A feedback loop between nonsense-mediated decay and the retrogene DUX4 in facioscapulohumeral muscular dystrophy

eLife

Volumn 2015, Issue 4, 2015, Pages

  Feng, Qing ^a   Snider, Lauren ^a   Jagannathan, Sujatha ^a   Tawil, Rabi ^b   van der Maarel, Silvère M ^c   Tapscott, Stephen J ^a,d   Bradley, Robert K ^a  

^a USA   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^d UNIVERSITY OF WASHINGTON   (United States)

Author keywords

DUX4; Facioscapulohumeral muscular dystrophy; FSHD; Nonsense mediated decay

Indexed keywords

DUX4 PROTEIN; HOMEODOMAIN PROTEIN; ISOPROTEIN; MESSENGER RNA; PROTEASOME; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; UPF1 PROTEIN; DUX4 PROTEIN, HUMAN; RETROPOSON; TRANSACTIVATOR PROTEIN; UPF1 PROTEIN, HUMAN;

ALTERNATIVE RNA SPLICING; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DUX4 RETROGENE; EPIGENETIC REPRESSION; FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY; FEEDBACK SYSTEM; FUORESCENCE MICROSCOPY; GENE; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MOLECULAR GENETICS; MYOTUBE; NONHUMAN; NONSENSE MEDIATED MRNA DECAY; PROTEIN DEGRADATION; REAL TIME POLYMERASE CHAIN REACTION; RNA ANALYSIS; RNA ISOLATION; RNA SPLICING; SKELETAL MUSCLE; WESTERN BLOTTING; ENZYME SPECIFICITY; GENETICS; METABOLISM; PROTEIN STABILITY; RETROPOSON;

FEEDBACK, PHYSIOLOGICAL; HOMEODOMAIN PROTEINS; HUMANS; MUSCULAR DYSTROPHY, FACIOSCAPULOHUMERAL; NONSENSE MEDIATED MRNA DECAY; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN STABILITY; RETROELEMENTS; RNA, MESSENGER; SUBSTRATE SPECIFICITY; TRANS-ACTIVATORS;

EID: 85006326562     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.04996     Document Type: Article

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