Immune monitoring technology primer: Single Cell Network Profiling (SCNP)

Journal for ImmunoTherapy of Cancer

Volumn 3, Issue 1, 2015, Pages

  Hawtin, Rachael E ^a   Cesano, Alessandra ^b  

^a Nodality   (United States)

^b AC Consulting   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TOLL LIKE RECEPTOR 4;

ANTIGEN SPECIFICITY; ARTICLE; CANCER PROGNOSIS; CLUSTER ANALYSIS; FLOW CYTOMETRY; HUMAN; IMMUNE RESPONSE; IMMUNE STATUS; IMMUNOHISTOCHEMISTRY; IMMUNOLOGICAL TOLERANCE; PRIORITY JOURNAL; SINGLE CELL NETWORK PROFILING; TUMOR CELL; VALIDATION PROCESS;

EID: 84997605209     PISSN: None     EISSN: 20511426     Source Type: Journal    
DOI: 10.1186/s40425-015-0075-z     Document Type: Article

References (16)

1. Cesano A, Rosen DB, O'Meara P, Putta S, Gayko U, Spellmeyer DC, et al. Functional pathway analysis in acute myeloid leukemia using single cell network profiling assay: effect of specimen source (Bone Marrow or Peripheral Blood) on assay readouts. Cytometry B Clin Cytom. 2012;82B:158-72.
2. Nodality web site: http://nodality.com/technology-analysis-visualization.html.
3. Lacayo NJ, Alonzo TA, Gayko U, Rosen DB, Westfall M, Purvis N, et al. Development and validation of a single-cell network profiling assay-based classifier to predict response to induction therapy in paediatric patients with de novo acute myeloid leukaemia: a report from the Children's Oncology Group. Br J Haematol. 2013;162(2):250-62.
4. Cesano A, Willman CL, Kopecky KJ, Gayko U, Putta S, Louie B, et al. Cell signaling-based classifier predicts response to induction 1 therapy in elderly patients with acute myeloid leukemia. PLoS One. 2015. doi: 10.1371/ journal.pone.0118485.
5. Cesano A, Spellmeyer D. Immune system functional pathway analysis using single cell network profiling (SCNP): a novel tool in cancer immunotherapy. Methods Mol Biol. 2014. doi: 10.1007/978-1-62703-727-3_31.
6. Le Scolan E, Liang S, Leung L, Tan N, Tai A, Putta S, et al. Functional activity, but not PD-1 expression level, differentiates primary CLL from healthy PD-1+ T cells using SCNP. In: AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics. 2014.
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8. Hawtin RE, Korver W, Evensen E, Longo D, Hotson D, Louie B, et al. Functional profiling of PBMC from SLE patients versus healthy controls identifies subgroups with disease-associated signaling differences. In: American College of Rheumatology Annual Meeting. 2014.
9. Hawtin RE, Korver W, Evensen E, Longo D, Hotson D, Louie B, et al. Functional analysis of interferon responsiveness in PBMC from SLE donors identifies subgroups with higher and lower disease activity. In: American College of Rheumatology Annual Meeting. 2014.
10. Ptacek J, Evensen E, Hawtin RE, Friedland G, Ware JR, Cordeiro J, et al. Single Cell Network Profiling (SCNP) identifies altered signaling between patient risk groups in B-cell Chronic Lymphocytic Leukemia (B-CLL). In: American Society for Hematology Annual Meeting. 2012.
11. Kornblau SM, Cohen AC, Soper D, Huang YW, Cesano A. Age-related changes of healthy bone marrow cell signaling in response to growth factors provide insight into low risk MDS. Cytometry B Clin Cytom. 2014;86(6):383-96.
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15. Rosen DB, Cordeiro JA, Cohen A, Lacayo N, Hogge D, Hawtin RE, et al. Assessing signaling pathways associated with in vitro resistance to cytotoxic agents in AML. Leuk Res. 2012;36(7):900-4.
16. Nodality web site: http://nodality.com/resources/pdf/Nodality_Cryopreservation_Protocol.pdf.