Mfsd2a+ hepatocytes repopulate the liver during injury and regeneration

Nature Communications

Volumn 7, Issue , 2016, Pages

  Pu, Wenjuan ^a,b   Zhang, Hui ^a,b   Huang, Xiuzhen ^a,b   Tian, Xueying ^a,b   He, Lingjuan ^a,b   Wang, Yue ^a,b   Zhang, Libo ^a,b   Liu, Qiaozhen ^a,b   Li, Yan ^a,b   Li, Yi ^a,b   Zhao, Huan ^a,b   Liu, Kuo ^a   Lu, Jie ^c   Zhou, Yingqun ^c   Huang, Pengyu ^d   Nie, Yu ^e   Yan, Yan ^f   Hui, Lijian ^b,d   Lui, Kathy O ^g   Zhou, Bin ^a,b,h  

^a Chinese Academy of Sciences   (China)

^b INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^c TONGJI UNIVERSITY   (China)

^d SHANGHAITECH UNIVERSITY   (China)

^e FUWAI HOSPITAL   (China)

^f FUDAN UNIVERSITY   (China)

^g CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^h JINAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ARG1 PROTEIN; COMPLEMENTARY DNA; CRE RECOMBINASE; CYTOCHROME P450 1A2; CYTOCHROME P450 2E1; EPITHELIAL CELL ADHESION MOLECULE; FIZZY RELATED PROTEIN; GLS2 PROTEIN; MAJOR FACILITATOR SUPER FAMILY DOMAIN CONTAINING 2A PROTEIN; MARKER; OAT PROTEIN; PCK1 PROTEIN; PROTEIN; RNASE4 PROTEIN; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN; TAMOXIFEN; UNCLASSIFIED DRUG; UVOMORULIN; CARRIER PROTEIN; MFSD2A PROTEIN, MOUSE;

CELLS AND CELL COMPONENTS; DIGESTIVE SYSTEM; GENE EXPRESSION; HISTOLOGY; HOMEOSTASIS; INJURY; REGENERATION;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; CELL POPULATION; CONTROLLED STUDY; GENE EXPRESSION; GENETIC ANALYSIS; LIVER CELL; LIVER INJURY; LIVER METABOLISM; LIVER REGENERATION; MALE; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; PARTIAL HEPATECTOMY; ZONATION; ANIMAL; CELL LINEAGE; CELL PROLIFERATION; GENETICS; INJURIES; LIVER; METABOLISM; PHYSIOLOGY; SURGERY;

ANIMALS; CELL LINEAGE; CELL PROLIFERATION; HEPATOCYTES; LIVER; LIVER REGENERATION; MEMBRANE TRANSPORT PROTEINS; MICE;

EID: 84996503278     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms13369     Document Type: Article

References (31)

1. Yanger, K. et al. Robust cellular reprogramming occurs spontaneously during liver regeneration. Genes Dev. 27, 719-724 (2013).
2. Tarlow, B. D. et al. Bipotential adult liver progenitors are derived from chronically injured mature hepatocytes. Cell Stem Cell 15, 605-618 (2014).
3. Grompe, M. Liver stem cells, where art thou? Cell Stem Cell 15, 257-258 (2014).
4. Miyajima, A., Tanaka, M., Itoh, T. Stem/progenitor cells in liver development, homeostasis, regeneration, and reprogramming. Cell Stem Cell 14, 561-574 (2014).
5. Malato, Y. et al. Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration. J. Clin. Invest. 121, 4850-4860 (2011).
6. Yanger, K. et al. Adult hepatocytes are generated by self-duplication rather than stem cell differentiation. Cell Stem Cell 15, 340-349 (2014).
7. Burke, Z. D. et al. Liver zonation occurs through a beta-catenin-dependent, c-Mycindependent mechanism. Gastroenterology 136, 2316-2324 e2311-2313 (2009).
8. Benhamouche, S. et al. Apc tumor suppressor gene is the 'zonation-keeper' of mouse liver. Dev. Cell 10, 759-770 (2006).
9. Stanger, B. Z. Probing hepatocyte heterogeneity. Cell Res. 25, 1181-1182 (2015).
10. Jungermann, K., Katz, N. Functional specialization of different hepatocyte populations. Physiol. Rev. 69, 708-764 (1989).
11. Colnot, S., Perret, C. Liver zonation. Mol. Pathol. Library 5, 7-16 (2011).
12. Braeuning, A. et al. Differential gene expression in periportal and perivenous mouse hepatocytes. FEBS J. 273, 5051-5061 (2006).
13. Font-Burgada, J. et al. Hybrid periportal hepatocytes regenerate the injured liver without giving rise to cancer. Cell 162, 766-779 (2015).
14. Wang, B., Zhao, L., Fish, M., Logan, C. Y., Nusse, R. Self-renewing diploid Axin2(\+) cells fuel homeostatic renewal of the liver. Nature 524, 180-185 (2015).
15. Nguyen, L. N. et al. Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. Nature 509, 503-506 (2014).
16. Ben-Zvi, A. et al. Mfsd2a is critical for the formation and function of the blood-brain barrier. Nature 509, 507-511 (2014).
17. Planas-Paz, L. et al. The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size. Nat. Cell Biol. 18, 467-479 (2016).
18. Hailfinger, S., Jaworski, M., Braeuning, A., Buchmann, A., Schwarz, M. Zonal gene expression in murine liver: lessons from tumors. Hepatology 43, 407-414 (2006).
19. Sell, S. Heterogeneity and plasticity of hepatocyte lineage cells. Hepatology 33, 738-750 (2001).
20. Michalopoulos, G. K., DeFrances, M. C. Liver regeneration. Science 276, 60-66 (1997).
21. Kopp, J. L., Grompe, M., Sander, M. Stem cells versus plasticity in liver and pancreas regeneration. Nat. Cell Biol. 18, 238-245 (2016).
22. Indra, A. et al. Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinases. Nucleic Acids Res. 27, 4324-4327 (1999).
23. Madisen, L. et al. A robust and high-throughput Cre reporting and characterization system for the whole mouse brain. Nat. Neurosci. 13, 133-140 (2010).
24. Tian, X. et al. Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries. Cell Res. 23, 1075-1090 (2013).
25. Mitchell, C., Willenbring, H. A reproducible and well-tolerated method for 2/3 partial hepatectomy in mice. Nat. Protoc. 3, 1167-1170 (2008).
26. Tag, C. G. et al. Bile duct ligation in mice: induction of inflammatory liver injury and fibrosis by obstructive cholestasis. J. Vis. Exp. 96, 52438-52440 (2015).
27. Liu, Q. et al. Genetic lineage tracing identifies in situ Kit-expressing cardiomyocytes. Cell Res. 26, 119-130 (2016).
28. He, L. et al. Genetic lineage tracing discloses arteriogenesis as the main mechanism for collateral growth in the mouse heart. Cardiovasc Res. 109, 419-430 (2016).
29. Zhang, H. et al. Yap1 is required for endothelial to mesenchymal transition of the atrioventricular cushion. J. Biol. Chem. 289, 18681-18692 (2014).
30. Li, W. C., Ralphs, K. L., Tosh, D. Isolation and culture of adult mouse hepatocytes. Methods Mol. Biol. 633, 185-196 (2010).
31. Zhou, B. et al. Adult mouse epicardium modulates myocardial injury by secreting paracrine factors. J. Clin. Invest. 121, 1894-1904 (2011).