Effect of Recipient Age and Stem Cell Source on the Association between Donor Telomere Length and Survival after Allogeneic Unrelated Hematopoietic Cell Transplantation for Severe Aplastic Anemia

Biology of Blood and Marrow Transplantation

Volumn 22, Issue 12, 2016, Pages 2276-2282

  Gadalla, Shahinaz M ^a   Wang, Tao ^b   Dagnall, Casey ^a,c   Haagenson, Michael ^d   Spellman, Stephen R ^d   Hicks, Belynda ^a,c   Jones, Kristine ^a,c   Katki, Hormuzd A ^a   Lee, Stephanie J ^b,e   Savage, Sharon A ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

^c FREDERICK NATIONAL LABORATORY FOR CANCER RESEARCH   (United States)

^d CENTER FOR INTERNATIONAL BLOOD AND MARROW TRANSPLANT RESEARCH   (United States)

^e Fred Hutchinson Cancer Research Center   (United States)

Author keywords

Aplastic anemia; Donor selection; Hematopoietic cell transplantation; Survival; Telomere length

Indexed keywords

CYCLOSPORIN; METHOTREXATE; MYCOPHENOLATE MOFETIL; TACROLIMUS;

ADULT; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ALLOGENEIC UNREALATED HEMATOPOIETIC STEM CELL TRANSPLANTATION; APLASTIC ANEMIA; ARTICLE; BLOOD SAMPLING; CD34 SELECTION; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; FOLLOW UP; GRAFT RECIPIENT; GRAFT VERSUS HOST REACTION; HLA MATCHING; HUMAN; MAJOR CLINICAL STUDY; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PERIPHERAL BLOOD STEM CELL; REAL TIME POLYMERASE CHAIN REACTION; T CELL DEPLETION; TELOMERE LENGTH; ADOLESCENT; AGE; AGED; BONE MARROW TRANSPLANTATION; CHILD; HEMATOPOIETIC STEM CELL TRANSPLANTATION; IMMUNOLOGY; INFANT; MIDDLE AGED; MORTALITY; PRESCHOOL CHILD; PROCEDURES; PROGNOSIS; STEM CELL; SURVIVAL; TELOMERE; ULTRASTRUCTURE; UNRELATED DONORS; YOUNG ADULT;

ADOLESCENT; ADULT; AGE FACTORS; AGED; ANEMIA, APLASTIC; BONE MARROW TRANSPLANTATION; CHILD; CHILD, PRESCHOOL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; INFANT; MIDDLE AGED; PROGNOSIS; REAL-TIME POLYMERASE CHAIN REACTION; STEM CELLS; SURVIVAL; TELOMERE; TRANSPLANT RECIPIENTS; UNRELATED DONORS; YOUNG ADULT;

EID: 85002614052     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2016.09.012     Document Type: Article

References (28)

1. 1 Young, N.S., Current concepts in the pathophysiology and treatment of aplastic anemia. Hematology Am Soc Hematol Educ Program 2013 (2013), 76–81.
2. 2 Young, N.S., Kaufman, D.W., The epidemiology of acquired aplastic anemia. Haematologica 93 (2008), 489–492.
3. 3 Kikuchi, A., Yabe, H., Kato, K., et al. Long-term outcome of childhood aplastic anemia patients who underwent allogeneic hematopoietic SCT from an HLA-matched sibling donor in Japan. Bone Marrow Transplant 48 (2013), 657–660.
4. 4 Scheinberg, P., Aplastic anemia: therapeutic updates in immunosuppression and transplantation. Hematology Am Soc Hematol Educ Program 2012 (2012), 292–300.
5. 5 Kojima, S., Matsuyama, T., Kato, S., et al. Outcome of 154 patients with severe aplastic anemia who received transplants from unrelated donors: the Japan Marrow Donor Program. Blood 100 (2002), 799–803.
6. 6 Deeg, H.J., O'Donnell, M., Tolar, J., et al. Optimization of conditioning for marrow transplantation from unrelated donors for patients with aplastic anemia after failure of immunosuppressive therapy. Blood 108 (2006), 1485–1491.
7. 7 Perez-Albuerne, E.D., Eapen, M., Klein, J., et al. Outcome of unrelated donor stem cell transplantation for children with severe aplastic anemia. Br J Haematol 141 (2008), 216–223.
8. 8 Szpecht, D., Gorczynska, E., Kalwak, K., et al. Matched sibling versus matched unrelated allogeneic hematopoietic stem cell transplantation in children with severe acquired aplastic anemia: experience of the Polish Pediatric Group for Hematopoietic Stem Cell Transplantation. Arch Immunol Ther Exp (Warsz) 60 (2012), 225–233.
9. 9 Bacigalupo, A., Socie, G., Schrezenmeier, H., et al. Bone marrow versus peripheral blood as the stem cell source for sibling transplants in acquired aplastic anemia: survival advantage for bone marrow in all age groups. Haematologica 97 (2012), 1142–1148.
10. 10 Bacigalupo, A., Bone marrow transplantation for acquired severe aplastic anemia. Hematol Oncol Clin North Am 28 (2014), 1145–1155.
11. 11 Bacigalupo, A., Socie, G., Hamladji, R.M., et al. Current outcome of HLA identical sibling versus unrelated donor transplants in severe aplastic anemia: an EBMT analysis. Haematologica 100 (2015), 696–702.
12. 12 Eapen, M., Le Rademacher, J., Antin, J.H., et al. Effect of stem cell source on outcomes after unrelated donor transplantation in severe aplastic anemia. Blood 118 (2011), 2618–2621.
13. 13 Gadalla, S.M., Wang, T., Haagenson, M., et al. Association between donor leukocyte telomere length and survival after unrelated allogeneic hematopoietic cell transplantation for severe aplastic anemia. JAMA 313 (2015), 594–602.
14. 14 Lin, J., Kaur, P., Countryman, P., Opresko, P.L., Wang, H., Unraveling secrets of telomeres: one molecule at a time. DNA Repair (Amst) 20 (2014), 142–153.
15. 15 Akiyama, M., Asai, O., Kuraishi, Y., et al. Shortening of telomeres in recipients of both autologous and allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant 25 (2000), 441–447.
16. 16 Akiyama, M., Hoshi, Y., Sakurai, S., Yamada, H., Yamada, O., Mizoguchi, H., Changes of telomere length in children after hematopoietic stem cell transplantation. Bone Marrow Transplant 21 (1998), 167–171.
17. 17 Lee, J., Kook, H., Chung, I., et al. Telomere length changes in patients undergoing hematopoietic stem cell transplantation. Bone Marrow Transplant 24 (1999), 411–415.
18. 18 Baerlocher, G.M., Rovo, A., Muller, A., et al. Cellular senescence of white blood cells in very long-term survivors after allogeneic hematopoietic stem cell transplantation: the role of chronic graft-versus-host disease and female donor sex. Blood 114 (2009), 219–222.
19. 19 Cawthon, R.M., Telomere measurement by quantitative PCR. Nucleic Acids Res, 30, 2002, e47.
20. 20 Callicott, R.J., Womack, J.E., Real-time PCR assay for measurement of mouse telomeres. Comp Med 56 (2006), 17–22.
21. 21 Kollman, C., Spellman, S.R., Zhang, M.J., et al. The effect of donor characteristics on survival after unrelated donor transplantation for hematologic malignancy. Blood 127 (2016), 260–267.
22. 22 Kollman, C., Howe, C.W., Anasetti, C., et al. Donor characteristics as risk factors in recipients after transplantation of bone marrow from unrelated donors: the effect of donor age. Blood 98 (2001), 2043–2051.
23. 23 Hemann, M.T., Strong, M.A., Hao, L.Y., Greider, C.W., The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell 107 (2001), 67–77.
24. 24 Engelhardt, M., Kumar, R., Albanell, J., Pettengell, R., Han, W., Moore, M.A., Telomerase regulation, cell cycle, and telomere stability in primitive hematopoietic cells. Blood 90 (1997), 182–193.
25. 25 Ruella, M., Rocci, A., Ricca, I., et al. Comparative assessment of telomere length before and after hematopoietic SCT: role of grafted cells in determining post-transplant telomere status. Bone Marrow Transplant 45 (2010), 505–512.
26. 26 Lincz, L.F., Scorgie, F.E., Sakoff, J.A., Fagan, K.A., Ackland, S.P., Enno, A., Telomere length predicts neutrophil recovery in the absence of G-CSF after autologous peripheral blood stem cell transplantation. Bone Marrow Transplant 34 (2004), 439–445.
27. 27 Elbers, C.C., Garcia, M.E., Kimura, M., et al. Comparison between southern blots and qPCR analysis of leukocyte telomere length in the health ABC study. J Gerontol A Biol Sci Med Sci 69 (2014), 527–531.
28. 28 Gutierrez-Rodrigues, F., Santana-Lemos, B.A., Scheucher, P.S., Alves-Paiva, R.M., Calado, R.T., Direct comparison of flow-FISH and qPCR as diagnostic tests for telomere length measurement in humans. PLoS ONE, 9, 2014, e113747.