370 scopus 로고
    • Azathioprine hepatotoxicity after liver transplantation
    • Sterneck M, Wiesner R, Ascher N, et al. Azathioprine hepatotoxicity after liver transplantation. Hepatology. 1991;14: 806-810.
    • (1991) Hepatology , vol.14 , pp. 806-810
    • Sterneck, M.1    Wiesner, R.2    Ascher, N.3
  • 13
    • 78649615066 scopus 로고    scopus 로고
    • Mitochondrial and immunoallergic injury increase risk of positive drug rechallenge after drug-induced liver injury: A systematic review
    • Hunt CM. Mitochondrial and immunoallergic injury increase risk of positive drug rechallenge after drug-induced liver injury: A systematic review. Hepatology. 2010;52:2216-2222.
    • (2010) Hepatology , vol.52 , pp. 2216-2222
    • Hunt, C.M.1
  • 15
    • 57249086242 scopus 로고    scopus 로고
    • Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States. Drug Induced Liver Injury Network (DILIN)
    • Update to 2015 paper
    • Chalasani N, Fontana RJ, Bonkovsky HL, et al. Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States. Drug Induced Liver Injury Network (DILIN). Gastroenterology. 2008;135: 1924-1934. (Update to 2015 paper).
    • (2008) Gastroenterology , vol.135 , pp. 1924
    • Chalasani, N.1    Fontana, R.J.2    Bonkovsky, H.L.3
  • 16
    • 23044473682 scopus 로고    scopus 로고
    • Outcome and prognostic markers in severe drug-induced liver disease
    • Björnsson E, Olsson R. Outcome and prognostic markers in severe drug-induced liver disease. Hepatology. 2005;42:481-489.
    • (2005) Hepatology , vol.42 , pp. 481-489
    • Björnsson, E.1    Olsson, R.2
  • 17
    • 84878325626 scopus 로고    scopus 로고
    • Incidence, presentation and outcomes in patients with drug-induced liver injury in the general population of Iceland
    • Björnsson ES, Bergmann OM, Björnsson HK, et al. Incidence, presentation and outcomes in patients with drug-induced liver injury in the general population of Iceland. Gastroenterology. 2013;144:1419-1425.
    • (2013) Gastroenterology , vol.144 , pp. 1419-1425
    • Björnsson, E.S.1    Bergmann, O.M.2    Björnsson, H.K.3
  • 18
    • 4544239107 scopus 로고    scopus 로고
    • Thiopurine drug adverse effects in a population of New Zealand patients with inflammatory bowel disease
    • Gearry RB, Barclay ML, Burt MJ, et al. Thiopurine drug adverse effects in a population of New Zealand patients with inflammatory bowel disease. Pharmacoepidemiol Drug Saf. 2004;13:563-567.
    • (2004) Pharmacoepidemiol Drug Saf , vol.13 , pp. 563-567
    • Gearry, R.B.1    Barclay, M.L.2    Burt, M.J.3
  • 19
    • 27644558550 scopus 로고    scopus 로고
    • Incidence, risk factors and clinical course of thiopurine-induced liver injury in patients with inflammatory bowel disease
    • Bastida G, Nos P, AguasM, et al. Incidence, risk factors and clinical course of thiopurine-induced liver injury in patients with inflammatory bowel disease. Aliment Pharmacol Ther. 2005;22:775-782.
    • (2005) Aliment Pharmacol Ther , vol.22 , pp. 775-782
    • Bastida, G.1    Nos, P.2    Aguas, M.3
  • 20
    • 34548614388 scopus 로고    scopus 로고
    • Liver injury in inflammatory bowel disease: Long-term follow-up study of 786 patients
    • Gisbert JP, Luna M, Gonzá lez-Lama Y, et al. Liver injury in inflammatory bowel disease: long-term follow-up study of 786 patients. Inflamm Bowel Dis. 2007;13:1106-1114.
    • (2007) Inflamm Bowel Dis , vol.13 , pp. 1106-1114
    • Gisbert, J.P.1    Luna, M.2    Gonzá Lez-Lama, Y.3
  • 21
    • 35449001530 scopus 로고    scopus 로고
    • Hepatotoxicity of 6-mercaptopurine (6-MP) and azathioprine (AZA) in adult IBD patients
    • Shaye OA, Yadegari M, Abreu MT, et al. Hepatotoxicity of 6-mercaptopurine (6-MP) and azathioprine (AZA) in adult IBD patients. Am J Gastroenterol. 2007;102:2488-2494.
    • (2007) Am J Gastroenterol , vol.102 , pp. 2488-2494
    • Shaye, O.A.1    Yadegari, M.2    Abreu, M.T.3
  • 22
    • 0016837110 scopus 로고
    • Hepatic veno-occlusive disease in a renal transplant patient receiving azathioprine
    • Marubbio AT, Danielson B. Hepatic veno-occlusive disease in a renal transplant patient receiving azathioprine. Gastroenterology. 1975;69:739-743.
    • (1975) Gastroenterology , vol.69 , pp. 739-743
    • Marubbio, A.T.1    Danielson, B.2
  • 23
    • 0024212041 scopus 로고
    • Portal hypertension secondary to azathioprine in myasthenia gravis
    • Fonseca V, Havard CW. Portal hypertension secondary to azathioprine in myasthenia gravis. Postgrad Med J. 1988;64: 950-952.
    • (1988) Postgrad Med J , vol.64 , pp. 950-952
    • Fonseca, V.1    Havard, C.W.2
  • 24
    • 0023689208 scopus 로고
    • Three cases of nodular regenerative hyperplasia of the liver following renal transplantation
    • Buffet C, Cantarovitch M, Pelletier G, et al. Three cases of nodular regenerative hyperplasia of the liver following renal transplantation. Nephrol Dial Transplant. 1988;3:327-330.
    • (1988) Nephrol Dial Transplant , vol.3 , pp. 327-330
    • Buffet, C.1    Cantarovitch, M.2    Pelletier, G.3
  • 25
    • 58149347349 scopus 로고    scopus 로고
    • Drug-induced Liver Injury Network (DILIN) prospective study: Rationale, design, and conduct
    • Fontana RJ, Watkins PB, Bonkovsky H, et al. Drug-induced Liver Injury Network (DILIN) prospective study: rationale, design, and conduct. Drug Saf. 2009;32:55-68.
    • (2009) Drug Saf , vol.32 , pp. 55-68
    • Fontana, R.J.1    Watkins, P.B.2    Bonkovsky, H.3
  • 26
    • 77952702755 scopus 로고    scopus 로고
    • Causality assessment in drug-induced liver injury using a structured expert opinion process: Comparions to the Roussel-Uclaf Causality Assessment Method
    • Rockey DC, Seeff LB, Rochon J, et al. Causality assessment in drug-induced liver injury using a structured expert opinion process: comparions to the Roussel-Uclaf Causality Assessment Method. Hepatology. 2010;51:2117-2126.
    • (2010) Hepatology , vol.51 , pp. 2117-2126
    • Rockey, D.C.1    Seeff, L.B.2    Rochon, J.3
  • 27
    • 0027362542 scopus 로고
    • Causality assessment of adverse reactions to drugs-I: A novel method based on the conclusions of international consensus meetings: Application to druginduced liver
    • Danan G, Benichou C. Causality assessment of adverse reactions to drugs-I. A novel method based on the conclusions of international consensus meetings: Application to druginduced liver injuries. J Clin Epidemiol. 1993;46:1323-1330.
    • (1993) J Clin Epidemiol , vol.46 , pp. 1323-1330
    • Danan, G.1    Benichou, C.2
  • 29
    • 77957192395 scopus 로고    scopus 로고
    • Incidence of nodular regenerative hyperplasia in inflammatory bowel disease patients treated with azathioprine
    • Seksik P, Mary JY, Beaugerie L, et al. Incidence of nodular regenerative hyperplasia in inflammatory bowel disease patients treated with azathioprine. Inflamm Bowel Dis. 2011;17: 565-572.
    • (2011) Inflamm Bowel Dis , vol.17 , pp. 565-572
    • Seksik, P.1    Mary, J.Y.2    Beaugerie, L.3
  • 30
    • 0029817846 scopus 로고    scopus 로고
    • The long-term outcome of ulcerative colitis treated with 6-mercaptopurine
    • George J, Present DH, Pou R, et al. The long-term outcome of ulcerative colitis treated with 6-mercaptopurine. Am J Gastroenterol. 1996;91:1711-1714.
    • (1996) Am J Gastroenterol , vol.91 , pp. 1711-1714
    • George, J.1    Present, D.H.2    Pou, R.3
  • 31
    • 0033770169 scopus 로고    scopus 로고
    • A multicenter trial of 6-mercaptopurine and prednisone in children with newly diagnosed Crohn's disease
    • Markowitz J, Grancher K, Kohn N, et al. A multicenter trial of 6-mercaptopurine and prednisone in children with newly diagnosed Crohn's disease. Gastroenterology. 2000;119: 895-902.
    • (2000) Gastroenterology , vol.119 , pp. 895-902
    • Markowitz, J.1    Grancher, K.2    Kohn, N.3
  • 32
    • 1842788679 scopus 로고    scopus 로고
    • Methylated metabolites of 6-mercaptopurine are associated with hepatotoxicity
    • Nygaard U, Toft N, Schmiegelow K. Methylated metabolites of 6-mercaptopurine are associated with hepatotoxicity. Clin Pharmacol Ther. 2004;75:274-281.
    • (2004) Clin Pharmacol Ther , vol.75 , pp. 274-281
    • Nygaard, U.1    Toft, N.2    Schmiegelow, K.3
  • 33
    • 3142557936 scopus 로고    scopus 로고
    • Acute and clinically relevant drug-induced liver injury: A population based case-control study
    • de Abajo FJ, Montero D, Madurga M, et al. Acute and clinically relevant drug-induced liver injury: A population based case-control study. Brit J Clin Pharmacol. 2004;58:71-80.
    • (2004) Brit J Clin Pharmacol , vol.58 , pp. 71-80
    • De Abajo, F.J.1    Montero, D.2    Madurga, M.3
  • 34
    • 0038441800 scopus 로고    scopus 로고
    • Bosentan for the treatment of pulmonary arterial hypertension
    • Kenyon KW, Nappi JM. Bosentan for the treatment of pulmonary arterial hypertension. Ann Pharmacother. 2003;37: 1055-1062.
    • (2003) Ann Pharmacother , vol.37 , pp. 1055-1062
    • Kenyon, K.W.1    Nappi, J.M.2
  • 35
    • 46249118651 scopus 로고    scopus 로고
    • Relationship between daily dose of oral medications and idiosyncratic drug-induced liver injury: Search for signals
    • Lammert C, Einarsson S, Saha C, et al. Relationship between daily dose of oral medications and idiosyncratic drug-induced liver injury: search for signals. Hepatology. 2008;47:2003-2009.
    • (2008) Hepatology , vol.47 , pp. 2003-2009
    • Lammert, C.1    Einarsson, S.2    Saha, C.3
  • 36
    • 4544363071 scopus 로고    scopus 로고
    • Liver transplantation for acute liver failure from drug induced liver injury in the United States
    • Russo MW, Galanko JA, Shrestha R, et al. Liver transplantation for acute liver failure from drug induced liver injury in the United States. Liver Transpl. 2004;10:1018-1023.
    • (2004) Liver Transpl , vol.10 , pp. 1018-1023
    • Russo, M.W.1    Galanko, J.A.2    Shrestha, R.3
  • 37
    • 68949091980 scopus 로고    scopus 로고
    • Phenotypic characterization of idiosyncratic drug-induced liver injury: The influence of age and sex
    • Lucena MI, Andrade RJ, Kaplowitz N, et al. Phenotypic characterization of idiosyncratic drug-induced liver injury: the influence of age and sex. Hepatology. 2009;49:2001-2009.
    • (2009) Hepatology , vol.49 , pp. 2001-2009
    • Lucena, M.I.1    Andrade, R.J.2    Kaplowitz, N.3
  • 38
    • 84915746578 scopus 로고    scopus 로고
    • Distinct phenotype of hepatotoxicity associated with illicit use of anabolic androgenic steroids
    • Robles-Diaz M, Gonzalez-Jimenez A, Medina-Caliz I, et al. Distinct phenotype of hepatotoxicity associated with illicit use of anabolic androgenic steroids. Aliment Pharmacol Ther. 2015;41:116-125.
    • (2015) Aliment Pharmacol Ther , vol.41 , pp. 116-125
    • Robles-Diaz, M.1    Gonzalez-Jimenez, A.2    Medina-Caliz, I.3
  • 39
    • 34250797604 scopus 로고    scopus 로고
    • Thiopurine-induced liver injury in patients with inflammatory bowel disease: A systematic review
    • Gisbert JP, Gonzalez-Lama Y, Mate J. Thiopurine-induced liver injury in patients with inflammatory bowel disease: A systematic review. Am J Gastroenterol. 2007;102:1518-1527.
    • (2007) Am J Gastroenterol , vol.102 , pp. 1518-1527
    • Gisbert, J.P.1    Gonzalez-Lama, Y.2    Mate, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.