Lactate levels and hemodynamic coherence in acute circulatory failure

Best Practice and Research: Clinical Anaesthesiology

Volumn 30, Issue 4, 2016, Pages 523-530

  Bakker, Jan ^a,b,c,d  

^a Department of Medicine   (United States)

^b NEW YORK UNIVERSITY   (United States)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

Author keywords

blood pressure; cardiac output; fluid resuscitation; inotropes; lactate; microcirculation; resuscitation; sepsis; septic shock; vasopressors

Indexed keywords

LACTIC ACID;

CARDIOGENIC SHOCK; CITRIC ACID CYCLE; GLUCOSE METABOLISM; HEART OUTPUT; HEMODYNAMICS; HUMAN; HYPOTENSION; HYPOVOLEMIA; INTRAABDOMINAL HYPERTENSION; ISCHEMIA; LACTATE BLOOD LEVEL; MEAN ARTERIAL PRESSURE; MICROCIRCULATION; PRIORITY JOURNAL; RESUSCITATION; REVIEW; SYSTEMIC CIRCULATION; BLOOD; PATHOPHYSIOLOGY; PERFUSION; SHOCK;

HEMODYNAMICS; HUMANS; LACTIC ACID; PERFUSION; SHOCK;

EID: 85000922941     PISSN: 15216896     EISSN: 1532169X     Source Type: Journal    
DOI: 10.1016/j.bpa.2016.11.001     Document Type: Review

References (63)

1. [1] Johnson, B.D., van Helmond, N., Curry, T.B., et al. Reductions in central venous pressure by lower body negative pressure or blood loss elicit similar hemodynamic responses. J Appl Physiol (1985) 117:2 (2014), 131–141.
2. [2] van Genderen, M.E., Bartels, S.A., Lima, A., et al. Peripheral perfusion index as an early predictor for central hypovolemia in awake healthy volunteers. Anesth Analg 116:2 (2013), 351–356.
3. [3] Bartels, S.A., Bezemer, R., Milstein, D.M., et al. The microcirculatory response to compensated hypovolemia in a lower body negative pressure model. Microvasc Res 82:3 (2011), 374–380.
4. [4] Lima, A., Beelen, P., Bakker, J., Use of a peripheral perfusion index derived from the pulse oximetry signal as a noninvasive indicator of perfusion. Crit Care Med 30:6 (2002), 1210–1213.
5. [5] Lima, A., Jansen, T.C., Van BOommel, J., et al. The prognostic value of the subjective assessment of peripheral perfusion in critically ill patients. Crit Care Med 37:3 (2009), 934–938.
6. [6] Edul, V.S., Enrico, C., Laviolle, B., et al. Quantitative assessment of the microcirculation in healthy volunteers and in patients with septic shock. Crit Care Med 40:5 (2012), 1443–1448.
7. [7] Trzeciak, S., McCoy, J.V., Phillip Dellinger, R., et al. Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis. Intensive Care Med 34:12 (2008), 2210–2217.
8. [8] Tachon, G., Harrois, A., Tanaka, S., et al. Microcirculatory alterations in traumatic hemorrhagic shock. Crit Care Med 42:6 (2014), 1433–1441.
9. [9] Ince, C., Hemodynamic coherence and the rationale for monitoring the microcirculation. Crit Care, 19(Suppl 3), 2015, S8.
10. [10] Astiz, M.E., DeGent, G.E., Lin, R.Y., et al. Microvascular function and rheologic changes in hyperdynamic sepsis. Crit Care Med 23 (1995), 265–271.
11. [11] Kirschenbaum, L.A., Astiz, M.E., Rackow, E.C., et al. Microvascular response in patients with cardiogenic shock. Crit Care Med 28:5 (2000), 1290–1294.
12. [12] Eichelbronner, O., Sielenkamper, A., Cepinskas, G., et al. Endotoxin promotes adhesion of human erythrocytes to human vascular endothelial cells under conditions of flow. Crit Care Med 28:6 (2000), 1865–1870.
13. [13] Bakker, J., Nijsten, M.W., Jansen, T.C., Clinical use of lactate monitoring in critically ill patients. Ann Intensive Care, 3(1), 2013, 12.
14. [14] Vary, T.C., Siegel, J.H., Nakatani, T., et al. Effect of sepsis on activity of pyruvate dehydrogenase complex in skeletal muscle and liver. Am J Physiol 250:6 Pt 1 (1986), E634–E640.
15. [15] Huckabee, W.E., Relationships of pyruvate and lactate during anaerobic metabolism. I. Effects of infusion of pyruvate or glucose and of hyperventilation. J Clin Invest 37:2 (1958), 244–254.
16. [16] Levy, B., Gibot, S., Franck, P., et al. Relation between muscle Na+K+ ATPase activity and raised lactate concentrations in septic shock: a prospective study. Lancet 365:9462 (2005), 871–875.
17. [17] Levy, B., Desebbe, O., Montemont, C., et al. Increased aerobic glycolysis through Beta-2 stimulation is a common mechanism involved in lactate formation during shock states. Shock 30:4 (2008), 417–421.
18. [18] Jansen, T.C., van Bommel, J., Bakker, J., Blood lactate monitoring in critically ill patients: a systematic health technology assessment. Crit Care Med 37:10 (2009), 2827–2839.
19. [19] Vincent, J.L., Serial blood lactate levels reflect both lactate production and clearance. Crit Care Med, 43(6), 2015, e209.
20. [20] Vincent, J.L., Lactic acidosis. N Engl J Med 372:11 (2015), 1077–1078.
21. [21] Levraut, J., Ciebiera, J.P., Chave, S., et al. Mild hyperlactatemia in stable septic patients is due to impaired lactate clearance rather than overproduction. Am J Respir Crit Care Med 157:4 (1998), 1021–1026.
22. [22] Tapia, P., Soto, D., Bruhn, A., et al. Impairment of exogenous lactate clearance in experimental hyperdynamic septic shock is not related to total liver hypoperfusion. Crit Care, 19(1), 2015, 188.
23. [23] Cain, S.M., Appearance of excess lactate in anesthetized dogs during anemic and hypoxic hypoxia. Am J Physiol 209:3 (1965), 604–610.
24. [24] Schumacker, P.T., Cain, S.M., The concept of a critical oxygen delivery. Intensive Care Med 13 (1987), 223–229.
25. [25] Cain, S.M., Oxygen supply dependency in the critically ill–a continuing conundrum. Adv Exp Med Biol 317 (1992), 35–45.
26. [26] Ronco, J.J., Montaner, J.S.G., Fenwick, J.C., et al. Pathologic dependence of oxygen consumption on oxygen delivery in acute respiratory failure secondary to AIDS-related Pneumocystis carinii pneumonia. Chest 98 (1990), 1463–1466.
27. [27] Ronco, J.J., Fenwick, J.C., Tweeddale, M.G., et al. Identification of the critical oxygen delivery for anaerobic metabolism in critically ill septic and nonseptic humans. JAMA 270:14 (1993), 1724–1730.
28. [28] Bakker, J., Vincent, J., The oxygen-supply dependency phenomenon is associated with increased blood lactate levels. J Crit Care 6:3 (1991), 152–159.
29. [29] Friedman, G., De Backer, D., Shahla, M., et al. Oxygen supply dependency can characterize septic shock. Intensive Care Med 24:2 (1998), 118–123.
30. [30] Zhang, H., Spapen, H., Benlabed, M., et al. Systemic oxygen extraction can be improved during repeated episodes of cardiac tamponade. J Crit Care 8:2 (1993), 93–99.
31. [31] Vincent, J.L., Quintairos, E.S.A., Couto, L. Jr., et al. The value of blood lactate kinetics in critically ill patients: a systematic review. Crit Care, 20(1), 2016, 257.
32. [32] Hernandez, G., Luengo, C., Bruhn, A., et al. When to stop septic shock resuscitation: clues from a dynamic perfusion monitoring. Ann Intensive Care, 4(30), 2014.
33. [33] van Iterson, M., Bezemer, R., Heger, M., et al. Microcirculation follows macrocirculation in heart and gut in the acute phase of hemorrhagic shock and isovolemic autologous whole blood resuscitation in pigs. Transfusion 52:7 (2012), 1552–1559.
34. [34] van Genderen, M.E., Klijn, E., Lima, A., et al. Microvascular perfusion as a target for fluid resuscitation in experimental circulatory shock. Crit Care Med 42:2 (2014), E96–E105.
35. [35] Legrand, M., Bezemer, R., Kandil, A., et al. The role of renal hypoperfusion in development of renal microcirculatory dysfunction in endotoxemic rats. Intensive Care Med 37:9 (2011), 1534–1542.
36. [36] Dubin, A., Pozo, M.O., Ferrara, G., et al. Systemic and microcirculatory responses to progressive hemorrhage. Intensive Care Med 35:3 (2009), 556–564.
37. [37] Dubin, A., Edul, V.S., Pozo, M.O., et al. Persistent villi hypoperfusion explains intramucosal acidosis in sheep endotoxemia. Crit Care Med 36:2 (2008), 535–542.
38. [38] Stenberg, T.A., Kildal, A.B., Sanden, E., et al. The acute phase of experimental cardiogenic shock is counteracted by microcirculatory and mitochondrial adaptations. PLoS One, 9(9), 2014, e105213.
39. [39] Ferrara, G., Kanoore Edul, V.S., Caminos Eguillor, J.F., et al. Effects of norepinephrine on tissue perfusion in a sheep model of intra-abdominal hypertension. Intensive Care Med Exp, 3(1), 2015, 46.
40. [40] Verdant, C.L., De Backer, D., Bruhn, A., et al. Evaluation of sublingual and gut mucosal microcirculation in sepsis: a quantitative analysis. Crit Care Med 37:11 (2009), 2875–2881.
41. [41] Edul, V.S., Ince, C., Navarro, N., et al. Dissociation between sublingual and gut microcirculation in the response to a fluid challenge in postoperative patients with abdominal sepsis. Ann Intensive Care, 4, 2014, 39.
42. [42] Boerma, E.C., van der Voort, P.H., Spronk, P.E., et al. Relationship between sublingual and intestinal microcirculatory perfusion in patients with abdominal sepsis. Crit Care Med 35:4 (2007), 1055–1060.
43. [43] LeDoux, D., Astiz, M.E., Carpati, C.M., et al. Effects of perfusion pressure on tissue perfusion in septic shock. Crit Care Med 28:8 (2000), 2729–2732.
44. [44] Dubin, A., Pozo, M.O., Casabella, C.A., et al. Increasing arterial blood pressure with norepinephrine does not improve microcirculatory blood flow: a prospective study. Crit Care, 13(3), 2009, R92.
45. [45] De Backer, D., Creteur, J., Dubois, M.J., et al. The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects. Crit Care Med 34:2 (2006), 403–408.
46. [46] den Uil, C.A., Lagrand, W.K., van der Ent, M., et al. Conventional hemodynamic resuscitation may fail to optimize tissue perfusion: an observational study on the effects of dobutamine, enoximone, and norepinephrine in patients with acute myocardial infarction complicated by cardiogenic shock. PLoS One, 9(8), 2014, e103978.
47. [47] Jhanji, S., Vivian-Smith, A., Lucena-Amaro, S., et al. Haemodynamic optimisation improves tissue microvascular flow and oxygenation after major surgery: a randomised controlled trial. Crit Care, 14(4), 2010, R151.
48. [48] De Backer, D., Creteur, J., Dubois, M.J., et al. Microvascular alterations in patients with acute severe heart failure and cardiogenic shock. Am Heart J 147:1 (2004), 91–99.
49. [49] Sakr, Y., Dubois, M.J., De Backer, D., et al. Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock. Crit Care Med 32:9 (2004), 1825–1831.
50. [50] De Backer, D., Creteur, J., Preiser, J.C., et al. Microvascular blood flow is altered in patients with sepsis. Am J Respir Crit Care Med 166:1 (2002), 98–104.
51. [51] Hernandez, G., Boerma, E.C., Dubin, A., et al. Severe abnormalities in microvascular perfused vessel density are associated to organ dysfunctions and mortality and can be predicted by hyperlactatemia and norepinephrine requirements in septic shock patients. J Crit Care 28(4):538 (2013), e9–14.
52. [52] De Backer, D., Ortiz, J.A., Salgado, D., Coupling microcirculation to systemic hemodynamics. Curr Opin Crit Care 16:3 (2010), 250–254.
53. [53] Bakker, J., Gris, P., Coffernils, M., et al. Serial blood lactate levels can predict the development of multiple organ failure following septic shock. Am J Surg 171:2 (1996), 221–226.
54. [54] Jansen, T.C., van Bommel, J., Woodward, R., et al. Association between blood lactate levels, Sequential Organ Failure Assessment subscores, and 28-day mortality during early and late intensive care unit stay: a retrospective observational study. Crit Care Med 37:8 (2009), 2369–2374.
55. [55] Hernandez, G., Teboul, J.L., Is the macrocirculation really dissociated from the microcirculation in septic shock?. Intensive Care Med 42:10 (2016), 1621–1624.
56. [56] Ince, C., Guerci, P., Why and when the microcirculation becomes disassociated from the macrocirculation. Intensive Care Med 42:10 (2016), 1645–1646.
57. [57] Hernandez, G., Lara, B., Enberg, L., et al. Peripheral perfusion response to the first fluid resuscitation predicts mortality in patients with sepsis-related acute circulatory dysfunction admitted to the emergency department. Intensive Care Med Exp, 4(Suppl 1), 2016, A170.
58. [58] Rivers, E., Nguyen, B., Havstad, S., et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 345:19 (2001), 1368–1377.
59. [59] Investigators, P., Yealy, D.M., Kellum, J.A., et al. A randomized trial of protocol-based care for early septic shock. N Engl J Med 370:18 (2014), 1683–1693.
60. [60] Investigators, A., Group, A.C.T., Peake, S.L., et al. Goal-directed resuscitation for patients with early septic shock. N Engl J Med 371:16 (2014), 1496–1506.
61. [61] Mouncey, P.R., Osborn, T.M., Power, G.S., et al. Trial of early, goal-directed resuscitation for septic shock. N Engl J Med 372:14 (2015), 1301–1311.
62. [62] Jansen, T.C., van Bommel, J., Schoonderbeek, F.J., et al. Early lactate-guided therapy in intensive care unit patients a multicenter, open-label, randomized controlled trial. Am J Respir Crit Care Med 182:6 (2010), 752–761.
63. [63] Dunser, M.W., Takala, J., Brunauer, A., et al. Re-thinking resuscitation: leaving blood pressure cosmetics behind and moving forward to permissive hypotension and a tissue perfusion-based approach. Crit Care, 17(5), 2013, 326.