3 Screen ELISA for High-Throughput Detection of Beta Cell Autoantibodies in Capillary Blood

Diabetes Technology and Therapeutics

Volumn 18, Issue 11, 2016, Pages 687-693

  Ziegler, Anette G ^a,b   Haupt, Florian ^a   Scholz, Marlon ^a   Weininger, Katharina ^a   Wittich, Susanne ^a   Löbner, Stephanie ^a   Matzke, Claudia ^a   Gezginci, Cigdem ^a   Riethausen, Stephanie ^a   Beyerlein, Andreas ^a   Zillmer, Stephanie ^a   Amoroso, Marie ^c   Coles, Rebecca ^c   Powell, Michael ^c   Furmaniak, Jadwiga ^c   Smith, Bernard Rees ^c   Winkler, Christiane ^a,b   Bonifacio, Ezio ^d,e   Achenbach, Peter ^a,b  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b Forschergruppe Diabetes EV   (Germany)

^c RSR LTD   (United Kingdom)

^d CENTER FOR REGENERATIVE THERAPIES DRESDEN   (Germany)

^e DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; DIMER; GLUTAMATE DECARBOXYLASE; INSULINOMA ASSOCIATED ANTIGEN 2; RECOMBINANT ANTIGEN; UNCLASSIFIED DRUG; ZINC TRANSPORTER; ZINC TRANSPORTER 8; CATION TRANSPORT PROTEIN; PTPRN PROTEIN, HUMAN; RECEPTOR LIKE PROTEIN TYROSINE PHOSPHATASE; SLC30A8 PROTEIN, HUMAN;

ADOLESCENT; ANTIBODY DETECTION; ARTICLE; BLOOD SAMPLING; CAPILLARY BLOOD; CHILD; ENZYME LINKED IMMUNOSORBENT ASSAY; HIGH THROUGHPUT SCREENING; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RELATIVE; SENSITIVITY AND SPECIFICITY; BLOOD; CAPILLARY; FEMALE; IMMUNOLOGY; MALE; PROCEDURES;

ADOLESCENT; AUTOANTIBODIES; CAPILLARIES; CATION TRANSPORT PROTEINS; CHILD; DIABETES MELLITUS, TYPE 1; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GLUTAMATE DECARBOXYLASE; HUMANS; INSULIN-SECRETING CELLS; MALE; RECEPTOR-LIKE PROTEIN TYROSINE PHOSPHATASES, CLASS 8; SENSITIVITY AND SPECIFICITY;

EID: 84997236730     PISSN: 15209156     EISSN: 15578593     Source Type: Journal    
DOI: 10.1089/dia.2016.0199     Document Type: Article

References (21)

1. Raab J, Haupt F, Scholz M, et al.: Capillary blood islet autoantibody screening for identifying pre-type 1 diabetes in the general population: design and initial results of the Fr1da study. BMJ Open 2016;6:e011144.
2. Ziegler AG, Rewers M, Simell O, et al.: Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children. JAMA 2013;309:2473-2479.
3. Törn C, Mueller PW, Schlosser M, et al.: Diabetes Antibody Standardization Program: evaluation of assays for autoantibodies to glutamic acid decarboxylase and islet antigen-2. Diabetologia 2008;51:846-852.
4. Schlosser M, Mueller PW, Törn C, et al.: Diabetes Antibody Standardization Program: evaluation of assays for insulin autoantibodies. Diabetologia 2010;53:2611-2620.
5. Lampasona V, Schlosser M, Mueller PW, et al.: Diabetes antibody standardization program: first proficiency evaluation of assays for autoantibodies to zinc transporter. Clin Chem 2011;57:1693-1702.
6. Bonifacio E, Yu L, Williams AK, et al.: Harmonization of glutamic acid decarboxylase and islet antigen-2 autoantibody assays for national institute of diabetes and digestive and kidney diseases consortia. J Clin Endocrinol Metab 2010;95:3360-3367.
7. Wasserfall C, Atkinson M, Jodoin E, et al.: Glutamic acid decarboxylase and IA-2 autoantibodies in type 1 diabetes: comparing sample substrates for autoantibody determinations. Paediatr Diabetes 2000;1:10-16.
8. Bazzigaluppi E, Bonfanti R, Bingley PJ, et al.: Capillary whole blood measurement of islet autoantibodies. Diabetes Care 1999;22:275-279.
9. Bingley PJ, Rafkin LE, Matheson D, et al.: Use of dried capillary blood sampling for islet autoantibody screening in relatives: a feasibility study. Diabetes Technol Ther 2015; 17:867-871.
10. Chen S, Willis J, Maclean C, et al.: Sensitive non-isotopic assays for autoantibodies to IA-2 and to a combination of both IA-2 and GAD65. Clin Chim Acta 2005;357: 74-83.
11. Ziegler AG, Hummel M, Schenker M, et al.: Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: the 2-year analysis of the German BABYDIAB Study. Diabetes 1999; 48:460-468.
12. Ziegler AG, Meier-Stiegen F, Winkler C, et al.: Prospective evaluation of risk factors for the development of islet autoimmunity and type 1 diabetes during puberty-TEENDIAB: study design. Pediatr Diabetes 2012;13:419-424.
13. Thümer L, Adler K, Bonifacio E, et al.: German new onset diabetes in the young incident cohort study: DiMelli study design and first-year results. Rev Diabet Stud 2010;7: 202-208.
14. Achenbach P, Lampasona V, Landherr U, et al.: Autoantibodies to zinc transporter 8 andSLC30A8 genotype stratify type 1 diabetes risk. Diabetologia 2009;52:1881-1888.
15. MiaoD, SteckAK, Zhang L, et al.: Electrochemiluminescence assays for insulin and glutamic acid decarboxylase autoantibodies improve prediction of type 1 diabetes risk. Diabetes Technol Ther 2015;17:119-127.
16. Burbelo PD, Lebovitz EE, Notkins AL: Luciferase immunoprecipitation systems formeasuring antibodies in autoimmune and infectious diseases. Transl Res 2015;165:325-335.
17. Zhao Z, Miao D, Michels A, et al.: A multiplex assay combining insulin, GAD, IA-2 and transglutaminase autoantibodies to facilitate screening for pre-type 1 diabetes and celiac disease. J Immunol Methods 2016;430:28-32.
18. Strebelow M, Schlosser M, Ziegler B, et al.: Karlsburg type I diabetes risk study of a general population: frequencies and interactions of the four major type I diabetes-associated autoantibodies studied in 9419 schoolchildren. Diabetologia 1999;42:661-670.
19. Bingley PJ, Bonifacio E, Williams AJ, et al.: Prediction of IDDM in the general population: strategies based on combinations of autoantibody markers. Diabetes 1997;46:1701-1710.
20. Gesualdo PD, Bautista KA, Waugh KC, et al.: Feasibility of screening for T1D and celiac disease in a pediatric clinic setting. Pediatr Diabetes 2016;17:441-448.
21. Williams AJ, Lampasona V, Schlosser M, et al.: Detection of antibodies directed to the N-terminal region of GAD is dependent on assay format and contributes to differences in the specificity of GAD autoantibody assays for type 1 diabetes. Diabetes 2015;64:3239-3246.