Folate, homocysteine and selected vitamins and minerals status in infertile women

European Journal of Contraception and Reproductive Health Care

Volumn 22, Issue 1, 2017, Pages 70-75

  La Vecchia, Irene ^a,b   Paffoni, Alessio ^a   Castiglioni, Marta ^a,b   Ferrari, Stefania ^a   Bortolus, Renata ^c   Ferraris Fusarini, Chiara ^a   Bettinardi, Nora ^a   Somigliana, Edgardo ^a   Parazzini, Fabio ^b  

^a FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY HOSPITAL OF VERONA   (Italy)

Author keywords

Folate; folic acid; homocysteine; infertility; micronutrients; preconceptional period

Indexed keywords

ALPHA TOCOPHEROL; CYANOCOBALAMIN; FERRITIN; FOLIC ACID; HOMOCYSTEINE; IRON; MINERAL; RETINOL; VITAMIN; TRACE ELEMENT; VITAMIN B COMPLEX;

ADULT; ARTICLE; BLOOD BIOCHEMISTRY; BODY MASS; CROSS-SECTIONAL STUDY; ERYTHROCYTE; FEMALE; FEMALE INFERTILITY; FERRITIN BLOOD LEVEL; FOLIC ACID BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IMMUNOASSAY; IN VITRO FERTILIZATION; IRON BLOOD LEVEL; MAJOR CLINICAL STUDY; MATERNAL WELFARE; MINERAL BLOOD LEVEL; NEURAL TUBE DEFECT; PRIORITY JOURNAL; SAMPLE SIZE; VENOUS BLOOD; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION; BLOOD;

ADULT; CROSS-SECTIONAL STUDIES; FEMALE; FERRITINS; FOLIC ACID; HOMOCYSTEINE; HUMANS; INFERTILITY, FEMALE; IRON; TRACE ELEMENTS; VITAMIN A; VITAMIN B 12; VITAMIN B COMPLEX; VITAMIN E;

EID: 85006172764     PISSN: 13625187     EISSN: 14730782     Source Type: Journal    
DOI: 10.1080/13625187.2016.1263292     Document Type: Article

References (38)

1. Keen CL, Clegg MS, Hanna LA, et al. The plausibility of micronutrient deficiencies being a significant contributing factor to the occurrence of pregnancy complications. J Nutr. 2003;133:1597S–1605S.
2. De-Regil LM, Peña-Rosas JP, Fernández-Gaxiola AC, et al. Effects and safety of periconceptional oral folate supplementation for preventing birth defects. Cochrane Database Syst Rev. 2015;12:CD007950.
3. Fekete K, Berti C, Trovato M, et al. Effect of folate intake on health outcomes in pregnancy:a systematic review and meta-analysis on birth weight, placental weight and length of gestation. Nutr J. 2012;11:75.
4. Gaskins AJ, Chiu YH, Williams PL, et al. Association between serum folate and vitamin B-12 and outcomes of assisted reproductive technologies. Am J Clin Nutr. 2015;102:943–950.
5. World Health Organization. Global prevalence of vitamin A deficiency in populations at risk 1995–2005. Geneva:WHO; 2009.
6. Clagett-Dame M, Knutson D., Vitamin A in reproduction and development. Nutrients. 2011;3:385–428.
7. Ruder EH, Hartman TJ, Blumberg J, et al. Oxidative stress and antioxidants:exposure and impact on female fertility. Hum Reprod Update. 2008;14:345–357.
8. Takasaki A, Tamura H, Miwa I, et al. Endometrial growth and uterine blood flow:a pilot study for improving endometrial thickness in the patients with a thin endometrium. Fertil Steril. 2010;93:1851–1858.
9. Rumbold A, Ota E, Hori H, et al. Vitamin E supplementation in pregnancy. Cochrane Database Syst Rev. 2015;9:CD004069.
10. Mei Z, Cogswell ME, Looker AC, et al. Assessment of iron status in US pregnant women from the National Health and Nutrition Examination Survey (NHANES), 1999–2006. Am J Clin Nutr. 2011;93:1312–1320.
11. Peña-Rosas JP, De-Regil LM, Dowswell T, et al. Daily oral iron supplementation during pregnancy. Cochrane Database Syst Rev. 2012;12:CD004736.
12. Bühling KJ, Grajecki D., The effect of micronutrient supplements on female fertility. Curr Opin Obstet Gynecol. 2013;25:173–180.
13. World Health Organization. Optimal serum and red blood cell folate concentrations in women of reproductive age for prevention of neural tube defects. Geneva:WHO; 2015.
14. Zappacosta B, Persichilli S, Iacoviello L, et al. Folate, vitamin B12 and homocysteine status in an Italian blood donor population. Nutr Metab Cardiovasc Dis. 2013;23:473–480.
15. Dhonukshe-Rutten RA, de Vries JH, de Bree A, et al. Dietary intake and status of folate and vitamin B12 and their association with homocysteine and cardiovascular disease in European populations. Eur J Clin Nutr. 2009;63:18–30.
16. Selhub J, Jacques PF, Rosenberg IH, et al. Serum total homocysteine concentrations in the third National Health and Nutrition Examination Survey (1991–1994):population reference ranges and contribution of vitamin status to high serum concentrations. Ann Intern Med. 1999;131:331–339.
17. World Health Organization. Serum retinol concentrations for determining the prevalence of vitamin A deficiency in populations. Vitamin and mineral nutrition information system. Geneva:WHO; 2011.
18. Kratz A, Ferraro M, Sluss PM, et al. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Laboratory reference values. N Engl J Med. 2004;351:1548–1563.
19. Saxena R., Bedside obstetrics and gynecology. 2nd ed. New Delhi:Jaypee Brothers Medical Publishers; 2014.
20. World Health Organization. Serum and red blood cell folate concentrations for assessing folate status in populations. Vitamin and mineral nutrition information system. Geneva:WHO; 2012.
21. Daly LE, Kirke PN, Molloy A, et al. Folate levels and neural tube defects. Implications for prevention. JAMA. 1995;274:1698–1702.
22. Tsang BL, Devine OJ, Cordero AM, et al. Assessing the association between the methylenetetrahydrofolate reductase (MTHFR) 677C > T polymorphism and blood folate concentrations:a systematic review and meta-analysis of trials and observational studies. Am J Clin Nutr. 2015;101:1286–1294.
23. Wilcken B, Bamforth F, Li Z, et al. Geographical and ethnic variation of the 677C > T allele of 5,10 methylenetetrahydrofolate reductase (MTHFR):findings from over 7000 newborns from 16 areas worldwide. J Med Genet. 2003;40:619–625.
24. Mastroiacovo P, Nilsen RM, Leoncini E, et al. Prevalence of maternal preconception risk factors:an Italian multicenter survey. Ital J Pediatr. 2014;40:91.
25. Kaehler ST, Baumgartner H, Jeske M, et al. Prevalence of hypovitaminosis D and folate deficiency in healthy young female Austrian students in a health care profession. Eur J Nutr. 2012;51:1021–1031.
26. Tinker SC, Hamner HC, Qi YP, et al. U.S. women of childbearing age who are at possible increased risk of a neural tube defect-affected pregnancy due to suboptimal red blood cell folate concentrations, National Health and Nutrition Examination Survey 2007 to 2012. Birth Defects Res A Clin Mol Teratol. 2015;103:517–526.
27. Cafolla A, Dragoni F, Girelli G, et al. Effect of folic acid and vitamin C supplementation on folate status and homocysteine level:a randomised controlled trial in Italian smoker-blood donors. Atherosclerosis. 2002;163:105–111.
28. Lussana F, Zighetti ML, Bucciarelli P, et al. Blood levels of homocysteine, folate, vitamin B6 and B12 in women using oral contraceptives compared to non-users. Thromb Res. 2003;112:37–41.
29. Sofi F, Vecchio S, Giuliani G, et al. Dietary habits, lifestyle and cardiovascular risk factors in a clinically healthy Italian population:the ‘Florence’ diet is not Mediterranean. Eur J Clin Nutr. 2005;59:584–591.
30. Lauria L, Lamberti A, Buoncristiano M, et al. [Pre- and post-natal assistance:promotion and assessment of operational models quality. The 2008–2009 and 2010–2011 surveys]. Rapporti ISTISAN. 2012;12/39:iii. Italian.
31. Gaskins AJ, Afeiche MC, Wright DL, et al. Dietary folate and reproductive success among women undergoing assisted reproduction. Obstet Gynecol. 2014;124:801–809.
32. Mojtabai R., Body mass index and serum folate in childbearing age women. Eur J Epidemiol. 2004;19:1029–1036.
33. Wilson RD, Johnson JA, Wyatt P, et al. Pre-conceptional vitamin/folic acid supplementation 2007:the use of folic acid in combination with a multivitamin supplement for the prevention of neural tube defects and other congenital anomalies. J Obstet Gynaecol Can. 2007;29:1003–1026.
34. West KP., Extent of vitamin A deficiency among preschool children and women of reproductive age. J Nutr. 2002;132:2857S–2866S.
35. Yang C, Chen J, Liu Z, et al. Prevalence and influence factors of vitamin A deficiency of Chinese pregnant women. Nutr J. 2016;15:12.
36. Andres RL, Day MC., Perinatal complications associated with maternal tobacco use. Semin Neonatol. 2000;5:231–241.
37. Parisi F, Berti C, Mandò C, et al. Effects of different regimens of iron prophylaxis on maternal iron status and pregnancy outcome:a randomized control trial. J Matern Fetal Neonatal Med. Forthcoming. [cited 2016 Sep 2]:[6 p.]. Author's manuscript available at http://dx.doi.org/10.1080/14767058.2016.1224841
38. Milman N. Iron and pregnancy–a delicate balance. Ann Hematol. 2006;85:559–565.