Neurochemical aftermath of repetitive mild traumatic brain injury

JAMA Neurology

Volumn 73, Issue 11, 2016, Pages 1308-1315

  Shahim, Pashtun ^a   Tegner, Yelverton ^b   Gustafsson, Bengt ^c   Gren, Magnus ^a   Ärlig, Johan ^a   Olsson, Martin ^a   Lehto, Niklas ^b   Engström, Asa ^b   Höglund, Kina ^a   Portelius, Erik ^a   Zetterberg, Henrik ^a,d   Blennow, Kaj ^a  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^b LULEÅ UNIVERSITY OF TECHNOLOGY   (Sweden)

^c Capio Artro Clinic   (Sweden)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; GLIAL FIBRILLARY ACIDIC PROTEIN; NEUROFILAMENT LIGHT PROTEIN; NEUROFILAMENT PROTEIN; NEUROGRANIN; TAU PROTEIN; UNCLASSIFIED DRUG; NEUROFILAMENT PROTEIN L;

ADULT; ARTICLE; ASTROCYTOSIS; AXONAL INJURY; CLINICAL ARTICLE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DISEASE SEVERITY; HOCKEY PLAYER; HUMAN; MALE; NEUROLOGIC DISEASE ASSESSMENT; NUCLEAR MAGNETIC RESONANCE IMAGING; POSTCONCUSSION SYNDROME; PRIORITY JOURNAL; PROTEIN CEREBROSPINAL FLUID LEVEL; REPETITIVE MILD TRAUMATIC BRAIN INJURY; RETURN TO SPORT; RIVERMEAD POST CONCUSSION SYMPTOMS QUESTIONNAIRE; SWEDE (PEOPLE); TRAUMATIC BRAIN INJURY; WHITE MATTER INJURY; BRAIN CONCUSSION; CEREBROSPINAL FLUID; CHRONIC BRAIN DISEASE; CLINICAL TRIAL; HOCKEY; INJURIES; MIDDLE AGED; MULTICENTER STUDY; SPORT INJURY; YOUNG ADULT;

ADULT; AMYLOID BETA-PEPTIDES; ATHLETIC INJURIES; BRAIN CONCUSSION; BRAIN DAMAGE, CHRONIC; CROSS-SECTIONAL STUDIES; GLIAL FIBRILLARY ACIDIC PROTEIN; HOCKEY; HUMANS; MALE; MIDDLE AGED; NEUROFILAMENT PROTEINS; NEUROGRANIN; POST-CONCUSSION SYNDROME; TAU PROTEINS; YOUNG ADULT;

EID: 84996761426     PISSN: 21686149     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamaneurol.2016.2038     Document Type: Article

References (36)

1. Warden D. Military TBI during the Iraq and Afghanistan wars. J Head Trauma Rehabil. 2006;21 (5):398-402.
2. Blennow K, Hardy J, Zetterberg H. The neuropathology and neurobiology of traumatic brain injury. Neuron. 2012;76(5):886-899.
3. Williams WH, Potter S, Ryland H. Mild traumatic brain injury and postconcussion syndrome: A neuropsychological perspective. J Neurol Neurosurg Psychiatry. 2010;81(10):1116-1122.
4. Corsellis JA, Bruton CJ, Freeman-Browne D. The aftermath of boxing. Psychol Med. 1973;3(3):270-303.
5. McKee AC, Cantu RC, Nowinski CJ, et al. Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury. J Neuropathol Exp Neurol. 2009;68(7):709-735.
6. Roberts GW, Allsop D, Bruton C. The occult aftermath of boxing. J Neurol Neurosurg Psychiatry. 1990;53(5):373-378.
7. Wisniewski K, Jervis GA, Moretz RC, Wisniewski HM. Alzheimer neurofibrillary tangles in diseases other than senile and presenile dementia. Ann Neurol. 1979;5(3):288-294.
8. Baugh CM, Stamm JM, Riley DO, et al. Chronic traumatic encephalopathy: neurodegeneration following repetitive concussive and subconcussive brain trauma. Brain Imaging Behav. 2012;6(2):244-254.
9. Goldstein LE, Fisher AM, Tagge CA, et al. Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model. Sci Transl Med. 2012;4(134):134ra60.
10. Toledo JB, Zetterberg H, van Harten AC, et al; Alzheimer's Disease Neuroimaging Initiative. Alzheimer's disease cerebrospinal fluid biomarker in cognitively normal subjects. Brain. 2015;138(pt 9):2701-2715.
11. Blennow K, de Leon MJ, Zetterberg H. Alzheimer's disease. Lancet. 2006;368(9533):387-403.
12. Hansson O, Zetterberg H, Buchhave P, Londos E, Blennow K, Minthon L. Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: A follow-up study. Lancet Neurol. 2006;5(3):228-234.
13. Mattsson N, Zetterberg H, Hansson O, et al. CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment. JAMA. 2009;302(4):385-393.
14. Mattsson N, Rosén E, Hansson O, et al. Age and diagnostic performance of Alzheimer disease CSF biomarkers. Neurology. 2012;78(7):468-476.
15. Kvartsberg H, Duits FH, Ingelsson M, et al. Cerebrospinal fluid levels of the synaptic protein neurogranin correlates with cognitive decline in prodromal Alzheimer's disease. Alzheimers Dement. 2015;11(10):1180-1190.
16. Portelius E, Zetterberg H, Skillbäck T, et al; Alzheimer's Disease Neuroimaging Initiative. Cerebrospinal fluid neurogranin: relation to cognition and neurodegeneration in Alzheimer's disease. Brain. 2015;138(pt 11):3373-3385.
17. Tarawneh R, D'Angelo G, Crimmins D, et al. Diagnostic and prognostic utility of the synaptic marker neurogranin in Alzheimer disease. JAMA Neurol. 2016;73(5):561-571.
18. Zetterberg H, Skillbäck T, Mattsson N, et al; Alzheimer's Disease Neuroimaging Initiative. Association of cerebrospinal fluid neurofilament light concentration with Alzheimer disease progression. JAMA Neurol. 2016;73(1):60-67.
19. Skillbäck T, Farahmand B, Bartlett JW, et al. CSF neurofilament light differs in neurodegenerative diseases and predicts severity and survival. Neurology. 2014;83(21):1945-1953.
20. McCrory P, Johnston K, MeeuwisseW, et al. Summary and agreement statement of the 2nd International Conference on Concussion in Sport, Prague 2004. Br J Sports Med. 2005;39(4):196-204.
21. McCrory P, Meeuwisse WH, AubryM, et al. Consensus statement on concussion in sport: The 4th International Conference on Concussion in Sport held in Zurich, November 2012. Br J Sports Med. 2013;47(5):250-258.
22. Lagarde E, Salmi LR, Holm LW, et al. Association of symptoms following mild traumatic brain injury with posttraumatic stress disorder vs. postconcussion syndrome. JAMA Psychiatry. 2014; 71(9):1032-1040.
23. Cifu DX,WalkerWC,West SL, et al. Hyperbaric oxygen for blast-related postconcussion syndrome: three-month outcomes. Ann Neurol. 2014;75(2): 277-286.
24. Norgren N, Rosengren L, Stigbrand T. Elevated neurofilament levels in neurological diseases. Brain Res. 2003;987(1):25-31.
25. Rosengren LE, Wikkelsø C, Hagberg L. A sensitive ELISA for glial fibrillary acidic protein: application in CSF of adults. J Neurosci Methods. 1994;51(2):197-204.
26. Perlbarg V, Puybasset L, Tollard E, Lehéricy S, Benali H, Galanaud D. Relation between brain lesion location and clinical outcome in patients with severe traumatic brain injury: A diffusion tensor imaging study using voxel-based approaches. Hum Brain Mapp. 2009;30(12):3924-3933.
27. Kinnunen KM, Greenwood R, Powell JH, et al. White matter damage and cognitive impairment after traumatic brain injury. Brain. 2011;134(pt 2): 449-463.
28. Petzold A, Tisdall MM, Girbes AR, et al. In vivo monitoring of neuronal loss in traumatic brain injury: A microdialysis study. Brain. 2011;134(pt 2): 464-483.
29. Zetterberg H, Hietala MA, Jonsson M, et al. Neurochemical aftermath of amateur boxing. Arch Neurol. 2006;63(9):1277-1280.
30. Neselius S, Brisby H, Theodorsson A, Blennow K, Zetterberg H, Marcusson J. CSF-biomarkers in Olympic boxing: diagnosis and effects of repetitive head trauma. PLoS One. 2012;7(4):e33606.
31. Neselius S, Brisby H, Granholm F, Zetterberg H, Blennow K. Monitoring concussion in a knocked-out boxer by CSF biomarker analysis. Knee Surg Sports Traumatol Arthrosc. 2015;23(9):2536-2539.
32. Blennow K, Mattsson N, Schöll M, Hansson O, Zetterberg H. Amyloid biomarkers in Alzheimer's disease. Trends Pharmacol Sci. 2015;36(5):297-309.
33. Palmqvist S, Mattsson N, Hansson O; Alzheimer's Disease Neuroimaging Initiative. Cerebrospinal fluid analysis detects cerebral amyloid-β accumulation earlier than positron emission tomography. Brain. 2016;139(pt 4):1226-1236.
34. Scott G, Ramlackhansingh AF, Edison P, et al. Amyloid pathology and axonal injury after brain trauma. Neurology. 2016;86(9):821-828.
35. Johnson VE, StewartW, Smith DH. Traumatic brain injury and amyloid-β pathology: A link to Alzheimer's disease? Nat Rev Neurosci. 2010;11(5): 361-370.
36. Teasdale GM, Murray GD, Nicoll JA. The association between APOE epsilon4, age and outcome after head injury: A prospective cohort study. Brain. 2005;128(pt 11):2556-2561.