Does Platelet Reactivity Predict Bleeding in Patients Needing Urgent Coronary Artery Bypass Grafting During Dual Antiplatelet Therapy?

Annals of Thoracic Surgery

Volumn 102, Issue 6, 2016, Pages 2010-2017

  Mahla, Elisabeth ^a   Prueller, Florian ^a   Farzi, Sylvia ^a   Pregartner, Gudrun ^a   Raggam, Reinhard B ^a   Beran, Elisabeth ^a   Toller, Wolfgang ^a   Berghold, Andrea ^a   Tantry, Udaya S ^b   Gurbel, Paul A ^b  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

^b INOVA HEART AND VASCULAR INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ADENOSINE PHOSPHATE; PURINERGIC RECEPTOR STIMULATING AGENT; VASODILATOR STIMULATED PHOSPHOPROTEIN; ANTITHROMBOCYTIC AGENT; FIBRINOGEN RECEPTOR; PURINERGIC P2Y RECEPTOR ANTAGONIST;

AGED; BLEEDING; BLOOD CLOTTING PARAMETERS; BLOOD VOLUME; CARDIOPULMONARY BYPASS; CONFERENCE PAPER; CORONARY ARTERY BYPASS GRAFT; DUAL ANTIPLATELET THERAPY; ENZYME ASSAY; ERYTHROCYTE TRANSFUSION; EUROSCORE; FEMALE; FIRST AID; HEMATOCRIT; HEMATOLOGICAL PARAMETERS; HUMAN; LIGHT TRANSMITTANCE AGGREGOMETRY; MAJOR CLINICAL STUDY; MALE; ON PUMP CORONARY ARTERY BYPASS GRAFTING; PLATELET REACTIVITY; PREDICTION; PREOPERATIVE PERIOD; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN DETERMINATION; THROMBOCYTE FUNCTION ANALYZER; ANTAGONISTS AND INHIBITORS; BLOOD; CHEMICALLY INDUCED; COMBINATION DRUG THERAPY; DRUG EFFECTS; EMERGENCY; HEART VALVE REPLACEMENT; MIDDLE AGED; OPERATIVE BLOOD LOSS; POSTOPERATIVE HEMORRHAGE; PRACTICE GUIDELINE; PREOPERATIVE CARE; THROMBOCYTE ACTIVATION;

AGED; ASPIRIN; BLOOD LOSS, SURGICAL; CORONARY ARTERY BYPASS; DRUG THERAPY, COMBINATION; EMERGENCIES; FEMALE; HEART VALVE PROSTHESIS IMPLANTATION; HUMANS; MALE; MIDDLE AGED; PLATELET ACTIVATION; PLATELET AGGREGATION INHIBITORS; PLATELET FUNCTION TESTS; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; POSTOPERATIVE HEMORRHAGE; PRACTICE GUIDELINES AS TOPIC; PREOPERATIVE CARE; PROSPECTIVE STUDIES; PURINERGIC P2Y RECEPTOR ANTAGONISTS;

EID: 84995912095     PISSN: 00034975     EISSN: 15526259     Source Type: Journal    
DOI: 10.1016/j.athoracsur.2016.05.003     Document Type: Conference Paper

References (25)

1. 1 Held, C., Asenblad, N., Bassand, J.P., et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes undergoing coronary artery bypass surgery: results from the PLATO (platelet inhibition and patient outcomes) trial. J Am Coll Cardiol 57 (2011), 672–684.
2. 2 Smith, P.K., Goodnough, L.T., Levy, J.H., et al. Mortality benefit with prasugrel in the TRITON-TIMI 38 coronary artery bypass grafting cohort: risk-adjusted retrospective data analysis. J Am Coll Cardiol 60 (2012), 388–396.
3. 3 Siller-Matula, J.M., Petre, A., Delle-Karth, G., et al. Impact of preoperative use of P2Y12 receptor inhibitors on clinical outcomes in cardiac and non-cardiac surgery: a systematic review and meta-analysis. Eur Heart J Acute Cardiovasc Care, 2015 May 5 [Epub ahead of print].
4. 4 Hajjar, L.A., Vincent, J.L., Galas, F.R., et al. Transfusion requirements after cardiac surgery: the TRACS randomized controlled trial. JAMA 304 (2010), 1559–1567.
5. 5 Windecker, S., Kolh, P., Alfonso, F., et al. 2014 ESC/EACTS guidelines on myocardial revascularization: the task force on myocardial revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). Developed with the special contribution of the European Association of Percutaneous Cardiovascular Interventions (EAPCI). Eur Heart J 35 (2014), 2541–2619.
6. 6 Mahla, E., Suarez, T.A., Bliden, K.P., et al. Platelet function measurement-based strategy to reduce bleeding and waiting time in clopidogrel-treated patients undergoing coronary artery bypass graft surgery: the timing based on platelet function strategy to reduce clopidogrel-associated bleeding related to CABG (Target-CABG) study. Circ Cardiovasc Interv 5 (2012), 261–269.
7. 7 Ferraris, V.A., Saha, S.P., Oestreich, J.H., et al. 2012 update to the Society of Thoracic Surgeons guideline on use of antiplatelet drugs in patients having cardiac and noncardiac operations. Ann Thorac Surg 94 (2012), 1761–1781.
8. 8 Wallentin, L., Becker, R.C., Budaj, A., et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 361 (2009), 1045–1057.
9. 9 Wiviott, S.D., Braunwald, E., McCabe, C.H., et al. Prasugrel versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 357 (2007), 2001–2015.
10. 10 Ferraris, V.A., Brown, J.R., Despotis, G.J., et al. 2011 Update to the Society of Thoracic Surgeons and the Society of Cardiovascular Anesthesiologists Blood Conservation Clinical Practice Guidelines. Ann Thorac Surg 91 (2011), 944–982.
11. 11 Gurbel, P.A., Bliden, K.P., Butler, K., et al. Randomized double-blind assessment of the ONSET and OFFSet of the antiplatelet Effects of Ticagrelor versus clopidogrel in patients with stable coronary artery disease: The ONSET/OFFSET Study. Circulation 120 (2009), 2577–2585.
12. 12 Sibbing, D., Schulz, S., Braun, S., et al. Antiplatelet effects of clopidogrel and bleeding in patients undergoing coronary stent placement. J Thromb Haemost 8 (2010), 250–256.
13. 13 Tsantes, A., Ikonomidis, I., Papadakis, I., et al. Evaluation of the role of the new innovance PFA P2Y test cartridge in detection of clopidogrel resistance. Platelets 23 (2012), 481–489.
14. 14 Gombotz, H., Rehak, P.H., Shander, A., Hofmann, A., Blood use in elective surgery: the Austrian Benchmark Study. Transfusion 47 (2007), 1468–1480.
15. 15 Mehran, R., Rao, S.V., Bhatt, D.L., et al. Standardized bleeding definitions for cardiovascular clinical trials: a consensus report from the Bleeding Academic Research Consortium. Circulation 123 (2011), 2736–2747.
16. 16 Nashef, S.A., Roques, F., Michel, P., et al. European system for cardiac operative risk evaluation (Euroscore). Eur J Cardiothorac Surg 16 (1999), 9–13.
17. 17 Tantry, U.S., Bonello, L., Aradi, D., et al. Consensus and update on the definition of on-treatment platelet reactivity to adenosine diphosphate associated with ischemia and bleeding. J Am Coll Cardiol 62 (2013), 2261–2273.
18. 18 Hansson, E.C., Jideus, L., Aberg, B., et al. Coronary artery bypass grafting-related bleeding complications in patients treated with ticagrelor or clopidogrel: a nationwide study. Eur Heart J 37 (2016), 189–197.
19. 19 Kwak, Y.L., Kim, J.C., Choi, Y.S., et al. Clopidogrel responsiveness regardless of the discontinuation date predicts increased blood loss and transfusion requirement after off-pump coronary artery bypass graft surgery. J Am Coll Cardiol 56 (2010), 1994–2002.
20. 20 Ranucci, M., Baryshnikova, E., Soro, G., et al. Multiple electrode whole-blood aggregometry and bleeding in cardiac surgery patients receiving thienopyridines. Ann Thorac Surg 91 (2011), 123–129.
21. 21 Mannacio, V., Meier, P., Antignano, A., et al. Individualized strategy for clopidogrel suspension in patients undergoing off-pump coronary surgery for acute coronary syndrome: a case-control study. J Thorac Cardiovasc Surg 148 (2014), 1299–1306.
22. 22 Levy, J.H., Welsby, I., Goodnough, L.T., Fibrinogen as a therapeutic target for bleeding: a review of critical levels and replacement therapy. Transfusion 54 (2014), 1389–1405.
23. 23 Sun, J.C., Whitlock, R., Cheng, J., et al. The effect of pre-operative aspirin on bleeding, transfusion, myocardial infarction, and mortality in coronary artery bypass surgery: a systematic review of randomized and observational studies. Eur Heart J 29 (2008), 1057–1071.
24. 24 Undas, A., Brummel-Ziedins, K., Mann, K.G., Why does aspirin decrease the risk of venous thromboembolism? On old and novel antithrombotic effects of acetyl salicylic acid. J Thromb Haemost 12 (2014), 1776–1787.
25. 25 Gurbel, P.A., Bliden, K.P., DiChiara, J., et al. Evaluation of dose-related effects of aspirin on platelet function: results from the ASpirin-Induced Platelet EffeCT (ASPECT) study. Circulation 115 (2007), 3156–3164.