Human MxA protein confers resistance to double-stranded RNA viruses of two virus families

Journal of General Virology

Volumn 88, Issue 4, 2007, Pages 1319-1323

  Mundt, Egbert ^a,b  

^a FEDERAL RESEARCH INSTITUTE FOR ANIMAL HEALTH   (Germany)

^b UNIVERSITY OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MYXOVIRUS RESISTANCE PROTEIN A; SINGLE STRANDED RNA;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CHICKEN; CONTROLLED STUDY; INFECTIOUS BURSAL DISEASE VIRUS; MUTANT; NONHUMAN; ORTHOMYXOVIRUS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REOVIRUS; VIROGENESIS; VIRUS GENOME; VIRUS INHIBITION; VIRUS REPLICATION; VIRUS RESISTANCE;

AMINO ACID SUBSTITUTION; ANIMALS; CERCOPITHECUS AETHIOPS; GTP-BINDING PROTEINS; HUMANS; INFECTIOUS BURSAL DISEASE VIRUS; MUTATION, MISSENSE; ORTHOREOVIRUS, MAMMALIAN; VERO CELLS; VIRUS REPLICATION;

DNA VIRUSES; INFECTIOUS BURSAL DISEASE VIRUS; MAMMALIA; ORTHOREOVIRUS; RNA VIRUSES;

EID: 34047102915     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/vir.0.82526-0     Document Type: Article

References (37)

1. Balachandran, S., Roberts, P. C., Brown, L. E., Truong, H., Pattnaik, A. K., Archer, D. R. & Barber, G. N. (2000). Essential role for the dsRNA-dependent protein kinase PKR in innate immunity to viral infection. Immunity 13, 129-141.
2. Bazzigher, L., Schwarz, A. & Staeheli, P. (1993). No enhanced influenza virus resistance of murine and avian cells expressing cloned duck Mx protein. Virology 195, 100-112.
3. Birghan, C., Mundt, E. & Gorbalenya, A. E. (2000). A non-canonical Lon proteinase deficient of the ATPase domain employs the Ser-Lys catalytic dyad to impose broad control over the life cycle of a double-stranded RNA virus. EMBO J 19, 114-123.
4. Chieux, V., Chehadeh, W., Harvey, J., Haller, O., Wattre, P. & Hober, D. (2001). Inhibition of coxsackievirus B4 replication in stably transfected cells expressing human MxA protein. Virology 283, 84-92.
5. De Benedetti, A., Williams, G. J., Comeau, L. & Baglioni, C. (1985). Inhibition of viral mRNA translation in interferon-treated L cells infected with reovirus. J Virol 55, 588-593.
6. Delmas, B., Kibenge, F. S. B., Leong, J. C., Mundt, E., Vakharia, V. N. & Wu, J. L. (2004). Birnaviridae. In Virus Taxonomy, Eighth Report of the International Committee on Taxonomy of Viruses, pp. 561-569. Edited by C. M. Fauquet, M. A. Mayo, J. Maniloff, U. Desselberger & L. A. Ball. London: Elsevier/Academic Press.
7. Emeny, J. M. & Morgan, M. J. (1979). Regulation of the interferon system: evidence that Vero cells have a genetic defect in interferon production. J Gen Virol 43, 247-252.
8. Flohr, F., Schneider-Schaulies, S., Haller, O. & Kochs, G. (1999). The central interactive region of human MxA GTPase is involved in GTPase activation and interaction with viral target structures. FEBS Lett 463, 24-28.
9. Frese, M., Kochs, G., Meier-Dieter, U., Sielber, J. & Haller, O. (1995). Human MxA protein inhibits tick-borne Thogoto virus but not Dhori virus. J Virol 69, 3904-3909.
10. Frese, M., Kochs, G., Feldmann, H., Hertkorn, C. & Haller, O. (1996). Inhibition of bunyaviruses, phleboviruses, and hantaviruses by human MxA protein. J Virol 70, 915-923.
11. Gordien, E., Rosmorduc, O., Peltelkian, C., Garreau, F., Brechot, C. & Kremsdorf, D. (2001). Inhibition of hepatitis B virus replication by the interferon-inducible MxA protein. J Virol 75, 2684-2691.
12. Granzow, H., Birghan, Ch., Mettenleiter, T. C., Beyer, J., Köllner, B. & Mundt, E. (1997). A second form of infectious bursal disease virus-associated tubules contains VP4. J Virol 71, 8879-8885.
13. Horisberger, M. A. (11992). Interferon-induced human protein MxA is a GTPase which binds transiently to cellular proteins. J Virol 66, 4705-4709.
14. Kaerber, G. (1931). Beitrag zur kollektiven Behandlung pharmakologischer Reihenversuche. Arch Exp Pathol Pharmakol 162, 480-483 (in German).
15. Ko, J. H., Jin, H. K, Asano, A., Takada, A., Ninomiya, A., Kida, H., Hokiyama, H., Ohara, M., Tsuzuki, M. & other authors (2002). Polymorphisms and the differential antiviral activity of the chicken Mx gene. Genome Res 12, 595-601.
16. Ko, J. H., Takada, A., Mitsuhashi, T., Agui, T. & Watanabe, T. (2004). Native antiviral specificity of chicken Mx protein depends on amino acid variation at position 631. Anim Genet 35, 119-122.
17. Kochs, G. & Haller, O. (1999a). GTP-bound human MxA protein interacts with the nucleocapsids of Thogoto virus (Orthomyxoviridae). J Biol Chem 274, 4370-4376.
18. Kochs, G. & Haller, O. (1999b). Interferon-induced human MxA GTPase blocks nuclear import of Thogoto virus nucleocapsids. Proc Natl Acad Sci U S A 96, 2082-2086.
19. Kochs, G., Janzen, C., Hohenberg, H. & Haller, O. (2002). Antivirally active MxA protein sequesters La Crosse virus nudeocapsid protein into perinuclear complexes. Proc Natl Acad Sci U S A 99, 3153-3158.
20. Landis, H., Simon-Jodicke, A., Kloti, A., Di Paolo, C., Schnorr, J. J., Schneider-Schaulies, S., Hefti, H. P. & Pavlovic, J. (1998). Human MxA protein confers resistance to Semliki Forest virus and inhibits the amplification of a Semliki Forest virus-based replicon in the absence of viral structural proteins. J Virol 72, 1516-1522.
21. Larsen, R., Rokenes, T. P. & Robertsen, B. (2004). Inhibition of infectious pancreatic necrosis virus replication by Atlantic salmon Mx1 protein. J Virol 78, 7938-7944.
22. Lee, S.-H. & Vidal, S. M. (2002). Functional diversity of Mx proteins: variations on a theme of host resistance to infection. Genome Res 12, 527-530.
23. Li, X. L., Blackford, J. A. & Hassel, B. A. (1998). RNase L mediates the antiviral effect of interferon through a selective reduction in viral RNA during encephalomyocarditis virus infection. J Virol 72, 2752-2759.
24. Mundt, E. (1999). Tissue culture infectivity of different strains of infectious bursal disease virus is determined by distinct amino acids in VP2. J Gen Virol 80, 2067-2076.
25. Mundt, E., Kollner, B. & Kretzschmar, D. (1997). VP5 of infectious bursal disease virus is not essential for viral replication in cell culture. J Virol 71, 5647-5651.
26. Mundt, E., de Haas, N. & van Loon, A. A. (2003). Development of a vaccine for immunization against classical as well as variant strains of infectious bursal disease virus using reverse genetics. Vaccine 21, 4616-4624.
27. Pavlovic, J., Züricher, T., Haller, O. & Staeheli, P. (1990). Resistance to influenza virus and vesicular stomatitis virus conferred by expression of human MxA protein. J Virol 64, 3370-3375.
28. Ponten, A., Sick, C., Weeber, M., Haller, O. & Kochs, G. (1997). Dominant-negative mutants of human MxA protein: domains in the carboxy-terminal moiety are important for oligomerization and antiviral activity. J Virol 71, 2591-2599.
29. Reichelt, M., Sterkz, S., Krijnse-Locker, J., Haller, O. & Kochs, G. (2004). Missorting of La Crosse virus nucleocapsid protein by the interferon-induced MxA GTPase involves smooth ER membranes. Traffic 5, 772-784.
30. Schneider-Schaulies, S., Schneider-Schaulies, J., Schuster, A., Bayer, M., Pavlovic, J. & ter Meulen, V. (1994). Cell type-specific MxA-mediated inhibition of measles virus transcription in human brain cells. J Virol 68, 6910-6917.
31. Schnorr, J. J., Schneider-Schaulies, S., Simon-Jodicke, A., Pavlovic, J., Horisberger, M. A. & ter Meulen, V. (1993). MxA-dependent inhibition of measles virus glycoprotein synthesis in a stably transfected human monocytic cell line. J Virol 67, 4760-4768.
32. Schwemmle, M., Weining, K. C., Richter, M. F., Schumacher, B. & Staehli, P. (1995). Vesicular stomatitis virus transcription inhibited by purified MxA protein. Virology 206, 545-554.
33. Smith, J. A., Schmechel, S. C., Williams, B. R. G., Silverman, R. H. & Schiff, L. A. (2005). Involvement of the interferon-regulated antiviral proteins PKR and RNase L in reovirus-induced shutoff of cellular translation. J Virol 79, 2240-2250.
34. Tyler, K. L. (2001). Mammalian reoviruses. In Fields Virology, 4th edn, pp. 1729-1945. Edited by D. M. Knipe & P. M. Howley. Philadelphia, USA: Lippincott Williams & Wilkins.
35. Tytell, A. A., Lampson, G. P., Field, A. K. & Hilleman, M. R. (1967). Inducers of interferon and host resistence. III. Double-stranded RNA from Reovirus type 3 virions (reo-3-RNA). Proc Natl Acad Sci U S A 58, 1719-1722.
36. Weber, F., Haller, O. & Kochs, G. (2000). MxA GTPase blocks reporter gene expression of reconstituted Thogoto virus ribonucleo-protein complexes. J Virol 74, 560-563.
37. Zürcher, T., Pavlovic, J. & Staehli, P. (1992). Mechanism of human MxA protein action: variants with changed antiviral properties. EMBO J 11, 1657-1661.