Acute toxicity and cytotoxicity effect of ethanolic extract of Spondias tuberose arruda bark: Hematological, biochemical and histopathological evaluation

Anais da Academia Brasileira de Ciencias

Volumn 88, Issue 3, 2016, Pages 1993-2004

  Barbosa, Humberto M ^a   Do Nascimento, Jailson N ^a   Araújo, Thiago A S ^b   Duarte, Filipe S ^a   Albuquerque, Ulysses P ^b   Vieira, Jeymesson R C ^a   De Santana, Edson R B ^a   Yara, Ricardo ^a   Lima, Cláudia S A ^a   Gomes, Dayane A ^a   Lira, Eduardo Carvalho ^a  

^a FEDERAL UNIVERSITY OF PERNAMBUCO   (Brazil)

^b UNIVERSIDADE FEDERAL RURAL DE PERNAMBUCO   (Brazil)

Author keywords

Acute toxicity; Cytotoxicity; Phytomedicine; Safety; Spondias tuberosa Arruda; Toxicology

Indexed keywords

ALCOHOL; PLANT EXTRACT;

ANACARDIACEAE; ANIMAL; CHEMISTRY; FEMALE; MEDICINAL PLANT; RAT; TIME FACTOR; TOXICITY; TOXICITY TESTING; WISTAR RAT;

ANACARDIACEAE; ANIMALS; ETHANOL; FEMALE; PLANT EXTRACTS; PLANTS, MEDICINAL; RATS; RATS, WISTAR; TIME FACTORS; TOXICITY TESTS, ACUTE;

EID: 84997482022     PISSN: 00013765     EISSN: 16782690     Source Type: Journal    
DOI: 10.1590/0001-3765201620160041     Document Type: Article

References (31)

1. Aguilar-Barajas E, Sork VL, González-Zamora A, Rocha-Ramirez V, Arro yo-Rodriguez V and Oyama K. 2014. Isolation and characterization of polymorphic microsatellite loci in Spondias radlkoferi (Anacardiaceae). Appl Plant Sci 3: 1-3
2. Ahmad M, Lim CP, Akowuah GA, Ismail NN, Hashim MA, Hor SY, Ang LF and Yam MF. 2013. Safety assessment of standardised methanol extract of Cinnamomum burmannii. Phytomedicine 15: 1124-1130
3. Da Silva AR, De Morais SM, Marques MM, de Oliveria DF, Barros CC, de Almeida RR, Vieira IG and Guedes MI. 2012. Chemical composition, antioxidant and antibacterial activities of two Spondias species from Northeastern Brazil. Pharm Biol 50: 740-746
4. De Sousa Araújo TA, Alencar NL, de Amorim EL and de Albuquerque UP. 2008. A new approach to study medicinal plants with tannins and flavonoids contents from the local knowledge. J Ethnopharmaco 120: 72-80
5. De Sousa Araújo TA, De Almeidae Castro VT, De Amorim EL and Albuquerque UP. 2012. Habitat influence on antioxidant activity and tannin concentrations of Spondias tuberosa. Pharma Biol 50: 754-759
6. Deng YX et al. 2013. Toxicological evaluation of neem (Azadirachta indica) oil: acute and subacute toxicity. Environ Toxicol Pharmacol 35: 240-246
7. Fernández SP, Wasowski C, Loscalzo LM, Granger RE, Joh nsto n GA, Paladini AC and Marder M. 2006. Central nervous system depressant action of flavonoid glycosides. Eur J Pharmacol 539: 168-176
8. Garner RJ. 1975. Veterinary Toxicology. London: Cassel and Collier Macmillan Publishers, 438 p.
9. Gautam MK and Goel RK. 2014. Toxicological Study of Ocimum sanctum Linn Leaves: Hematological, Biochemical, and Histopathological Studies. J Toxicol, p. 1-9
10. Geran RI, Greenberg NH, Macdonald MM, Schumacher AM and Abbott BJ. 1972. Protocols for screening chemical agents and natural products against animal and other biological systems. Cancer Chemother Rep 3: 17-19
11. Goutma n JD, Waxemberg MD, Donate-Oliver F, Pomata PE and Calvo DJ. 2003. Flavonoid modulation of ionic currents mediated by GABA(A) and GABA(C) receptors. Eur J Pharmacol 461: 79-87
12. Griebel G, Perrau lt G, Tan S, Schoemaker H and Sanger DJ. 1999. Pharmacological studies on synthetic flavonoids: comparison with diazepam. Neuropharmacology 38: 965-977
13. Jäger AK and Saaby L. 2011. Flavonoids and the CNS. Molecules 16: 1471-1485
14. Lins Neto EM, Peroni N and De Albuquerque UP. 2010. Traditional Knowledge and Management of Umbu (Spondias tuberosa, Anacardiaceae): An Endemic Species from the Semi–Arid Region of Northeastern Brazil. Econ Bot 64: 11-21
15. Lins Neto EM, Peroni N, Maranhão CM, Maciel MI and De Albuquerque UP. 2012. Analysis of umbu (Spondias tuberosa Arruda (Anacardiaceae) in different landscape management regimes: A process of incipient domestication? Environ Monit Assessm 184: 4489-4499
16. Luka J, Badau SJ, Mba ya AW, Gadzama JJ and Kumshe HA. 2014. Acute toxicity study and effect of prolonged administration (28 days) of crude ethanolic root extract of Diospyros mespiliformis (Ebenaceae) on clinical, haematological and biochemical parameters of albino rats. J Ethnopharmacol 15: 268-273
17. Melo MC, Gadelha DN, Oliveira TK and Bra ndt CT. 2014. Alcohol extract of Schinu sterebinthifolius raddi (anacardiaceae) as a local antimicrobial agent in severe autogenously fecal peritonitis in rats. Acta Cir Bras 29: 52-56
18. Miller A and Schaal B. 2005. Domestication of a Mesoamerican cultivated fruit tree, Spondias purpurea. Proc Natl Acad Sci USA 102: 12801-12806
19. Nort ier JL and Vanherweghem JL. 2007. For patients taking herbal therapy-lessons from aristolochic acid nephropathy. Nephrol Dial Transplant 22: 1512-1517
20. OECD. 2001. “Acute Oral Toxicity: Acute Toxic Class Method.” Test Guideline 423, 2001.
21. Ojewole JA. 2005. Anti-inflamatory, analgesic and hypoglycemic effects of Magnifera indica Linn (Anacardiaceae) stem-bark aqueous extract. Methods Find Exp Clin Pharmacol 27: 547-554
22. Olson H et al. 2000. Concordance of the toxicity of pharmaceuticals in humans and in animals. Regul Toxicol Pharmacol 32: 56-57
23. Pan X, Chang F, Liu Y, Xu A, Shen Y and Huang Z. 2009. Mouse toxicity of Anabaena flos-aquae from Lake Dianchi, China. Environ Toxicol 24: 10-18
24. Reichen J and Paum gart ner G. 1980. Excretory function of the liver. Int Rev Physiol 21: 103-150
25. Santhosh S, Sini TK, Anandan R and Mathew PT. 2007. Hepatoprotetive activity of chitosan against isoniazid and fifampicin-induced toxicity in experimental rats. Eur J Pharmacol 15: 69-73
26. Singleto n VL, Ortho fer R and Lamuela-Raventós RM. 1999. Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent. Methods Enzymol 299: 152-178
27. Tadjimukhamedov FK, Huang G, Ouyang Z and Cooks RG. 2012. Rapid detection of urushiol allergens of Toxicodendron genus using leaf spray mass spectrometry. Analyst 137: 1082-1084
28. Viola H, Wasowski C, Levi de Stein M, Wolfman C, Silveira R, Dajas F, Medina JH and Paladini AC. 1995. Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects. Planta Med 61: 213-216
29. Wagner H and Bladt S. 1996. Plant Drug Analysis: A Thin Layer Chromatography Atlas, 2nd ed., Hedelberg, Germany: Springer-Verlag, 384 p.
30. Woisky RG and Salatino A. 1998. Analysis of propolis: some parameters and procedure for chemical quality control. J Apicultural Research 37: 99-105
31. Zielinski AA, Ávila S, Ito V, Nogueira A, Wosiacki G and Haminiuk CW. 2014. The association between chromaticity, phenolics, carotenoids, and in vitro antioxidant activity of frozen fruit pulp in Brazil: an application of chemometrics. J Food Sci 79: 510-516