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Volumn 1, Issue 2, 2011, Pages 47-66

Clozapine-related EEG changes and seizures: Dose and plasma-level relationships

Author keywords

antiepileptic; clozapine; seizure; valproate

Indexed keywords

CARBAMAZEPINE; CLOZAPINE; ERYTHROMYCIN; GABAPENTIN; LAMOTRIGINE; LORAZEPAM; PHENOBARBITAL; PHENYTOIN; PREGABALIN; TOPIRAMATE; VALPROIC ACID; VALPROMIDE;

EID: 84997941905     PISSN: 20451253     EISSN: 20451261     Source Type: Journal    
DOI: 10.1177/2045125311405566     Document Type: Review
Times cited : (117)

References (98)
  • 2
    • 0027996189 scopus 로고
    • Myoclonic seizures and “leg folding” phenomena with clozapine therapy: report of two cases
    • Antelo R.E. Stanilla J.K. Martin-Llonch N. (1994) Myoclonic seizures and “leg folding” phenomena with clozapine therapy: report of two cases. Biol Psychiatry 36: 759–762.
    • (1994) Biol Psychiatry , vol.36 , pp. 759-762
    • Antelo, R.E.1    Stanilla, J.K.2    Martin-Llonch, N.3
  • 4
    • 0025870973 scopus 로고
    • Seizures during clozapine therapy
    • Baker R.W. Conley R.R. (1991) Seizures during clozapine therapy. Am J Psychiatry 148: 1265–1266.
    • (1991) Am J Psychiatry , vol.148 , pp. 1265-1266
    • Baker, R.W.1    Conley, R.R.2
  • 5
    • 0033380080 scopus 로고    scopus 로고
    • Valproic acid for seizure prophylaxis during clozapine therapy: where's the evidence?
    • Balen R.M. Procyshyn R.M. (1999) Valproic acid for seizure prophylaxis during clozapine therapy: where's the evidence? Int J Psychiatry Clin Pract 3: 249–251.
    • (1999) Int J Psychiatry Clin Pract , vol.3 , pp. 249-251
    • Balen, R.M.1    Procyshyn, R.M.2
  • 6
    • 15844430786 scopus 로고    scopus 로고
    • Clozapine-induced stuttering, facial tics and myoclonic seizures: a case report
    • Begum M. (2005) Clozapine-induced stuttering, facial tics and myoclonic seizures: a case report. Aust NZ J Psychiatry 39: 202–202.
    • (2005) Aust NZ J Psychiatry , vol.39 , pp. 202
    • Begum, M.1
  • 8
    • 0030998532 scopus 로고    scopus 로고
    • Use of clozapine in a mental handicap hospital-report of the first 17 patients
    • Boachie A. McGinnity M.G.A. (1997) Use of clozapine in a mental handicap hospital-report of the first 17 patients. Ir J Psychol Med 14: 16–19.
    • (1997) Ir J Psychol Med , vol.14 , pp. 16-19
    • Boachie, A.1    McGinnity, M.G.A.2
  • 9
    • 0037385145 scopus 로고    scopus 로고
    • A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently manic or hypomanic patients with bipolar I disorder
    • Bowden C.L. Calabrese J.R. Sachs G. Yatham L.N. Asghar S.A. Hompland M. et al. (2003) A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently manic or hypomanic patients with bipolar I disorder. Arch Gen Psychiatry 60: 392–400.
    • (2003) Arch Gen Psychiatry , vol.60 , pp. 392-400
    • Bowden, C.L.1    Calabrese, J.R.2    Sachs, G.3    Yatham, L.N.4    Asghar, S.A.5    Hompland, M.6
  • 10
    • 84925612125 scopus 로고    scopus 로고
    • 59th edn, London: BMJ Group and Pharmaceutical Press
    • British Medical Association (2010) British National Formulary, 59th edn, London: BMJ Group and Pharmaceutical Press.
    • (2010) British National Formulary
  • 11
    • 33845693026 scopus 로고    scopus 로고
    • Optimizing therapy of seizures in adult patients with psychiatric comorbidity
    • Brodtkorb E. Mula M. (2006) Optimizing therapy of seizures in adult patients with psychiatric comorbidity. Neurology 67(Suppl. 4): S39–S44.
    • (2006) Neurology , vol.67 , pp. S39-S44
    • Brodtkorb, E.1    Mula, M.2
  • 12
  • 14
    • 0033665791 scopus 로고    scopus 로고
    • A case of pharmacokinetic interference in comedication of clozapine and valproic acid
    • Conca A. Beraus W. Konig P. Waschgler R. (2000) A case of pharmacokinetic interference in comedication of clozapine and valproic acid. Pharmacopsychiatry 33: 234–235.
    • (2000) Pharmacopsychiatry , vol.33 , pp. 234-235
    • Conca, A.1    Beraus, W.2    Konig, P.3    Waschgler, R.4
  • 15
    • 15244362235 scopus 로고    scopus 로고
    • Lamotrigine and the risk of malformations in pregnancy
    • Cunnington M. Tennis P. (2005) Lamotrigine and the risk of malformations in pregnancy. Neurology 64: 955–960.
    • (2005) Neurology , vol.64 , pp. 955-960
    • Cunnington, M.1    Tennis, P.2
  • 18
    • 0028096998 scopus 로고
    • Seizures during clozapine therapy
    • Devinsky O. Pacia S.V. (1994) Seizures during clozapine therapy. J Clin Psychiatry 55(Suppl. B): 153–156.
    • (1994) J Clin Psychiatry , vol.55 , pp. 153-156
    • Devinsky, O.1    Pacia, S.V.2
  • 19
    • 38349195054 scopus 로고    scopus 로고
    • Clozapine-induced drop-attack and myoclonus
    • Dhar R. Singh T. Charvan B.S. (2008) Clozapine-induced drop-attack and myoclonus. German J Psychiatry 11: 29–31.
    • (2008) German J Psychiatry , vol.11 , pp. 29-31
    • Dhar, R.1    Singh, T.2    Charvan, B.S.3
  • 22
    • 0034088152 scopus 로고    scopus 로고
    • Clozapine weight gain, plus topiramate weight loss
    • Dursun S.M. Devarajan S. (2000) Clozapine weight gain, plus topiramate weight loss. Can J Psychiatry 45: 198–198.
    • (2000) Can J Psychiatry , vol.45 , pp. 198
    • Dursun, S.M.1    Devarajan, S.2
  • 23
    • 0344979751 scopus 로고    scopus 로고
    • Clozapine plus lamotrigine in treatment-resistant schizophrenia
    • Dursun S.M. McIntosh D. Milliken H. (1999) Clozapine plus lamotrigine in treatment-resistant schizophrenia. Arch Gen Psychiatry 56: 950–950.
    • (1999) Arch Gen Psychiatry , vol.56 , pp. 950
    • Dursun, S.M.1    McIntosh, D.2    Milliken, H.3
  • 25
    • 0033045133 scopus 로고    scopus 로고
    • Small effects of valproic acid on the plasma concentrations of clozapine and its major metabolites in patients with schizophrenic or affective disorders
    • Facciola G. Avenoso A. Scordo M.G. Madia A.G. Ventimiglia A. Perucca E. et al. (1999) Small effects of valproic acid on the plasma concentrations of clozapine and its major metabolites in patients with schizophrenic or affective disorders. Ther Drug Monit 21: 341–345.
    • (1999) Ther Drug Monit , vol.21 , pp. 341-345
    • Facciola, G.1    Avenoso, A.2    Scordo, M.G.3    Madia, A.G.4    Ventimiglia, A.5    Perucca, E.6
  • 26
    • 12444318532 scopus 로고    scopus 로고
    • A case of clozapine-induced tonic-clonic seizures managed with valproate: implications for clinical care
    • Foster R. Olajide D. (2005) A case of clozapine-induced tonic-clonic seizures managed with valproate: implications for clinical care. J Psychopharmacol 19: 93–96.
    • (2005) J Psychopharmacol , vol.19 , pp. 93-96
    • Foster, R.1    Olajide, D.2
  • 27
    • 0030944756 scopus 로고    scopus 로고
    • Clozapine-induced electroencephalogram changes as a function of clozapine serum levels
    • Freudenreich O. Weiner R.D. McEvoy J.P. (1997) Clozapine-induced electroencephalogram changes as a function of clozapine serum levels. Biol Psychiatry 42: 132–137.
    • (1997) Biol Psychiatry , vol.42 , pp. 132-137
    • Freudenreich, O.1    Weiner, R.D.2    McEvoy, J.P.3
  • 28
    • 0028143954 scopus 로고
    • Seizure following addition of erythromycin to clozapine treatment
    • Funderburg L.G. Vertrees J.E. True J.E. Miller A.L. (1994) Seizure following addition of erythromycin to clozapine treatment. Am J Psychiatry 151: 1840–1841.
    • (1994) Am J Psychiatry , vol.151 , pp. 1840-1841
    • Funderburg, L.G.1    Vertrees, J.E.2    True, J.E.3    Miller, A.L.4
  • 29
    • 55649094658 scopus 로고    scopus 로고
    • Phenytoin intoxication in a clozapine-related prolonged seizure
    • Gandelman-Marton R. Theitler J. Klein C. Rabey J.M. (2008) Phenytoin intoxication in a clozapine-related prolonged seizure. J Emerg Med 35: 407–409.
    • (2008) J Emerg Med , vol.35 , pp. 407-409
    • Gandelman-Marton, R.1    Theitler, J.2    Klein, C.3    Rabey, J.M.4
  • 30
    • 58149374246 scopus 로고    scopus 로고
    • Lamotrigine for treatment of bipolar depression: independent meta-analysis and meta-regression of individual patient data from five randomised trials
    • Geddes J.R. Calabrese J.R. Goodwin G.M. (2009) Lamotrigine for treatment of bipolar depression: independent meta-analysis and meta-regression of individual patient data from five randomised trials. Br J Psychiatry 194: 4–9.
    • (2009) Br J Psychiatry , vol.194 , pp. 4-9
    • Geddes, J.R.1    Calabrese, J.R.2    Goodwin, G.M.3
  • 31
    • 0025856825 scopus 로고
    • Myoclonic epileptic seizures during clozapine treatment: a report of three cases
    • Gouzoulis E. Grunze H. von B.U. (1991) Myoclonic epileptic seizures during clozapine treatment: a report of three cases. Eur Arch Psychiatry Clin Neurosci 240: 370–372.
    • (1991) Eur Arch Psychiatry Clin Neurosci , vol.240 , pp. 370-372
    • Gouzoulis, E.1    Grunze, H.2    von, B.U.3
  • 32
    • 0027314609 scopus 로고
    • Myoclonic seizures followed by grand mal seizures during clozapine treatment
    • Gouzoulis E. Ozdaglar A. Kasper J. (1993) Myoclonic seizures followed by grand mal seizures during clozapine treatment. Am J Psychiatry 150: 1128a–1128a.
    • (1993) Am J Psychiatry , vol.150 , pp. 1128a-1128a
    • Gouzoulis, E.1    Ozdaglar, A.2    Kasper, J.3
  • 33
    • 0037662808 scopus 로고    scopus 로고
    • Serum clozapine levels: a review of their clinical utility
    • Greenwood-Smith C. Lubman D.I. Castle D.J. (2003) Serum clozapine levels: a review of their clinical utility. J Psychopharmacol 17: 234–238.
    • (2003) J Psychopharmacol , vol.17 , pp. 234-238
    • Greenwood-Smith, C.1    Lubman, D.I.2    Castle, D.J.3
  • 35
    • 0036200192 scopus 로고    scopus 로고
    • Myoclonic and generalized tonic clonic seizures during combined treatment with low doses of clozapine and haloperidol
    • Haberfellner E.M. (2002) Myoclonic and generalized tonic clonic seizures during combined treatment with low doses of clozapine and haloperidol. Eur Psychiatry 17: 55–55.
    • (2002) Eur Psychiatry , vol.17 , pp. 55
    • Haberfellner, E.M.1
  • 36
    • 35048827065 scopus 로고    scopus 로고
    • Adverse effects of atypical antipsychotics: differential risk and clinical implications
    • Haddad P.M. Sharma S.G. (2007) Adverse effects of atypical antipsychotics: differential risk and clinical implications. CNS Drugs 21: 911–936.
    • (2007) CNS Drugs , vol.21 , pp. 911-936
    • Haddad, P.M.1    Sharma, S.G.2
  • 38
    • 0025046470 scopus 로고
    • Clozapine and seizures
    • Haller E. Binder R.L. (1990) Clozapine and seizures. Am J Psychiatry 147: 1069–1071.
    • (1990) Am J Psychiatry , vol.147 , pp. 1069-1071
    • Haller, E.1    Binder, R.L.2
  • 40
    • 24944518595 scopus 로고    scopus 로고
    • Worsening of psychosis after replacement of adjunctive valproate with topiramate in a schizophrenia patient
    • Hofer A. Fleischhacker W.W. Hummer M. (2003) Worsening of psychosis after replacement of adjunctive valproate with topiramate in a schizophrenia patient. J Clin Psychiatry 64: 1267–1268.
    • (2003) J Clin Psychiatry , vol.64 , pp. 1267-1268
    • Hofer, A.1    Fleischhacker, W.W.2    Hummer, M.3
  • 41
    • 45949086800 scopus 로고    scopus 로고
    • Increased frequency of isolated cleft palate in infants exposed to lamotrigine during pregnancy
    • Holmes L.B. Baldwin E.J. Smith C.R. Habecker E. Glassman L. Wong S.L. et al. (2008) Increased frequency of isolated cleft palate in infants exposed to lamotrigine during pregnancy. Neurology 70: 2152–2158.
    • (2008) Neurology , vol.70 , pp. 2152-2158
    • Holmes, L.B.1    Baldwin, E.J.2    Smith, C.R.3    Habecker, E.4    Glassman, L.5    Wong, S.L.6
  • 43
    • 0036995011 scopus 로고    scopus 로고
    • Gabapentin-induced paradoxical exacerbation of psychosis in a patient with schizophrenia
    • Jablonowski K. Margolese H.C. Chouinard G. (2002) Gabapentin-induced paradoxical exacerbation of psychosis in a patient with schizophrenia. Can J Psychiatry 47: 975–976.
    • (2002) Can J Psychiatry , vol.47 , pp. 975-976
    • Jablonowski, K.1    Margolese, H.C.2    Chouinard, G.3
  • 44
    • 0028318482 scopus 로고
    • Fluvoxamine inhibition and carbamazepine induction of the metabolism of clozapine: evidence from a therapeutic drug monitoring service
    • Jerling M. Lindstrom L. Bondesson U. Bertilsson L. (1994) Fluvoxamine inhibition and carbamazepine induction of the metabolism of clozapine: evidence from a therapeutic drug monitoring service. Ther Drug Monit 16: 368–374.
    • (1994) Ther Drug Monit , vol.16 , pp. 368-374
    • Jerling, M.1    Lindstrom, L.2    Bondesson, U.3    Bertilsson, L.4
  • 45
    • 0028070783 scopus 로고
    • Concurrent use of clozapine and valproate in affective and psychotic disorders
    • Kando J.C. Tohen M. Castillo J. Centorrino F. (1994) Concurrent use of clozapine and valproate in affective and psychotic disorders. J Clin Psychiatry 55: 255–257.
    • (1994) J Clin Psychiatry , vol.55 , pp. 255-257
    • Kando, J.C.1    Tohen, M.2    Castillo, J.3    Centorrino, F.4
  • 46
    • 0023911409 scopus 로고    scopus 로고
    • Clozapine in treatment-resistant schizophrenics
    • Kane J.M. (1998) Clozapine in treatment-resistant schizophrenics. Psychopharmacol Bull 24: 62–67.
    • (1998) Psychopharmacol Bull , vol.24 , pp. 62-67
    • Kane, J.M.1
  • 48
    • 0035158095 scopus 로고    scopus 로고
    • Gabapentin for clozapine-related seizures
    • Landry P. (2001) Gabapentin for clozapine-related seizures. Am J Psychiatry 158: 1930–1931.
    • (2001) Am J Psychiatry , vol.158 , pp. 1930-1931
    • Landry, P.1
  • 49
    • 0033003027 scopus 로고    scopus 로고
    • Seizures after discontinuation of low-dose lorazepam from originally seizure-free clozapine regimen: combined effects?
    • Lane H.Y. Su K.P. Chang W.H. (1999) Seizures after discontinuation of low-dose lorazepam from originally seizure-free clozapine regimen: combined effects? J Clin Psychiatry 60: 408–409.
    • (1999) J Clin Psychiatry , vol.60 , pp. 408-409
    • Lane, H.Y.1    Su, K.P.2    Chang, W.H.3
  • 51
    • 0026836705 scopus 로고
    • Clinical profile of clozapine: adverse reactions and agranulocytosis
    • Lieberman J.A. Safferman A.Z. (1992) Clinical profile of clozapine: adverse reactions and agranulocytosis. Psychiatr Q 63: 51–70.
    • (1992) Psychiatr Q , vol.63 , pp. 51-70
    • Lieberman, J.A.1    Safferman, A.Z.2
  • 53
    • 0027068038 scopus 로고
    • Clinical picture and long-term course of epileptic seizures that occur during clozapine treatment
    • Liukkonen J. Koponen H.J. Nousiainen U. (1992) Clinical picture and long-term course of epileptic seizures that occur during clozapine treatment. Psychiatry Res 44: 107–112.
    • (1992) Psychiatry Res , vol.44 , pp. 107-112
    • Liukkonen, J.1    Koponen, H.J.2    Nousiainen, U.3
  • 54
    • 0028917675 scopus 로고
    • Valproic acid effects on serum concentrations of clozapine and norclozapine
    • Longo L.P. Salzman C. (1995) Valproic acid effects on serum concentrations of clozapine and norclozapine. Am J Psychiatry 152: 650–650.
    • (1995) Am J Psychiatry , vol.152 , pp. 650
    • Longo, L.P.1    Salzman, C.2
  • 55
    • 33846252819 scopus 로고    scopus 로고
    • Clozapine and speech dysfluency: two case reports
    • Lyall M. Pryor A. Murray K. (2007) Clozapine and speech dysfluency: two case reports. Psychiatr Bull 31: 16–18.
    • (2007) Psychiatr Bull , vol.31 , pp. 16-18
    • Lyall, M.1    Pryor, A.2    Murray, K.3
  • 57
    • 9344235447 scopus 로고    scopus 로고
    • Clozapine dosage, serum levels, efficacy, and side-effect profiles: a comparison of Korean-American and Caucasian patients
    • Matsuda K.T. Cho M.C. Lin K.M. Smith M.W. Young A.S. Adams J.A. (1996) Clozapine dosage, serum levels, efficacy, and side-effect profiles: a comparison of Korean-American and Caucasian patients. Psychopharmacol Bull 32: 253–257.
    • (1996) Psychopharmacol Bull , vol.32 , pp. 253-257
    • Matsuda, K.T.1    Cho, M.C.2    Lin, K.M.3    Smith, M.W.4    Young, A.S.5    Adams, J.A.6
  • 58
    • 0028026791 scopus 로고
    • Seizures following smoking cessation in a clozapine responder
    • McCarthy R.H. (1994) Seizures following smoking cessation in a clozapine responder. Pharmacopsychiatry 27: 210–211.
    • (1994) Pharmacopsychiatry , vol.27 , pp. 210-211
    • McCarthy, R.H.1
  • 59
    • 0024512591 scopus 로고
    • Valproate in psychiatric disorders: literature review and clinical guidelines
    • McElroy S.L. Keck P.E. Jr Pope H.G. Jr Hudson J.I. (1989) Valproate in psychiatric disorders: literature review and clinical guidelines. J Clin Psychiatry 50(Suppl): 23–29.
    • (1989) J Clin Psychiatry , vol.50 , pp. 23-29
    • McElroy, S.L.1    Keck, P.E.2    Pope, H.G.3    Hudson, J.I.4
  • 60
    • 0028021213 scopus 로고
    • Valproic acid treatment of clozapine induced myoclonus
    • Meltzer H.Y. Ranjan R. (1994) Valproic acid treatment of clozapine induced myoclonus. Am J Psychiatry 151: 1246–1247.
    • (1994) Am J Psychiatry , vol.151 , pp. 1246-1247
    • Meltzer, H.Y.1    Ranjan, R.2
  • 61
    • 0026078295 scopus 로고
    • Effect of phenytoin on plasma clozapine concentrations in two patients
    • Miller D.D. (1991) Effect of phenytoin on plasma clozapine concentrations in two patients. J Clin Psychiatry 52: 23–25.
    • (1991) J Clin Psychiatry , vol.52 , pp. 23-25
    • Miller, D.D.1
  • 62
    • 0034077062 scopus 로고    scopus 로고
    • Review and management of clozapine side effects
    • Miller D.D. (2000) Review and management of clozapine side effects. J Clin Psychiatry 61: 14–17.
    • (2000) J Clin Psychiatry , vol.61 , pp. 14-17
    • Miller, D.D.1
  • 64
    • 0033850942 scopus 로고    scopus 로고
    • Drug induced seizures: general principles in assessment, management and prevention
    • Murphy K. Delanty N. (2000) Drug induced seizures: general principles in assessment, management and prevention. CNS Drugs 14: 135–146.
    • (2000) CNS Drugs , vol.14 , pp. 135-146
    • Murphy, K.1    Delanty, N.2
  • 65
    • 77952113100 scopus 로고    scopus 로고
    • Use of lamotrigine in a patient with a clozapine-related seizure
    • Muzyk A. Gala G. Kahn D.A. (2010) Use of lamotrigine in a patient with a clozapine-related seizure. J Psychiatr Pract 16: 125–128.
    • (2010) J Psychiatr Pract , vol.16 , pp. 125-128
    • Muzyk, A.1    Gala, G.2    Kahn, D.A.3
  • 68
    • 0030049703 scopus 로고    scopus 로고
    • Electroencephalographic findings with low-dose clozapine treatment in psychotic Parkinsonian patients
    • Neufeld M.Y. Rabey J.M. Orlov E. Korcyzn A. (1996) Electroencephalographic findings with low-dose clozapine treatment in psychotic Parkinsonian patients. Clin Neuropharmacol 19: 81–86.
    • (1996) Clin Neuropharmacol , vol.19 , pp. 81-86
    • Neufeld, M.Y.1    Rabey, J.M.2    Orlov, E.3    Korcyzn, A.4
  • 69
  • 70
    • 0028897012 scopus 로고
    • Clozapine serum levels and side effects during steady state treatment of schizophrenic patients: a cross-sectional study
    • Olesen O.V. Thomsen K. Jensen P.N. Wulff C.H. Rasmussen N.A. Refshammer C. et al. (1995) Clozapine serum levels and side effects during steady state treatment of schizophrenic patients: a cross-sectional study. Psychopharmacology (Berl) 117: 371–378.
    • (1995) Psychopharmacology (Berl) , vol.117 , pp. 371-378
    • Olesen, O.V.1    Thomsen, K.2    Jensen, P.N.3    Wulff, C.H.4    Rasmussen, N.A.5    Refshammer, C.6
  • 71
    • 0028125185 scopus 로고
    • Clozapine-related seizures: experience with 5,629 patients
    • Pacia S.V. Devinsky O. (1994) Clozapine-related seizures: experience with 5,629 patients. Neurology 44: 2247–2249.
    • (1994) Neurology , vol.44 , pp. 2247-2249
    • Pacia, S.V.1    Devinsky, O.2
  • 72
    • 0036198889 scopus 로고    scopus 로고
    • Clozapine, norclozapine plasma levels, their sum and ratio in 50 psychotic patients: influence of patient-related variables
    • Palego L. Biondi L. Giannaccini G. Sarno N. Elmi S. Ciapparelli A. et al. (2002) Clozapine, norclozapine plasma levels, their sum and ratio in 50 psychotic patients: influence of patient-related variables. Prog Neuropsychopharmacol Biol Psychiatry 26: 473–480.
    • (2002) Prog Neuropsychopharmacol Biol Psychiatry , vol.26 , pp. 473-480
    • Palego, L.1    Biondi, L.2    Giannaccini, G.3    Sarno, N.4    Elmi, S.5    Ciapparelli, A.6
  • 73
    • 0034856674 scopus 로고    scopus 로고
    • Increased risk of neutropenia and agranulocytosis with sodium valproate used adjunctively with clozapine
    • Pantelis C. Adesanya A. (2001) Increased risk of neutropenia and agranulocytosis with sodium valproate used adjunctively with clozapine. Aust NZ J Psychiatry 35: 544–545.
    • (2001) Aust NZ J Psychiatry , vol.35 , pp. 544-545
    • Pantelis, C.1    Adesanya, A.2
  • 74
    • 77952118055 scopus 로고    scopus 로고
    • Epanutin Capsules 25, 50, 100 and 300 mg
    • Pfizer (2010) Summary of Product Characteristics. Epanutin Capsules 25, 50, 100 and 300 mg.
    • (2010) Summary of Product Characteristics
  • 75
  • 77
    • 0029923825 scopus 로고    scopus 로고
    • Clozapine-induced myoclonus and generalized seizures
    • Sajatovic M. Meltzer H.Y. (1996) Clozapine-induced myoclonus and generalized seizures. Biol Psychiatry 39: 367–370.
    • (1996) Biol Psychiatry , vol.39 , pp. 367-370
    • Sajatovic, M.1    Meltzer, H.Y.2
  • 78
    • 0034091444 scopus 로고    scopus 로고
    • A comparison of the effects of clozapine and olanzapine on the EEG in patients with schizophrenia
    • Schuld A. Kuhn M. Haack M. Kraus T. Hinxe-Selch D. Lechner C. et al. (2000) A comparison of the effects of clozapine and olanzapine on the EEG in patients with schizophrenia. Pharmacopsychiatry 33: 109–111.
    • (2000) Pharmacopsychiatry , vol.33 , pp. 109-111
    • Schuld, A.1    Kuhn, M.2    Haack, M.3    Kraus, T.4    Hinxe-Selch, D.5    Lechner, C.6
  • 79
    • 0031783666 scopus 로고    scopus 로고
    • Clozapine-induced seizures and EEG abnormalities in ambulatory psychiatric patients
    • Silvestri R.C. Bromfield E.B. Khoshbin S. (1998) Clozapine-induced seizures and EEG abnormalities in ambulatory psychiatric patients. Ann Pharmacother 32: 1147–1151.
    • (1998) Ann Pharmacother , vol.32 , pp. 1147-1151
    • Silvestri, R.C.1    Bromfield, E.B.2    Khoshbin, S.3
  • 80
    • 0017810335 scopus 로고
    • Clozapine plasma levels and convulsions
    • Simpson G.M. Cooper T.A. (1978) Clozapine plasma levels and convulsions. Am J Psychiatry 135: 99–100.
    • (1978) Am J Psychiatry , vol.135 , pp. 99-100
    • Simpson, G.M.1    Cooper, T.A.2
  • 81
    • 0031852710 scopus 로고    scopus 로고
    • Effect of fluoxetine on the plasma concentrations of clozapine and its major metabolites in patients with schizophrenia
    • Spina E. Avenoso A. Facciola G. Fabrazzo M. Monteleone P. Maj M. et al. (1998) Effect of fluoxetine on the plasma concentrations of clozapine and its major metabolites in patients with schizophrenia. Int Clin Psychopharmacol 13: 141–145.
    • (1998) Int Clin Psychopharmacol , vol.13 , pp. 141-145
    • Spina, E.1    Avenoso, A.2    Facciola, G.3    Fabrazzo, M.4    Monteleone, P.5    Maj, M.6
  • 82
    • 0032823040 scopus 로고    scopus 로고
    • Clozapine-induced stuttering: epileptic brain activity?
    • Supprian T. Retz W. Deckert J. (1999) Clozapine-induced stuttering: epileptic brain activity? Am J Psychiatry 156: 1663–1664.
    • (1999) Am J Psychiatry , vol.156 , pp. 1663-1664
    • Supprian, T.1    Retz, W.2    Deckert, J.3
  • 83
    • 0031982378 scopus 로고    scopus 로고
    • Clozapine-induced myoclonic seizures and valproic acid
    • Taner E. Cosar B. Isik E. (1998) Clozapine-induced myoclonic seizures and valproic acid. Int J Psychiatry Clin Pract 2: 53–55.
    • (1998) Int J Psychiatry Clin Pract , vol.2 , pp. 53-55
    • Taner, E.1    Cosar, B.2    Isik, E.3
  • 85
    • 60149100470 scopus 로고    scopus 로고
    • Reasons for discontinuing clozapine: matched, case-control comparison with risperidone long-acting injection
    • Taylor D.M. Douglas-Hall P. Olofinjana B. Whiskey E. Thomas A. (2009b) Reasons for discontinuing clozapine: matched, case-control comparison with risperidone long-acting injection. Br J Psychiatry 194: 165–167.
    • (2009) Br J Psychiatry , vol.194 , pp. 165-167
    • Taylor, D.M.1    Douglas-Hall, P.2    Olofinjana, B.3    Whiskey, E.4    Thomas, A.5
  • 86
    • 0028340404 scopus 로고
    • Dose-dependent stuttering and dystonia in a patient taking clozapine
    • Thomas P. Lalaux N. Vaiva G. Goudemand M. (1994) Dose-dependent stuttering and dystonia in a patient taking clozapine. Am J Psychiatry 151: 1096a–1096a.
    • (1994) Am J Psychiatry , vol.151 , pp. 1096a-1096a
    • Thomas, P.1    Lalaux, N.2    Vaiva, G.3    Goudemand, M.4
  • 88
    • 62649086513 scopus 로고    scopus 로고
    • The efficacy of lamotrigine in clozapine-resistant schizophrenia: a systematic review and meta-analysis
    • Tiihonen J. Wahlbeck K. Kiviniemi V. (2009) The efficacy of lamotrigine in clozapine-resistant schizophrenia: a systematic review and meta-analysis. Schizophr Res 109: 10–14.
    • (2009) Schizophr Res , vol.109 , pp. 10-14
    • Tiihonen, J.1    Wahlbeck, K.2    Kiviniemi, V.3
  • 89
    • 0028239331 scopus 로고
    • Clozapine and seizures: a review
    • Toth P. Frankenburg F.R. (1994) Clozapine and seizures: a review. Can J Psychiatry 39: 236–238.
    • (1994) Can J Psychiatry , vol.39 , pp. 236-238
    • Toth, P.1    Frankenburg, F.R.2
  • 91
    • 0029906397 scopus 로고    scopus 로고
    • EEG abnormalities in clozapine-treated schizophrenic patients
    • Treves I.A. Neufeld M.Y. (1996) EEG abnormalities in clozapine-treated schizophrenic patients. Eur Neuropsychopharmacol 6: 93–94.
    • (1996) Eur Neuropsychopharmacol , vol.6 , pp. 93-94
    • Treves, I.A.1    Neufeld, M.Y.2
  • 93
    • 0033008580 scopus 로고    scopus 로고
    • Evidence of clozapine's effectiveness in schizophrenia: a systematic review and meta-analysis of randomized trials
    • Wahlbeck K. Cheine M. Essali A. Adams C. (1999) Evidence of clozapine's effectiveness in schizophrenia: a systematic review and meta-analysis of randomized trials. Am J Psychiatry 156: 990–999.
    • (1999) Am J Psychiatry , vol.156 , pp. 990-999
    • Wahlbeck, K.1    Cheine, M.2    Essali, A.3    Adams, C.4
  • 95
    • 38449090342 scopus 로고    scopus 로고
    • Clozapine (Clozaril®), seizures, and EEG abnormalities
    • White D.M. Van Cott A.C. (2007) Clozapine (Clozaril®), seizures, and EEG abnormalities. Am J Electroneurod T 47: 190–197.
    • (2007) Am J Electroneurod T , vol.47 , pp. 190-197
    • White, D.M.1    Van Cott, A.C.2
  • 96
    • 0026692747 scopus 로고
    • Clinical review of clozapine treatment in a state hospital
    • Wilson W.H. (1992) Clinical review of clozapine treatment in a state hospital. Hosp Community Psychiatry 43: 700–703.
    • (1992) Hosp Community Psychiatry , vol.43 , pp. 700-703
    • Wilson, W.H.1
  • 97
    • 0028305355 scopus 로고
    • Seizures associated with clozapine treatment in a state hospital
    • Wilson W.H. Claussen A.M. (1994) Seizures associated with clozapine treatment in a state hospital. J Clin Psychiatry 55: 184–188.
    • (1994) J Clin Psychiatry , vol.55 , pp. 184-188
    • Wilson, W.H.1    Claussen, A.M.2
  • 98
    • 34547578326 scopus 로고    scopus 로고
    • Clozapine-induced seizures: recognition and treatment
    • Wong J. Delva N. (2007) Clozapine-induced seizures: recognition and treatment. Can J Psychiatry 52: 457–463.
    • (2007) Can J Psychiatry , vol.52 , pp. 457-463
    • Wong, J.1    Delva, N.2


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