Transfusion: -80°C frozen blood products are safe and effective in military casualty care

PLoS ONE

Volumn 11, Issue 12, 2016, Pages

  Noorman, Femke ^a   Van Dongen, Thijs T C F ^b   Plat, Marie Christine J ^c   Badloe, John F ^a   Hess, John R ^d   Hoencamp, Rigo ^e  

^a Sanquin Bloedbank Regio Zuidwest Rotterdam   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c Military Health Care Expertise and Coordination Center   (Netherlands)

^d UNIVERSITY OF WASHINGTON   (United States)

^e LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AFGHANISTAN; ARMY; ARTICLE; BATTLE INJURY; BLEEDING; BLOOD GROUP ABO INCOMPATIBILITY; BLOOD SAFETY; BLOOD STORAGE; BLOOD TRANSFUSION; BLOOD TRANSFUSION REACTION; CHILD; CLINICAL EFFECTIVENESS; CLINICAL PROTOCOL; CONTROLLED STUDY; CRYOPRESERVATION; ERYTHROCYTE TRANSFUSION; FEMALE; HOSPITAL MORTALITY; HUMAN; INJURY SEVERITY; MAJOR CLINICAL STUDY; MALE; MILITARY MEDICINE; MORTALITY; NETHERLANDS; OUTCOME ASSESSMENT; PATIENT SAFETY; PLASMA TRANSFUSION; RETROSPECTIVE STUDY; THROMBOCYTE TRANSFUSION; ADOLESCENT; BLOOD GROUP ABO SYSTEM; COLD; METABOLISM; PLASMA; PROCEDURES; SOLDIER; WOUNDS AND INJURIES; YOUNG ADULT;

BLOOD GROUP ABO SYSTEM;

ABO BLOOD-GROUP SYSTEM; ADOLESCENT; ADULT; AFGHANISTAN; BLOOD PRESERVATION; BLOOD SAFETY; BLOOD TRANSFUSION; CHILD; COLD TEMPERATURE; CRYOPRESERVATION; ERYTHROCYTE TRANSFUSION; FEMALE; HOSPITAL MORTALITY; HUMANS; MALE; MILITARY MEDICINE; MILITARY PERSONNEL; NETHERLANDS; PLASMA; PLATELET TRANSFUSION; RETROSPECTIVE STUDIES; WOUNDS AND INJURIES; YOUNG ADULT;

EID: 85006060213     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0168401     Document Type: Article

References (63)

1. Hakre S, Peel SA, O'Connell RJ, Sanders-Buell EE, Jagodzinski LL, Eggleston JC, et al. Transfusiontransmissible viral infections among US military recipients of whole blood and platelets during Operation Enduring Freedom and Operation Iraqi Freedom. Transfusion. 2011; 51(3):473-85. doi: 10.1111/j. 1537-2995.2010.02906.x PMID: 20946199
2. Chandler MH, Roberts M, Sawyer M, Myers G. The US military experience with fresh whole blood during the conflicts in Iraq and Afghanistan. Semin Cardiothorac Vasc Anesth. 2012; 16(3):153-9. doi: 10.1177/1089253212452344 PMID: 22927704
3. Beckett A, Callum J, da Luz LT, Schmid J, Funk C, Glassberg E, et al. Fresh whole blood transfusion capability for Special Operations Forces. Can J Surg. 2015; 58(3 Suppl 3):S153-6. doi: 10.1503/cjs. 012614 PMID: 26100776
4. Strandenes G, Berseus O, Cap AP, Hervig T, Reade M, Prat N, et al. Low titer group O whole blood in emergency situations. Shock. 2014; 41 Suppl 1:70-5.
5. Olszewski A, Korzeniewski K, Lass A. Selected epidemiological aspects of fresh whole blood application in the Polish Field Hospital in Afghanistan. Int Marit Health. 2014; 65(1):23-7. doi: 10.5603/MH. 2014.0006 PMID: 24677124
6. Lelkens CC, Koning JG, de Kort B, Floot IB, Noorman F. Experiences with frozen blood products in the Netherlands military. Transfus Apher Sci. 2006; 34(3):289-98. doi: 10.1016/j.transci.2005.11.008 PMID: 16815757
7. Holley A, Marks DC, Johnson L, Reade MC, Badloe JF, Noorman F. Frozen blood products: clinically effective and potentially ideal for remote Australia. Anaesth Intensive Care. 2013; 41(1):10-9. PMID: 23362885
8. Henkelman S, Noorman F, Badloe JF, Lagerberg JW. Utilization and quality of cryopreserved red blood cells in transfusion medicine. Vox Sang. 2015; 108(2):103-12. doi: 10.1111/vox.12218 PMID: 25471135
9. Neuhaus SJ, Wishaw K, Lelkens C. Australian experience with frozen blood products on military operations. Med J Aust. 2010; 192(4):203-5. PMID: 20170457
10. Ellis AM, Smith F. Management of IED injury: A case reflective of contemporary treatment and understanding of resources required to safe life. ADF Health. 2010; 11(1):25-33.
11. Hess JR, Holcomb JB. Transfusion practice in military trauma. Transfus Med. 2008; 18(3):143-50. doi: 10.1111/j.1365-3148.2008.00855.x PMID: 18598276
12. van Dongen TT, Idenburg FJ, Tan EC, Rasmussen TE, Hamming JF, Leenen LP, et al. Combat related vascular injuries: Dutch experiences from a role 2 MTF in Afghanistan. Injury. 2015; 39(10):epub 2015 Sep 8.
13. Idenburg FJ, van Dongen TT, Tan EC, Hamming JH, Leenen LP, Hoencamp R. Pediatric Surgical Care in a Dutch Military Hospital in Afghanistan. World J Surg. 2015; 39(10):2413-21. doi: 10.1007/s00268-015-3136-z PMID: 26156845
14. Hoencamp R, Idenburg FJ, Hamming JF, Tan EC. Incidence and epidemiology of casualties treated at the Dutch role 2 enhanced medical treatment facility at multi national base Tarin Kowt, Afghanistan in the period 2006-2010. World J Surg. 2014; 38(7):1713-8. doi: 10.1007/s00268-014-2462-x PMID: 24481991
15. Hoencamp R, Huizinga EP, van Dongen TT, Idenburg FJ, Ramasamy A, Leenen LP, et al. Impact of explosive devices in modern armed conflicts: in-depth analysis of Dutch battle casualties in Southern Afghanistan. World J Surg. 2014; 38(10):2551-7. doi: 10.1007/s00268-014-2645-5 PMID: 24844658
16. Valeri CR, Pivacek LE, Gray AD, Cassidy GP, Leavy ME, Dennis RC, et al. The safety and therapeutic effectiveness of human red cells stored at -80 degrees C for as long as 21 years. Transfusion. 1989; 29 (5):429-37. PMID: 2734823
17. Valeri CR, Ragno G, Pivacek LE, Cassidy GP, Srey R, Hansson-Wicher M, et al. An experiment with glycerol-frozen red blood cells stored at -80 degrees C for up to 37 years. Vox Sang. 2000; 79(3):168-74 doi: 31236 PMID: 11111236
18. Valeri CR, Ragno G. The effect of storage of fresh-frozen plasma at -80 degrees C for as long as 14 years on plasma clotting proteins. Transfusion. 2005; 45(11):1829-30. doi: 10.1111/j.1537-2995.2005. 00614.x PMID: 16271115
19. Noorman F, Strelitski R, Badloe JF. Frozen Platelets Can Be Stored For 4 Years at -80°C Without Affecting In Vitro Recovery, Morphology, Receptor Expression And Coagulation Profile. Transfusion. 2014; 54(Suppl):74A.
20. Schreiber MA, McCully BH, Holcomb JB, Robinson BR, Minei JP, Stewart R, et al. Transfusion of cryopreserved packed red blood cells is safe and effective after trauma: a prospective randomized trial. Ann Surg. 2015; 262(3):426-33; discussion 32-3. doi: 10.1097/SLA.0000000000001404 PMID: 26258311
21. Spinella PC, Dunne J, Beilman GJ, O'Connell RJ, Borgman MA, Cap AP, et al. Constant challenges and evolution of US military transfusion medicine and blood operations in combat. Transfusion. 2012; 52(5):1146-53. doi: 10.1111/j.1537-2995.2012.03594.x PMID: 22575063
22. Bohonek M, Petras M, Turek I, Urbanova J, Hradek T, Chmatal P, et al. Quality evaluation of frozen apheresis red blood cell storage with 21-day postthaw storage in additive solution 3 and saline-adenineglucose-mannitol: biochemical and chromium-51 recovery measures. Transfusion. 2010; 50(5):1007-13 doi: 10.1111/j.1537-2995.2009.02532.x PMID: 20051061
23. Cotton BA, Gunter OL, Isbell J, Au BK, Robertson AM, Morris JA Jr., et al. Damage control hematology: the impact of a trauma exsanguination protocol on survival and blood product utilization. J Trauma. 2008; 64(5):1177-82; discussion 82-3. doi: 10.1097/TA.0b013e31816c5c80 PMID: 18469638
24. Shaz BH, Dente CJ, Nicholas J, MacLeod JB, Young AN, Easley K, et al. Increased number of coagulation products in relationship to red blood cell products transfused improves mortality in trauma patients. Transfusion. 2010; 50(2):493-500. doi: 10.1111/j.1537-2995.2009.02414.x PMID: 19804568
25. Johansson PI, Stensballe J. Effect of Haemostatic Control Resuscitation on mortality in massively bleeding patients: a before and after study. Vox Sang. 2009; 96(2):111-8. doi: 10.1111/j.1423-0410.2008.01130.x PMID: 19152603
26. Pidcoke HF, Aden JK, Mora AG, Borgman MA, Spinella PC, Dubick MA, et al. Ten-year analysis of transfusion in Operation Iraqi Freedom and Operation Enduring Freedom: increased plasma and platelet use correlates with improved survival. J Trauma Acute Care Surg. 2012; 73(6 Suppl 5):S445-52. doi: 10.1097/TA.0b013e3182754796 PMID: 23192068
27. Borgman MA, Spinella PC, Perkins JG, Grathwohl KW, Repine T, Beekley AC, et al. The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital. J Trauma. 2007; 63(4):805-13. doi: 10.1097/TA.0b013e3181271ba3 PMID: 18090009
28. Perkins JG, Cap AP, Spinella PC, Blackbourne LH, Grathwohl KW, Repine TB, et al. An evaluation of the impact of apheresis platelets used in the setting of massively transfused trauma patients. J Trauma. 2009; 66(4 Suppl):S77-84; discussion S-5. doi: 10.1097/TA.0b013e31819d8936 PMID: 19359974
29. Perkins JG, Cap AP, Spinella PC, Shorr AF, Beekley AC, Grathwohl KW, et al. Comparison of platelet transfusion as fresh whole blood versus apheresis platelets for massively transfused combat trauma patients (CME). Transfusion. 2011; 51(2):242-52. doi: 10.1111/j.1537-2995.2010.02818.x PMID: 20796254
30. Holcomb JB, Tilley BC, Baraniuk S, Fox EE, Wade CE, Podbielski JM, et al. Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial. JAMA. 2015; 313(5):471-82. doi: 10.1001/jama.2015.12 PMID: 25647203
31. Inaba K, Branco BC, Rhee P, Blackbourne LH, Holcomb JB, Spinella PC, et al. Impact of the duration of platelet storage in critically ill trauma patients. J Trauma. 2011; 71(6):1766-73; discussion 73-4. doi: 10.1097/TA.0b013e31823bdbf9 PMID: 22182887
32. Torrance HD, Vivian ME, Brohi K, Prowle JR, Pearse RM, Owen HC, et al. Changes in gene expression following trauma are related to the age of transfused packed red blood cells. J Trauma Acute Care Surg. 2015; 78(3):535-42. doi: 10.1097/TA.0000000000000534 PMID: 25710424
33. Muller MC, van Stein D, Binnekade JM, van Rhenen DJ, Vlaar AP. Low-risk transfusion-related acute lung injury donor strategies and the impact on the onset of transfusion-related acute lung injury: a metaanalysis. Transfusion. 2015; 55(1):164-75. doi: 10.1111/trf.12816 PMID: 25135630
34. Valeri CR. Hemostatic effectiveness of liquid-preserved and previously frozen human platelets. N Engl J Med. 1974; 290(7):353-8. doi: 10.1056/NEJM197402142900702 PMID: 4810115
35. Slichter SJ, Jones M, Ransom J, Gettinger I, Jones MK, Christoffel T, et al. Review of in vivo studies of dimethyl sulfoxide cryopreserved platelets. Transfus Med Rev. 2014; 28(4):212-25. doi: 10.1016/j. tmrv.2014.09.001 PMID: 25439164
36. Mittag D, Sran A, Chan KS, Boland MP, Bandala-Sanchez E, Huet O, et al. Stored red blood cell susceptibility to in vitro transfusion-associated stress conditions is higher after longer storage and increased by storage in saline-adenine-glucose-mannitol compared to AS-1. Transfusion. 2015; 55 (9):2197-206. doi: 10.1111/trf.13138 PMID: 25968419
37. Sparrow RL. Red blood cell storage duration and trauma. Transfus Med Rev. 2015; 29(2):120-6. doi: 10.1016/j.tmrv.2014.09.007 PMID: 25573415
38. Stanworth SJ, Morris TP, Gaarder C, Goslings JC, Maegele M, Cohen MJ, et al. Reappraising the concept of massive transfusion in trauma. Crit Care. 2010; 14(6):R239. doi: 10.1186/cc9394 PMID: 21192812
39. Snyder CW, Weinberg JA, McGwin G Jr., Melton SM, George RL, Reiff DA, et al. The relationship of blood product ratio to mortality: survival benefit or survival bias? J Trauma. 2009; 66(2):358-62; discussion 62-4. doi: 10.1097/TA.0b013e318196c3ac PMID: 19204508
40. Morton AP, Moore EE, Wohlauer MV, Lo K, Silliman CC, Burlew CC, et al. Revisiting early postinjury mortality: are they bleeding because they are dying or dying because they are bleeding? J Surg Res. 2013; 179(1):5-9. doi: 10.1016/j.jss.2012.05.054 PMID: 23138049
41. Kautza BC, Cohen MJ, Cuschieri J, Minei JP, Brackenridge SC, Maier RV, et al. Changes in massive transfusion over time: an early shift in the right direction? J Trauma Acute Care Surg. 2012; 72(1):106-11 doi: 10.1097/TA.0b013e3182410a3c PMID: 22310123
42. Markov NP, Du Bose JJ, Scott D, Propper BW, Clouse WD, Thompson B, et al. Anatomic distribution and mortality of arterial injury in the wars in Afghanistan and Iraq with comparison to a civilian benchmark. J Vasc Surg. 2012; 56(3):728-36. doi: 10.1016/j.jvs.2012.02.048 PMID: 22795520
43. Hoencamp R, Vermetten E, Tan EC, Putter H, Leenen LP, Hamming JF. Systematic review of the prevalence and characteristics of battle casualties from NATO coalition forces in Iraq and Afghanistan. Injury. 2014; 45(7):1028-34. doi: 10.1016/j.injury.2014.02.012 PMID: 24878294
44. Langan NR, Eckert M, Martin MJ. Changing patterns of in-hospital deaths following implementation of damage control resuscitation practices in US forward military treatment facilities. JAMA Surg. 2014; 149(9):904-12. doi: 10.1001/jamasurg.2014.940 PMID: 25029432
45. Hirshberg A, Dugas M, Banez EI, Scott BG, Wall MJ Jr., Mattox KL. Minimizing dilutional coagulopathy in exsanguinating hemorrhage: a computer simulation. J Trauma. 2003; 54(3):454-63. doi: 10.1097/01. TA.0000053245.08642.1F PMID: 12634523
46. Khuri SF, Healey N, MacGregor H, Barnard MR, Szymanski IO, Birjiniuk V, et al. Comparison of the effects of transfusions of cryopreserved and liquid-preserved platelets on hemostasis and blood loss after cardiopulmonary bypass. J Thorac Cardiovasc Surg. 1999; 117(1):172-83; discussion 83-4. PMID: 9869772
47. Johnson L, Coorey CP, Marks DC. The hemostatic activity of cryopreserved platelets is mediated by phosphatidylserine-expressing platelets and platelet microparticles. Transfusion. 2014; 54(8):1917-26. doi: 10.1111/trf.12578 PMID: 24527873
48. Johnson L, Reade MC, Hyland RA, Tan S, Marks DC. In vitro comparison of cryopreserved and liquid platelets: potential clinical implications. Transfusion. 2014.
49. Raynel S, Padula MP, Marks DC, Johnson L. Cryopreservation alters the membrane and cytoskeletal protein profile of platelet microparticles. Transfusion. 2015; 55(10):2422-32. doi: 10.1111/trf.13165 PMID: 26046916
50. Noorman F, Strelitski R., Badloe JF. 80°C Frozen platelets are activated compared to 24-hour liquid stored platelets and quality of frozen platelets is unaffected by a quick preparation method (15 min) which can be used to prepare platelets for the early treatment of trauma patients in military theatre. Transfusion. 2012; 52(Suppl S3):33A.
51. Windelov NA, Johansson PI, Sorensen AM, Perner A, Wanscher M, Larsen CF, et al. Low level of procoagulant platelet microparticles is associated with impaired coagulation and transfusion requirements in trauma patients. J Trauma Acute Care Surg. 2014; 77(5):692-700. doi: 10.1097/TA. 0000000000000437 PMID: 25494419
52. Matijevic N, Wang YW, Holcomb JB, Kozar R, Cardenas JC, Wade CE. Microvesicle phenotypes are associated with transfusion requirements and mortality in subjects with severe injuries. J Extracell Vesicles. 2015; 4:29338. doi: 10.3402/jev.v4.29338 PMID: 26689982
53. Valeri CR, Ragno G. The survival and function of baboon red blood cells, platelets, and plasma proteins: a review of the experience from 1972 to 2002 at the Naval Blood Research Laboratory, Boston, Massachusetts. Transfusion. 2006; 46(8 Suppl):1S-42S. doi: 10.1111/j.1537-2995.2006.00922.x PMID: 16889560
54. Dumont LJ, Cancelas JA, Dumont DF, Siegel AH, Szczepiorkowski ZM, Rugg N, et al. A randomized controlled trial evaluating recovery and survival of 6% dimethyl sulfoxide-frozen autologous platelets in healthy volunteers. Transfusion. 2013; 53(1):128-37. doi: 10.1111/j.1537-2995.2012.03735.x PMID: 22671278
55. Allen CJ, Murray CR, Meizoso JP, Ray JJ, Teisch LF, Ruiz XD, et al. Coagulation Profile Changes Due to Thromboprophylaxis and Platelets in Trauma Patients at High-Risk for Venous Thromboembolism. Am Surg. 2015; 81(7):663-8. PMID: 26140884
56. Harr JN, Moore EE, Chin TL, Ghasabyan A, Gonzalez E, Wohlauer MV, et al. Platelets are dominant contributors to hypercoagulability after injury. J Trauma Acute Care Surg. 2013; 74(3):756-62; discussion 62-5. doi: 10.1097/TA.0b013e3182826d7e PMID: 23425732
57. Pommerening MJ, Rahbar E, Minei K, Holcomb JB, Wade CE, Schreiber MA, et al. Splenectomy is associated with hypercoagulable thrombelastography values and increased risk of thromboembolism. Surgery. 2015; 158(3):618-26. doi: 10.1016/j.surg.2015.06.014 PMID: 26209572
58. Thiels CA, Aho JM, Zietlow SP, Jenkins DH. Use of unmanned aerial vehicles for medical product transport. Air Med J. 2015; 34(2):104-8. doi: 10.1016/j.amj.2014.10.011 PMID: 25733117
59. Hess JR, Hiippala S. Optimizing the use of blood products in trauma care. Crit Care. 2005; 9 Suppl 5: S10-4.
60. Stubbs JR, Zielinski MD, Jenkins D. The state of the science of whole blood: lessons learned at Mayo Clinic. Transfusion. 2016; 56 Suppl 2:S173-81.
61. Reade MC, Marks DC, Johnson L, Irving DO, Holley AD. Frozen platelets for rural Australia: the CLIP trial. Anaesth Intensive Care. 2013; 41(6):804-5. PMID: 24180724
62. Slichter SJ, Dumont DF, Cancelas JA. Phase 1 Safety Study of Dimethyl Sulfoxide Cryopreserved Platelets (CPP1-05). Clinical Trialsgov Identifier:NCT02078284. 2014.
63. Reade MC. A pilot multicentre blinded randomised controlled clinical trial of frozen platelets vs. conventional liquid-stored platelets for the management of post-surgical bleeding. Trial ID: ACTRN12612001261808. 2012.