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Volumn 30, Issue 1, 2017, Pages 12-20

Managing nonalcoholic fatty liver disease in atients living with HIV

Author keywords

HIV; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Treatment

Indexed keywords

ANTIRETROVIRAL THERAPY; DIET; DISEASE COURSE; DYSLIPIDEMIA; ELASTOGRAPHY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFLAMMATION; INSULIN RESISTANCE; LIFESTYLE MODIFICATION; LIVER FIBROSIS; LIVER TOXICITY; METABOLIC SYNDROME X; MORBIDITY; MORTALITY; NONALCOHOLIC FATTY LIVER; OXIDATIVE STRESS; PATHOGENESIS; PATHOPHYSIOLOGY; PREVALENCE; REVIEW; RISK FACTOR; WEIGHT REDUCTION; COMPLICATION; FATTY LIVER;

EID: 85004025706     PISSN: 09517375     EISSN: 14736527     Source Type: Journal    
DOI: 10.1097/QCO.0000000000000344     Document Type: Review
Times cited : (17)

References (65)
  • 1
    • 79960029926 scopus 로고    scopus 로고
    • Systematic review: The epidemiology and natural history of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis in adults
    • Vernon G, Baranova A, Younossi ZM. Systematic review: the epidemiology and natural history of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis in adults. Aliment Pharmacol Ther 2011; 34:274-285.
    • (2011) Aliment Pharmacol Ther , vol.34 , pp. 274-285
    • Vernon, G.1    Baranova, A.2    Younossi, Z.M.3
  • 2
    • 84861591910 scopus 로고    scopus 로고
    • The diagnosis and management of nonalcoholic fatty liver disease: Practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology
    • Chalasani N, Younossi Z, Lavine JE, et al. The diagnosis and management of nonalcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology. Gastroenterology 2012; 142:1592-1609.
    • (2012) Gastroenterology , vol.142 , pp. 1592-1609
    • Chalasani, N.1    Younossi, Z.2    Lavine, J.E.3
  • 3
    • 84976479130 scopus 로고    scopus 로고
    • Global epidemiology of nonalcoholic fatty liver disease - Meta-analytic assessment of prevalence, incidence, and outcomes
    • Younossi ZM, Koenig AB, Abdelatif D, et al. Global epidemiology of nonalcoholic fatty liver disease - meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology 2016; 64:73-84.
    • (2016) Hepatology , vol.64 , pp. 73-84
    • Younossi, Z.M.1    Koenig, A.B.2    Abdelatif, D.3
  • 4
    • 84904417292 scopus 로고    scopus 로고
    • Trends in underlying causes of death in people with HIV from 1999 to 2011 (D:A:D): A multicohort collaboration
    • Smith CJ, Ryom L, Weber R, et al. Trends in underlying causes of death in people with HIV from 1999 to 2011 (D:A:D): a multicohort collaboration. Lancet 2014; 384:241-248.
    • (2014) Lancet , vol.384 , pp. 241-248
    • Smith, C.J.1    Ryom, L.2    Weber, R.3
  • 5
    • 84877893973 scopus 로고    scopus 로고
    • The changing epidemiology of liver disease in HIV patients
    • Soriano V, Barreiro P, Sherman KE. The changing epidemiology of liver disease in HIV patients. AIDS Rev 2013; 15:25-31.
    • (2013) AIDS Rev , vol.15 , pp. 25-31
    • Soriano, V.1    Barreiro, P.2    Sherman, K.E.3
  • 6
    • 80555136061 scopus 로고    scopus 로고
    • Meta-analysis: Natural history of nonalcoholic fatty liver disease (NAFLD) and diagnostic accuracy of noninvasive tests for liver disease severity
    • Musso G, Gambino R, Cassader M, Pagano G. Meta-analysis: natural history of nonalcoholic fatty liver disease (NAFLD) and diagnostic accuracy of noninvasive tests for liver disease severity. Ann Med 2011; 43:617-649.
    • (2011) Ann Med , vol.43 , pp. 617-649
    • Musso, G.1    Gambino, R.2    Cassader, M.3    Pagano, G.4
  • 7
    • 84989322099 scopus 로고    scopus 로고
    • Noninvasive imaging methods to determine severity of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis
    • Hannah WN Jr, Harrison SA. Noninvasive imaging methods to determine severity of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. Hepatology 2016; 64:2234-2243.
    • (2016) Hepatology , vol.64 , pp. 2234-2243
    • Hannah, W.N.1    Harrison, S.A.2
  • 8
    • 84888298670 scopus 로고    scopus 로고
    • Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials
    • Noureddin M, Lam J, Peterson MR, et al. Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials. Hepatology 2013; 58:1930-1940.
    • (2013) Hepatology , vol.58 , pp. 1930-1940
    • Noureddin, M.1    Lam, J.2    Peterson, M.R.3
  • 9
    • 0023241784 scopus 로고
    • Hepatic disease in patients with the acquired immune deficiency syndrome (AIDS)
    • Schneiderman DJ, Arenson DM, Cello JP, et al. Hepatic disease in patients with the acquired immune deficiency syndrome (AIDS). Hepatology 1987; 7:925-930.
    • (1987) Hepatology , vol.7 , pp. 925-930
    • Schneiderman, D.J.1    Arenson, D.M.2    Cello, J.P.3
  • 10
    • 0021925047 scopus 로고
    • The liver in the acquired immunodeficiency syndrome: A clinical and histologic study
    • Lebovics E, Thung SN, Schaffner F, Radensky PW. The liver in the acquired immunodeficiency syndrome: a clinical and histologic study. Hepatology 1985; 5:293-298.
    • (1985) Hepatology , vol.5 , pp. 293-298
    • Lebovics, E.1    Thung, S.N.2    Schaffner, F.3    Radensky, P.W.4
  • 11
    • 84899994190 scopus 로고    scopus 로고
    • Risk factors for fatty liver in the Multicenter AIDS Cohort Study
    • Price JC, Seaberg EC, Latanich R, et al. Risk factors for fatty liver in the Multicenter AIDS Cohort Study. Am J Gastroenterol 2014; 109:695-704.
    • (2014) Am J Gastroenterol , vol.109 , pp. 695-704
    • Price, J.C.1    Seaberg, E.C.2    Latanich, R.3
  • 12
    • 84929206718 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis and hepatic fibrosis in HIV-1-monoinfected adults with elevated aminotransferase levels on antiretroviral therapy
    • Morse CG, McLaughlin M, Matthews L, et al. Nonalcoholic steatohepatitis and hepatic fibrosis in HIV-1-monoinfected adults with elevated aminotransferase levels on antiretroviral therapy. Clin Infect Dis 2015; 60: 1569-1578.
    • (2015) Clin Infect Dis , vol.60 , pp. 1569-1578
    • Morse, C.G.1    McLaughlin, M.2    Matthews, L.3
  • 14
    • 37349086107 scopus 로고    scopus 로고
    • Magnetic resonance spectroscopy of hepatic lipid content and associated risk factors in HIV infection
    • Hadigan C, Liebau J, Andersen R, et al. Magnetic resonance spectroscopy of hepatic lipid content and associated risk factors in HIV infection. J Acquir Immune Defic Syndr 2007; 46:312-317.
    • (2007) J Acquir Immune Defic Syndr , vol.46 , pp. 312-317
    • Hadigan, C.1    Liebau, J.2    Andersen, R.3
  • 15
    • 46349092154 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease in HIV-infected patients referred to a metabolic clinic: Prevalence, characteristics, and predictors
    • Guaraldi G, Squillace N, Stentarelli C, et al. Nonalcoholic fatty liver disease in HIV-infected patients referred to a metabolic clinic: prevalence, characteristics, and predictors. Clin Infect Dis 2008; 47:250-257.
    • (2008) Clin Infect Dis , vol.47 , pp. 250-257
    • Guaraldi, G.1    Squillace, N.2    Stentarelli, C.3
  • 16
    • 84900315893 scopus 로고    scopus 로고
    • Traditional but not HIV-related factors are associated with nonalcoholic fatty liver disease in Asian patients with HIV-1 infection
    • Nishijima T, Gatanaga H, Shimbo T, et al. Traditional but not HIV-related factors are associated with nonalcoholic fatty liver disease in Asian patients with HIV-1 infection. PLoS One 2014; 9:e87596.
    • (2014) PLoS One , vol.9 , pp. e87596
    • Nishijima, T.1    Gatanaga, H.2    Shimbo, T.3
  • 17
    • 84922481098 scopus 로고    scopus 로고
    • Prevalence and factors associated with liver steatosis as measured by transient elastography with controlled attenuation parameter in HIV-infected patients
    • Macias J, Gonzalez J, Tural C, et al. Prevalence and factors associated with liver steatosis as measured by transient elastography with controlled attenuation parameter in HIV-infected patients. AIDS 2014; 28:1279-1287.
    • (2014) AIDS , vol.28 , pp. 1279-1287
    • Macias, J.1    Gonzalez, J.2    Tural, C.3
  • 18
    • 84957638076 scopus 로고    scopus 로고
    • Hepatic steatosis in individuals living with HIV measured by controlled attenuation parameter: A cross-sectional study
    • SulyokM,MakaraM, Rupnik Z, et al. Hepatic steatosis in individuals living with HIV measured by controlled attenuation parameter: a cross-sectional study. Eur J Gastroenterol Hepatol 2015; 27:679-685.
    • (2015) Eur J Gastroenterol Hepatol , vol.27 , pp. 679-685
    • Sulyok, M.1    Makara, M.2    Rupnik, Z.3
  • 19
    • 84872936878 scopus 로고    scopus 로고
    • Hepatic steatosis in human immunodeficiency virus: A prospective study in patients without viral hepatitis, diabetes, or alcohol abuse
    • Sterling RK, Smith PG, Brunt EM. Hepatic steatosis in human immunodeficiency virus: a prospective study in patients without viral hepatitis, diabetes, or alcohol abuse. J Clin Gastroenterol 2013; 47:182-187.
    • (2013) J Clin Gastroenterol , vol.47 , pp. 182-187
    • Sterling, R.K.1    Smith, P.G.2    Brunt, E.M.3
  • 20
    • 84885713169 scopus 로고    scopus 로고
    • Noninvasive assessment of liver steatosis and fibrosis in HIV/HCV- and HCV-infected patients
    • Li Vecchi V, Giannitrapani L, Di Carlo P, et al. Noninvasive assessment of liver steatosis and fibrosis in HIV/HCV- and HCV-infected patients. Ann Hepatol 2013; 12:740-748.
    • (2013) Ann Hepatol , vol.12 , pp. 740-748
    • Li Vecchi, V.1    Giannitrapani, L.2    Di Carlo, P.3
  • 21
    • 84978897538 scopus 로고    scopus 로고
    • Liver fibrosis and fatty liver in Asian HIVinfected patients
    • Lui G, Wong VW, Wong GL, et al. Liver fibrosis and fatty liver in Asian HIVinfected patients. Aliment Pharmacol Ther 2016; 44:411-421.
    • (2016) Aliment Pharmacol Ther , vol.44 , pp. 411-421
    • Lui, G.1    Wong, V.W.2    Wong, G.L.3
  • 22
    • 34447325127 scopus 로고    scopus 로고
    • HIV-positive patients with nonalcoholic fatty liver disease have a lower body mass index and are more physically active than HIV-negative patients
    • Mohammed SS, Aghdassi E, Salit IE, et al. HIV-positive patients with nonalcoholic fatty liver disease have a lower body mass index and are more physically active than HIV-negative patients. J Acquir Immune Defic Syndr 2007; 45:432-438.
    • (2007) J Acquir Immune Defic Syndr , vol.45 , pp. 432-438
    • Mohammed, S.S.1    Aghdassi, E.2    Salit, I.E.3
  • 23
    • 84986201496 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease diagnosed by transient elastography with controlled attenuation parameter in unselected HIV monoinfected patients
    • Vuille-Lessard E, Lebouche B, Lennox L, et al. Nonalcoholic fatty liver disease diagnosed by transient elastography with controlled attenuation parameter in unselected HIV monoinfected patients. AIDS 2016; 30:2635-2643.
    • (2016) AIDS , vol.30 , pp. 2635-2643
    • Vuille-Lessard, E.1    Lebouche, B.2    Lennox, L.3
  • 24
    • 84995451852 scopus 로고    scopus 로고
    • Prevalence and predictors of liver steatosis and fibrosis in unselected patients with HIV mono-infection
    • [Epub ahead of print]
    • Lombardi R, Sambatakou H, Mariolis I, et al. Prevalence and predictors of liver steatosis and fibrosis in unselected patients with HIV mono-infection. Dig Liver Dis 2016. [Epub ahead of print]
    • (2016) Dig Liver Dis
    • Lombardi, R.1    Sambatakou, H.2    Mariolis, I.3
  • 25
    • 61949414868 scopus 로고    scopus 로고
    • Liver damage underlying unexplained transaminase elevation in human immunodeficiency virus-1 mono-infected patients on antiretroviral therapy
    • Ingiliz P, Valantin MA, Duvivier C, et al. Liver damage underlying unexplained transaminase elevation in human immunodeficiency virus-1 mono-infected patients on antiretroviral therapy. Hepatology 2009; 49:436-442.
    • (2009) Hepatology , vol.49 , pp. 436-442
    • Ingiliz, P.1    Valantin, M.A.2    Duvivier, C.3
  • 26
    • 84921439750 scopus 로고    scopus 로고
    • Clinical, biochemical and histological differences between HIV-associated NAFLD and primary NAFLD: A case-control study
    • Vodkin I, Valasek MA, Bettencourt R, et al. Clinical, biochemical and histological differences between HIV-associated NAFLD and primary NAFLD: a case-control study. Aliment Pharmacol Ther 2015; 41:368-378. Although the natural history of NAFLD among patients with HIV is not described, this article suggests that these patients may be at higher risk of the more aggressive forms of the disease, including NASH and fibrosis, compared with matched controls with NAFLD in the general population.
    • (2015) Aliment Pharmacol Ther , vol.41 , pp. 368-378
    • Vodkin, I.1    Valasek, M.A.2    Bettencourt, R.3
  • 27
    • 84989814072 scopus 로고    scopus 로고
    • Changes in liver steatosis evaluated by transient elastography with the controlled attenuation parameter in HIVinfected patients
    • Macias J, Real LM, Rivero-Juarez A, et al. Changes in liver steatosis evaluated by transient elastography with the controlled attenuation parameter in HIVinfected patients. HIV Med 2016; 17:766-773.
    • (2016) HIV Med , vol.17 , pp. 766-773
    • Macias, J.1    Real, L.M.2    Rivero-Juarez, A.3
  • 28
    • 80051578427 scopus 로고    scopus 로고
    • Fatty liver disease is associated with underlying cardiovascular disease in HIV-infected persons
    • Crum-Cianflone N, Krause D, Wessman D, et al. Fatty liver disease is associated with underlying cardiovascular disease in HIV-infected persons. HIV Med 2011; 12:463-471.
    • (2011) HIV Med , vol.12 , pp. 463-471
    • Crum-Cianflone, N.1    Krause, D.2    Wessman, D.3
  • 29
    • 84959121845 scopus 로고    scopus 로고
    • Management of NAFLD: A stage-based approach
    • Rinella ME, Sanyal AJ. Management of NAFLD: a stage-based approach. Nat Rev Gastroenterol Hepatol 2016; 13:196-205. This is a well written and succinct review of the current approach to NAFLD treatment, based upon the disease stage. Although this review does not include recommendations specifically for patients with NAFLD and HIV, it provides important insights into the current landscape of treatment in the general population.
    • (2016) Nat Rev Gastroenterol Hepatol , vol.13 , pp. 196-205
    • Rinella, M.E.1    Sanyal, A.J.2
  • 30
    • 84957812743 scopus 로고    scopus 로고
    • The multiple-hit pathogenesis of nonalcoholic fatty liver disease (NAFLD)
    • Buzzetti E, Pinzani M, Tsochatzis EA. The multiple-hit pathogenesis of nonalcoholic fatty liver disease (NAFLD). Metabolism 2016; 65: 1038-1048.
    • (2016) Metabolism , vol.65 , pp. 1038-1048
    • Buzzetti, E.1    Pinzani, M.2    Tsochatzis, E.A.3
  • 31
    • 84930656108 scopus 로고    scopus 로고
    • NAFLD: A multisystem disease
    • Byrne CD, Targher G. NAFLD: a multisystem disease. J Hepatol 2015; 62 (1 Suppl):S47-S64.
    • (2015) J Hepatol , vol.62 , Issue.1 , pp. S47-S64
    • Byrne, C.D.1    Targher, G.2
  • 32
    • 84859634051 scopus 로고    scopus 로고
    • Prospective evaluation of hepatic steatosis in HIV-infected patients with or without hepatitis Cvirus co-infection
    • Li Vecchi V, Soresi M, Giannitrapani L, et al. Prospective evaluation of hepatic steatosis in HIV-infected patients with or without hepatitis Cvirus co-infection. Int J Infect Dis 2012; 16:e397-e402.
    • (2012) Int J Infect Dis , vol.16 , pp. e397-e402
    • Li Vecchi, V.1    Soresi, M.2    Giannitrapani, L.3
  • 33
    • 84969509083 scopus 로고    scopus 로고
    • Interaction between alcohol consumption patterns, antiretroviral therapy type, and liver fibrosis in persons living with HIV
    • Bilal U, Lau B, Lazo M, et al. Interaction between alcohol consumption patterns, antiretroviral therapy type, and liver fibrosis in persons living with HIV. AIDS Patient Care STDS 2016; 30:200-207.
    • (2016) AIDS Patient Care STDS , vol.30 , pp. 200-207
    • Bilal, U.1    Lau, B.2    Lazo, M.3
  • 34
    • 84978897538 scopus 로고    scopus 로고
    • Liver fibrosis and fatty liver in Asian HIVinfected patients
    • Lui G, Wong VW, Wong GL, et al. Liver fibrosis and fatty liver in Asian HIVinfected patients. Aliment Pharmacol Ther 2016; 44:411-421.
    • (2016) Aliment Pharmacol Ther , vol.44 , pp. 411-421
    • Lui, G.1    Wong, V.W.2    Wong, G.L.3
  • 35
    • 77956624153 scopus 로고    scopus 로고
    • Clinical syndromes and consequences of antiretroviral-related hepatotoxicity
    • Nunez M. Clinical syndromes and consequences of antiretroviral-related hepatotoxicity. Hepatology 2010; 52:1143-1155.
    • (2010) Hepatology , vol.52 , pp. 1143-1155
    • Nunez, M.1
  • 36
    • 75649129691 scopus 로고    scopus 로고
    • High prevalence of the metabolic syndrome in HIV-infected patients: Impact of different definitions of the metabolic syndrome
    • Worm SW, Friis-Moller N, Bruyand M, et al. High prevalence of the metabolic syndrome in HIV-infected patients: impact of different definitions of the metabolic syndrome. AIDS 2010; 24:427-435.
    • (2010) AIDS , vol.24 , pp. 427-435
    • Worm, S.W.1    Friis-Moller, N.2    Bruyand, M.3
  • 37
    • 84878388296 scopus 로고    scopus 로고
    • Systematic review of antiretroviral-associated lipodystrophy: Lipoatrophy, but not central fat gain, is an antiretroviral adverse drug reaction
    • de Waal R, Cohen K, Maartens G. Systematic review of antiretroviral-associated lipodystrophy: lipoatrophy, but not central fat gain, is an antiretroviral adverse drug reaction. PLoS One 2013; 8:e63623.
    • (2013) PLoS One , vol.8 , pp. e63623
    • De Waal, R.1    Cohen, K.2    Maartens, G.3
  • 39
    • 84954288595 scopus 로고    scopus 로고
    • The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota
    • Boursier J, Mueller O, Barret M, et al. The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota. Hepatology 2016; 63:764-775.
    • (2016) Hepatology , vol.63 , pp. 764-775
    • Boursier, J.1    Mueller, O.2    Barret, M.3
  • 40
    • 84947865190 scopus 로고    scopus 로고
    • Gut microbiota diversity predicts immune status in HIV-1 infection
    • Nowak P, Troseid M, Avershina E, et al. Gut microbiota diversity predicts immune status in HIV-1 infection. AIDS 2015; 29:2409-2418.
    • (2015) AIDS , vol.29 , pp. 2409-2418
    • Nowak, P.1    Troseid, M.2    Avershina, E.3
  • 41
    • 84872174074 scopus 로고    scopus 로고
    • Microbial translocation in the pathogenesis of HIV infection and AIDS
    • Marchetti G, Tincati C, Silvestri G. Microbial translocation in the pathogenesis of HIV infection and AIDS. Clin Microbiol Rev 2013; 26:2-18.
    • (2013) Clin Microbiol Rev , vol.26 , pp. 2-18
    • Marchetti, G.1    Tincati, C.2    Silvestri, G.3
  • 42
    • 84889634755 scopus 로고    scopus 로고
    • Systematic review with meta-analysis: Nonalcoholic steatohepatitis - A case for personalised treatment based on pathogenic targets
    • Younossi ZM, Reyes MJ, Mishra A, et al. Systematic review with meta-analysis: nonalcoholic steatohepatitis - a case for personalised treatment based on pathogenic targets. Aliment Pharmacol Ther 2014; 39:3-14.
    • (2014) Aliment Pharmacol Ther , vol.39 , pp. 3-14
    • Younossi, Z.M.1    Reyes, M.J.2    Mishra, A.3
  • 43
    • 84924938800 scopus 로고    scopus 로고
    • Fibrosis progression in nonalcoholic fatty liver vs nonalcoholic steatohepatitis: A systematic review and meta-analysis of paired-biopsy studies
    • e1- e9; quiz e39-e40
    • Singh S, Allen AM, Wang Z, et al. Fibrosis progression in nonalcoholic fatty liver vs nonalcoholic steatohepatitis: a systematic review and meta-analysis of paired-biopsy studies. Clin Gastroenterol Hepatol 2015; 13:643-654.e1- e9; quiz e39-e40.
    • (2015) Clin Gastroenterol Hepatol , vol.13 , pp. 643-654
    • Singh, S.1    Allen, A.M.2    Wang, Z.3
  • 44
    • 84878330831 scopus 로고    scopus 로고
    • Prospective histopathologic evaluation of lifestyle modification in nonalcoholic fatty liver disease: A randomized trial
    • Eckard C, Cole R, Lockwood J, et al. Prospective histopathologic evaluation of lifestyle modification in nonalcoholic fatty liver disease: a randomized trial. Ther Adv Gastroenterol 2013; 6:249-259.
    • (2013) Ther Adv Gastroenterol , vol.6 , pp. 249-259
    • Eckard, C.1    Cole, R.2    Lockwood, J.3
  • 45
    • 0033862761 scopus 로고    scopus 로고
    • Clinical manifestations and management of antiretroviral nucleoside analog-related mitochondrial toxicity
    • discussion 898
    • Moyle G. Clinical manifestations and management of antiretroviral nucleoside analog-related mitochondrial toxicity. Clin Ther 2000; 22:911-936; discussion 898.
    • (2000) Clin Ther , vol.22 , pp. 911-936
    • Moyle, G.1
  • 46
    • 84867215594 scopus 로고    scopus 로고
    • Hepatic steatosis and steatohepatitis in human immunodeficiency virus/hepatitis C virus-coinfected patients
    • Macias J, Berenguer J, Japon MA, et al. Hepatic steatosis and steatohepatitis in human immunodeficiency virus/hepatitis C virus-coinfected patients. Hepatology 2012; 56:1261-1270.
    • (2012) Hepatology , vol.56 , pp. 1261-1270
    • Macias, J.1    Berenguer, J.2    Japon, M.A.3
  • 47
    • 85010215159 scopus 로고    scopus 로고
    • [cited 2016 September 28]
    • AASLD 2016 [cited 2016 September 28]. Available from: http://hcvguidelines.org/.
    • (2016) AASLD
  • 48
    • 84952637806 scopus 로고    scopus 로고
    • Targeting gut-liver axis for the treatment of nonalcoholic steatohepatitis: Translational and clinical evidence
    • Federico A, Dallio M, Godos J, et al. Targeting gut-liver axis for the treatment of nonalcoholic steatohepatitis: translational and clinical evidence. Transl Res 2016; 167:116-124.
    • (2016) Transl Res , vol.167 , pp. 116-124
    • Federico, A.1    Dallio, M.2    Godos, J.3
  • 49
    • 84932147864 scopus 로고    scopus 로고
    • Efficacy of rifaximin on circulating endotoxins and cytokines in patients with nonalcoholic fatty liver disease
    • Gangarapu V, Ince AT, Baysal B, et al. Efficacy of rifaximin on circulating endotoxins and cytokines in patients with nonalcoholic fatty liver disease. Eur J Gastroenterol Hepatol 2015; 27:840-845.
    • (2015) Eur J Gastroenterol Hepatol , vol.27 , pp. 840-845
    • Gangarapu, V.1    Ince, A.T.2    Baysal, B.3
  • 50
    • 84939509426 scopus 로고    scopus 로고
    • Rifaximin has a marginal impact on microbial translocation, T-cell activation and inflammation in HIV-positive immune nonresponders to antiretroviral therapy - ACTG A5286
    • Tenorio AR, Chan ES, Bosch RJ, et al. Rifaximin has a marginal impact on microbial translocation, T-cell activation and inflammation in HIV-positive immune nonresponders to antiretroviral therapy - ACTG A5286. J Infect Dis 2015; 211:780-790.
    • (2015) J Infect Dis , vol.211 , pp. 780-790
    • Tenorio, A.R.1    Chan, E.S.2    Bosch, R.J.3
  • 51
    • 84963739666 scopus 로고    scopus 로고
    • Review article: Emerging antifibrotic therapies in the treatment of nonalcoholic steatohepatitis
    • Noureddin M, Anstee QM, Loomba R. Review article: emerging antifibrotic therapies in the treatment of nonalcoholic steatohepatitis. Aliment Pharmacol Ther 2016; 43:1109-1123.
    • (2016) Aliment Pharmacol Ther , vol.43 , pp. 1109-1123
    • Noureddin, M.1    Anstee, Q.M.2    Loomba, R.3
  • 52
    • 84988462353 scopus 로고    scopus 로고
    • Current and upcoming pharmacotherapy for nonalcoholic fatty liver disease
    • [Epub ahead of print]
    • Rotman Y, Sanyal AJ. Current and upcoming pharmacotherapy for nonalcoholic fatty liver disease. Gut 2016. [Epub ahead of print]
    • (2016) Gut
    • Rotman, Y.1    Sanyal, A.J.2
  • 53
    • 85010204304 scopus 로고    scopus 로고
    • Bile acids and nonalcoholic fatty liver disease: Molecular insights and therapeutic perspectives
    • [Epub ahead of print]
    • Arab JP, Karpen SJ, Dawson PA, et al. Bile acids and nonalcoholic fatty liver disease: molecular insights and therapeutic perspectives. Hepatology 2016. [Epub ahead of print]
    • (2016) Hepatology
    • Arab, J.P.1    Karpen, S.J.2    Dawson, P.A.3
  • 54
    • 77951874018 scopus 로고    scopus 로고
    • Pioglitazone, Vitamin E, or placebo for nonalcoholic steatohepatitis
    • Sanyal AJ, Chalasani N, Kowdley KV, et al. Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. N Engl J Med 2010; 362:1675-1685.
    • (2010) N Engl J Med , vol.362 , pp. 1675-1685
    • Sanyal, A.J.1    Chalasani, N.2    Kowdley, K.V.3
  • 55
    • 19944427642 scopus 로고    scopus 로고
    • Meta-analysis: High-dosage Vitamin E supplementation may increase all-cause mortality
    • Miller ER 3rd, Pastor-Barriuso R, Dalal D, et al. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med 2005; 142:37-46.
    • (2005) Ann Intern Med , vol.142 , pp. 37-46
    • Miller, E.R.1    Pastor-Barriuso, R.2    Dalal, D.3
  • 56
    • 80053954605 scopus 로고    scopus 로고
    • Vitamin E and the risk of prostate cancer: The Selenium and Vitamin E Cancer Prevention Trial (SELECT)
    • Klein EA, Thompson IM Jr, Tangen CM, et al. Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA 2011; 306:1549-1556.
    • (2011) JAMA , vol.306 , pp. 1549-1556
    • Klein, E.A.1    Thompson, I.M.2    Tangen, C.M.3
  • 57
    • 84969801284 scopus 로고    scopus 로고
    • Sitagliptin vs. placebo for nonalcoholic fatty liver disease: A randomized controlled trial
    • Cui J, Philo L, Nguyen P, et al. Sitagliptin vs. placebo for nonalcoholic fatty liver disease: a randomized controlled trial. J Hepatol 2016; 65:369-376.
    • (2016) J Hepatol , vol.65 , pp. 369-376
    • Cui, J.1    Philo, L.2    Nguyen, P.3
  • 58
    • 84929266699 scopus 로고    scopus 로고
    • Farnesoid X nuclear receptor ligand obeticholic acid for noncirrhotic, nonalcoholic steatohepatitis (FLINT): A multicentre, randomised, placebo-controlled trial
    • Neuschwander-Tetri BA, Loomba R, Sanyal AJ, et al. Farnesoid X nuclear receptor ligand obeticholic acid for noncirrhotic, nonalcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial. Lancet 2015; 385:956-965.
    • (2015) Lancet , vol.385 , pp. 956-965
    • Neuschwander-Tetri, B.A.1    Loomba, R.2    Sanyal, A.J.3
  • 59
    • 84960140218 scopus 로고    scopus 로고
    • Elafibranor, an agonist of the peroxisome proliferator-activated receptor-alpha and -delta, induces resolution of nonalcoholic ateatohepatitis without fibrosis worsening
    • e5
    • Ratziu V, Harrison SA, Francque S, et al. Elafibranor, an agonist of the peroxisome proliferator-activated receptor-alpha and -delta, induces resolution of nonalcoholic ateatohepatitis without fibrosis worsening. Gastroenterology 2016; 150:1147-1159 e5.
    • (2016) Gastroenterology , vol.150 , pp. 1147-1159
    • Ratziu, V.1    Harrison, S.A.2    Francque, S.3
  • 60
    • 84945539188 scopus 로고    scopus 로고
    • Liver histology and clinical trials for nonalcoholic steatohepatitis-perspectives from 2 pathologists
    • Kleiner DE, Bedossa P. Liver histology and clinical trials for nonalcoholic steatohepatitis-perspectives from 2 pathologists. Gastroenterology 2015; 149:1305-1308.
    • (2015) Gastroenterology , vol.149 , pp. 1305-1308
    • Kleiner, D.E.1    Bedossa, P.2
  • 61
    • 84945185644 scopus 로고    scopus 로고
    • Comparative effectiveness of pharmacological interventions for nonalcoholic steatohepatitis: A systematic review and network meta-analysis
    • Singh S, Khera R, Allen AM, et al. Comparative effectiveness of pharmacological interventions for nonalcoholic steatohepatitis: a systematic review and network meta-analysis. Hepatology 2015; 62:1417-1432.
    • (2015) Hepatology , vol.62 , pp. 1417-1432
    • Singh, S.1    Khera, R.2    Allen, A.M.3
  • 62
    • 84904543851 scopus 로고    scopus 로고
    • Effect of tesamorelin on visceral fat and liver fat in HIV-infected patients with abdominal fat accumulation: A randomized clinical trial
    • Stanley TL, Feldpausch MN, Oh J, et al. Effect of tesamorelin on visceral fat and liver fat in HIV-infected patients with abdominal fat accumulation: a randomized clinical trial. JAMA 2014; 312:380-389.
    • (2014) JAMA , vol.312 , pp. 380-389
    • Stanley, T.L.1    Feldpausch, M.N.2    Oh, J.3
  • 63
    • 84918843434 scopus 로고    scopus 로고
    • The fatty acid-bile acid conjugate Aramchol reduces liver fat content in patients with nonalcoholic fatty liver disease
    • e1
    • Safadi R, Konikoff FM, Mahamid M, et al. The fatty acid-bile acid conjugate Aramchol reduces liver fat content in patients with nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol 2014; 12:2085-2091.e1.
    • (2014) Clin Gastroenterol Hepatol , vol.12 , pp. 2085-2091
    • Safadi, R.1    Konikoff, F.M.2    Mahamid, M.3
  • 64
    • 84960425749 scopus 로고    scopus 로고
    • A 48-week randomized phase 2b study evaluating cenicriviroc versus efavirenz in treatment-naive HIV-infected adults with C-C chemokine receptor type 5-tropic virus
    • Thompson M, Saag M, DeJesus E, et al. A 48-week randomized phase 2b study evaluating cenicriviroc versus efavirenz in treatment-naive HIV-infected adults with C-C chemokine receptor type 5-tropic virus. AIDS 2016; 30:869-878.
    • (2016) AIDS , vol.30 , pp. 869-878
    • Thompson, M.1    Saag, M.2    DeJesus, E.3
  • 65
    • 84930654328 scopus 로고    scopus 로고
    • Current efforts and trends in the treatment of NASH
    • Ratziu V, Goodman Z, Sanyal A. Current efforts and trends in the treatment of NASH. J Hepatol 2015; 62 (1 Suppl):S65-S75.
    • (2015) J Hepatol , vol.62 , Issue.1 , pp. S65-S75
    • Ratziu, V.1    Goodman, Z.2    Sanyal, A.3


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