Multimodal Cognitive Enhancement Therapy for Patients with Mild Cognitive Impairment and Mild Dementia: A Multi- Center, Randomized, Controlled, Double-Blind, Crossover Trial

Journal of Alzheimer's Disease

Volumn 55, Issue 2, 2017, Pages 787-796

  Han, Ji Won ^a   Lee, Hyeonggon ^b   Hong, Jong Woo ^a   Kim, Kayoung ^a   Kim, Taehyun ^a   Byun, Hye Jin ^a   Ko, Ji Won ^a   Youn, Jong Chul ^c   Ryu, Seung Ho ^d   Lee, Nam Jin ^e   Pae, Chi Un ^f   Kim, Ki Woong ^a,g  

^a Seoul National University Bundang Hospital   (South Korea)

^b Seoul National University Hospital   (South Korea)

^c Kyunggi Provincial Hospital for Elderly   (South Korea)

^d Konkuk University School of Medicine   (South Korea)

^e Jeonju City Welfare Hospital for the Elderly   (South Korea)

^f The Catholic University of Korea   (South Korea)

^g Seoul National University   (South Korea)

Author keywords

Cognitive interventions; cognitive therapy; cognitive training; dementia; mild cognitive impairment; mild dementia; multimodal cognitive enhancement therapy; non pharmacologic treatment; randomized controlled trials

Indexed keywords

AGED; ALZHEIMER DISEASE; ARTICLE; ASSESSMENT OF HUMANS; ASSESSMENT SCALE COGNITIVE SUBSCALE; CLINICAL DEMENTIA RATING; COGNITION; COGNITIVE REMEDIATION THERAPY; CONTROLLED STUDY; CROSSOVER PROCEDURE; DEMENTIA; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MEMORY; MILD COGNITIVE IMPAIRMENT; MINI MENTAL STATE EXAMINATION; MULTICENTER STUDY; MULTIINFARCT DEMENTIA; MULTIMODAL COGNITIVE ENHANCEMENT THERAPY; MUSIC THERAPY; PATIENT COMPLIANCE; PHYSIOTHERAPY; PRIORITY JOURNAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; RANGE OF MOTION; REVISED MEMORY AND BEHAVIOR PROBLEMS CHECKLIST; THERAPY EFFECT; TREATMENT DURATION; CLINICAL TRIAL; COGNITIVE DEFECT; COGNITIVE THERAPY; FOLLOW UP; OUTCOME ASSESSMENT; PROCEDURES; PSYCHOLOGICAL RATING SCALE; TIME FACTOR; VERY ELDERLY;

AGED; AGED, 80 AND OVER; COGNITIVE DYSFUNCTION; COGNITIVE THERAPY; CROSS-OVER STUDIES; DEMENTIA; DOUBLE-BLIND METHOD; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; OUTCOME ASSESSMENT (HEALTH CARE); PSYCHIATRIC STATUS RATING SCALES; TIME FACTORS;

EID: 84999154602     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-160619     Document Type: Article

References (43)

1. Wilson RS, Mendes De Leon CF, Barnes LL, Schneider JA, Bienias JL, Evans DA, Bennett DA (2002) Participation in cognitively stimulating activities and risk of incident Alzheimer disease. JAMA 287, 742-748.
2. Alzheimer's Disease International (2011)World Alzheimer Report 2011: The Benefits of Early Diagnosis and Intervention. Alzheimer's Disease International, London.
3. Stern Y, Moeller JR, Anderson KE, Luber B, Zubin NR, DiMauro AA, Park A, Campbell CE, Marder K, Bell K, Van Heertum R, Sackeim HA (2000) Different brain networks mediate task performance in normal aging and AD: Defining compensation. Neurology 55, 1291-1297.
4. Karp A, Paillard-Borg S,Wang HX, Silverstein M,Winblad B, Fratiglioni L (2006) Mental, physical and social components in leisure activities equally contribute to decrease dementia risk. Dement Geriatr Cogn Disord 21, 65-73.
5. de Andrade LP, Gobbi LT, Coelho FG, Christofoletti G, Costa JL, Stella F (2013) Benefits of multimodal exercise intervention for postural control and frontal cognitive functions in individuals with Alzheimer's disease: A controlled trial. J Am Geriatr Soc 61, 1919-1926.
6. Coelho FG, Andrade LP, Pedroso RV, Santos-Galduroz RF, Gobbi S, Costa JL, Gobbi LT (2013) Multimodal exercise intervention improves frontal cognitive functions and gait in Alzheimer's disease: A controlled trial. Geriatr Gerontol Int 13, 198-203.
7. Graessel E, Stemmer R, Eichenseer B, Pickel S, Donath C, Kornhuber J, Luttenberger K (2011) Non-pharmacological, multicomponent group therapy in patients with degenerative dementia: A 12-month randomizied, controlled trial. BMC Med 9, 129.
8. Viola LF, Nunes PV,Yassuda MS, Aprahamian I, Santos FS, Santos GD, Brum PS, Borges SM, Oliveira AM, ChavesGF, Ciasca EC, Ferreira RC, Paula VJ, Takeda OH, Mirandez RM,Watari R, Falcao DV, Cachioni M, Forlenza OV (2011) Effects of a multidisciplinary cognitive rehabilitation program for patients with mild Alzheimer's disease. Clinics (Sao Paulo) 66, 1395-1400.
9. Burgener SC, Yang Y, Gilbert R, Marsh-Yant S (2008) The effects of a multimodal intervention on outcomes of persons with early-stage dementia. Am J Alzheimers Dis Other Demen 23, 382-394.
10. Onor ML, Trevisiol M, Negro C, Signorini A, Saina M, Aguglia E (2007) Impact of a multimodal rehabilitative intervention on demented patients and their caregivers. Am J Alzheimers Dis Other Demen 22, 261-272.
11. Olazaran J, Muniz R, Reisberg B, Pena-Casanova J, del Ser T, Cruz-Jentoft AJ, Serrano P, Navarro E, Garcia de la RochaML,Frank A, Galiano M, Fernandez-BullidoY, Serra JA, Gonzalez-Salvador MT, Sevilla C (2004) Benefits of cognitive-motor intervention in MCI and mild to moderate Alzheimer disease. Neurology 63, 2348-2353.
12. Davis RN, Massman PJ, Doody RS (2001) Cognitive intervention in Alzheimer disease: A randomized placebocontrolled study. Alzheimer Dis Assoc Disord 15, 1-9.
13. Nascimento CM, Ayan C, Cancela JM, Gobbi LT, Gobbi S, Stella F (2014) Effect of a multimodal exercise program on sleep disturbances and instrumental activities of daily living performance on Parkinson's and Alzheimer's disease patients. Geriatr Gerontol Int 14, 259-266.
14. Luttenberger K, Hofner B, Graessel E (2012) Are the effects of a non-drug multimodal activation therapy of dementia sustainable? Follow-up study 10 months after completion of a randomised controlled trial. BMC Neurol 12, 151.
15. Luttenberger K, Donath C, Uter W, Graessel E (2012) Effects of multimodal nondrug therapy on dementia symptoms and need for care in nursing home residents with degenerative dementia:Arandomized-controlled study with 6-month follow-up. J Am Geriatr Soc 60, 830-840.
16. Burgener SC, Marsh-Yant S, Nega KK (2011) A combined, multimodal intervention for individuals with dementia. Res Gerontol Nurs 4, 64-75.
17. Kim KW, Park JH, Kim MH, Kim MD, Kim BJ, Kim SK, Kim JL, Moon SW, Bae JN, Woo JI, Ryu SH, Yoon JC, Lee NJ, Lee DY, Lee DW, Lee SB, Lee JJ, Lee JY, Lee CU, Chang SM, Jhoo JH, ChoMJ(2011)Anationwide survey on the prevalence of dementia and mild cognitive impairment in South Korea. J Alzheimers Dis 23, 281-291.
18. Kurz A, Pohl C, Ramsenthaler M, Sorg C (2009) Cognitive rehabilitation in patients with mild cognitive impairment. Int J Geriatr Psychiatry 24, 163-168.
19. Li H, Li J, Li N, Li B, Wang P, Zhou T (2011) Cognitive intervention for persons with mild cognitive impairment: A meta-analysis. Ageing Res Rev 10, 285-296.
20. Kim KW, Han JW, Byun HJ (2015) Banzac-Whalzac Brain Fitness, National Institute of Dementia, Korea.
21. Martin M, Clare L, Altgassen AM, Cameron MH, Zehnder F (2011) Cognition-based interventions for healthy older people and people with mild cognitive impairment. Cochrane Database Syst Rev CD006220.
22. Woods B, Aguirre E, Spector AE, Orrell M (2012) Cognitive stimulation to improve cognitive functioning in people with dementia. Cochrane Database Syst Rev 2, CD005562.
23. Ministry of Health andWelfare (2013) Development of cognitive rehabilitation services for the community-dwelling mild dementia patients. Ministry of Health and Welfare, Korea.
24. Winblad B, Palmer K, Kivipelto M, Jelic V, Fratiglioni L, Wahlund LO, Nordberg A, Backman L, Albert M, Almkvist O, Arai H, Basun H, Blennow K, de Leon M, DeCarli C, Erkinjuntti T, Giacobini E, Graff C, Hardy J, Jack C, Jorm A, Ritchie K, van Duijn C, Visser P, Petersen RC (2004) Mild cognitive impairment-beyond controversies, towards a consensus: Report of the InternationalWorking Group on Mild Cognitive Impairment. J Intern Med 256, 240-246.
25. American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders, ed 4 (DSM-IV), American Psychiatric Association, Washington, D.C.
26. Matts JP, Lachin JM (1988) Properties of permuted-block randomization in clinical trials. Control Clin Trials 9, 327-344.
27. Harlowe D (1984) ROM dance: A range of motion exercise and relaxation program, St. Mary's Hospital Medical Center.
28. Craig P, Dieppe P, Macintyre S, Michie S, Nazareth I, Petticrew M, Medical Research Council Group (2008) Developing and evaluating complex interventions: The new Medical Research Council guidance. BMJ 337, a1655.
29. Pomeroy VM, Warren CM, Honeycombe C, Briggs RS, Wilkinson DG, Pickering RM, Steiner A (1999) Mobility and dementia: Is physiotherapy treatment during respite care effective? Int J Geriatr Psychiatry 14, 389-397.
30. Netz Y, Axelrad S, Argov E (2007) Group physical activity for demented older adults feasibility and effectiveness. Clin Rehabil 21, 977-986.
31. Kim TH, Jhoo JH, Park JH, Kim JL, Ryu SH, Moon SW, Choo IH, Lee DW, Yoon JC, Do YJ, Lee SB, Kim MD, Kim KW (2010) Korean version of mini mental status examination for dementia screening and its' short form. Psychiatry Investig 7, 102-108.
32. Youn JC, Lee DY, Kim KW, Lee JH, Jhoo JH, Lee KU, Ha J, Woo JI (2002) Development of the Korean version of Alzheimer's Disease Assessment Scale (ADAS-K). Int J Geriatr Psychiatry 17, 797-803.
33. Teri L, Truax P, Logsdon R, Uomoto J, Zarit S, Vitaliano PP (1992) Assessment of behavioral problems in dementia: The revised memory and behavior problems checklist. Psychol Aging 7, 622-631.
34. Kim JY, Park JH, Lee JJ, Huh Y, Lee SB, Han SK, Choi SW, LeeDY, KimKW,Woo JI (2008) Standardization of the Korean version of the geriatric depression scale: Reliability, validity, and factor structure. Psychiatry Investig 5, 232-238.
35. Suh G-H (2003) Development of theKoreanVersion of Disability Assessment for Dementia Scale (DAD-K) to assess function in dementia. J Korean Geriatr Soc 7, 278-287.
36. Logsdon RGGL, McCurry SM, Teri L (1999) Quality of life in Alzheimer's disease: Patient and caregiver reports. J Mental Health Aging 5, 21-32.
37. Feldman H, Sauter A, Donald A, Gelinas I, Gauthier S, Torfs K, ParysW, MehnertA(2001) The disability assessment for dementia scale: A 12-month study of functional ability in mild to moderate severity Alzheimer disease. Alzheimer Dis Assoc Disord 15, 89-95.
38. Cohen J (1977) Statistical Power Analysis for the Behavioral Sciences, Academic Press Inc., Orlando, FL.
39. Birks J (2006) Cholinesterase inhibitors for Alzheimer's disease. Cochrane Database Syst Rev CD005593.
40. Van der Mussele S, Bekelaar K, Le Bastard N, Vermeiren Y, Saerens J, Somers N, Marien P, Goeman J, De Deyn PP, Engelborghs S (2013) Prevalence and associated behavioral symptoms of depression in mild cognitive impairment and dementia due to Alzheimer's disease. Int J Geriatr Psychiatry 28, 947-958.
41. Clare L, Woods RT, Moniz Cook ED, Orrell M, Spector A (2003) Cognitive rehabilitation and cognitive training for early-stage Alzheimer's disease and vascular dementia. Cochrane Database Syst Rev CD003260.
42. Wong GH, Ng CK, Lai CK, Lee MN, Lum TY, Jiang N, Shie HW, Wu JY, Dai DL (2014) Development of six arts, a culturally appropriate multimodal nonpharmacological intervention in dementia. Gerontologist 55, 865-874.
43. Dannhauser TM, Cleverley M, Whitfield TJ, Fletcher BC, Stevens T,Walker Z (2014) A complex multimodal activity intervention to reduce the risk of dementia in mild cognitive impairment-ThinkingFit: Pilot and feasibility study for a randomized controlled trial. BMC Psychiatry 14, 129.