Polymorphism g80a in the reduced folate carrier gene and its relationship to survival and risk of relapse in acute lymphoblastic leukemia

Journal of Investigative Medicine

Volumn 60, Issue 7, 2012, Pages 1064-1067

  Leyva Vázquez, Marco Antonio ^a   Organista Nava, Jorge ^b   Gómez Gómez, Yazmín ^b   Contreras Quiroz, Adriana ^a   Flores Alfaro, Eugenia ^a   Illades Aguiar, Berenice ^a  

^a Guerrero State University   (Mexico)

^b INSTITUTO DE FISIOLOGÍA CELULAR   (Mexico)

Author keywords

Acute lymphoblastic leukemia; G80A polymorphism; Reduced folate carrier; Risk of relapse

Indexed keywords

CYTARABINE; FOLINIC ACID; HYDROCORTISONE; METHOTREXATE; REDUCED FOLATE CARRIER;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; AGE DISTRIBUTION; ARTICLE; CANCER CHEMOTHERAPY; CANCER PATIENT; CANCER RECURRENCE; CANCER SURVIVAL; CHILD; DNA POLYMORPHISM; FEMALE; GENETIC ASSOCIATION; GENOTYPE; HUMAN; INFANT; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MEXICO; MORTALITY; OVERALL SURVIVAL; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RETROSPECTIVE STUDY; RISK FACTOR; SCHOOL CHILD; TREATMENT OUTCOME; TREATMENT RESPONSE; LEUKEMIA RELAPSE; MORTALITY RISK;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INFANT; KAPLAN-MEIER ESTIMATE; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; RECURRENCE; REDUCED FOLATE CARRIER PROTEIN; RISK FACTORS;

EID: 85006165378     PISSN: 17088267     EISSN: 17088267     Source Type: Journal    
DOI: 10.2310/JIM.0b013e31826803c1     Document Type: Article

References (14)

1. Mejia-Arangure J, Bonilla M, Lorenzana R, et al. Incidence of leukemias in children from El Salvador and Mexico City between 1996 and 2000: population-based data. BMC Cancer. 2005;5:33-38.
2. Salud/INEGI, S.d., Fuente: base de datos de defunciones INEGI/Secretaria de Salud, Direccio'n General de Informacio'n en Salud, Me'xico. Febrary, 2006. Available at: http://www.inegi.org.mx/. Accessed April 29, 2008.
3. Sierra EE, Goldman ID. Recent advances in the understanding of the mechanism of membrane transport of folates and antifolates. Semin Oncol. 1999;26:11-23.
4. Laverdiere C, Chiasson S, Costea I,et al. Polymorphism G80A in the reduced folate carrier gene and its relationship to methotrexate plasma levels and outcome of childhood acute lymphoblastic leukemia. Blood. 2002;100:3832-3834.
5. Seguro-popular: Secretaria de Salud/Seguro Popular. August 03, 2007.
6. Available at: http://seguropopular.col.gob.mx:81/repss/protocolos/6LLAEH. pdf. Accessed May 4, 2009.
7. Gómez-Gómez Y, Organista-Nava J, Saavedra-Herrera MV, et al. Survival and risk of relapse of acute lymphoblastic leukemia in Mexican population is affected by dihydrofolate reductase gene polymorphisms. Experimental and Therapeutic Medicine. 2012;3:665-672.
8. Dervieux T, Furst D, Lein DO, et al. Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis. Arthritis Rheum. 2004;50:2766-2774.
9. Organista-Nava J, Gómez-Gómez Y, Saavedra-Herrera MV, et al. Polymorphisms of the F-glutamyl hydrolase gene and risk of relapse to acute lymphoblastic leukemia in Mexico. Leukemia Res. 2010;34:728-732.
10. INMEGEN. Mapa gene'tico de los mexicanos. May, 2009 Available at: http://www.inmegen.gob.mx/. Accessed June 18, 2009.
11. Silva-Zolezzi I, Hidalgo-Miranda A, Estrada-Gil J, et al. Analysis of genomic diversity in Mexican Mestizo populations to develop genomic medicine in Mexico. Proc Natl Acad Sci U S A. 2009;106:8611.
12. Morin I, Devlin AM, Leclerc D, et al. Evaluation of genetic variants in the reduced folate carrier and in glutamate carboxypeptidase II for spina bifida risk. Mol Genet Metab. 2003;79:197-200.
13. Levy AS, Sather HN, Steinherz PG, et al. Reduced folate carrier and dihydrofolate reductase expression in acute lymphocytic leukemia may predict outcome: a Children's Cancer Group study. J Pediatr Hematol Oncol. 2003;25:688-695.
14. Jansen G, Mauritz R, Drori S, et al. A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance. J Biol Chem. 1998;273:30189-30198.