Extensive Proliferation of a Subset of Differentiated, yet Plastic, Medial Vascular Smooth Muscle Cells Contributes to Neointimal Formation in Mouse Injury and Atherosclerosis Models

Circulation Research

Volumn 119, Issue 12, 2016, Pages 1313-1323

  Chappell, Joel ^a   Harman, Jennifer L ^a   Narasimhan, Vagheesh M ^d   Yu, Haixiang ^a   Foote, Kirsty ^a   Simons, Benjamin D ^a,b,c   Bennett, Martin R ^a   Jørgensen, Helle F ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

atherosclerosis; lineage tracing; macrophages; neointima; phenotype; vascular diseases vascular smooth muscle

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CYAN FLUORESCENT PROTEIN; GREEN FLUORESCENT PROTEIN; MAC3 PROTEIN; PROTEIN; TAMOXIFEN; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; BLOOD VESSEL INJURY; CELL COUNT; CELL EXPANSION; CELL PLASTICITY; CELL PROLIFERATION; CELL STRUCTURE; CONFOCAL MICROSCOPY; GENE EXPRESSION; IN VIVO STUDY; MOUSE; NEOINTIMA; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; VASCULAR SMOOTH MUSCLE CELL; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CYTOLOGY; DISEASE MODEL; KNOCKOUT MOUSE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SMOOTH MUSCLE CELL; TRANSGENIC MOUSE; VASCULAR SMOOTH MUSCLE;

ANIMALS; ATHEROSCLEROSIS; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NEOINTIMA; VASCULAR SYSTEM INJURIES;

EID: 85002703310     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.116.309799     Document Type: Article

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