Left ventricular deformation at rest predicts exercise-induced elevation in pulmonary artery wedge pressure in patients with unexplained dyspnoea

European Journal of Heart Failure

Volumn 19, Issue 1, 2017, Pages 101-110

  Biering Sørensen, Tor ^a,b   Santos, Mário ^c   Rivero, Jose ^a   McCullough, Shane D ^a   West, Erin ^a   Opotowsky, Alexander R ^a,d   Waxman, Aaron B ^a   Systrom, David M ^a   Shah, Amil M ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c University of Porto   (Portugal)

^d BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

2D Speckle tracking echocardiography; Dyspnoea; Heart failure with preserved ejection fraction; Invasive cardiopulmonary stress testing; Left ventricular filling pressure; Myocardial deformation

Indexed keywords

ADULT; ARTICLE; CARDIOPULMONARY EXERCISE TEST; CARDIOVASCULAR PARAMETERS; CIRCUMFERENTIAL STRAIN; CIRCUMFERENTIAL STRAIN TO LONGITUDINAL STRAIN RATIO; DYSPNEA; ECHOCARDIOGRAPHY; FEMALE; HEART CATHETERIZATION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART STROKE VOLUME; HEMODYNAMIC MONITORING; HUMAN; LEFT VENTRICULAR DEFORMATION; LONGITUDINAL STRAIN; LUNG WEDGE PRESSURE; MAJOR CLINICAL STUDY; MALE; PREDICTIVE VALUE; PRIORITY JOURNAL; PULMONARY HYPERTENSION; PULMONARY VEIN; PULMONARY VENOUS HYPERTENSION; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY; AGED; DIAGNOSTIC IMAGING; DIASTOLE; EXERCISE; EXERCISE TEST; HEART FAILURE; HEART VENTRICLE; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; REST; SYSTOLE;

ADULT; AGED; CARDIAC CATHETERIZATION; DIASTOLE; DYSPNEA; ECHOCARDIOGRAPHY; EXERCISE; EXERCISE TEST; FEMALE; HEART FAILURE; HEART VENTRICLES; HUMANS; MALE; MIDDLE AGED; PULMONARY WEDGE PRESSURE; REST; STROKE VOLUME; SYSTOLE;

EID: 85006025219     PISSN: 13889842     EISSN: 18790844     Source Type: Journal    
DOI: 10.1002/ejhf.659     Document Type: Article

References (33)

1. Shah AM, Solomon SD. Myocardial deformation imaging: current status and future directions. Circulation 2012;125:e244–e248.
2. Kuznetsova T, Herbots L, Richart T, D'hooge J, Thijs L, Fagard RH, Herregods M-C, Staessen JA. Left ventricular strain and strain rate in a general population. Eur Heart J 2008;29:2014–2023.
3. Narayanan A, Aurigemma GP, Chinali M, Hill JC, Meyer TE, Tighe DA. Cardiac mechanics in mild hypertensive heart disease: a speckle-strain imaging study. Circ Cardiovasc Imaging 2009;2:382–390.
4. Jensen MT, Sogaard P, Andersen HU, Bech J, Fritz Hansen T, Biering-Sørensen T, Jørgensen PG, Galatius S, Madsen JK, Rossing P, Jensen JS. Global longitudinal strain is not impaired in type 1 diabetes patients without albuminuria. JACC Cardiovasc Imaging 2015;8:400–410.
5. Nasir K, Rosen BD, Kramer HJ, Edvardsen T, Bluemke DA, Liu K, Lima JA. Regional left ventricular function in individuals with mild to moderate renal insufficiency: the Multi-Ethnic Study of Atherosclerosis. Am Heart J 2007;153:545–551.
6. Wong CY, O'Moore-Sullivan T, Leano R, Byrne N, Beller E, Marwick TH. Alterations of left ventricular myocardial characteristics associated with obesity. Circulation 2004;110:3081–3087.
7. Kraigher-Krainer E, Shah AM, Gupta DK, Santos A, Claggett B, Pieske B, Zile MR, Voors AA, Lefkowitz MP, Packer M, McMurray JJ, Solomon SD, PARAMOUNT Investigators. Impaired systolic function by strain imaging in heart failure with preserved ejection fraction. J Am Coll Cardiol 2014;63:447–456.
8. Shah AM, Claggett B, Sweitzer NK, Shah SJ, Anand IS, Liu L, Pitt B, Pfeffer MA, Solomon SD. Prognostic importance of impaired systolic function in heart failure with preserved ejection fraction and the impact of spironolactone. Circulation 2015;132:402–414.
9. Tan YT, Wenzelburger F, Lee E, Heatlie G, Leyva F, Patel K, Frenneaux M, Sanderson JE. The pathophysiology of heart failure with normal ejection fraction: exercise echocardiography reveals complex abnormalities of both systolic and diastolic ventricular function involving torsion, untwist, and longitudinal motion. J Am Coll Cardiol 2009;54:36–46.
10. Borlaug BA, Olson TP, Lam CS, Flood KS, Lerman A, Johnson BD, Redfield MM. Global cardiovascular reserve dysfunction in heart failure with preserved ejection fraction. J Am Coll Cardiol 2010;56:845–854.
11. Santos M, Opotowsky AR, Shah AM, Tracy J, Waxman AB, Systrom DM. Central cardiac limit to aerobic capacity in patients with exertional pulmonary venous hypertension: implications for heart failure with preserved ejection fraction. Circ Heart Fail 2015;8:278–285.
12. Borlaug BA, Nishimura RA, Sorajja P, Lam CS, Redfield MM. Exercise haemodynamics enhance diagnosis of early heart failure with preserved ejection fraction. Circ Heart Fail 2010;3:588–595.
13. Santos M, Rivero J, McCullough SD, West E, Opotowsky AR, Waxman AB, Systrom DM, Shah AM. E/e′ ratio in patients with unexplained dyspnea: lack of accuracy in estimating left ventricular filling pressure. Circ Heart Fail 2015;8:749–756.
14. Du Bois D, Du Bois EF. A formula to estimate the approximate surface area if height and weight be known. 1916. Nutrition 1989;5:303–311.
15. Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, Picard MH, Roman MJ, Seward J, Shanewise JS, Solomon SD, Spencer KT, Sutton MSJ, Stewart WJ. Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr 2005;18:1440–1463.
16. Nagueh SF, Appleton CP, Gillebert TC, Marino PN, Oh JK, Smiseth OA, Waggoner AD, Flachskampf FA, Pellikka PA, Evangelista A. Recommendations for the evaluation of left ventricular diastolic function by echocardiography. J Am Soc Echocardiogr 2009;22:107–133.
17. Shah AM, Cheng S, Skali H, Wu J, Mangion JR, Kitzman D, Matsushita K, Konety S, Butler KR, Fox ER, Cook N, Ni H, Coresh J, Mosley TH, Heiss G, Folsom AR, Solomon SD. Rationale and design of a multicenter echocardiographic study to assess the relationship between cardiac structure and function and heart failure risk in a biracial cohort of community-dwelling elderly persons: the Atherosclerosis Risk in Communities study. Circ Cardiovasc Imaging 2014;7:173–181.
18. Cuzick J. A Wilcoxon-type test for trend. Stat Med 1985;4:87–90.
19. Sengupta PP, Krishnamoorthy VK, Korinek J, Narula J, Vannan MA, Lester SJ, Tajik JA, Seward JB, Khandheria BK, Belohlavek M. Left ventricular form and function revisited: applied translational science to cardiovascular ultrasound imaging. J Am Soc Echocardiogr 2007;20:539–551.
20. Streeter DD, Spotnitz HM, Patel DP, Ross J, Sonnenblick EH. Fiber orientation in the canine left ventricle during diastole and systole. Circ Res 1969;24:339–347.
21. Reimer KA, Lowe JE, Rasmussen MM, Jennings RB. The wavefront phenomenon of ischemic cell death. 1. Myocardial infarct size vs duration of coronary occlusion in dogs. Circulation 1977;56:786–794.
22. Tops LF, Den Uijl DW, Delgado V, Marsan NA, Zeppenfeld K, Holman E, Wall EE van der, Schalij MJ, Bax JJ. Long-term improvement in left ventricular strain after successful catheter ablation for atrial fibrillation in patients with preserved left ventricular systolic function. Circ Arrhythm Electrophysiol 2009;2:249–257.
23. Biering-Sørensen T, Hoffmann S, Mogelvang R, Zeeberg Iversen A, Galatius S, Fritz-Hansen T, Bech J, Jensen JS. Myocardial strain analysis by 2-dimensional speckle tracking echocardiography improves diagnostics of coronary artery stenosis in stable angina pectoris. Circ Cardiovasc Imaging 2014;7:58–65.
24. Chung J, Abraszewski P, Yu X, Liu W, Krainik AJ, Ashford M, Caruthers SD, McGill JB, Wickline SA. Paradoxical increase in ventricular torsion and systolic torsion rate in type I diabetic patients under tight glycemic control. J Am Coll Cardiol 2006;47:384–390.
25. Biering-Sørensen T, Solomon SD. Assessing contractile function when ejection fraction is normal: a case for strain imaging. Circ Cardiovasc Imaging 2015;8:e004181.
26. Yip GW, Zhang Y, Tan PY, Wang M, Ho PY, Brodin LA, Sanderson JE. Left ventricular long-axis changes in early diastole and systole: impact of systolic function on diastole. Clin Sci Lond Engl 1979 2002;102:515–522.
27. Aurigemma GP, Silver KH, Priest MA, Gaasch WH. Geometric changes allow normal ejection fraction despite depressed myocardial shortening in hypertensive left ventricular hypertrophy. J Am Coll Cardiol 1995;26:195–202.
28. Henein MY, Gibson DG. Normal long axis function. Heart 1999;81:111–113.
29. Tan YT, Wenzelburger FW, Sanderson JE, Leyva F. Exercise-induced torsional dyssynchrony relates to impaired functional capacity in patients with heart failure and normal ejection fraction. Heart 2013;99:259–266.
30. Borlaug BA, Melenovsky V, Russell SD, Kessler K, Pacak K, Becker LC, Kass DA. Impaired chronotropic and vasodilator reserves limit exercise capacity in patients with heart failure and a preserved ejection fraction. Circulation 2006;114:2138–2147.
31. Wang J, Fang F, Yip GW, Sanderson JE, Feng W, Xie JM, Luo XX, Lee AP, Lam YY. Importance of chronotropic response and left ventricular long-axis function for exercise performance in patients with heart failure and preserved ejection fraction. Int J Cardiol 2016;202:339–343.
32. Leosco D, Parisi V, Pellegrino T, Pagano G, Femminella GD, Bevilacqua A, Paolillo S, Formisano R, Ferro G, Lucia C de, Prastaro M, Filardi PP, Cuocolo A, Rengo G, Ferrara N. Alterations of left ventricular deformation and cardiac sympathetic derangement in patients with systolic heart failure: a 3D speckle tracking echocardiography and cardiac (123)I-MIBG study. Eur J Nucl Med Mol Imaging 2015;42:1601–1611.
33. 123I-MIBG scintigraphy predicts an impairment in myocardial functional reserve during dobutamine stress in patients with idiopathic dilated cardiomyopathy. Eur J Nucl Med Mol Imaging 2013;40:262–270.