Characterization of pediatric Philadelphia-negative B-cell precursor acute lymphoblastic leukemia with kinase fusions in Japan

Blood Cancer Journal

Volumn 6, Issue 5, 2016, Pages

  Imamura, T ^a   Kiyokawa, N ^b   Kato, M ^c   Imai, C ^d   Okamoto, Y ^e   Yano, M ^a   Ohki, K ^f   Yamashita, Y ^g   Kodama, Y ^e   Saito, A ^h   Mori, M ⁱ   Ishimaru, S ^j   Deguchi, T ^k   Hashii, Y ^l   Shimomura, Y ^m   Hori, T ^m   Kato, K ⁿ   Goto, H ^o   Ogawa, C ^p   Koh, K ⁱ   Taki, T ^q   Manabe, A ^r   Sato, A ^s   Kikuta, A ^t   Adachi, S ^u   Horibe, K ^g   Ohara, A ^v   Watanabe, A ^w   Kawano, Y ^e   Ishii, E ^x   Shimada, H ^y   more..

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^b NATIONAL RESEARCH INSTITUTE FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^e KAGOSHIMA UNIVERSITY   (Japan)

^f Gunma Children's Medical Center   (Japan)

^g NATIONAL HOSPITAL ORGANIZATION NAGOYA MEDICAL CENTER   (Japan)

^h KOBE CHILDREN S HOSPITAL   (Japan)

ⁱ SAITAMA CHILDREN'S MEDICAL CENTER   (Japan)

^j TOKYO METROPOLITAN CHILDREN'S MEDICAL CENTER   (Japan)

^k MIE UNIVERSITY   (Japan)

^l OSAKA UNIVERSITY   (Japan)

^m AICHI MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

ⁿ Ibaraki Children's Hospital   (Japan)

^o KANAGAWA CHILDREN'S MEDICAL CENTER   (Japan)

^p NATIONAL CANCER CENTER HOSPITAL   (Japan)

^q KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^r ST LUKE'S INTERNATIONAL HOSPITAL   (Japan)

^s MIYAGI CHILDREN S HOSPITAL   (Japan)

^t FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

^u KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^v TOHO UNIVERSITY   (Japan)

^w NAKADORI GENERAL HOSPITAL   (Japan)

^x EHIME UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^y KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

more..

Author keywords

[No Author keywords available]

Indexed keywords

IKAROS TRANSCRIPTION FACTOR; IKZF1 PROTEIN, HUMAN; JANUS KINASE 2; ONCOPROTEIN; PROTEIN TYROSINE KINASE; TUMOR MARKER;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; CHEMISTRY; CHILD; COHORT ANALYSIS; FEMALE; GENE DELETION; GENETIC PREDISPOSITION; GENETICS; HUMAN; INFANT; JAPAN; MALE; MORTALITY; MULTIMODALITY CANCER THERAPY; MUTATION; PRESCHOOL CHILD; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; PROTEIN DOMAIN; TREATMENT OUTCOME;

ADOLESCENT; BIOMARKERS, TUMOR; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; COMBINED MODALITY THERAPY; FEMALE; GENE DELETION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IKAROS TRANSCRIPTION FACTOR; INFANT; JANUS KINASE 2; JAPAN; MALE; MUTATION; ONCOGENE PROTEINS, FUSION; PRECURSOR B-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN-TYROSINE KINASES; TREATMENT OUTCOME;

EID: 84996741403     PISSN: None     EISSN: 20445385     Source Type: Journal    
DOI: 10.1038/BCJ.2016.28     Document Type: Article

References (26)

1. Inaba H, Greaves M, Mullighan CG. Acute lymphoblastic leukemia. Lancet 2013; 381: 1943–1955.
2. Schultz KR, Carroll A, Heerema NA, Bowman WP, Aledo A, Slayton WB et al. Long-term follow-up of imatinib in pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia: Children’s Oncology Group Study AALL0031. Leukemia 2014; 28: 1467–1471.
3. Mullighan CG, Su X, Zhang J, Radtke I, Phillips LA, Miller CB et al. Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia. N Engl J Med 2009; 360: 470–480.
4. Holmfeldt L, Wei L, Diaz-Flores E, Walsh M, Zhang J, Ding L et al. The genomic landscape of hypodiploid acute lymphoblastic leukemia. Nat Genet 2013; 45: 242–252.
5. Chen IM, Harvey RC, Mullighan CG, Gastier-Foster J, Wharton W, Kang H et al. Outcome modeling with CRLF2, IKZF1, JAK, and minimal residual disease in pediatric acute lymphoblastic leukemia: a Children's Oncology Group study. Blood 2012; 119: 3512–3522.
6. Roberts KG, Morin RD, Zhang J, Hirst M, Zhao Y, Su X et al. Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia. Cancer Cell 2012; 22: 153–166.
7. Roberts KG, Li Y, Payne-Turner D, Harvey RC, Yang D, Pei K et al. Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia. N Engl J Med 2014; 371: 1005–1015.
8. Weston BW, Hayden MA, Roberts KG, Bowyer S, Hsu J, Fedoriw G et al. Tyrosine kinase inhibitor therapy induces remission in a patients with refractory EBF1-PDGFRB-positive acute lymphoblastic leukemia. J Clin Oncol 2013; 31: e413–e416.
9. Lengline E, Beldjord K, Dombret H, Soulier J, Boissel N, Clappier E. Successful tyrosine kinase inhibitor therapy in a refractory B-cell precursor acute lympho-blastic leukemia with EBF1-PDGFRB fusion. Haematologica 2013; 98: e146–e148.
10. Roberts KG, Pei D, Campana D, Payne-Turner D, Li Y, Chen C et al. Outcomes of children with BCR-ABL-like acute lymphoblastic leukemia treated with risk-directed therapy based on the levels of minimal residual disease. J Clin Oncol 2014; 32: 3012–3020.
11. Hasegawa D, Hara J, Suenobu S. Successful abolition of prophylactic cranial irradiation in children with non-T acute lymphoblastic leukemia (ALL) in the Japan Association of Childhood Leukemia Study (JACLS) ALL-02 trial. Blood (ASH Annual Meeting Abstracts) 2011; 118: 653.
12. Suzuki N, Yumura-Yagi K, Yoshida M, Hara J, Nishimura S, Kudo T et al. Outcome of childhood acute lymphoblastic leukemia with induction failure treated by the Japan Association of Childhood Leukemia study (JACLS) ALL F-protocol. Pediatr Blood Cancer 2010; 54: 71–78.
13. Kato M, Manabe A, Koh K, Inukai T, Kiyokawa N, Fukushima T et al. Treatment outcome of adolescent acute lymphoblastic leukemia treated on Tokyo Children’s Cancer Study Group (TCCSG) clinical trials. Int J Hematol 2014; 100: 180–187.
14. Hyakuna N, Shimomura Y, Watanabe A, Taga T, Kikuta A, Matsushita T et al. Assessment of corticosteroid-induced osteonecrosis in children undergoing chemotherapy for acute lymphoblastic leukemia: a report from the Japanese Childhood Cancer and Leukemia Study Group. J Pediatr Hematol Oncol 2014; 36: 22–29.
15. Okamoto Y, Koga Y, Inagaki J, Ozono S, Ueda K, Shimoura M et al. Effective VCR/DEX pulse maintenance therapy in the KYCCSG ALL-02 protocol for pediatric acute lymphoblastic leukemia. Int J Hematol 2016; 103: 202–209.
16. Masuzawa A, Kiyotani C, Osumi T, Shioda Y, Iijima K, Tomita O et al. Poor responses to tyrosine kinase inhibitors in a child with precursor B-cell acute lymphoblastic leukemia with SNX2-ABL1 chimeric transcript. Eur J Haematol 2014; 92: 263–267.
17. McPherson A, Hormozdiari F, Zayed A, Guiliany R, Ha G, Sun MG et al. R deFuse: an algorithm for gene fusion discovery in tumor RNA-Seq data. PLoS Comput Biol 2011; 7: e1001138.
18. Kobayashi K, Mitsui K, Ichikawa H, Nakabayashi K, Matsuoka M, Kojima Y et al. ATF7IP as a novel PDGFRB fusion partner in acute lymphoblastic leukaemia in children. Br J Haematol 2014; 165: 836–841.
19. Asai D, Imamura T, Suenobu S, Saito A, Hasegawa D, Deguchi T et al. IKZF1 deletion is associated with a poor outcome in pediatric B-cell precursor acute lymphoblastic leukemia in Japan. Cancer Med 2013; 2: 412–419.
20. Yano M, Imamura T, Asai D, Kiyokawa N, Nakabayashi K, Matsumoto K et al. Identification of novel kinase fusion transcripts in pediatric B cell precursor acute lymphoblastic leukaemia with IKZF1 deletion. Br J Haematol 2015; 171: 813–817.
21. Yano M, Imamura T, Asai D, Moriya-Saito A, Suenobu S, Hasegawa D et al. An overall characterization of pediatric acute lymphoblastic leukemia with CRLF2 overexpression. Genes Chromosomes Cancer 2014; 53: 815–823.
22. Mullighan CG, Miller CB, Radtke I, Phillips LA, Dalton J, Ma J et al. BCR-ABL1 lymphoblastic leukemia is characterized by the deletion of Ikaros. Nature 2008; 453: 110–114.
23. Den Boer ML, van Slegtenhorst M, De Menezes RX, Cheok MH, Buijs-Gladdines JGCAM, Peters STCJM et al. A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study. Lancet Oncol 2009; 10: 125–134.
24. Manabe A, Kawasaki H, Shimada H, Kato I, Kodama Y, Sato A et al. Imatinib use immediately before stem cell transplantation in children with Philadelphia chromosome-positive acute lymphoblastic leukemia: results from Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) Study Ph+ALL04. Cancer Med 2015; 4: 682–689.
25. Conter V, Bartram CR, Valsecchi MG, Schrauder A, Panzer-Grumayer R, Moricke A et al. Molecular response to treatment redefines all prognostic factors in children and adolescents with B-cell precursor acute lymphoblastic leukemia: results in 3184 patients of the AIEOP-BFM ALL 2000 study. Blood 2010; 115: 3206–3214.
26. van der Veer A, Waanders E, Pieters R, Willemse ME, van Reijmersdal SV, Russell LJ et al. Independent prognostic value of BCR-ABL1 like signature and IKZF1 deletion, but not high CRLF2 expression, in children with B-cell precursor ALL. Blood 2013; 122: 2622–2629.