Exosomes and breast cancer: A comprehensive review of novel therapeutic strategies from diagnosis to treatment

Cancer Gene Therapy

Volumn 24, Issue 1, 2017, Pages 6-12

  Wu, C Y ^a   Du, S L ^a   Zhang, J ^a   Liang, A L ^a   Liu, Y J ^a  

^a GUANGDONG MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BREAST CANCER; CANCER DIAGNOSIS; CANCER GROWTH; CANCER RESISTANCE; CARCINOGENESIS; EXOSOME; HUMAN; METASTASIS; NONHUMAN; PRIORITY JOURNAL; REVIEW; TUMOR INVASION; ANIMAL; BREAST TUMOR; CELL COMMUNICATION; CELL TRANSFORMATION; DISEASE EXACERBATION; DRUG DELIVERY SYSTEM; DRUG RESISTANCE; FEMALE; IMMUNOMODULATION; METABOLISM; TRANSPORT AT THE CELLULAR LEVEL;

BIOLOGICAL MARKER;

ANIMALS; BIOLOGICAL TRANSPORT; BIOMARKERS; BREAST NEOPLASMS; CELL COMMUNICATION; CELL TRANSFORMATION, NEOPLASTIC; DISEASE PROGRESSION; DRUG DELIVERY SYSTEMS; DRUG RESISTANCE, NEOPLASM; EXOSOMES; FEMALE; HUMANS; IMMUNOMODULATION; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS;

EID: 85006257477     PISSN: 09291903     EISSN: 14765500     Source Type: Journal    
DOI: 10.1038/cgt.2016.69     Document Type: Review

References (34)

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18. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. Cancer J Clin 2015; 65: 87-108.
19. Fan L, Strasser-Weippl K, Li J-J St, Louis J, Finkelstein DM, Yu K-D et al. Breast cancer in China. Lancet Oncol 2014; 15: e279-e289.
20. Kruger S, Abd Elmageed ZY, Hawke DH, Worner PM, Jansen DA, Abdel-Mageed AB et al. Molecular characterization of exosome-like vesicles from breast cancer cells. BMC Cancer 2014; 14: 44.
21. Harris DA, Patel SH, Gucek M, Hendrix A, Westbroek W, Taraska JW. Exosomes released from breast cancer carcinomas stimulate cell movement. PLoS One 2015; 10: e0117495.
22. Pan BT, Teng K, Wu C, Adam M, Johnstone RM. Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes. J Cell Biol 1985; 101: 942-948.
23. Yu B, Zhang X, Li X. Exosomes derived from mesenchymal stem cells. Int J Mol Sci 2014; 15: 4142-4157.
24. Lorraine OD. Expanding on exosomes and ectosomes in cancer. N Engl J Med 2015; 372: 2359-2362.
25. Ferguson SW, Nguyen J. Exosomes as therapeutics: The implications of molecular composition and exosomal heterogeneity. J Control Rel 2016; 228: 179-190.
26. ELA S, Mager I, Breakefield XO, Wood MJ. Extracellular vesicles: biology and emerging therapeutic opportunities. Nat Rev Drug Discov 2013; 12: 347-357.
27. Vlassov AV, Magdaleno S, Setterquist R, Conrad R. Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials. Biochim Biophys Acta 2012; 1820: 940-948.
28. Thery C, Zitvogel L, Amigorena S. Exosomes: composition, biogenesis and function. Nat Rev Immunol 2002; 2: 569-579.
29. Nanbo A, Kawanishi E, Yoshida R, Yoshiyama H. Exosomes derived from Epstein-Barr virus-infected cells are internalized via caveola-dependent endocytosis and promote phenotypic modulation in target cells. J Virol 2013; 87: 10334-10347.
30. Braicu C, Tomuleasa C, Monroig P, Cucuianu A, Berindan-Neagoe I, Calin GA. Exosomes as divine messengers: Are they the Hermes of modern molecular oncology? Cell Death Differ 2015; 22: 34-45.
31. Gupta A, Pulliam L. Exosomes as mediators of neuroinflammation. J Neuroinflamm 2014; 11: 68.
32. Gangoda L, Boukouris S, Liem M, Kalra H, Mathivanan S. Extracellular vesicles including exosomes are mediators of signal transduction: Are they protective or pathogenic? Proteomics 2015; 15: 260-271.
33. Wubbolts R, Leckie RS, Veenhuizen PT, Schwarzmann G, Mobius W, Hoernschemeyer J et al. Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation. J Biol Chem 2003; 278: 10963-10972.
34. Thery C, Boussac M, Veron P, Ricciardi-Castagnoli P, Raposo G, Garin J et al. Proteomic analysis of dendritic cell-derived exosomes: A secreted subcellular compartment distinct from apoptotic vesicles. J Immunol 2001; 166: 7309-7318.