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1
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56749106312
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Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein
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COI: 1:CAS:528:DC%2BD1cXhtl2gurnL, PID: 18997196
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Ridker PM, Danielson E, Fonseca FAH, et al. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. NEJM. 2008;359:2195–207.
-
(2008)
NEJM
, vol.359
, pp. 2195-2207
-
-
Ridker, P.M.1
Danielson, E.2
Fonseca, F.A.H.3
-
2
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77549087054
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Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials
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COI: 1:CAS:528:DC%2BC3cXisFart74%3D, PID: 20167359
-
Sattar N, Preiss D, Murray HM, et al. Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials. Lancet. 2010;375:735–42.
-
(2010)
Lancet
, vol.375
, pp. 735-742
-
-
Sattar, N.1
Preiss, D.2
Murray, H.M.3
-
3
-
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84921493092
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HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials
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COI: 1:CAS:528:DC%2BC2cXhs1agtLvF, PID: 25262344, This paper demonstrates the power to link genetics and clinical trial data to improve causal understanding of the effects of drug therapy on adverse effects; in this case, examining the diabetogenic effects of statins
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•Swerdlow DI, Preiss D, Kuchenbaecker KB, et al. HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials. Lancet. 2015;385:351–61. This paper demonstrates the power to link genetics and clinical trial data to improve causal understanding of the effects of drug therapy on adverse effects; in this case, examining the diabetogenic effects of statins.
-
(2015)
Lancet
, vol.385
, pp. 351-361
-
-
Swerdlow, D.I.1
Preiss, D.2
Kuchenbaecker, K.B.3
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4
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79959428660
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Risk of incident diabetes with intensive-dose compared with moderate-dose statin therapy: a meta-analysis
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COI: 1:CAS:528:DC%2BC3MXotVantLs%3D, PID: 21693744
-
Preiss D, Seshasai SR, Welsh P, et al. Risk of incident diabetes with intensive-dose compared with moderate-dose statin therapy: a meta-analysis. JAMA. 2011;305:2556–64.
-
(2011)
JAMA
, vol.305
, pp. 2556-2564
-
-
Preiss, D.1
Seshasai, S.R.2
Welsh, P.3
-
5
-
-
84995908011
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Diabetogenic effect of statins: a comprehensive review on the clinical relevance, underlying pathomechanisms and rationale for tailored statin therapy
-
Ostrowska M, Adamski P, Kosinski M, et al. Diabetogenic effect of statins: a comprehensive review on the clinical relevance, underlying pathomechanisms and rationale for tailored statin therapy. Folia Med Copernicana. 2015;3:145–53.
-
(2015)
Folia Med Copernicana
, vol.3
, pp. 145-153
-
-
Ostrowska, M.1
Adamski, P.2
Kosinski, M.3
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6
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35248901000
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Long-term follow-up of the West of Scotland Coronary Prevention Study
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COI: 1:CAS:528:DC%2BD2sXhtFKmur%2FK, PID: 17928595
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Ford I, Murray H, Packard C, et al. Long-term follow-up of the West of Scotland Coronary Prevention Study. NEJM. 2007;357:1477–86.
-
(2007)
NEJM
, vol.357
, pp. 1477-1486
-
-
Ford, I.1
Murray, H.2
Packard, C.3
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7
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0037164314
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PROspective Study of Pravastatin in the Elderly at Risk. Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial
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COI: 1:CAS:528:DC%2BD38XovFegt7o%3D, PID: 12457784
-
Shepherd J, Blauw GJ, Murphy MB, PROSPER Study Group, et al. PROspective Study of Pravastatin in the Elderly at Risk. Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial. Lancet. 2002;360:1623–30.
-
(2002)
Lancet
, vol.360
, pp. 1623-1630
-
-
Shepherd, J.1
Blauw, G.J.2
Murphy, M.B.3
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8
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84924358878
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Association between familial hypercholesterolaemia and prevalence of type 2 diabetes mellitus
-
COI: 1:CAS:528:DC%2BC2MXlt1Kjsr4%3D, PID: 25756439
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Besseling J, Kastelein JJP, Defesche JC, et al. Association between familial hypercholesterolaemia and prevalence of type 2 diabetes mellitus. JAMA. 2015;313:1029–36.
-
(2015)
JAMA
, vol.313
, pp. 1029-1036
-
-
Besseling, J.1
Kastelein, J.J.P.2
Defesche, J.C.3
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9
-
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84946509188
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Using Genetic variants to assess the relationship between circulating lipids and type 2 diabetes
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COI: 1:CAS:528:DC%2BC2MXhtFynsrrP, PID: 25948681, Demonstrates the power of genetics to improve understanding of complex biological links, but also the potential caveats one must consider
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•Fall T, Xie W, Poon W, et al. Using Genetic variants to assess the relationship between circulating lipids and type 2 diabetes. Diabetes. 2015;64:2676–84. Demonstrates the power of genetics to improve understanding of complex biological links, but also the potential caveats one must consider.
-
(2015)
Diabetes
, vol.64
, pp. 2676-2684
-
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Fall, T.1
Xie, W.2
Poon, W.3
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10
-
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84987890774
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Coulhoun HM, Ginsberg HN, Robinson JG et al.: No effect of PCSK9 inhibitor alirocumab on the incidence of diabetes in a pooled analysis from 10 ODYSSEY phase 3 studies; ehw292 [Epub ahead of print]. The first study to examine whether there is any obvious and immediate effect of PCSK9 inhibition (alirocumab in this case) on diabetes risk and glycaemia levels
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Coulhoun HM, Ginsberg HN, Robinson JG et al.: No effect of PCSK9 inhibitor alirocumab on the incidence of diabetes in a pooled analysis from 10 ODYSSEY phase 3 studies. European Heart Journal. 2016; ehw292 [Epub ahead of print]. The first study to examine whether there is any obvious and immediate effect of PCSK9 inhibition (alirocumab in this case) on diabetes risk and glycaemia levels.
-
(2016)
European Heart Journal
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11
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84899846576
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A 52-week placebo-controlled trial of evolocumab in hyperlipidaemia
-
COI: 1:CAS:528:DC%2BC2cXot12jtbw%3D, PID: 24678979
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Blom DJ, Hala T, Bolognese M, et al. A 52-week placebo-controlled trial of evolocumab in hyperlipidaemia. NEJM. 2014;370:1809–19.
-
(2014)
NEJM
, vol.370
, pp. 1809-1819
-
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Blom, D.J.1
Hala, T.2
Bolognese, M.3
-
12
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84995940241
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Effects of long-term, monthly administration of the PCSK9 inhibitor evolocumab in patients with dysglycemia or metabolic syndrome
-
Henry RR, Holman RR, Giugliano RP, et al. Effects of long-term, monthly administration of the PCSK9 inhibitor evolocumab in patients with dysglycemia or metabolic syndrome. Can J Diabetes. 2014;38:S18.
-
(2014)
Can J Diabetes
, vol.38
, pp. S18
-
-
Henry, R.R.1
Holman, R.R.2
Giugliano, R.P.3
-
13
-
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84957928187
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Lipid-lowering efficacy of the PCSK9 inhibitor evolocumab (AMG 145) in patients with type 2 diabetes: a meta-analysis of individual patient data
-
COI: 1:CAS:528:DC%2BC28Xhs1yisb%2FP, PID: 26868195
-
Sattar N, Preiss D, Robinson JG, et al. Lipid-lowering efficacy of the PCSK9 inhibitor evolocumab (AMG 145) in patients with type 2 diabetes: a meta-analysis of individual patient data. Lancet Diabetes Endocrinol. 2016;4:403–10.
-
(2016)
Lancet Diabetes Endocrinol
, vol.4
, pp. 403-410
-
-
Sattar, N.1
Preiss, D.2
Robinson, J.G.3
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14
-
-
84995776151
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••Lotta LA, Sharp SJ, Burgess S, et al. Association Between low-density lipoprotein cholesterol-lowering genetic variants and risk of type 2 diabetes: A meta-analysis;4;316(13):1383-1391. This is the first large genetic study of PCSK9 snps and diabetes risk and shows a significant higher risk, albeit modestly so, but with stronger associations with diabetes for genes encoding the molecular targets for ezetimibe
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••Lotta LA, Sharp SJ, Burgess S, et al. Association Between low-density lipoprotein cholesterol-lowering genetic variants and risk of type 2 diabetes: A meta-analysis. JAMA. 2016;4;316(13):1383-1391. This is the first large genetic study of PCSK9 snps and diabetes risk and shows a significant higher risk, albeit modestly so, but with stronger associations with diabetes for genes encoding the molecular targets for ezetimibe.
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(2016)
JAMA
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15
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84994253432
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•Sattar N. PCSK9 inhibitors and diabetes risk: a question worth asking?. doi:. This commentary pulls together the existing evidence for statins and PCSK9 and risks of diabetes and gives clinical implications as well as important areas for future research
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•Sattar N. PCSK9 inhibitors and diabetes risk: a question worth asking? Eur Heart J. 2016. doi:10.1093/eurheartj/ehw346. This commentary pulls together the existing evidence for statins and PCSK9 and risks of diabetes and gives clinical implications as well as important areas for future research.
-
(2016)
Eur Heart J.
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16
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0023001772
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Fifteen year mortality in coronary drug project patients: long-term benefit with niacin
-
COI: 1:STN:280:DyaL2s%2FlvVCqtQ%3D%3D, PID: 3782631
-
Canner PL, Berge KG, Wenger NK, et al. Fifteen year mortality in coronary drug project patients: long-term benefit with niacin. J Am Coll Cardiol. 1986;8:1245–55.
-
(1986)
J Am Coll Cardiol
, vol.8
, pp. 1245-1255
-
-
Canner, P.L.1
Berge, K.G.2
Wenger, N.K.3
-
17
-
-
84904252744
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Effects of extended-release niacin with laropiprant in high-risk patients
-
HPS2-THRIVE collaborative group, Landray MJ, Haynes R, et al. Effects of extended-release niacin with laropiprant in high-risk patients. NEJM. 2014;371:203–12.
-
(2014)
NEJM
, vol.371
, pp. 203-212
-
-
-
18
-
-
84855171302
-
Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy
-
AIM-HIGH investivators, Boden WE, Probstfield JL, et al. Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy. NEJM. 2011;365:2255–67.
-
(2011)
NEJM
, vol.365
, pp. 2255-2267
-
-
-
19
-
-
42149136762
-
Effects of niacin on glucose control in patients with dyslipidemia
-
COI: 1:CAS:528:DC%2BD1cXltFWhs78%3D, PID: 18380993
-
Goldberg RB, Jacobson TA. Effects of niacin on glucose control in patients with dyslipidemia. Mayo Clin Proc. 2008;83:470–80.
-
(2008)
Mayo Clin Proc
, vol.83
, pp. 470-480
-
-
Goldberg, R.B.1
Jacobson, T.A.2
-
20
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84875540714
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Effects of niacin on the incidence of new onset diabetes and cardiovascular events in patients with normoglycaemia and impaired fasting glucose
-
COI: 1:CAS:528:DC%2BC3sXotlOnsLs%3D, PID: 23521322
-
Sazonov V, Maccubbin D, Sisk CM, et al. Effects of niacin on the incidence of new onset diabetes and cardiovascular events in patients with normoglycaemia and impaired fasting glucose. Int J Clin Pract. 2013;67:297–302.
-
(2013)
Int J Clin Pract
, vol.67
, pp. 297-302
-
-
Sazonov, V.1
Maccubbin, D.2
Sisk, C.M.3
-
21
-
-
84958880102
-
Niacin therapy and the risk of new-onset diabetes: a meta-aaalysis of randomised controlled trials
-
COI: 1:CAS:528:DC%2BC28XhsVWgt7zL, PID: 26370223, A well-conducted meta-analysis of trials of Niacin and its risk for diabetes
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•Goldie C, Taylor AJ, Nguyen P, et al. Niacin therapy and the risk of new-onset diabetes: a meta-aaalysis of randomised controlled trials. Heart. 2016;102:198–203. A well-conducted meta-analysis of trials of Niacin and its risk for diabetes.
-
(2016)
Heart
, vol.102
, pp. 198-203
-
-
Goldie, C.1
Taylor, A.J.2
Nguyen, P.3
-
22
-
-
84864753387
-
Lipid-altering efficacy of ezetimibe plus statin and statin monotherapy and identification of factors associated with treatment response: a pooled analysis of over 21,000 subjects from 27 clinical trials
-
COI: 1:CAS:528:DC%2BC38Xjs1GmsLY%3D, PID: 22410123
-
Morrone D, Weintraub WS, Toth PP, et al. Lipid-altering efficacy of ezetimibe plus statin and statin monotherapy and identification of factors associated with treatment response: a pooled analysis of over 21,000 subjects from 27 clinical trials. Atherosclerosis. 2012;223:251–61.
-
(2012)
Atherosclerosis
, vol.223
, pp. 251-261
-
-
Morrone, D.1
Weintraub, W.S.2
Toth, P.P.3
-
23
-
-
84931411520
-
Ezetimibe added to statin therapy after acute coronary syndromes
-
COI: 1:CAS:528:DC%2BC2MXhtFyrtbbF, PID: 26039521
-
Cannon CP, Blazing MA, Giugliano RP, et al. Ezetimibe added to statin therapy after acute coronary syndromes. NEJM. 2015;372:2387–97.
-
(2015)
NEJM
, vol.372
, pp. 2387-2397
-
-
Cannon, C.P.1
Blazing, M.A.2
Giugliano, R.P.3
-
24
-
-
84930002972
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A randomized, double-blind, placebo-controlled study of the effect of ezetimibe on glucose metabolism in subjects with type 2 diabetes mellitus and hypercholesterolaemia
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PID: 25929253
-
Saito I, Azuma K, Kakikawa T, et al. A randomized, double-blind, placebo-controlled study of the effect of ezetimibe on glucose metabolism in subjects with type 2 diabetes mellitus and hypercholesterolaemia. Lipids Health Dis. 2015;14:40.
-
(2015)
Lipids Health Dis
, vol.14
, pp. 40
-
-
Saito, I.1
Azuma, K.2
Kakikawa, T.3
-
26
-
-
77952708442
-
Effects of fibrates on cardiovascular outcomes: a systematic review and meta-analysis
-
COI: 1:CAS:528:DC%2BC3cXmsleksrc%3D, PID: 20462635
-
Jun M, Foote C, Licheng LV, et al. Effects of fibrates on cardiovascular outcomes: a systematic review and meta-analysis. Lancet. 2010;375:1875–84.
-
(2010)
Lancet
, vol.375
, pp. 1875-1884
-
-
Jun, M.1
Foote, C.2
Licheng, L.V.3
-
27
-
-
28044452217
-
Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial
-
COI: 1:STN:280:DC%2BD2MnjtVCnsg%3D%3D, PID: 16310551
-
Keech A, Simes RJ, Barter P, et al. Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial. Lancet. 2005;366:1849–61.
-
(2005)
Lancet
, vol.366
, pp. 1849-1861
-
-
Keech, A.1
Simes, R.J.2
Barter, P.3
-
28
-
-
84864928988
-
A neutral risk on the development of new-onset diabetes mellitus (NODM) in Taiwanese patients with dyslipidaemia treated with fibrates
-
PID: 22919315
-
Lee CY, Huang KH, Lin CC, et al. A neutral risk on the development of new-onset diabetes mellitus (NODM) in Taiwanese patients with dyslipidaemia treated with fibrates. Scientific World Journal. 2012;2012:392734.
-
(2012)
Scientific World Journal
, vol.2012
, pp. 392734
-
-
Lee, C.Y.1
Huang, K.H.2
Lin, C.C.3
-
29
-
-
2442660528
-
Peroxisome proliferator-activated receptor ligand bezafibrate for prevention of type 2 diabetes mellitus in patients with coronary artery disease
-
COI: 1:CAS:528:DC%2BD2cXjs1eisrY%3D, PID: 15123532
-
Tenenbaum A, Motro M, Fisman EZ, et al. Peroxisome proliferator-activated receptor ligand bezafibrate for prevention of type 2 diabetes mellitus in patients with coronary artery disease. Circulation. 2004;109:2197–202.
-
(2004)
Circulation
, vol.109
, pp. 2197-2202
-
-
Tenenbaum, A.1
Motro, M.2
Fisman, E.Z.3
-
30
-
-
62749204385
-
The L162V polymorphism of the peroxysome proliferator activated receptor alpha gene (PPARA) is not asocialted with type 2 diabetes, BMI or body fat composition
-
COI: 1:CAS:528:DC%2BD1MXltVCjur0%3D
-
Silbernagel G, Stefan N, Hoffmann MM, et al. The L162V polymorphism of the peroxysome proliferator activated receptor alpha gene (PPARA) is not asocialted with type 2 diabetes, BMI or body fat composition. Exp Clin Endocrine Diabetes. 2009;117:113–8.
-
(2009)
Exp Clin Endocrine Diabetes
, vol.117
, pp. 113-118
-
-
Silbernagel, G.1
Stefan, N.2
Hoffmann, M.M.3
-
31
-
-
73749087527
-
Differing effect of statins on insulin sensitivity in non-diabetics: a systematic review and meta-analysis
-
COI: 1:CAS:528:DC%2BC3cXntVaquw%3D%3D, PID: 19913318
-
Baker WL, Talati R, White CM, et al. Differing effect of statins on insulin sensitivity in non-diabetics: a systematic review and meta-analysis. Diabetes Res Clin Pract. 2010;87:98–107.
-
(2010)
Diabetes Res Clin Pract
, vol.87
, pp. 98-107
-
-
Baker, W.L.1
Talati, R.2
White, C.M.3
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