Two crystal structures reveal design for repurposing the C-Ala domain of human AlaRS

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 50, 2016, Pages 14300-14305

  Sun, Litao ^a   Song, Youngzee ^a   Blocquel, David ^a   Yang, Xiang Lei ^a   Schimmel, Paul ^a,b  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Appended domain; DNA binding; Evolution; Splice variant; Structural plasticity

Indexed keywords

ALANINE; AMINO ACID TRANSFER RNA LIGASE; DNA; ALANINE TRANSFER RNA LIGASE; ARCHAEAL PROTEIN;

AMINOACYLATION; ARCHAEOGLOBUS FULGIDUS; CARBOXY TERMINAL SEQUENCE; COMPARATIVE STUDY; CONFERENCE PAPER; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME STRUCTURE; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; ALTERNATIVE RNA SPLICING; AMINO ACID SEQUENCE; ANIMAL; BINDING SITE; CHEMISTRY; CONSERVED SEQUENCE; ENZYMOLOGY; GENETICS; KINETICS; METABOLISM; MOLECULAR EVOLUTION; MOLECULAR MODEL; PROTEIN DOMAIN; PROTEIN MULTIMERIZATION; PROTEIN QUATERNARY STRUCTURE; SEQUENCE HOMOLOGY; STATIC ELECTRICITY; X RAY CRYSTALLOGRAPHY;

ALANINE-TRNA LIGASE; ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; ARCHAEAL PROTEINS; ARCHAEOGLOBUS FULGIDUS; BINDING SITES; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; DNA; EVOLUTION, MOLECULAR; HUMANS; KINETICS; MODELS, MOLECULAR; PROTEIN DOMAINS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; SEQUENCE HOMOLOGY, AMINO ACID; STATIC ELECTRICITY;

EID: 85005950075     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1617316113     Document Type: Article

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