Forearm vasodilator responses to a β-adrenergic receptor agonist in premenopausal and postmenopausal women

Physiological Reports

Volumn 2, Issue 6, 2014, Pages

  Harvey, Ronee E ^a   Barnes, Jill N ^b   Charkoudian, Nisha ^c   Curry, Timothy B ^b   Eisenach, John H ^b   Hart, Emma C ^d   Joyner, Michael J ^b  

^a Mayo Clinic   (United States)

^b MAYO CLINIC   (United States)

^c U S ARMY RESEARCH INSTITUTE OF ENVIRONMENTAL MEDICINE   (United States)

^d UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Endothelium; Menopause; adrenoreceptor

Indexed keywords

ISOPRENALINE; NORADRENALIN;

ADULT; ARTICLE; FEMALE; FOREARM BLOOD FLOW; HUMAN; HUMAN EXPERIMENT; MEAN ARTERIAL PRESSURE; NORMAL HUMAN; POSTMENOPAUSE; PREMENOPAUSE; PULSE PRESSURE; SYSTOLIC BLOOD PRESSURE; VASODILATATION; VEIN OCCLUSION PLETHYSMOGRAPHY;

EID: 85003587485     PISSN: None     EISSN: 2051817X     Source Type: Journal    
DOI: 10.14814/phy2.12032     Document Type: Article

References (15)

1. Burt, V. L., P. Whelton, E. J. Roccella, C. Brown, J. A. Cutler, M. Higgins, et al. 1995. Prevalence of hypertension in the US adult population. Results from the Third National Health and Nutrition Examination Survey, 1988-1991. Hypertension 25:305-313.
2. Casey, D. P., T. B. Curry, and M. J. Joyner. 2008. Measuring muscle blood flow: a key link between systemic and regional metabolism. Curr. Opin. Clin. Nut. Metab. Care 11:580-586.
3. Cutler, J. A., P. D. Sorlie, M. Wolz, T. Thom, L. E. Fields, and E. J. Roccella. 2008. Trends in hypertension prevalence, awareness, treatment, and control rates in United States adults between 1988-1994 and 1999-2004. Hypertension 52:818-827.
4. Eisenach, J. H., E. S. Clark, N. Charkoudian, F. A. Dinenno, J. L. Atkinson, R. D. Fealey, et al. 2002. Effects of chronic sympathectomy on vascular function in the human forearm. J. Appl. Physiol. 92:2019-2025.
5. Eisenach, J. H., D. R. Schroeder, T. L. Pike, C. P. Johnson, W. G. Schrage, E. M. Snyder, et al. 2006. Dietary sodium restriction and beta2-adrenergic receptor polymorphism modulate cardiovascular function in humans. J. Physiol. 574:955-965.
6. Fleg, J. L. 1986. Alterations in cardiovascular structure and function with advancing age. Am. J. Cardiol. 57:33C-44C.
7. Garovic, V. D., M. J. Joyner, N. M. Dietz, E. Boerwinkle, and S. T. Turner. 2003. Beta(2)-adrenergic receptor polymorphism and nitric oxide-dependent forearm blood flow responses to isoproterenol in humans. J. Physiol. 546:583-589.
8. Gracia, C. R., M. D. Sammel, E. W. Freeman, H. Lin, E. Langan, S. Kapoor, et al. 2005. Defining menopause status: creation of a new definition to identify the early changes of the menopausal transition. Menopause 12:128-135.
9. Greenfield, A. D., R. J. Whitney, and J. F. Mowbray. 1963. Methods for the investigation of peripheral blood flow. Br. Med. Bull. 19:101-109.
10. Hart, E. C., N. Charkoudian, B. G. Wallin, T. B. Curry, J. H. Eisenach, and M. J. Joyner. 2009. Sex differences in sympathetic neural-hemodynamic balance: implications for human blood pressure regulation. Hypertension 53:571-576.
11. Hart, E. C., N. Charkoudian, B. G. Wallin, T. B. Curry, J. Eisenach, and M. J. Joyner. 2011. Sex and ageing differences in resting arterial pressure regulation: the role of the beta-adrenergic receptors. J. Physiol. 589:5285-5297.
12. Kneale, B. J., P. J. Chowienczyk, S. E. Brett, D. J. Coltart, and J. M. Ritter. 2000. Gender differences in sensitivity to adrenergic agonists of forearm resistance vasculature. J. Am. Coll. Cardiol. 36:1233-1238.
13. Martin, E. A., W. T. Nicholson, J. H. Eisenach, N. Charkoudian, and M. J. Joyner. 2006. Bimodal distribution of vasodilator responsiveness to adenosine due to difference in nitric oxide contribution: implications for exercise hyperemia. J. Appl. Physiol. 101:492-499.
14. Sherwood, A., S. B. Park, J. W. Hughes, J. A. Blumenthal, A. Hinderliter, R. Trivedi, et al. 2010. Cardiovascular hemodynamics during stress in premenopausal versus postmenopausal women. Menopause 17:403-409.
15. Stein, C. M., R. Nelson, R. Deegan, H. He, M. Wood, and A. J. Wood. 1995. Forearm beta adrenergic receptor-mediated vasodilation is impaired, without alteration of forearm norepinephrine spillover, in borderline hypertension. J. Clin. Investig. 96:579-585.