Impairment of coronary flow reserve evaluated by phase contrast cine-magnetic resonance imaging in patients with heart failure with preserved ejection fraction

Journal of the American Heart Association

Volumn 5, Issue 2, 2016, Pages 1-9

  Kato, Shingo ^a   Saito, Naka ^b   Kirigaya, Hidekuni ^b   Gyotoku, Daiki ^b   Iinuma, Naoki ^b   Kusakawa, Yuka ^b   Iguchi, Kohei ^b   Nakachi, Tatsuya ^b   Fukui, Kazuki ^b   Futaki, Masaaki ^b   Iwasawa, Tae ^b   Kimura, Kazuo ^c   Umemura, Satoshi ^d  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b Kanagawa Prefectural Cardiovascular and Respiratory Center Hospital   (Japan)

^c YOKOHAMA CITY UNIVERSITY MEDICAL CENTER   (Japan)

^d YOKOHAMA CITY UNIVERSITY HOSPITAL   (Japan)

Author keywords

Coronary flow reserve; Heart failure with preserved ejection fraction; Hypertension; Left ventricular hypertrophy

Indexed keywords

ADENOSINE TRIPHOSPHATE; BRAIN NATRIURETIC PEPTIDE; BIOLOGICAL MARKER; VASODILATOR AGENT;

AGED; ARTICLE; CARDIOVASCULAR PARAMETERS; CINE MAGNETIC RESONANCE IMAGING; CLINICAL ARTICLE; COMORBIDITY; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CORONARY FLOW RESERVE; CORONARY SINUS BLOOD FLOW; DISEASE SEVERITY; E E' RATIO; ECHOCARDIOGRAPHY; FEMALE; HEART FAILURE WITH PRESERVED EJECTION FRACTION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE HYPERTROPHY; HUMAN; HYPERTENSION; LEFT ATRIAL DIMENSION; MALE; MICROANGIOPATHY; NUCLEAR MAGNETIC RESONANCE SCANNER; PHARMACOLOGIC STRESS TESTING; PRIORITY JOURNAL; REAL TIME ULTRASOUND SCANNER; SEX DIFFERENCE; BLOOD; BLOOD FLOW; BLOOD FLOW VELOCITY; BREATH HOLDING; CASE CONTROL STUDY; CHI SQUARE DISTRIBUTION; CORONARY SINUS; FRACTIONAL FLOW RESERVE; HEART FAILURE; HEART LEFT VENTRICLE FUNCTION; HEART STROKE VOLUME; HYPERTROPHY, LEFT VENTRICULAR; MULTIVARIATE ANALYSIS; MYOCARDIAL PERFUSION IMAGING; PATHOPHYSIOLOGY; PREDICTIVE VALUE; PROCEDURES; PROSPECTIVE STUDY; SEVERITY OF ILLNESS INDEX; STATISTICAL MODEL; VERY ELDERLY;

ADENOSINE TRIPHOSPHATE; AGED; AGED, 80 AND OVER; BIOMARKERS; BLOOD FLOW VELOCITY; BREATH HOLDING; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; CORONARY SINUS; FEMALE; FRACTIONAL FLOW RESERVE, MYOCARDIAL; HEART FAILURE; HUMANS; HYPERTENSION; HYPERTROPHY, LEFT VENTRICULAR; LINEAR MODELS; MAGNETIC RESONANCE IMAGING, CINE; MALE; MULTIVARIATE ANALYSIS; MYOCARDIAL PERFUSION IMAGING; NATRIURETIC PEPTIDE, BRAIN; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; REGIONAL BLOOD FLOW; SEVERITY OF ILLNESS INDEX; STROKE VOLUME; VASODILATOR AGENTS; VENTRICULAR FUNCTION, LEFT;

EID: 85002243999     PISSN: None     EISSN: 20479980     Source Type: Journal    
DOI: 10.1161/JAHA.115.002649     Document Type: Article

References (36)

1. Bhatia RS, Tu JV, Lee DS, Austin PC, Fang J, Haouzi A, Gong Y, Liu PP. Outcome of heart failure with preserved ejection fraction in a population-based study. N Engl J Med. 2006;355:260-269.
2. Redfield MM, Jacobsen SJ, Burnett JC Jr, Mahoney DW, Bailey KR, Rodeheffer RJ. Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic. JAMA. 2003;289:194- 202.
3. Udelson JE. Heart failure with preserved ejection fraction. Circulation. 2011;124:e540-e543.
4. Owan TE, Hodge DO, Herges RM, Jacobsen SJ, Roger VL, Redfield MM. Trends in prevalence and outcome of heart failure with preserved ejection fraction. N Engl J Med. 2006;355:251-259.
5. Borlaug BA, Paulus WJ. Heart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatment. Eur Heart J. 2011;32:670-679.
6. Lee DS, Gona P, Vasan RS, Larson MG, Benjamin EJ, Wang TJ, Tu JV, Levy D. Relation of disease pathogenesis and risk factors to heart failure with preserved or reduced ejection fraction: insights from the Framingham Heart Study of the National Heart, Lung, and Blood Institute. Circulation. 2009;119:3070-3077.
7. Borlaug BA. The pathophysiology of heart failure with preserved ejection fraction. Nat Rev Cardiol. 2014;11:507-515.
8. Zile MR, Gaasch WH, Anand IS, Haass M, Little WC, Miller AB, Lopez-Sendon J, Teerlink JR, White M, McMurray JJ, Komajda M, McKelvie R, Ptaszynska A, Hetzel SJ, Massie BM, Carson PE. Mode of death in patients with heart failure and a preserved ejection fraction: results from the Irbesartan in Heart Failure with Preserved Ejection Fraction Study (I-Preserve) trial. Circulation. 2010;121:1393-1405.
9. Paterson I, Michelakis ED. The role of Doppler echocardiography in pulmonary artery hypertension: the importance of proving the obvious. Chest. 2011;139:973-975.
10. Akiyama E, Sugiyama S, Matsuzawa Y, Konishi M, Suzuki H, Nozaki T, Ohba K, Matsubara J, Maeda H, Horibata Y, Sakamoto K, Sugamura K, Yamamuro M, Sumida H, Kaikita K, Iwashita S, Matsui K, Kimura K, Umemura S, Ogawa H. Incremental prognostic significance of peripheral endothelial dysfunction in patients with heart failure with normal left ventricular ejection fraction. J Am Coll Cardiol. 2012;60:1778-1786.
11. Ouzounian M, Lee DS, Liu PP. Diastolic heart failure: mechanisms and controversies. Nat Clin Pract Cardiovasc Med. 2008;5:375-386.
12. Kawada N, Sakuma H, Yamakado T, Takeda K, Isaka N, Nakano T, Higgins CB. Hypertrophic cardiomyopathy: MR measurement of coronary blood flow and vasodilator flow reserve in patients and healthy subjects. Radiology. 1999;211:129-135.
13. Schwitter J, DeMarco T, Kneifel S, von Schulthess GK, Jorg MC, Arheden H, Ruhm S, Stumpe K, Buck A, Parmley WW, Luscher TF, Higgins CB. Magnetic resonance-based assessment of global coronary flow and flow reserve and its relation to left ventricular functional parameters: a comparison with positron emission tomography. Circulation. 2000;101:2696-2702.
14. van RossumAC, Visser FC, HofmanMB, Galjee MA, Westerhof N, Valk J. Global left ventricular perfusion: noninvasive measurement with cineMR imaging and phase velocity mapping of coronary venous outflow. Radiology. 1992;182:685-691.
15. Lund GK, Wendland MF, Shimakawa A, Arheden H, Stahlberg F, Higgins CB, Saeed M. Coronary sinus flow measurement by means of velocity-encoded cine MR imaging: validation by using flow probes in dogs. Radiology. 2000;217:487-493.
16. Watzinger N, Lund GK, Saeed M, Reddy GP, Araoz PA, Yang M, Schwartz AB, Bedigian M, Higgins CB. Myocardial blood flow in patients with dilated cardiomyopathy: quantitative assessment with velocity-encoded cine magnetic resonance imaging of the coronary sinus. J Magn Reson Imaging. 2005;21:347-353.
17. Arheden H, Saeed M, Tornqvist E, Lund G, Wendland MF, Higgins CB, Stahlberg F. Accuracy of segmented MR velocity mapping to measure small vessel pulsatile flow in a phantom simulating cardiac motion. J Magn Reson Imaging. 2001;13:722-728.
18. Lund GK, Watzinger N, Saeed M, Reddy GP, Yang M, Araoz PA, Curatola D, Bedigian M, Higgins CB. Chronic heart failure: global left ventricular perfusion and coronary flow reserve with velocity-encoded cine MR imaging: initial results. Radiology. 2003;227:209-215.
19. Borlaug BA, Melenovsky V, Russell SD, Kessler K, Pacak K, Becker LC, Kass DA. Impaired chronotropic and vasodilator reserves limit exercise capacity in patients with heart failure and a preserved ejection fraction. Circulation. 2006;114:2138-2147.
20. Tan YT, Wenzelburger F, Lee E, Heatlie G, Leyva F, Patel K, Frenneaux M, Sanderson JE. The pathophysiology of heart failure with normal ejection fraction: exercise echocardiography reveals complex abnormalities of both systolic and diastolic ventricular function involving torsion, untwist, and longitudinal motion. J Am Coll Cardiol. 2009;54:36-46.
21. Wachter R, Schmidt-Schweda S, Westermann D, Post H, Edelmann F, Kasner M, Luers C, Steendijk P, Hasenfuss G, Tschope C, Pieske B. Blunted frequencydependent upregulation of cardiac output is related to impaired relaxation in diastolic heart failure. Eur Heart J. 2009;30:3027-3036.
22. Paulus WJ, Tschope C, Sanderson JE, Rusconi C, Flachskampf FA, Rademakers FE, Marino P, Smiseth OA, De Keulenaer G, Leite-Moreira AF, Borbely A, Edes I, Handoko ML, Heymans S, Pezzali N, Pieske B, Dickstein K, Fraser AG, Brutsaert DL. How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the heart failure and echocardiography associations of the European Society of Cardiology. Eur Heart J. 2007;28:2539-2550.
23. Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ernande L, Flachskampf FA, Foster E, Goldstein SA, Kuznetsova T, Lancellotti P, Muraru D, Picard MH, Rietzschel ER, Rudski L, Spencer KT, Tsang W, Voigt JU. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr. 2015;28:1-39.e14.
24. Siegrist PT, Gaemperli O, Koepfli P, Schepis T, Namdar M, Valenta I, Aiello F, Fleischmann S, Alkadhi H, Kaufmann PA. Repeatability of cold pressor testinduced flow increase assessed with H(2)(15)O and PET. J Nucl Med. 2006;47:1420-1426.
25. Naya M, Tsukamoto T, Morita K, Katoh C, Furumoto T, Fujii S, Tamaki N, Tsutsui H. Olmesartan, but not amlodipine, improves endothelium-dependent coronary dilation in hypertensive patients. J Am Coll Cardiol. 2007;50:1144- 1149.
26. Furuyama H, Odagawa Y, Katoh C, Iwado Y, Yoshinaga K, Ito Y, Noriyasu K, Mabuchi M, Kuge Y, Kobayashi K, Tamaki N. Assessment of coronary function in children with a history of Kawasaki disease using (15)O-water positron emission tomography. Circulation. 2002;105:2878-2884.
27. Alexanderson E, Rodriguez-Valero M, Martinez A, Calleja R, Lamothe PA, Sierra C, Garcia-Rojas L, Talayero JA, Cruz P, Meave A, Alexanderson G. Endothelial dysfunction in recently diagnosed type 2 diabetic patients evaluated by PET. Mol Imaging Biol. 2009;11:1-5.
28. Kato S, Fukui K, Kawaguchi J, Ishii N, Koga M, Kusakawa Y, Kusama I, Nakachi T, Nakagawa T, Terauchi Y, Uchino K, Kimura K, Umemura S. Relationship between coronary flow reserve evaluated by phase-contrast cine cardiovascular magnetic resonance and serum eicosapentaenoic acid. J Cardiovasc Magn Reson. 2013;15:106.
29. Vaccarino V, Khan D, Votaw J, Faber T, Veledar E, Jones DP, Goldberg J, Raggi P, Quyyumi AA, Bremner JD. Inflammation is related to coronary flow reserve detected by positron emission tomography in asymptomatic male twins. J Am Coll Cardiol. 2011;57:1271-1279.
30. Setoguchi M, Hashimoto Y, Sasaoka T, Ashikaga T, Isobe M. Risk factors for rehospitalization in heart failure with preserved ejection fraction compared with reduced ejection fraction. Heart Vessels. 2014;30:595-603.
31. Watson CJ, Gupta SK, O'Connell E, Thum S, Glezeva N, Fendrich J, Gallagher J, Ledwidge M, Grote-Levi L, McDonald K, Thum T. MicroRNA signatures differentiate preserved from reduced ejection fraction heart failure. Eur J Heart Fail. 2015;17:405-415.
32. Maeder MT, Thompson BR, Brunner-La Rocca HP, Kaye DM. Hemodynamic basis of exercise limitation in patients with heart failure and normal ejection fraction. J Am Coll Cardiol. 2010;56:855-863.
33. Borlaug BA, Nishimura RA, Sorajja P, Lam CS, Redfield MM. Exercise hemodynamics enhance diagnosis of early heart failure with preserved ejection fraction. Circ Heart Fail. 2010;3:588-595.
34. Kato S, Saito N, Kirigaya H, Gyotoku D, Iinuma N, Kusakawa Y, Iguchi K, Nakachi T, Fukui K, Futaki M, Iwasawa T, Taguri M, Kimura K, Umemura S. Prognostic significance of quantitative assessment of focal myocardial fibrosis in patients with heart failure with preserved ejection fraction. Int J Cardiol. 2015;191:314-319.
35. Westermann D, Kasner M, Steendijk P, Spillmann F, Riad A, Weitmann K, Hoffmann W, Poller W, Pauschinger M, Schultheiss HP, Tschope C. Role of left ventricular stiffness in heart failure with normal ejection fraction. Circulation. 2008;117:2051-2060.
36. Krum H, Abraham WT. Heart failure. Lancet. 2009;373:941-955.