Vitamin D supplementation for treatment and prevention of pneumonia in under-five children: A randomized double-blind placebo controlled trial

Indian Pediatrics

Volumn 53, Issue 11, 2016, Pages 967-976

  Gupta, Piyush ^a   Dewan, Pooja ^a   Shah, Dheeraj ^a   Sharma, Nisha ^a   Bedi, Nidhi ^a   Kaur, Iqbal R ^a   Bansal, Ajay Kumar ^a   Madhu, S V ^a  

^a UNIVERSITY COLLEGE OF MEDICAL SCIENCES   (India)

Author keywords

Cholecalciferol; LRTI; Micronutrient Therapy; Outcome; Prevention

Indexed keywords

CATHELICIDIN; COLECALCIFEROL; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; PLACEBO; VITAMIN D;

ARTICLE; CHILD; CONTROLLED STUDY; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG MEGADOSE; FEMALE; HUMAN; HYPERCALCEMIA; IMMUNOGLOBULIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; PNEUMONIA; PRESCHOOL CHILD; RANDOMIZED CONTROLLED TRIAL; RECURRENCE RISK; RECURRENT DISEASE; SINGLE DRUG DOSE; TREATMENT OUTCOME; VITAMIN SUPPLEMENTATION; VOMITING; DIETARY SUPPLEMENT; INFANT;

CHILD, PRESCHOOL; DIETARY SUPPLEMENTS; FEMALE; HUMANS; INFANT; MALE; PNEUMONIA; RECURRENCE; VITAMIN D;

EID: 84997080376     PISSN: 00196061     EISSN: 09747559     Source Type: Journal    
DOI: 10.1007/s13312-016-0970-5     Document Type: Article

References (29)

1. World Health Organization. Pneumonia fact sheet N 331. From http://www.who.int/mediacentre/factsheets/fs331/en. Accessed January 23, 2016.
2. McNally JD, Leis K, Matheson LA, Karuananyake C, Sankaran K, Rosenberg AM. Vitamin D deficiency in young children with severe acute lower respiratory infection. Pediatr Pulmonol. 2009;44:981–8.
3. Roth DE, Shah R, Black RE, Baqui AH. Vitamin D status and acute lower respiratory infection in early childhood in Sylhet, Bangladesh. Acta Paediatr. 2010;99:389–93.
4. Karatekin G, Kaya A, Saliho Églu O, Balci H, NuhoÉglu A. Association of subclinical vitamin D deficiency in newborns with acute lower respiratory infection and their mothers. Eur J Clin Nutr. 2009;63:473–7.
5. Ahmed P, Babaniyi IB, Yusuf KK, Dodd C, Langdon G, Steinhoff M, Dawodu A. Vitamin D status and hospitalization for childhood acute lower respiratory tract infections in Nigeria. Paediatr Int Child Health. 2015; 35:151–6.
6. Shah N, Ramankutty V, Premila PG, Sathy N. Risk factors for severe pneumonia in children in south Kerala: a hospital-based case-control study. J Trop Pediatr. 1994;40:201–6.
7. Banajeh SM. Nutritional rickets and vitamin D deficiencyassociation with the outcomes of childhood very severe pneumonia: A prospective cohort study. Pediatr Pulmonol. 2009;44:1207–15.
8. Wayse V, Yousafzai A, Mogale K, Filteau S. Association of subclinical vitamin D deficiency with severe acute lower respiratory infection in Indian children under 5 y. Eur J Clin Nutr. 2004;58:563–7.
9. Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik SR, et al. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science. 2006;311:1770–3.
10. Muhe L, Lulseged S, Mason KE, Simoes EAF. Case control study of the role of nutritional rickets in the risk of developing pneumonia in Ethiopian children. Lancet. 1997;349:1801–4.
11. Urashima M, Segawa T, Okazaki M, Kurihara M, Wada Y, Ida H. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am J Clin Nutr. 2010;91:1255–60.
12. Majak P, Olszowiec-Chlebna M, Smejda K, Stelmach I. Vitamin D supplementation in children may prevent asthma exacerbation triggered by acute respiratory infection. J Allergy Clin Immunol. 2011;127:1294–6.
13. Camargo CA Jr, Ganmaa D, Frazier AL, Kirchberg FF, Stuart JJ, Kleinman K, et al. Randomized trial of vitamin D supplementation and risk of acute respiratory infection in Mongolia. Pediatrics. 2012;130:e561–7.
14. Manaseki-Holland S, Qader G, Isaq Masher M, Bruce J, Zulf Mughal M, Chandramohan D, et al. Effects of vitamin D supplementation to children diagnosed with pneumonia in Kabul: a randomized controlled trial. Trop Med Int Health. 2010;15:1148–55.
15. Manaseki-Holland S, Maroof Z, Bruce J, Mughal MZ, Masher MI, Bhutta ZA, et al. Effect on the incidence of pneumonia of vitamin D supplementation by quarterly bolus dose to infants in Kabul: a randomized controlled superiority trial. Lancet. 2012;379:1419–27.
16. Choudhary N, Gupta P. Vitamin D supplementation for severe pneumonia-a randomized controlled trial. Indian Pediatr. 2012;49:449–54.
17. Charan J, Goyal JP, Saxena D, Yadav P. Vitamin D for prevention of respiratory tract infections: A systematic review and meta-analysis. J Pharmacol Pharmacother. 2012;3:300–3.
18. World Health Organization. Technical bases for the WHO Recommendations on the Management of Pneumonia in Children at First level Health Care. Report no. WHO/ARI/91·20. Geneva: WHO; 1995.
19. WHO Child and Adolescent Health and Development (CAH). Integrated management of neonatal and childhood illness and HIV. Physician Chart Booklet. New Delhi: Ministry of Health and Family Welfare, Govt. of India; 2007.
20. World Health Organization. Physical status: The Use and Interpretation of Anthropometry. Report of WHO Expert Committee. Geneva: WHO; 1987.
21. World Health Organization Anthro for personal computers, version 3·2·2, 2011: Software for assessing growth and development of the world’s children. Geneva: WHO; 2010. http://www.who.int/childgrowth/software/en/ accessed September 2011.
22. World Health Organization, Multicentre Growth Reference Study Group. WHO Child Growth Standards: Length/height-for-age, weight-for-age, weight-for-length, weight-for-height and body mass index-for-age: Methods and development. Geneva: World Health Organization; 2006.
23. Agarwal R, Singh V, Yewale V. RTI Facts. Indian Academy of Pediatrics Consensus Guidelines on Rational Management of Respiratory Tract Infections in Children. Mumbai: Indian Academy of Pediatrics; 2006.
24. Institute of Medicine Food and Nutrition Board. Dietary Reference Intakes for Calcium and Vitamin D. Washington, DC: National Academy Press; 2011.
25. Nicholson JF, Pesce MA. Reference ranges for laboratory tests and procedures. In: Behrman RE, Kliegman RM, editors. Nelson Textbook of Pediatrics. 17th edition. Philadelphia: Saunders; 2003 P 2396–427.
26. Hollick MF. The role of vitamin D for bone health and fracture prevention. Curr Osteoporos Rep. 2006;4:96–102.
27. Bhalla AK, Amento EP, Clemens TL, Holick MF, Krane SM. Specific high-affinity receptors for 1,25-dihydroxyvitamin D3 in human peripheral blood mononuclear cells; presence in monocytes and induction in T lymphocytes following activation. J Clin Endocrinol Metab. 1983;57:1308–10.
28. Provvedini DM, Deftos LJ, Manolagas SC. 1,25-dihydroxyvitamin D3 promotes in vitro morphologic and enzymatic changes in normal human monocytes consistent with their differentiation into macrophages. Bone. 1986;7:23–8.
29. Pletz MW, Terkamp C, Schumacher U, Rohde G, Schütte H, Welte T, et al; CAPNETZ-Study Group. Vitamin D deficiency in community acquired pneumonia: low levels of 1,25(OH)2 D are associated with disease severity. Respir Res. 2014;15:53.