메뉴 건너뛰기




Volumn 17, Issue 8, 2016, Pages 1047-1060

Conventional versus hypofractionated high-dose intensity-modulated radiotherapy for prostate cancer: 5-year outcomes of the randomised, non-inferiority, phase 3 CHHiP trial

(29)  Dearnaley, David a,b   Syndikus, Isabel c   Mossop, Helen a   Khoo, Vincent a,b   Birtle, Alison d   Bloomfield, David e   Graham, John f   Kirkbride, Peter g   Logue, John h   Malik, Zafar c   Money Kyrle, Julian i   O'Sullivan, Joe M j   Panades, Miguel k   Parker, Chris a,b   Patterson, Helen l   Scrase, Christopher m   Staffurth, John n   Stockdale, Andrew o   Tremlett, Jean e   Bidmead, Margaret b   more..


Author keywords

[No Author keywords available]

Indexed keywords

AGED; ARTICLE; BLADDER DISEASE; CANCER LOCALIZATION; CANCER RADIOTHERAPY; CANCER RISK; CANCER STAGING; CONTROLLED STUDY; CONVENTIONAL RADIOTHERAPY; ENTEROPATHY; FOLLOW UP; GAMMA RADIATION; HUMAN; HYPOFRACTIONATED RADIOTHERAPY; INTENSITY MODULATED RADIATION THERAPY; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; PROSTATE CANCER; RADIATION INJURY; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT; RISK FACTOR; TREATMENT DURATION; TREATMENT RESPONSE; CLINICAL TRIAL; COMPARATIVE STUDY; INTERNATIONAL COOPERATION; MIDDLE AGED; MULTICENTER STUDY; PATHOLOGY; PROCEDURES; PROSTATIC NEOPLASMS; SURVIVAL RATE; TREATMENT OUTCOME; VERY ELDERLY;

EID: 84995969003     PISSN: 14702045     EISSN: 14745488     Source Type: Journal    
DOI: 10.1016/S1470-2045(16)30102-4     Document Type: Article
Times cited : (991)

References (35)
  • 1
    • 84995960088 scopus 로고    scopus 로고
    • Prostate cancer statistics – key facts
    • (accessed Feb 1, 2016).
    • 1 Cancer Research UK. Prostate cancer statistics – key facts. http://info.cancerresearchuk.org/cancerstats/keyfacts/prostate-cancer/, 2015 (accessed Feb 1, 2016).
    • (2015)
  • 2
    • 84869492886 scopus 로고    scopus 로고
    • Global burden of cancer in 2008: a systematic analysis of disability-adjusted life-years in 12 world regions
    • 2 Soerjomataram, I, Lortet-Tieulent, J, Parkin, DM, et al. Global burden of cancer in 2008: a systematic analysis of disability-adjusted life-years in 12 world regions. Lancet 380 (2012), 1840–1850.
    • (2012) Lancet , vol.380 , pp. 1840-1850
    • Soerjomataram, I.1    Lortet-Tieulent, J.2    Parkin, D.M.3
  • 3
    • 34247516968 scopus 로고    scopus 로고
    • NCCN clinical practice guidelines in oncology (NCCN guidelines) for prostate cancer
    • (accessed Feb 1, 2016).
    • 3 NCCN clinical practice guidelines in oncology (NCCN guidelines) for prostate cancer. http:\www.nccn.org, 2011 (accessed Feb 1, 2016).
    • (2011)
  • 4
    • 84943665811 scopus 로고    scopus 로고
    • A systematic review of randomised controlled trials of radiotherapy for localised prostate cancer
    • 4 Wolff, RF, Ryder, S, Bossi, A, et al. A systematic review of randomised controlled trials of radiotherapy for localised prostate cancer. Eur J Cancer 51 (2015), 2345–2367.
    • (2015) Eur J Cancer , vol.51 , pp. 2345-2367
    • Wolff, R.F.1    Ryder, S.2    Bossi, A.3
  • 5
    • 84881557290 scopus 로고    scopus 로고
    • Systematic review of hypofractionated radiation therapy for prostate cancer
    • 5 Zaorsky, NG, Ohri, N, Showalter, TN, Dicker, AP, Den, RB, Systematic review of hypofractionated radiation therapy for prostate cancer. Cancer Treat Rev 39 (2013), 728–736.
    • (2013) Cancer Treat Rev , vol.39 , pp. 728-736
    • Zaorsky, N.G.1    Ohri, N.2    Showalter, T.N.3    Dicker, A.P.4    Den, R.B.5
  • 6
    • 84897400934 scopus 로고    scopus 로고
    • Escalated-dose versus control-dose conformal radiotherapy for prostate cancer: long-term results from the MRC RT01 randomised controlled trial
    • 6 Dearnaley, DP, Jovic, G, Syndikus, I, et al. Escalated-dose versus control-dose conformal radiotherapy for prostate cancer: long-term results from the MRC RT01 randomised controlled trial. Lancet Oncol 15 (2014), 464–473.
    • (2014) Lancet Oncol , vol.15 , pp. 464-473
    • Dearnaley, D.P.1    Jovic, G.2    Syndikus, I.3
  • 7
    • 84880579682 scopus 로고    scopus 로고
    • National Institute for Health and Care Excellence (NICE) clinical guideline: prostate cancer: diagnosis and treatment (CG175)
    • (accessed Feb 1, 2016).
    • 7 National Institute for Health and Care Excellence. National Institute for Health and Care Excellence (NICE) clinical guideline: prostate cancer: diagnosis and treatment (CG175). http://www.nice.org.uk/guidance/cg175, 2014 (accessed Feb 1, 2016).
    • (2014)
  • 8
    • 84929153949 scopus 로고    scopus 로고
    • High dose versus conventional dose in external beam radiotherapy of prostate cancer: a meta-analysis of long-term follow-up
    • 8 Hou, Z, Li, G, Bai, S, High dose versus conventional dose in external beam radiotherapy of prostate cancer: a meta-analysis of long-term follow-up. J Cancer Res Clin Oncol 141 (2015), 1063–1071.
    • (2015) J Cancer Res Clin Oncol , vol.141 , pp. 1063-1071
    • Hou, Z.1    Li, G.2    Bai, S.3
  • 9
    • 0036140325 scopus 로고    scopus 로고
    • Direct evidence that prostate tumors show high sensitivity to fractionation (low alpha/beta ratio), similar to late-responding normal tissue
    • 9 Brenner, DJ, Martinez, AA, Edmundson, GK, Mitchell, C, Thames, HD, Armour, EP, Direct evidence that prostate tumors show high sensitivity to fractionation (low alpha/beta ratio), similar to late-responding normal tissue. Int J Radiat Oncol Biol Phys 52 (2002), 6–13.
    • (2002) Int J Radiat Oncol Biol Phys , vol.52 , pp. 6-13
    • Brenner, D.J.1    Martinez, A.A.2    Edmundson, G.K.3    Mitchell, C.4    Thames, H.D.5    Armour, E.P.6
  • 11
    • 38149102436 scopus 로고    scopus 로고
    • Question of dose, fractionation and technique: ingredients for testing hypofractionation in prostate cancer – the CHHiP trial
    • 11 Khoo, VS, Dearnaley, DP, Question of dose, fractionation and technique: ingredients for testing hypofractionation in prostate cancer – the CHHiP trial. Clin Oncol (R Coll Radiol) 20 (2008), 12–14.
    • (2008) Clin Oncol (R Coll Radiol) , vol.20 , pp. 12-14
    • Khoo, V.S.1    Dearnaley, D.P.2
  • 13
    • 84855336943 scopus 로고    scopus 로고
    • Conventional versus hypofractionated high-dose intensity-modulated radiotherapy for prostate cancer: preliminary safety results from the CHHiP randomised controlled trial
    • 13 Dearnaley, D, Syndikus, I, Sumo, G, et al. Conventional versus hypofractionated high-dose intensity-modulated radiotherapy for prostate cancer: preliminary safety results from the CHHiP randomised controlled trial. Lancet Oncol 13 (2012), 43–54.
    • (2012) Lancet Oncol , vol.13 , pp. 43-54
    • Dearnaley, D.1    Syndikus, I.2    Sumo, G.3
  • 14
    • 0027979775 scopus 로고
    • Predicting the risk of lymph node involvement using the pre-treatment prostate specific antigen and Gleason score in men with clinically localized prostate cancer
    • 14 Roach, M 3rd, Marquez, C, Yuo, HS, et al. Predicting the risk of lymph node involvement using the pre-treatment prostate specific antigen and Gleason score in men with clinically localized prostate cancer. Int J Radiat Oncol Biol Phys 28 (1994), 33–37.
    • (1994) Int J Radiat Oncol Biol Phys , vol.28 , pp. 33-37
    • Roach, M.1    Marquez, C.2    Yuo, H.S.3
  • 15
    • 0027938462 scopus 로고
    • Indications for and the significance of seminal vesicle irradiation during 3D conformal radiotherapy for localized prostate cancer
    • 15 Diaz, A, Roach, M 3rd, Marquez, C, et al. Indications for and the significance of seminal vesicle irradiation during 3D conformal radiotherapy for localized prostate cancer. Int J Radiat Oncol Biol Phys 30 (1994), 323–329.
    • (1994) Int J Radiat Oncol Biol Phys , vol.30 , pp. 323-329
    • Diaz, A.1    Roach, M.2    Marquez, C.3
  • 16
    • 38149088769 scopus 로고    scopus 로고
    • A comparison of treatment planning techniques used in two randomised UK external beam radiotherapy trials for localised prostate cancer
    • 16 South, CP, Khoo, VS, Naismith, O, Norman, A, Dearnaley, DP, A comparison of treatment planning techniques used in two randomised UK external beam radiotherapy trials for localised prostate cancer. Clin Oncol (R Coll Radiol) 20 (2008), 15–21.
    • (2008) Clin Oncol (R Coll Radiol) , vol.20 , pp. 15-21
    • South, C.P.1    Khoo, V.S.2    Naismith, O.3    Norman, A.4    Dearnaley, D.P.5
  • 17
    • 0029281350 scopus 로고
    • LENT SOMA tables
    • 17 LENT SOMA tables. Radiother Oncol 35 (1995), 17–60.
    • (1995) Radiother Oncol , vol.35 , pp. 17-60
  • 18
    • 34047159109 scopus 로고    scopus 로고
    • The early toxicity of escalated versus standard dose conformal radiotherapy with neo-adjuvant androgen suppression for patients with localised prostate cancer: results from the MRC RT01 trial (ISRCTN47772397)
    • 18 Dearnaley, DP, Sydes, MR, Langley, RE, et al. The early toxicity of escalated versus standard dose conformal radiotherapy with neo-adjuvant androgen suppression for patients with localised prostate cancer: results from the MRC RT01 trial (ISRCTN47772397). Radiother Oncol 83 (2007), 31–41.
    • (2007) Radiother Oncol , vol.83 , pp. 31-41
    • Dearnaley, D.P.1    Sydes, M.R.2    Langley, R.E.3
  • 19
    • 0028969271 scopus 로고
    • Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC)
    • 19 Cox, JD, Stetz, J, Pajak, TF, Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC). Int J Radiat Oncol Biol Phys 31 (1995), 1341–1346.
    • (1995) Int J Radiat Oncol Biol Phys , vol.31 , pp. 1341-1346
    • Cox, J.D.1    Stetz, J.2    Pajak, T.F.3
  • 20
    • 84951310242 scopus 로고    scopus 로고
    • Hypofractionated radiotherapy versus conventionally fractionated radiotherapy for patients with intermediate-risk localised prostate cancer: 2-year patient-reported outcomes of the randomised, non-inferiority, phase 3 CHHiP trial
    • 20 Wilkins, A, Mossop, H, Syndikus, I, et al. Hypofractionated radiotherapy versus conventionally fractionated radiotherapy for patients with intermediate-risk localised prostate cancer: 2-year patient-reported outcomes of the randomised, non-inferiority, phase 3 CHHiP trial. Lancet Oncol 16 (2015), 1605–1616.
    • (2015) Lancet Oncol , vol.16 , pp. 1605-1616
    • Wilkins, A.1    Mossop, H.2    Syndikus, I.3
  • 21
    • 33745184874 scopus 로고    scopus 로고
    • Defining biochemical failure following radiotherapy with or without hormonal therapy in men with clinically localized prostate cancer: recommendations of the RTOG-ASTRO Phoenix Consensus Conference
    • 21 Roach, M 3rd, Hanks, G, Thames, H Jr, et al. Defining biochemical failure following radiotherapy with or without hormonal therapy in men with clinically localized prostate cancer: recommendations of the RTOG-ASTRO Phoenix Consensus Conference. Int J Radiat Oncol Biol Phys 65 (2006), 965–974.
    • (2006) Int J Radiat Oncol Biol Phys , vol.65 , pp. 965-974
    • Roach, M.1    Hanks, G.2    Thames, H.3
  • 22
    • 84941775271 scopus 로고    scopus 로고
    • A systematic review of hypofractionation for primary management of prostate cancer
    • 22 Koontz, BF, Bossi, A, Cozzarini, C, Wiegel, T, D'Amico, A, A systematic review of hypofractionation for primary management of prostate cancer. Eur Urol 68 (2015), 683–691.
    • (2015) Eur Urol , vol.68 , pp. 683-691
    • Koontz, B.F.1    Bossi, A.2    Cozzarini, C.3    Wiegel, T.4    D'Amico, A.5
  • 23
    • 84880827823 scopus 로고    scopus 로고
    • Biological dose escalation and hypofractionation: what is there to be gained and how will it best be done?
    • 23 Tree, AC, Alexander, EJ, Van As, NJ, Dearnaley, DP, Khoo, V, Biological dose escalation and hypofractionation: what is there to be gained and how will it best be done?. Clin Oncol (R Coll Radiol) 25 (2013), 483–498.
    • (2013) Clin Oncol (R Coll Radiol) , vol.25 , pp. 483-498
    • Tree, A.C.1    Alexander, E.J.2    Van As, N.J.3    Dearnaley, D.P.4    Khoo, V.5
  • 24
    • 78649982102 scopus 로고    scopus 로고
    • Confirmation of a low alpha/beta ratio for prostate cancer treated by external beam radiation therapy alone using a post-treatment repeated-measures model for PSA dynamics
    • 24 Proust-Lima, C, Taylor, JM, Secher, S, et al. Confirmation of a low alpha/beta ratio for prostate cancer treated by external beam radiation therapy alone using a post-treatment repeated-measures model for PSA dynamics. Int J Radiat Oncol Biol Phys 79 (2011), 195–201.
    • (2011) Int J Radiat Oncol Biol Phys , vol.79 , pp. 195-201
    • Proust-Lima, C.1    Taylor, J.M.2    Secher, S.3
  • 25
    • 83955161787 scopus 로고    scopus 로고
    • Dose-fractionation sensitivity of prostate cancer deduced from radiotherapy outcomes of 5,969 patients in seven international institutional datasets: alpha/beta=1·4 (0·9–2·2) Gy
    • 25 Miralbell, R, Roberts, SA, Zubizarreta, E, Hendry, JH, Dose-fractionation sensitivity of prostate cancer deduced from radiotherapy outcomes of 5,969 patients in seven international institutional datasets: alpha/beta=1·4 (0·9–2·2) Gy. Int J Radiat Oncol Biol Phys 82 (2012), e17–e24.
    • (2012) Int J Radiat Oncol Biol Phys , vol.82 , pp. e17-e24
    • Miralbell, R.1    Roberts, S.A.2    Zubizarreta, E.3    Hendry, J.H.4
  • 26
    • 84871382056 scopus 로고    scopus 로고
    • Meta-analysis of the alpha/beta ratio for prostate cancer in the presence of an overall time factor: bad news, good news, or no news?
    • 26 Vogelius, IR, Bentzen, SM, Meta-analysis of the alpha/beta ratio for prostate cancer in the presence of an overall time factor: bad news, good news, or no news?. Int J Radiat Oncol Biol Physs 85 (2013), 89–94.
    • (2013) Int J Radiat Oncol Biol Physs , vol.85 , pp. 89-94
    • Vogelius, I.R.1    Bentzen, S.M.2
  • 27
    • 84867552706 scopus 로고    scopus 로고
    • Prostate alpha/beta revisited–an analysis of clinical results from 14 168 patients
    • 27 Dasu, A, Toma-Dasu, I, Prostate alpha/beta revisited–an analysis of clinical results from 14 168 patients. Acta Oncol 51 (2012), 963–974.
    • (2012) Acta Oncol , vol.51 , pp. 963-974
    • Dasu, A.1    Toma-Dasu, I.2
  • 28
    • 84943407312 scopus 로고    scopus 로고
    • What is the ideal radiotherapy dose to treat prostate cancer? A meta-analysis of biologically equivalent dose escalation
    • 28 Zaorsky, NG, Palmer, JD, Hurwitz, MD, Keith, SW, Dicker, AP, Den, RB, What is the ideal radiotherapy dose to treat prostate cancer? A meta-analysis of biologically equivalent dose escalation. Radiother Oncol 115 (2015), 295–300.
    • (2015) Radiother Oncol , vol.115 , pp. 295-300
    • Zaorsky, N.G.1    Palmer, J.D.2    Hurwitz, M.D.3    Keith, S.W.4    Dicker, A.P.5    Den, R.B.6
  • 29
    • 79951953933 scopus 로고    scopus 로고
    • Acute and late toxicity in a randomized trial of conventional versus hypofractionated three-dimensional conformal radiotherapy for prostate cancer
    • 29 Arcangeli, G, Fowler, J, Gomellini, S, et al. Acute and late toxicity in a randomized trial of conventional versus hypofractionated three-dimensional conformal radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys 79 (2011), 1013–1021.
    • (2011) Int J Radiat Oncol Biol Phys , vol.79 , pp. 1013-1021
    • Arcangeli, G.1    Fowler, J.2    Gomellini, S.3
  • 30
    • 84891606493 scopus 로고    scopus 로고
    • Randomized trial of hypofractionated external-beam radiotherapy for prostate cancer
    • 30 Pollack, A, Walker, G, Horwitz, EM, et al. Randomized trial of hypofractionated external-beam radiotherapy for prostate cancer. J Clin Oncol 31 (2013), 3860–3868.
    • (2013) J Clin Oncol , vol.31 , pp. 3860-3868
    • Pollack, A.1    Walker, G.2    Horwitz, E.M.3
  • 31
    • 84897891063 scopus 로고    scopus 로고
    • Risk of late toxicity in men receiving dose-escalated hypofractionated intensity modulated prostate radiation therapy: results from a randomized trial
    • 31 Hoffman, KE, Voong, KR, Pugh, TJ, et al. Risk of late toxicity in men receiving dose-escalated hypofractionated intensity modulated prostate radiation therapy: results from a randomized trial. Int J Radiat Oncol Biol Phys 88 (2014), 1074–1084.
    • (2014) Int J Radiat Oncol Biol Phys , vol.88 , pp. 1074-1084
    • Hoffman, K.E.1    Voong, K.R.2    Pugh, T.J.3
  • 32
    • 84924955384 scopus 로고    scopus 로고
    • Hypofractionated versus conventionally fractionated radiotherapy for patients with prostate cancer (HYPRO): acute toxicity results from a randomised non-inferiority phase 3 trial
    • 32 Aluwini, S, Pos, F, Schimmel, E, et al. Hypofractionated versus conventionally fractionated radiotherapy for patients with prostate cancer (HYPRO): acute toxicity results from a randomised non-inferiority phase 3 trial. Lancet Oncol 16 (2015), 274–283.
    • (2015) Lancet Oncol , vol.16 , pp. 274-283
    • Aluwini, S.1    Pos, F.2    Schimmel, E.3
  • 33
    • 84883290461 scopus 로고    scopus 로고
    • A randomized hypofractionation dose escalation trial for high risk prostate cancer patients: interim analysis of acute toxicity and quality of life in 124 patients
    • 33 Norkus, D, Karklelyte, A, Engels, B, et al. A randomized hypofractionation dose escalation trial for high risk prostate cancer patients: interim analysis of acute toxicity and quality of life in 124 patients. Radiat Oncol, 8, 2013, 206.
    • (2013) Radiat Oncol , vol.8 , pp. 206
    • Norkus, D.1    Karklelyte, A.2    Engels, B.3
  • 34
    • 77952590675 scopus 로고    scopus 로고
    • Late gastrointestinal toxicity after dose-escalated conformal radiotherapy for early prostate cancer: results from the UK Medical Research Council RT01 trial (ISRCTN47772397)
    • 34 Syndikus, I, Morgan, RC, Sydes, MR, Graham, JD, Dearnaley, DP, Late gastrointestinal toxicity after dose-escalated conformal radiotherapy for early prostate cancer: results from the UK Medical Research Council RT01 trial (ISRCTN47772397). Int J Radiat Oncol Biol Phys 77 (2010), 773–783.
    • (2010) Int J Radiat Oncol Biol Phys , vol.77 , pp. 773-783
    • Syndikus, I.1    Morgan, R.C.2    Sydes, M.R.3    Graham, J.D.4    Dearnaley, D.P.5
  • 35
    • 84881553796 scopus 로고    scopus 로고
    • Radiotherapy demand and activity in England 2006–2020
    • 35 Round, CE, Williams, MV, Mee, T, et al. Radiotherapy demand and activity in England 2006–2020. Clin Oncol (R Coll Radiol) 25 (2013), 522–530.
    • (2013) Clin Oncol (R Coll Radiol) , vol.25 , pp. 522-530
    • Round, C.E.1    Williams, M.V.2    Mee, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.