High-dimensional analysis of the aging immune system: Verification of age-associated differences in immune signaling responses in healthy donors

Journal of Translational Medicine

Volumn 12, Issue 1, 2014, Pages

  Longo, Diane M ^a   Louie, Brent ^a   Ptacek, Jason ^a   Friedland, Greg ^a   Evensen, Erik ^a   Putta, Santosh ^a   Atallah, Michelle ^a   Spellmeyer, David ^a   Wang, Ena ^b,c   Pos, Zoltan ^d   Marincola, Francesco M ^b,c   Schaeffer, Andrea ^e   Lukac, Suzanne ^e   Railkar, Radha ^e   Beals, Chan R ^e   Cesano, Alessandra ^a   Carayannopoulos, Leonidas N ^e   Hawtin, Rachael E ^a  

^a Nodality   (United States)

^b SIDRA MEDICAL AND RESEARCH CENTER   (Qatar)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^e MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Aging; Immune signaling; Multi parameter flow cytometry; Systems immunology

Indexed keywords

ALPHA INTERFERON; CD20 ANTIGEN; CD3 ANTIGEN; CD40 LIGAND; CD45RA ANTIGEN; GAMMA INTERFERON; IMMUNOGLOBULIN D ANTIBODY; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 27; INTERLEUKIN 4; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; RESIQUIMOD;

ADULT; AGED; AGING; ARTICLE; B LYMPHOCYTE; COHORT ANALYSIS; CYTOTOXIC T LYMPHOCYTE; DONOR; FEMALE; FLOW CYTOMETRY; HELPER CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; INTRACELLULAR SIGNALING; MALE; MONOCYTE; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; QUANTITATIVE ANALYSIS; SENESCENCE; SINGLE CELL NETWORK PROFILING; IMMUNOLOGY; SIGNAL TRANSDUCTION;

ADULT; AGED; AGING; COHORT STUDIES; HEALTHY VOLUNTEERS; HUMANS; SIGNAL TRANSDUCTION;

EID: 84902745196     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-12-178     Document Type: Article

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