Effect of Insulin and Metformin Combination Treatment on Colon Adenoma and Advanced Adenoma Among DM II

Journal of Gastrointestinal Cancer

Volumn 47, Issue 4, 2016, Pages 404-408

  Jain, Deepanshu ^a   Chhoda, Ankit ^b   Uribe, Jorge ^a  

^a ALBERT EINSTEIN MEDICAL CENTER   (United States)

^b LOK NAYAK HOSPITAL   (India)

Author keywords

Adenoma; Advanced adenoma; Diabetes mellitus type II; Insulin; Metformin

Indexed keywords

INSULIN; METFORMIN; ANTIDIABETIC AGENT; ANTINEOPLASTIC AGENT;

ADULT; AGED; ARTICLE; CANCER SCREENING; COLON ADENOMA; COLONOSCOPY; CONTROLLED STUDY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; RETROSPECTIVE STUDY; ADENOMA; COLORECTAL NEOPLASMS; DIABETES COMPLICATIONS; EARLY CANCER DIAGNOSIS;

ADENOMA; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; COLORECTAL NEOPLASMS; DIABETES COMPLICATIONS; EARLY DETECTION OF CANCER; FEMALE; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; MALE; METFORMIN; RETROSPECTIVE STUDIES;

EID: 85002965943     PISSN: 19416628     EISSN: 19416636     Source Type: Journal    
DOI: 10.1007/s12029-016-9842-4     Document Type: Article

References (24)

1. Bond JH. Clinical evidence for the adenoma-carcinoma sequence, and the management of patients with colorectal adenomas. Semin Gastrointest Dis. 2000. PMID:11057945
2. Ries LAG, Eisner MP, Kosary CL et al. SEER Cancer Statistics Review, 1975-2002, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2002/, based on November 2004 SEER data submission, posted to the SEER web site 2005.
3. Rex DK, Johnson DA, Anderson JC, Schoenfeld PS, Burke CA, Inadomi JM. Colorectal Cancer Screening Guidelines. doi:10.1038/ajg.2009.104
4. Eddi R, Karki A, Shah A, DeBari VA, DePasquale JR. Association of type 2 diabetes and colon adenomas. J Gastrointest Cancer. 2012. doi: 10.1007/s12029-011-9316-7. PMID:21894459
5. Giovannucci E. Metabolic syndrome, hyperinsulinemia, and colon cancer: a review. Am J Clin Nutr. 2007. PMID:18265477
6. Kim BC, Shin A, Hong CW et al. Association of colorectal adenoma with components of metabolic syndrome. Cancer Causes Control. 2012;23. doi: 10.1007/s10552-012-9942-9. PMID:22450737
7. Elwing JE, Gao F, Davidson NO, Early DS. Type 2 diabetes mellitus: the impact on colorectal adenoma risk in women. Am J Gastroenterol. 2006. doi:10.1111/j.1572-0241.2006.00651.x. PMID:16790036
8. Yang Y-X, Hennessy S, Lewis JD. Insulin therapy and colorectal cancer risk among type 2 diabetes mellitus patients. Gastroenterology 127:1044–1050. DOI: http://dx.doi.org/10.1053/j.gastro.2004.07.011. PMID:15480982
9. Wong P, Weiner MG, Hwang WT, Yang YX. Insulin therapy and colorectal adenomas in patients with diabetes mellitus. Cancer Epidemiol Biomarkers Prev. 2012;Epub 2012 Aug. doi: 10.1158/1055-9965.EPI-12-0771. PMID:22879206
10. Zhou G, Myers R, Li Y et al. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 2001;108:1167–1174. doi:10.1172/JCI13505. PMID:11602624
11. Libby G, Donnelly LA, Donnan PT, Alessi DR, Morris AD, Evans JM. New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes. Diabetes Care 2009, 32(9):620-625. Epub 2009 Jun 29. doi: 10.2337/dc08-2175. PMID:19564453
12. Currie CJ, Poole CD, Gale EA. The influence of glucose-lowering therapies on cancer risk in type 2 diabetes. Diabetologia 2009, 52(9):1766. Epub 2009 Jul 2. doi: 10.1007/s00125-009-1440-6. PMID:19572116
13. Larsson SC, Orsini N, Wolk A. Diabetes mellitus and risk of colorectal cancer: a meta-analysis. Journal of the National Cancer Institute. 2005;97(22):1679–87. doi: 10.1093/jnci/dji375 PMID:16288121
14. Sandhu MS, Dunger DB, Giovannucci EL. Insulin, insulin-like growth factor-I (IGF-I), IGF binding proteins, their biologic interactions, and colorectal cancer. Journal of the National Cancer Institute. 2002;94(13):972–80. doi: 10.1093/jnci/94.13.972. PMID:12096082
15. Giovannucci E. Insulin, insulin-like growth factors and colon cancer: a review of the evidence. J Nutr. 2001;131(11 Suppl):3109S–20S. PMID:11694656
16. LeRoith D, Baserga R, Helman L, Roberts CT. Insulin-like growth factors and cancer. Annals of Internal Medicine. 1995;122(1):54–9. comment. doi:10.7326/0003-4819-122-1-199501010-00009. PMID:7619109
17. Renehan AG, Painter JE, Atkin WS, Potten CS, Shalet SM, O’Dwyer ST. High-risk colorectal adenomas and serum insulin-like growth factors. British Journal of Surgery. 2001;88(1):107–13. doi:10.1046/j.1365-2168.2001.01645.x.
18. Teramukai S, Rohan T, Lee K-Y, Eguchi H, Oda T, Kono S. Insulin-like growth factor (IGF)-I, IGF-binding protein-3 and colorectal adenomas in Japanese men. Japanese Journal of Cancer Research. 2002;93(11):1187–94. PMID:12460458
19. Renehan AG, Painter JE, O’Halloran D et al. Circulating insulin-like growth factor II and colorectal adenomas. J Clin Endocrinol Metab. 2000;85(9):3402–8. DOI: http://dx.doi.org/10.1210/jcem.85.9.6770. PMID:10999841
20. Schoen RE, Weissfeld JL, Kuller LH et al. Insulin-like growth factor-I and insulin are associated with the presence and advancement of adenomatous polyps. Gastroenterology. 2005;129(2):464–75. DOI: http://dx.doi.org/10.1053/j.gastro.2005.05.051. PMID:16083703
21. Shaw RJ, Lamia KA, Vasquez D et al. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 2005;310:1642–6. DOI:10.1126/science.1120781. PMID:16308421
22. Zhang ZJ, Zheng ZJ, Kan H et al. Reduced risk of colorectal cancer with metformin therapy in patients with type 2 diabetes: a meta-analysis. Diabetes Care. 2011;34(10):2323-8. doi: 10.2337/dc11-0512. Review. PMID: 21949223
23. Higurashi T, Takahashi H, Endo H et al. Metformin efficacy and safety for colorectal polyps: a double-blind randomized controlled trial. BMC Cancer. 2012; 12: 118. Published online 2012 March 26. doi: 10.1186/1471-2407-12-118. PMCID: PMC3353167
24. Yang YX, Habel LA, Capra AM et al. Serial glycosylated hemoglobin levels and risk of colorectal neoplasia among patients with type 2 diabetes mellitus. Cancer Epidemiol Biomarkers Prev. 2010;19(12):3027-36. doi: 10.1158/1055-9965.EPI-10-0486. Epub 2010 Oct 11. PMID: 20937982