Production of transgenic pigs over-expressing the antiviral gene Mx1

Cell Regeneration

Volumn 3, Issue 1, 2014, Pages 3:11-

  Yan, Quanmei ^a   Yang, Huaqiang ^a   Yang, Dongshan ^a   Zhao, Bentian ^a   Ouyang, Zhen ^a   Liu, Zhaoming ^a   Fan, Nana ^a   Ouyang, Hongsheng ^b   Gu, Weiwang ^c   Lai, Liangxue ^a,b  

^a GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH   (China)

^b JILIN UNIVERSITY   (China)

^c SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

Antiviral breeding; Innate resistance; Somatic cell nuclear transfer

Indexed keywords

MESSENGER RNA; MX1 PROTEIN; MYXOVIRUS RESISTANCE PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL NUCLEUS TRANSPLANTATION; CELL PROLIFERATION; CLASSICAL SWINE FEVER VIRUS; CONTROLLED STUDY; FETUS; GENE; GENE OVEREXPRESSION; IMMUNOFLUORESCENCE TEST; INFLUENZA VIRUS A; MX1 GENE; NONHUMAN; PRIORITY JOURNAL; SKIN FIBROBLAST; TRANSGENIC PIG; VIROGENESIS;

ANIMALIA; CLASSICAL SWINE FEVER VIRUS; INFLUENZA A VIRUS; ORTHOMYXOVIRIDAE; SUIDAE;

EID: 84999309381     PISSN: None     EISSN: 20459769     Source Type: Journal    
DOI: 10.1186/2045-9769-3-11     Document Type: Article

References (44)

1. Le Bon DF. Tough, Links between innate and adaptive immunity via type I interferon. Curr Opin Immunol 2002, 14:432-436. 10.1016/S0952-7915(02)00354-0, 12088676.
2. Haller O, Arnheiter H, Lindenmann J, Gresser I. Host gene influences sensitivity to interferon action selectively for influenza virus. Nature 1980, 283:660-662. 10.1038/283660a0, 7354853.
3. Haller O, Kochs G, Weber F. Interferon, Mx, and viral countermeasures. Cytokine Growth Factor Rev 2007, 18:425-433. 10.1016/j.cytogfr.2007.06.001, 17683972.
4. Pavlovic J, Haller O, Staeheli P. Human and mouse Mx proteins inhibit different steps of the influenza virus multiplication cycle. J Virol 1992, 66:2564-2569. 289059, 1548781.
5. Tumpey TM, Szretter KJ, Van Hoeven N, Katz JM, Kochs G, Haller O, García-Sastre A, Staeheli P. The Mx1 Gene Protects Mice against the Pandemic 1918 and Highly Lethal Human H5N1 Influenza Viruses. J Virol 2007, 81:10818-10821. 10.1128/JVI.01116-07, 2045488, 17652381.
6. Haller O, Frese M, Rost D, Nuttall PA, Kochs G. Tick-borne Thogoto virus infection in mice is inhibited by the orthomyxovirus resistance gene product Mx1. J Virol 1995, 69:2596-2601. 188937, 7884909.
7. Andersson I, Bladh L, Mousavi-Jazi M, Magnusson KE, Lundkvist A, Haller O, Mirazimi A. The Mx1 Gene Protects Mice against the Pandemic 1918 and Highly Lethal Human H5N1 Influenza Viruses. J Virol 2004, 78:4323-4329. 10.1128/JVI.78.8.4323-4329.2004, 374267, 15047845.
8. Kochs G, Janzen C, Hohenberg H, Haller O. Antivirally active MxA protein sequesters La Crosse virus nucleocapsid protein into perinuclear complexes. Proc Natl Acad Sci U S A 2002, 99:3153-3158. 10.1073/pnas.052430399, 122488, 11880649.
9. Staeheli P, Pavlovic J. Inhibition of vesicular stomatitis virus mRNA synthesis by human MxA protein. J Virol 1991, 65:4498-4501. 248893, 1649344.
10. Schneider-Schaulies S, Schneider-Schaulies J, Schuster A, Bayer M, Pavlovic J, ter Meulen V. Cell type-specific MxA-mediated inhibition of measles virus transcription in human brain cells. J Virol 1994, 68:6910-6917. 237126, 7933071.
11. Khaiboullina SF, Rizvanov AA, Deyde VM, St Jeor SC. Andes virus stimulates interferon - inducible MxA protein expression in endothelial cells. J Med Virol 2005, 75:267-275. 10.1002/jmv.20266, 15602733.
12. Kraus AA, Raftery MJ, Giese T, Ulrich R, Zawatzky R, Hippenstiel S, Suttorp N, Krüger DH, Schönrich G. Differential antiviral response of endothelial cells after infection with pathogenic and nonpathogenic hantaviruses. J Virol 2004, 78:6143-6150. 10.1128/JVI.78.12.6143-6150.2004, 416501, 15163707.
13. Zürcher T, Pavlovic J, Staeheli P. Mechanism of human MxA protein action: variants with changed antiviral properties. EMBO J 1992, 11:1657-1661. 556616, 1314172.
14. Mundt E. Human MxA protein confers resistance to double-stranded RNA viruses of two virus families. J Gen Virol 2007, 88:1319-1323. 10.1099/vir.0.82526-0, 17374778.
15. Staeheli P, Haller O, Boll W, Lindenmann J, Weissmann C. Mx protein: constitutive expression in 3T3 cells transformed with cloned Mx cDNA confers selective resistance to influenza virus. Cell 1986, 44:147-158. 10.1016/0092-8674(86)90493-9, 3000619.
16. Dittmann J, Stertz S, Grimm D, Steel J, García-Sastre A, Haller O, Kochs G. Influenza A virus strains differ in sensitivity to the antiviral action of Mx-GTPase. J Virol 2008, 82:3624-3631. 10.1128/JVI.01753-07, 2268464, 18199636.
17. Asano A, Ko JH, Morozumi T, Hamashima N. Polymorphisms and the antiviral property of porcine Mx1 protein. J Vet Med Sci 2002, 64:1085-1089. 10.1292/jvms.64.1085, 12520098.
18. Nakajima E, Morozumi T, Tsukamoto K, Watanabe T, Plastow G, Mitsuhashi T. A naturally occurring variants of porcine Mx1 associated with increased susceptibility to influenza virus in vitro. Biochem Genet 2007, 45:11-24. 10.1007/s10528-006-9045-y, 17203407.
19. Ko JH, Jin HK, Asano A, Takada A, Ninomiya A, Kida H, Hokiyama H, Ohara M, Tsuzuki M, Nishibori M, Mizutani M, Watanabe T. Polymorphisms and the differential antiviral activity of the chicken Mx gene. Genome Res 2002, 12:595-601. 10.1101/gr.210702. Article published online before print in March 2002, 187515, 11932243.
20. Kolb E, Laine E, Strehler D, Staeheli P. Resistance to influenza virus infection of Mx transgenic mice expressing Mx protein under the control of two constitutive promoters. J Virol 1992, 66:1709-1716. 240917, 1371172.
21. Pavlovic J, Arzet HA, Hefti HP, Frese M, Rost D, Ernst B, Kolb E, Staeheli P, Haller O. Enhanced virus resistance of transgenic mice expressing the human MxA protein. J Virol 1995, 69:4506-4510. 189194, 7769712.
22. Ito T, Couceiro JN, Kelm S, Baum LG, Krauss S, Castrucci MR, Donatelli I, Kida H, Paulson JC, Webster RG, Kawaoka Y. Molecular basis for the generation in pigs of influenza A viruses with pandemic potential. J Virol 1998, 72:7367-7373. 109961, 9696833.
23. Smith GJ, Vijaykrishna D, Bahl J, Lycett SJ, Worobey M, Pybus OG, Ma SK, Cheung CL, Raghwani J, Bhatt S, Peiris JS, Guan Y, Rambaut A. Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic. Nature 2009, 459:1122-1125. 10.1038/nature08182, 19516283.
24. Müller M, Brenig B, Winnacker EL, Brem G. Transgenic pigs carrying cDNA copies encoding the murine Mx1 protein which confers resistance to influenza virus infection. Gene 1992, 121:263-270. 10.1016/0378-1119(92)90130-H, 1446823.
25. Lai L, Kang JX, Li R, Wang J, Witt WT, Yong HY, Hao Y, Wax DM, Murphy CN, Rieke A, Samuel M, Linville ML, Korte SW, Evans RW, Starzl TE, Prather RS, Dai Y. Generation of cloned transgenic pigs rich in omega-3 fatty acids. Nat Biotechnol 2006, 24:435-436. 10.1038/nbt1198, 2976610, 16565727.
26. Yang D, Wang CE, Zhao B, Li W, Ouyang Z, Liu Z, Yang H, Fan P, O'Neill A, Gu W, Yi H, Li S, Lai L, Li XJ. Expression of Huntington's disease protein results in apoptotic neurons in the brains of cloned transgenic pigs. Hum Mol Genet 2010, 19:3983-3994. 10.1093/hmg/ddq313, 2947404, 20660116.
27. Yang D, Yang H, Li W, Zhao B, Ouyang Z, Liu Z, Zhao Y, Fan N, Song J, Tian J, Li F, Zhang J, Chang L, Pei D, Chen YE, Lai L. Generation of PPARγ mono-allelic knockout pigs via zinc-finger nucleases and nuclear transfer cloning. Cell Res 2011, 21:979-982. 10.1038/cr.2011.70, 3203707, 21502977.
28. Gaush CR, Smith TF. Replication and plaque assay of influenza virus in an established line of canine kidney cells. Appl Microbiol 1968, 16:588-594. 547475, 5647517.
29. Youil R, Su Q, Toner TJ, Szymkowiak C, Kwan WS, Rubin B, Petrukhin L, Kiseleva I, Shaw AR, DiStefano D. Comparative study of influenza virus replication in Vero and MDCK cell lines. J Virol Methods 2004, 120:23-31. 10.1016/j.jviromet.2004.03.011, 15234806.
30. Yu X, Tu C, Li H, Hu R, Chen C, Li Z, Zhang M, Yin Z. DNA-mediated protection against classical swine fever virus. Vaccine 2001, 19:1520-1525. 10.1016/S0264-410X(00)00334-0, 11163677.
31. Morozumi T, Sumantri C, Nakajima E, Kobayashi E, Asano A, Oishi T, Mitsuhashi T, Watanabe T, Hamasima N. Three types of polymorphisms in exon 14 in porcine Mx1 gene. Biochem Genet 2001, 39:251-260. 10.1023/A:1010230715605, 11590831.
32. Palm M, Leroy M, Thomas A, Linden A, Desmecht D. Differential anti-influenza activity among allelic variants at the Sus scrofa Mx1 locus. J Interferon Cytokine Res 2007, 27:147-155. 10.1089/jir.2006.0119, 17316142.
33. Donnelly ML, Luke G, Mehrotra A, Li X, Hughes LE, Gani D, Ryan MD. Analysis of the aphthovirus 2A/2B polyprotein 'cleavage' mechanism indicates not a proteolytic reaction, but a novel translational effect: a putative ribosomal 'skip'. J Gen Virol 2001, 82:1013-1025.
34. Szymczak AL, Workman CJ, Wang Y, Vignali KM, Dilioglou S, Vanin EF, Vignali DA. Correction of multi-gene deficiency in vivo using a single 'self-cleaving' 2A peptide-based retroviral vector. Nat Biotechnol 2004, 22:589-594. 10.1038/nbt957, 15064769.
35. Trichas G, Begbie J, Srinivas S. Use of the viral 2A peptide for bicistronic expression in transgenic mice. BMC Biol 2008, 6:40. 10.1186/1741-7007-6-40, 2553761, 18793381.
36. Lee SH, Vidal SM. Functional diversity of Mx proteins: variations on a theme of host resistance to infection. Genome Res 2002, 12:527-530. 10.1101/gr.20102, 11932237.
37. Palm M, Garigliany MM, Cornet F, Desmecht D. Interferon-induced Sus scrofa Mx1 blocks endocytic traffic of incoming influenza A virus particles. Vet Res 2010, 41:29. 10.1051/vetres/2010001, 2826089, 20167191.
38. Müller M, Winnacker EL, Brem G. Molecular cloning of porcine Mx cDNAs: New members of a family of interferon-inducible proteins with homology to GTP-binding proteins. J Interferon Res 1992, 12:119-129. 10.1089/jir.1992.12.119, 1578186.
39. Horisberger MA. Virus-specific effects of recombinant porcine interferon-gamma and the induction of Mx proteins in pig cells. J Interferon Res 1992, 12:439-444. 10.1089/jir.1992.12.439, 1337754.
40. Zhang X, Shin J, Molitor TW, Schook LB, Rutherford MS. Molecular responses of macrophages to porcine reproductive and respiratory syndrome virus infection. Virology 1999, 262:152-162. 10.1006/viro.1999.9914, 10489349.
41. Su J, Yang C, Zhu Z, Wang Y, Jang S, Liao L. Enhanced grass carp reovirus resistance of Mx-transgenic rare minnow (Gobiocypris rarus). Fish Shellfish Immunol 2009, 26:828-835. 10.1016/j.fsi.2008.12.007, 19138747.
42. Castrucci MR, Donatelli I, Sidoli L, Barigazzi G, Kawaoka Y, Webster RG. Genetic reassortment between avian and human influenza A viruses in Italian pigs. Virology 1993, 193:503-506. 10.1006/viro.1993.1155, 8438586.
43. Claas EC, Kawaoka Y, de Jong JC, Masurel N, Webster RG. Infection of children with avian-human reassortant influenza virus from pigs in Europe. Virology 1994, 204:453-457. 10.1006/viro.1994.1553, 8091678.
44. Kida H, Ito T, Yasuda J, Shimizu Y, Itakura C, Shortridge KF, Kawaoka Y, Webster RG. Potential for transmission of avian influenza viruses to pigs. J Gen Virol 1994, 75:2183-2188. 10.1099/0022-1317-75-9-2183, 8077918.