Open-label placebo treatment in chronic low back pain: A randomized controlled trial

Pain

Volumn 157, Issue 12, 2016, Pages 2766-2772

  Carvalho, Cláudia ^a   Caetano, Joaquim Machado ^b   Cunha, Lidia ^c   Rebouta, Paula ^c   Kaptchuk, Ted J ^d   Kirsch, Irving ^d  

^a INSTITUTO SUPERIOR DE PSICOLOGIA APLICADA   (Portugal)

^b NOVA MEDICAL SCHOOL   (Portugal)

^c HOSPITAL EGAS MONIZ   (Portugal)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PLACEBO; ANALGESIC AGENT;

ADULT; ARTICLE; CHRONIC PAIN; CLINICAL OUTCOME; CONTROLLED STUDY; DISABILITY; DISEASE SEVERITY; EFFECT SIZE; FEMALE; FOLLOW UP; HUMAN; LOW BACK PAIN; MAJOR CLINICAL STUDY; MALE; NUMERIC RATING SCALE; OPEN STUDY; OUTCOME ASSESSMENT; PAIN ASSESSMENT; PILL; PLACEBO EFFECT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; ROLAND MORRIS DISABILITY QUESTIONNAIRE; TREATMENT DURATION; ALTERNATIVE MEDICINE; ANALYSIS OF VARIANCE; MIDDLE AGED; PAIN MEASUREMENT; PROCEDURES; RETROSPECTIVE STUDY; TREATMENT OUTCOME; YOUNG ADULT;

ADULT; ANALGESICS; ANALYSIS OF VARIANCE; CHRONIC PAIN; FEMALE; HUMANS; LOW BACK PAIN; MALE; MIDDLE AGED; MIND-BODY THERAPIES; PAIN MEASUREMENT; PLACEBOS; RETROSPECTIVE STUDIES; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84997785052     PISSN: 03043959     EISSN: 18726623     Source Type: Journal    
DOI: 10.1097/j.pain.0000000000000700     Document Type: Article

References (33)

1. Ackerman JM, Nocera CC, Bargh JA. Incidental haptic sensations influence social judgments and decisions. Science 2010;328:1712-15.
2. Andersson GB. Epidemiological features of chronic low-back pain. Lancet 1999;354:581-5.
3. Bishop FL, Aizlewood L, Adams AE. When and why placebo-prescribing is acceptable and unacceptable: a focus group study of patients' views. PLoS One 2014;9:e101822.
4. Blease C, Colloca L, Kaptchuk TJ. Are open-label placebos Ethical? Informed consent and ethical equivocations. Bioethics 2016;30(6): 407-414.
5. Chaparro LE, Furlan AD, Deshpande A, Mailis-Gagnon A, Atlas S, Turk DC. Opioids compared with placebo or other treatments for chronic low back pain: an update of the Cochrane Review. Spine 2014;39:556-63.
6. Dunn KM, Croft PR. Classification of low back pain in primary care: using "bothersomeness" to identify the most severe cases. Spine 2005;30: 1887-92.
7. Dworkin RH, Turk DC, Farrar JT, Haythornthwaite JA, Jensen MP, Katz NP, Kerns RD, Stucki G, Allen RR, Bellamy N, Carr DB, Chandler J, Cowan P, Dionne R, Galer BS, Hertz S, Jadad AR, Kramer LD, Manning DC, Martin S, McCormick CG, McDermott MP, McGrath P, Quessy S, Rappaport BA, Robbins W, Robinson JP, Rothman M, Royal MA, Simon L, Stauffer JW, SteinW, Tollett J,Wernicke J,WitterJ. Core outcome measures for chronic pain clinical trials: IMMPACT recommendations. PAIN 2005;113:9-19.
8. Eaves ER, Nichter M, Ritenbaugh C. Ways of hoping: navigating the Paradox of hope and despair in chronic pain. Culture, Medicine, and Psychiatry 2015:1-24.
9. Farrar JT, Young JP Jr, LaMoreaux L, Werth JL, Poole RM. Clinical importance of changes in chronic pain intensity measured on an 11-point numerical pain rating scale. PAIN 2001;94:149-58.
10. Henschke N, Kuijpers T, Rubinstein SM, van Middelkoop M, Ostelo R, Verhagen A, Koes BW, van Tulder MW. Injection therapy and denervation procedures for chronic low-back pain: a systematic review. Eur Spine J 2010;19:1425-49.
11. Hoy D, March L, Brooks P, Blyth F, Woolf A, Bain C, Williams G, Smith E, Vos T, Barendregt J. The global burden of low back pain: estimates from the Global Burden of Disease 2010 study. Ann Rheum Dis 2014;73: 968-74.
12. Hró bjartsson A, Kaptchuk TJ, Miller FG. Placebo effect studies are susceptible to response bias and to other types of biases. J Clin Epidemiol 2011;64:1223-9.
13. Hull SC, Colloca L, Avins A, Gordon NP, Somkin CP, Kaptchuk TJ, Miller FG. Patients' attitudes about the use of placebo treatments: telephone survey. BMJ 2013;347:f3757.
14. IOM. Relieving Pain in America. Washington DC: Institute of Medicine of the National Academies, 2011.
15. Jensen KB, Kaptchuk TJ, Chen X,KirschI, IngvarM,Gollub RL, KongJ.A Neural Mechanism for Nonconscious Activation of Conditioned Placebo and Nocebo Responses. Cerebral Cortex 2015;25:3903-10.
16. Jensen KB, Kaptchuk TJ, Kirsch I, Raicek J, Lindstrom KM, Berna C, Gollub RL, Ingvar M, Kong J. Nonconscious activation of placebo and nocebo pain responses. Proceedings of the National Academy of Sciences 2012;109:15959-64.
17. Kaptchuk TJ, Friedlander E, Kelley JM, Sanchez MN, Kokkotou E, Singer JP, Kowalczykowski M, Miller FG, Kirsch I, Lembo AJ. Placebos without deception: a randomized controlled trial in irritable bowel syndrome. PLoS One 2010;5:e15591.
18. Kaptchuk TJ, Miller FG. Placebo effects in medicine. N Engl J Med 2015; 373:8-9.
19. Kelley JM, Kaptchuk TJ, Cusin C, Lipkin S, Fava M. Open-label placebo for major depressive disorder: a pilot randomized controlled trial. Psychother Psychosom 2012;81:312-14.
20. Kirsch I. Changing expectations: A key to effective psychotherapy. Belmont, CA: Brooks/Cole; 1990.
21. Kirsch I, Kong J, Sadler P, Spaeth R, Cook A, Kaptchuk TJ, Gollub R. Expectancy and conditioning in placebo analgesia: Separate or connected processes? Psychology of Consciousness. Theory, Research, and Practice 2014;1:51-59.
22. Machado GC, Maher CG, Ferreira PH, Pinheiro MB, Lin C-WC, Day RO, McLachlan AJ, Ferreira ML. Efficacy and safety of paracetamol for spinal pain and osteoarthritis: systematic review and meta-analysis of randomised placebo controlled trials. BMJ 2015;350. h1225;1-13.
23. Monteiro J, Fáisca L, Nunes O, Hipó lito J. Roland Morris disability questionnaire-adaptation and validation for the Portuguese speaking patients with back pain [in Portuguese]. Acta Méd Port 2010;23:761-6.
24. Murray CJ, AbrahamJ,Ali MK, Alvarado M,Atkinson C,Baddour LM, Bartels DH, Benjamin EJ, Bhalla K, Birbeck G. The state of US health, 1990-2010: burden of diseases, injuries, and risk factors. JAMA 2013;310:591-606.
25. Park LC, Covi L. Nonblind placebotrial.ArchGen Psychiatry1965;12:336-45.
26. Roelofs P, Deyo RA, Koes BW, Scholten R, Van Tulder MW. Non-steroidal anti-inflammatory drugs for low back pain. Cochrane Database Syst Rev 2008;1.
27. Rutherford BR, Mori S, Sneed JR, Pimontel MA, Roose SP. Contribution of spontaneous improvementto placebo responseindepression:a meta-analytic review. J Psychiatr Res 2012;46:697-702.
28. Sandler A, Bodfish J. Open-label use of placebos in the treatment of ADHD: a pilot study. Child Care Health Dev 2008;34:104-10.
29. Tilburt JC, Emanuel EJ, Kaptchuk TJ, Curlin FA, Miller FG. Prescribing "placebo treatments": results of national survey of US internists and rheumatologists. BMJ 2008;337:a1938.
30. Violante F, Mattioli S, Bonfiglio R. Low-back pain. In: Lotti M, Bleecker M, editors. Handbook of Clinical Neurology. Vol. 131. Elsevier, 2015. p. 398-410.
31. Vos T,Flaxman AD, Naghavi M,Lozano R, Michaud C, Ezzati M, Shibuya K, Salomon JA, Abdalla S, Aboyans V. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2013;380:2163-96.
32. Wager TD, Atlas LY. The neuroscience of placebo effects: connecting context, learning and health. Nat Rev Neurosci 2015;16:403-18.
33. Williams CM, Maher CG, Latimer J,McLachlan AJ,Hancock MJ, Day RO, Lin CWC. Efficacy of paracetamol for acute low-back pain: a double-blind, randomised controlled trial. Lancet 2014;384:1586-96.