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Volumn 27, Issue 6, 2017, Pages 618-624

In vitro human epidermal permeation of nicotine from electronic cigarette refill liquids and implications for dermal exposure assessment

Author keywords

Consumer exposure; Ejuice; Electronic nicotine delivery systems; Nicotine poisoning; Occupational exposure

Indexed keywords

FLAVORING AGENT; NICOTINE; PROPYLENE GLYCOL;

EID: 85001755128     PISSN: 15590631     EISSN: 1559064X     Source Type: Journal    
DOI: 10.1038/jes.2016.68     Document Type: Article
Times cited : (18)

References (34)
  • 1
    • 84901373578 scopus 로고    scopus 로고
    • E-cigarettes: A scientific review
    • Grana R, Benowitz N, Glantz SA.E-cigarettes: a scientific review. Circulation2014; 129: 1972–1986.
    • (2014) Circulation , vol.129 , pp. 1972-1986
    • Grana, R.1    Benowitz, N.2    Glantz, S.A.3
  • 3
    • 85051301820 scopus 로고    scopus 로고
    • Food and Drug Administration Press Release
    • FDA. FDA and Public Health Experts Warn About Electronic Cigarettes. Food and Drug Administration Press Release. Available at 2009: http://www.fda.gov/newsevents/newsroom/pressannouncements/ucm173222.htm. Accessed 21 November 2016.
    • (2016) FDA and Public Health Experts Warn about Electronic Cigarettes
  • 4
    • 84896962498 scopus 로고    scopus 로고
    • Safety evaluation and risk assessment of electronic cigarettes as tobacco cigarette substitutes: A systematic review
    • Konstantinos EF, Polosa R.Safety evaluation and risk assessment of electronic cigarettes as tobacco cigarette substitutes: a systematic review. Ther Adv Drug Saf2014; 5(2): 67–86.
    • (2014) Ther Adv Drug Saf , vol.5 , Issue.2 , pp. 67-86
    • Konstantinos, E.F.1    Polosa, R.2
  • 5
    • 84897540030 scopus 로고    scopus 로고
    • Notes from the field: Calls to Poison centers for exposures to electronic cigarettes — United States, September 2010–February 2014
    • Chatham-Stephens K, Law R, Taylor E, Melstrom P, Bunnell R, Wang Bet al.Notes from the field: calls to Poison centers for exposures to electronic cigarettes — United States, September 2010–February 2014. MMWR2014; 63: 292–293.
    • (2014) MMWR , vol.63 , pp. 292-293
    • Chatham-Stephens, K.1    Law, R.2    Taylor, E.3    Melstrom, P.4    Bunnell, R.5    Wang, B.6
  • 6
    • 84903936589 scopus 로고    scopus 로고
    • New York Times, 23 March 2014, 21 November 2016
    • Richtel M,Selling a poison by the barrel: liquid nicotine for e-cigarettes. New York Times, 23 March 2014. Available at http://www.nytimes.com/2014/03/24/business/selling-a-poison-by-the-barrel-liquid-nicotine-for-e-cigarettes.html?_r=0. Accessed 21 November 2016.
    • Selling a Poison by the Barrel: Liquid Nicotine for E-Cigarettes
    • Richtel, M.1
  • 7
    • 84927582389 scopus 로고    scopus 로고
    • Forbes, 24 March, Available at, Accessed 21 November 2016
    • Glatter R, The real dangers of liquid nicotine. Forbes, 24 March2014. Available athttp://www.forbes.com/sites/robertglatter/2014/03/24/the-real-danger-of-liquidnicotine/. Accessed 21 November 2016.
    • (2014) The Real Dangers of Liquid Nicotine
    • Glatter, R.1
  • 10
    • 0344538502 scopus 로고
    • Nicotine poisoning by absorption through the skin
    • Faulkner JM.Nicotine poisoning by absorption through the skin. JAMA1933; 100: 1664–1665.
    • (1933) JAMA , vol.100 , pp. 1664-1665
    • Faulkner, J.M.1
  • 11
    • 0023248707 scopus 로고
    • Prolonged absorption with development of tolerance to toxic effects after cutaneous exposure to nicotine
    • Benowitz NL, Lake T, Keller KH, Lee BL.Prolonged absorption with development of tolerance to toxic effects after cutaneous exposure to nicotine. Clin Pharmacol Ther1987; 42: 119–120.
    • (1987) Clin Pharmacol Ther , vol.42 , pp. 119-120
    • Benowitz, N.L.1    Lake, T.2    Keller, K.H.3    Lee, B.L.4
  • 12
    • 0035203334 scopus 로고    scopus 로고
    • Case report: Acute nicotine poisoning associated with a traditional remedy for eczema
    • Davis P, Levy S, Pahari A, Martinez D.Case report: acute nicotine poisoning associated with a traditional remedy for eczema. Arch Dis Child2001; 85: 500–502.
    • (2001) Arch Dis Child , vol.85 , pp. 500-502
    • Davis, P.1    Levy, S.2    Pahari, A.3    Martinez, D.4
  • 13
    • 0023679802 scopus 로고
    • Nicotine skin penetration characteristics using aqueous and nonaqueous vehicles, anionic polymers, and silicone matrices
    • Aungst BJ.Nicotine skin penetration characteristics using aqueous and nonaqueous vehicles, anionic polymers, and silicone matrices. Drug Dev Ind Pharm1988; 14: 1481–1494.
    • (1988) Drug Dev Ind Pharm , vol.14 , pp. 1481-1494
    • Aungst, B.J.1
  • 14
    • 0033180201 scopus 로고    scopus 로고
    • In vitro test of nicotine’s permeability through human skin. Risk evaluation and safety aspects
    • Zorin S, Kuylenstierna F, Thulin H.In vitro test of nicotine’s permeability through human skin. Risk evaluation and safety aspects. Ann Occup Hyg1999; 43: 405–413.
    • (1999) Ann Occup Hyg , vol.43 , pp. 405-413
    • Zorin, S.1    Kuylenstierna, F.2    Thulin, H.3
  • 15
    • 0033623754 scopus 로고    scopus 로고
    • Evaluation of the Göttingen minipig skin for transdermal in vitro permeation studies
    • Qvist MH, Hoeck U, Kreilgaard B, Madsen F, Frokjaer S.Evaluation of the Göttingen minipig skin for transdermal in vitro permeation studies. Eur J Pharm Sci2000; 11: 59–68.
    • (2000) Eur J Pharm Sci , vol.11 , pp. 59-68
    • Qvist, M.H.1    Hoeck, U.2    Kreilgaard, B.3    Madsen, F.4    Frokjaer, S.5
  • 16
    • 84902135713 scopus 로고    scopus 로고
    • Concentration dependency in nicotine skin penetration flux from aqueous solutions reflects vehicle induced changes in nicotine stratum corneum retention
    • Kuswahyuning R, Roberts MS.Concentration dependency in nicotine skin penetration flux from aqueous solutions reflects vehicle induced changes in nicotine stratum corneum retention. Pharm Res2014; 31: 1501–1511.
    • (2014) Pharm Res , vol.31 , pp. 1501-1511
    • Kuswahyuning, R.1    Roberts, M.S.2
  • 17
    • 84958121408 scopus 로고    scopus 로고
    • Effect of frozen human epidermis storage duration and cryoprotectant on barrier function using two model compounds
    • Barbero AM, Frasch HF.Effect of frozen human epidermis storage duration and cryoprotectant on barrier function using two model compounds. Skin Pharmacol Physiol2016; 29: 31–40.
    • (2016) Skin Pharmacol Physiol , vol.29 , pp. 31-40
    • Barbero, A.M.1    Frasch, H.F.2
  • 18
    • 11844253191 scopus 로고    scopus 로고
    • Application of solid-phase microextraction to in vitro skin permeation experiments: Example using diethyl phthalate
    • Frasch HF, Barbero AM.Application of solid-phase microextraction to in vitro skin permeation experiments: example using diethyl phthalate. Toxicol In Vitro2005; 19: 253–259.
    • (2005) Toxicol in Vitro , vol.19 , pp. 253-259
    • Frasch, H.F.1    Barbero, A.M.2
  • 20
    • 25644432500 scopus 로고    scopus 로고
    • Organization for Economic Co-Operation and Development: Paris
    • OECD. OECD Guideline for the Testing of Chemicals. Organization for Economic Co-Operation and Development: Paris, 2004.
    • (2004) OECD Guideline for the Testing of Chemicals
  • 21
    • 33644620075 scopus 로고    scopus 로고
    • Limonene GP1/PG organogel as a vehicle in transdermal delivery of haloperidol
    • Lim PFC, Liu XY, Kang L, Ho PCL, Chan YW, Chan SY.Limonene GP1/PG organogel as a vehicle in transdermal delivery of haloperidol. Int J Pharm2006; 311: 157–164.
    • (2006) Int J Pharm , vol.311 , pp. 157-164
    • Lim, P.1    Liu, X.Y.2    Kang, L.3    Ho, P.4    Chan, Y.W.5    Chan, S.Y.6
  • 22
    • 41849132168 scopus 로고    scopus 로고
    • In vivo immunomodulatory, cumulative skin irritation, sensitization and effect of d-limonene on permeation of 6-mercaptopurine through transdermal drug delivery
    • Candrashekar NS, Hiremath SR.In vivo immunomodulatory, cumulative skin irritation, sensitization and effect of d-limonene on permeation of 6-mercaptopurine through transdermal drug delivery. Biol Pharm Bull2008; 31: 656–661.
    • (2008) Biol Pharm Bull , vol.31 , pp. 656-661
    • Candrashekar, N.S.1    Hiremath, S.R.2
  • 23
    • 84924765817 scopus 로고    scopus 로고
    • The transient dermal exposure II: Post-exposure absorption and evaporation of volatile compounds
    • Frasch HF, Bunge AL.The transient dermal exposure II: post-exposure absorption and evaporation of volatile compounds. J Pharm Sci2015; 104: 1499–1507.
    • (2015) J Pharm Sci , vol.104 , pp. 1499-1507
    • Frasch, H.F.1    Bunge, A.L.2
  • 25
    • 0021270837 scopus 로고
    • Daily intake of nicotine during cigarette smoking
    • Benowitz NL, Jacob P III. Daily intake of nicotine during cigarette smoking. Clin Pharmacol Ther1984; 35: 499–504.
    • (1984) Clin Pharmacol Ther , vol.35 , pp. 499-504
    • Benowitz, N.L.1    Jacob, P.2
  • 26
    • 0022370841 scopus 로고
    • Analytical cigarette yields as predictors of smoke bioavailability
    • Gori GB, Lynch CJ.Analytical cigarette yields as predictors of smoke bioavailability. Regul Toxicol Pharmacol1985; 5: 314–326.
    • (1985) Regul Toxicol Pharmacol , vol.5 , pp. 314-326
    • Gori, G.B.1    Lynch, C.J.2
  • 27
    • 0035139080 scopus 로고    scopus 로고
    • Pharmacokinetics of nicotine in healthy elderly people
    • Molander L, Hansson A, Lunell E.Pharmacokinetics of nicotine in healthy elderly people. Clin Pharmacol Ther2001; 69: 57–65.
    • (2001) Clin Pharmacol Ther , vol.69 , pp. 57-65
    • Molander, L.1    Hansson, A.2    Lunell, E.3
  • 28
    • 84892577122 scopus 로고    scopus 로고
    • How much nicotine kills a human? Tracing back the generally accepted lethal dose to dubious self-experiments in the nineteenth century
    • Mayer B.How much nicotine kills a human? Tracing back the generally accepted lethal dose to dubious self-experiments in the nineteenth century. Arch Toxicol2014; 88: 5–7.
    • (2014) Arch Toxicol , vol.88 , pp. 5-7
    • Mayer, B.1
  • 29
    • 14144253640 scopus 로고    scopus 로고
    • Metabolism and disposition kinetics of nicotine
    • Hukkanen J, Jacob P 3rd, Benowitz NL.Metabolism and disposition kinetics of nicotine. Pharmacol Rev2005; 57: 79–115.
    • (2005) Pharmacol Rev , vol.57 , pp. 79-115
    • Hukkanen, J.1    Jacob, P.2    Benowitz, N.L.3
  • 30
    • 0030472812 scopus 로고    scopus 로고
    • Self-poisoning among adults using multiple transdermal nicotine patches
    • Woolf A, Burkhart K, Caraccio T, Litovitz T.Self-poisoning among adults using multiple transdermal nicotine patches. J Toxicol Clin Toxicol1996; 34: 691–698.
    • (1996) J Toxicol Clin Toxicol , vol.34 , pp. 691-698
    • Woolf, A.1    Burkhart, K.2    Caraccio, T.3    Litovitz, T.4
  • 31
    • 0030931639 scopus 로고    scopus 로고
    • A cadaver study on volume and surface area of the fingertip
    • Murai M, Lau HK, Pereira BP, Pho RW.A cadaver study on volume and surface area of the fingertip. J Hand Surg Am1997; 22(5): 935–941.
    • (1997) J Hand Surg Am , vol.22 , Issue.5 , pp. 935-941
    • Murai, M.1    Lau, H.K.2    Pereira, B.P.3    Pho, R.W.4
  • 33
    • 85051298258 scopus 로고    scopus 로고
    • Engineering Toolbox. Liquids kinematic viscosities. The Engineering Tool Box, November
    • Engineering Toolbox. Liquids kinematic viscosities. The Engineering Tool Boxhttp://www.engineeringtoolbox.com/kinematic-viscosity-d_397.html. Accessed November2016.
    • (2016)
  • 34
    • 85051284917 scopus 로고    scopus 로고
    • Edition. Ch. 7 National Center for Environmental Assessment: Washington, DC, 2011 EPA/600/R-09/052F
    • EPA. Dermal Exposure Factors. Exposure Factors Handbook: 2011Edition. Ch. 7 National Center for Environmental Assessment: Washington, DC, 2011 EPA/600/R-09/052F.
    • Dermal Exposure Factors. Exposure Factors Handbook: 2011


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.