MicroRNA-206 attenuates the growth and angiogenesis in non-small cell lung cancer cells by blocking the 14-3-3z/STAT3/HIF-1a/VEGF signaling

Oncotarget

Volumn 7, Issue 48, 2016, Pages 79805-79813

  Xue, Dong ^a   Yang, Ye ^b   Liu, Yawei ^a   Wang, Peiwen ^b   Dai, Yi ^b   Liu, Qinqiang ^a   Chen, Lijun ^b   Shen, Jian ^a   Ju, Huanyu ^a   Li, Yuan ^b   Tan, Zhenguo ^a  

^a THE SECOND AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

Author keywords

14 3 3 ; Angiogenesis; Lung cancer; MicroRNA 206; Signal transduction

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; MICRORNA; MICRORNA 206; STAT3 PROTEIN; STRATIFIN; UNCLASSIFIED DRUG; VASCULOTROPIN; MIRN206 MICRORNA, HUMAN; PROTEIN 14 3 3; VASCULOTROPIN A;

14 3 3 SIGMA GENE; 3' UNTRANSLATED REGION; A549 CELL LINE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CANCER INHIBITION; CONTROLLED STUDY; DOWN REGULATION; GENE OVEREXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; INHIBITION KINETICS; LUNG CANCER CELL LINE; MAJOR CLINICAL STUDY; MOUSE; NON SMALL CELL LUNG CANCER; NONHUMAN; PHARMACOLOGICAL BLOCKING; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TUMOR GROWTH; TUMOR VASCULARIZATION; UPREGULATION; A-549 CELL LINE; ANIMAL; BAGG ALBINO MOUSE; CELL CULTURE; CELL PROLIFERATION; GENETICS; LUNG TUMOR; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); NUDE MOUSE; PATHOLOGY; PHYSIOLOGY; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULARIZATION;

14-3-3 PROTEINS; A549 CELLS; ANIMALS; CARCINOMA, NON-SMALL-CELL LUNG; CELL PROLIFERATION; CELLS, CULTURED; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LUNG NEOPLASMS; MICE; MICE, INBRED BALB C; MICE, NUDE; MICRORNAS; NEOVASCULARIZATION, PATHOLOGIC; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84998881948     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.12972     Document Type: Article

References (36)

1. Torre, L.A., F. Bray, R.L. Siegel, J. Ferlay, J. Lortet-Tieulent, A. Jemal. Global cancer statistics, 2012. CA Cancer J Clin. 2015; 65:87-108.
2. Reck, M., D.F. Heigener, T. Mok, J.C. Soria, K.F. Rabe . Management of non-small-cell lung cancer: recent developments. Lancet. 2013; 382:709-719.
3. Chen, Q.Y., D.M. Jiao, Y.Q. Wu, J. Chen, J. Wang, X.L. Tang, H. Mou, H.Z. Hu, J. Song, J. Yan, L.J. Wu, J. Chen, Z. Wang. MiR-206 inhibits HGF-induced epithelial-mesenchymal transition and angiogenesis in non-small cell lung cancer via c-Met /PI3k/Akt/mTOR pathway. Oncotarget. 2016; 7:18247-18261. doi: 10.18632/oncotarget.7570.
4. Sobin, L.H., C.C. Compton. TNM seventh edition: what's new, what's changed: communication from the International Union Against Cancer and the American Joint Committee on Cancer. Cancer. 2010; 116:5336-5339.
5. Halasz, L.M., H. Uno, M. Hughes, T. D'Amico, E.U. Dexter, S.B. Edge, J.A. Hayman, J.C. Niland, G.A. Otterson, K.M. Pisters, R. Theriault, J.C. Weeks, R.S. Punglia. Comparative effectiveness of stereotactic radiosurgery versus whole-brain radiation therapy for patients with brain metastases from breast or non-small cell lung cancer. Cancer. 2016; 122:2091-2100.
6. Tang, Y., J. Qu, J. Wu, H. Liu, T. Chu, J. Xiao, Y. Zhou. Effect of Surgery on Quality of Life of Patients with Spinal Metastasis from Non-Small-Cell Lung Cancer. J Bone Joint Surg Am. 2016; 98:396-402.
7. Wang, Z.D., S.Q. Wei, Q.Y. Wang. Targeting oncogenic KRAS in non-small cell lung cancer cells by phenformin inhibits growth and angiogenesis. Am J Cancer Res. 2015; 5:3339-3349.
8. Qi, W., X. Liu, D. Qiao, J.D. Martinez. Isoform-specific expression of 14-3-3 proteins in human lung cancer tissues. Int J Cancer. 2005; 113:359-363.
9. Chen, C.H., S.M. Chuang, M.F. Yang, J.W. Liao, S.L. Yu, J.J. Chen. A novel function of YWHAZ/beta-catenin axis in promoting epithelial-mesenchymal transition and lung cancer metastasis. Mol Cancer Res. 2012; 10:1319-1331.
10. Zhao, G.Y., J.Y. Ding, C.L. Lu, Z.W. Lin, J. Guo. The overexpression of 14-3-3zeta and Hsp27 promotes non-small cell lung cancer progression. Cancer. 2014; 120:652-663.
11. Fan, T., R. Li, N.W. Todd, Q. Qiu, H.B. Fang, H. Wang, J. Shen, R.Y. Zhao, N.P. Caraway, R.L. Katz, S.A. Stass, F. Jiang. Up-regulation of 14-3-3zeta in lung cancer and its implication as prognostic and therapeutic target. Cancer Res. 2007; 67:7901-7906.
12. Chen, D., W. Guo, Z. Qiu, Q. Wang, Y. Li, L. Liang, L. Liu, S. Huang, Y. Zhao, X. He. MicroRNA-30d-5p inhibits tumour cell proliferation and motility by directly targeting CCNE2 in non-small cell lung cancer. Cancer Lett. 2015; 362:208-217.
13. Huang, H., Y. Jiang, Y. Wang, T. Chen, L. Yang, H. He, Z. Lin, T. Liu, T. Yang, D.W. Kamp, B. Wu, G. Liu. miR-5100 promotes tumor growth in lung cancer by targeting Rab6. Cancer Lett. 2015; 362:15-24.
14. Sun, C., C. Huang, S. Li, C. Yang, Y. Xi, L. Wang, F. Zhang, Y. Fu, D. Li. Hsa-miR-326 targets CCND1 and inhibits non-small cell lung cancer development. Oncotarget. 2016; 7:8341-8359. doi: 10.18632/oncotarget.7071.
15. Sun, C., M. Sang, S. Li, X. Sun, C. Yang, Y. Xi, L. Wang, F. Zhang, Y. Bi, Y. Fu, D. Li. Hsa-miR-139-5p inhibits proliferation and causes apoptosis associated with down-regulation of c-Met. Oncotarget. 2015; 6:39756-39792. doi: 10.18632/oncotarget.5476.
16. Sun, C., Z. Liu, S. Li, C. Yang, R. Xue, Y. Xi, L. Wang, S. Wang, Q. He, J. Huang, S. Xie, W. Jiang, D. Li. Down-regulation of c-Met and Bcl2 by microRNA-206, activates apoptosis, and inhibits tumor cell proliferation, migration and colony formation. Oncotarget. 2015; 6:25533-25574. doi: 10.18632/oncotarget.4575.
17. Zhang, Y.J., F. Xu, Y.J. Zhang, H.B. Li, J.C. Han, L. Li. miR-206 inhibits non small cell lung cancer cell proliferation and invasion by targeting SOX9. Int J Clin Exp Med. 2015; 8:9107-9113.
18. Alteri, A., F. De Vito, G. Messina, M. Pompili, A. Calconi, P. Visca, M. Mottolese, C. Presutti, M. Grossi. Cyclin D1 is a major target of miR-206 in cell differentiation and transformation. Cell Cycle. 2013; 12:3781-3790.
19. Coelho, A.L., M.P. Gomes, R.J. Catarino, C. Rolfo, A.M. Lopes, R.M. Medeiros, A.M. Araujo. Angiogenesis in NSCLC: is vessel co-option the trunk that sustains the branches? Oncotarget. 2016; epub ahead of print. doi: 10.18632/oncotarget.7794.
20. Jackson, A.L., B. Zhou, W.Y. Kim. HIF, hypoxia and the role of angiogenesis in non-small cell lung cancer. Expert Opin Ther Targets. 2010; 14:1047-1057.
21. Dodd, K.M., J. Yang, M.H. Shen, J.R. Sampson, A.R. Tee. mTORC1 drives HIF-1alpha and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3. Oncogene. 2015; 34:2239-2250.
22. Zhang, J., F. Chen, W. Li, Q. Xiong, M. Yang, P. Zheng, C. Li, J. Pei, F. Ge. 14-3-3zeta interacts with stat3 and regulates its constitutive activation in multiple myeloma cells. PLoS One. 2012; 7:e29554.
23. Lee, J.J., J.S. Lee, M.N. Cui, H.H. Yun, H.Y. Kim, S.H. Lee, J.H. Lee. BIS targeting induces cellular senescence through the regulation of 14-3-3 zeta/STAT3/SKP2/p27 in glioblastoma cells. Cell Death Dis. 2014; 5 e1537.
24. Raponi, M., L. Dossey, T. Jatkoe, X. Wu, G. Chen, H. Fan, D.G. Beer. MicroRNA classifiers for predicting prognosis of squamous cell lung cancer. Cancer Res. 2009; 69:5776-5783.
25. He, Y., Z. Zhou, W.L. Hofstetter, Y. Zhou, W. Hu, C. Guo, L. Wang, W. Guo, A. Pataer, A.M. Correa, Y. Lu, J. Wang, L. Diao, et al. Aberrant expression of proteins involved in signal transduction and DNA repair pathways in lung cancer and their association with clinical parameters. PLoS One. 2012; 7:e31087.
26. Frezzetti, D., M. Gallo, C. Roma, A. D'Alessio, M.R. Maiello, S. Bevilacqua, N. Normanno, A. De Luca. Vascular Endothelial Growth Factor A Regulates the Secretion of Different Angiogenic Factors in Lung Cancer Cells. J Cell Physiol. 2016; 231:1514-1521.
27. Wan, J., W. Wu. Hyperthermia induced HIF-1α expression of lung cancer through AKT and ERK signaling pathways. J Exp Clin Cancer Res. 2016; 35:119.
28. Qian, J., H. Bai, Z. Gao, Y.U. Dong, J. Pei, M. Ma, B. Han. Downregulation of HIF-1alpha inhibits the proliferation and invasion of non-small cell lung cancer NCI-H157 cells. Oncol Lett. 2016; 11:1738-1744.
29. Pan, B., J. Shen, J. Cao, Y. Zhou, L. Shang, S. Jin, S. Cao, D. Che, F. Liu, Y. Yu. Interleukin-17 promotes angiogenesis by stimulating VEGF production of cancer cells via the STAT3/GIV signaling pathway in non-small-cell lung cancer. Sci Rep. 2015; 5 16053.
30. Chen, J.F., E.M. Mandel, J.M. Thomson, Q. Wu, T.E. Callis, S.M. Hammond, F.L. Conlon, D.Z. Wang. The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation. Nat Genet. 2006; 38:228-233.
31. Crawford, M., K. Batte, L. Yu, X. Wu, G.J. Nuovo, C.B. Marsh, G.A. Otterson, S.P. Nana-Sinkam. MicroRNA 133B targets pro-survival molecules MCL-1 and BCL2L2 in lung cancer. Biochem Biophys Res Commun. 2009; 388:483-489.
32. Moriya, Y., N. Nohata, T. Kinoshita, M. Mutallip, T. Okamoto, S. Yoshida, M. Suzuki, I. Yoshino, N. Seki. Tumor suppressive microRNA-133a regulates novel molecular networks in lung squamous cell carcinoma. J Hum Genet. 2012; 57:38-45.
33. Nasser, M.W., J. Datta, G. Nuovo, H. Kutay, T. Motiwala, S. Majumder, B. Wang, S. Suster, S.T. Jacob, K. Ghoshal. Down-regulation of micro-RNA-1 (miR-1) in lung cancer. Suppression of tumorigenic property of lung cancer cells and their sensitization to doxorubicin-induced apoptosis by miR-1. J Biol Chem. 2008; 283:33394-33405.
34. Nohata, N., T. Hanazawa, H. Enokida, N. Seki. microRNA-1/133a and microRNA-206/133b clusters: dysregulation and functional roles in human cancers. Oncotarget. 2012; 3:9-21. doi: 10.18632/oncotarget.424.
35. Yan, H., X. Dong, X. Zhong, J. Ye, Y. Zhou, X. Yang, J. Shen, J. Zhang. Inhibitions of epithelial to mesenchymal transition and cancer stem cells-like properties are involved in miR-148a-mediated anti-metastasis of hepatocellular carcinoma. Mol Carcinog. 2014; 53:960-969.
36. Shen, J., F. Jiang, Y. Yang, G. Huang, F. Pu, Q. Liu, L. Chen, L. Ju, M. Lu, F. Zhou, C. Zhang, X. Luo, X. Yang, et al. 14-3-3eta, a novel growth-promoting factor in hepatocellular carcinoma, not only in tumor but also in intratumoral vessels. J Hepatol. 2016; epub ahead of print.