The effect of exercise on vascular function and stiffness in type 2 diabetes: A systematic review and meta-analysis

Current Diabetes Reviews

Volumn 12, Issue 4, 2016, Pages 369-383

  Way, Kimberley Larisa ^a   Keating, Shelley Elizabeth ^a   Baker, Michael Kevin ^a,b   Chuter, Vivienne Helaine ^c   Johnson, Nathan Anthony ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b AUSTRALIAN CATHOLIC UNIVERSITY   (Australia)

^c UNIVERSITY OF NEWCASTLE   (Australia)

Author keywords

Aerobic; Endothelial function; Endothelial independent dilation; Flow mediated dilation; Pulse wave velocity; Resistance training

Indexed keywords

CARBOHYDRATE; FAT; GLYCERYL TRINITRATE; OXYGEN; PROTEIN;

AEROBIC EXERCISE; ARTERIAL STIFFNESS; BODY MASS; BODY WEIGHT; CARDIOVASCULAR FUNCTION; CLINICAL TRIAL (TOPIC); EXERCISE; HEART RATE; HUMAN; KINESIOTHERAPY; META ANALYSIS; METABOLIC EQUIVALENT; MUSCLE FUNCTION; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PULSE WAVE; RESISTANCE TRAINING; REVIEW; SYSTEMATIC REVIEW; VASCULAR SMOOTH MUSCLE; WHOLE BODY VIBRATION; CARDIOVASCULAR DISEASES; COMPLICATION; DIABETES MELLITUS, TYPE 2; DIABETIC ANGIOPATHIES; MORTALITY; PATHOPHYSIOLOGY; PHYSIOLOGY;

CARDIOVASCULAR DISEASES; CARDIOVASCULAR PHYSIOLOGICAL PHENOMENA; DIABETES MELLITUS, TYPE 2; DIABETIC ANGIOPATHIES; EXERCISE; HUMANS; RESISTANCE TRAINING; VASCULAR STIFFNESS;

EID: 84995686956     PISSN: 15733998     EISSN: 18756417     Source Type: Journal    
DOI: 10.2174/1573399811666150817124601     Document Type: Review

References (54)

1. Haffner SM, Lehto S, Rönnemaa T, Pyörälä K, Laakso M. Mortality from Coronary Heart Disease in Subjects with Type 2 Diabetes and in Nondiabetic Subjects with and without Prior Myocardial Infarction. N Engl J Med. 1998; 339(4): 229-34.
2. Zieman SJ, Melenovsky V, Kass DA. Mechanisms, pathophysiology, and therapy of arterial stiffness. Arterioscler. Thromb. Vasc. Biol. 2005; 25(5): 932-43.
3. Schreuder T, Maessen M, Tack C, Thijssen D, Hopman M. Lifelong physical activity restores metabolic and cardiovascular function in type 2 diabetes. Eur J Appl Physiol. 2014; 114(3): 619-27.
4. Colberg SR, Parson HK, Nunnold T, Herriott MT, Vinik AI. Effect of an 8-week resistance training program on cutaneous perfusion in type 2 diabetes. Microvasc Res 2006; 71(2): 121-27.
5. Ismail-Beigi FMDP. Pathogenesis and Glycemic Management of Type 2 Diabetes Mellitus: A Physiological Approach. Arch Iran Med. 2012; 15(4): 239-46.
6. Allen JD, Stabler T, Kenjale AA, Ham KL, Robbins JL. Diabetes status differentiates endothelial function and plasma nitrite response to exercise stress in peripheral arterial disease following supervised training. J Diabetes Compli. 2014; 28(2): 219-25.
7. Stults B, Jones RE. Management of Hypertension in Diabetes. Diabetes Spectrum. 2006; 19(1): 25-31.
8. Stehouwer CDA, Henry RMA, Ferreira I. Arterial stiffness in diabetes and the metabolic syndrome: a pathway to cardiovascular disease. Diabetologia. 2008; 51(4): 527-39.
9. Sullivan PW, Morrato EH, Ghushchyan V, Wyatt HR, Hill JO. Obesity, Inactivity, and the Prevalence of Diabetes and Diabetes-Related Cardiovascular Comorbidities in the U.S., 2000– 2002. Diabetes care. 2005; 28(7): 1599-603.
10. Tanasescu M, Leitzmann MF, Rimm EB, Hu FB. Physical activity in relation to cardiovascular disease and total mortality among men with type 2 diabetes. Circulation. 2003; 107(19): 2435-39.
11. Cohen N, Delaney C, David D, Paul ZZ, Shaw J. Improved endothelial function in type 2 diabetes following a resistance training program. Diabetes. 2004; 53: A175-A75.
12. Cohen ND, Dunstan DW, Robinson C, Vulikh E, Zimmet PZ. Improved endothelial function following a 14-month resistance exercise training program in adults with type 2 diabetes. Diabetes Res Clinic Pract 2008; 79(3): 405-11.
13. da Silva CA, Ribeiro JP, Canto JCAU, da Silva RE, Silva Junior GB. High-intensity aerobic training improves endotheliumdependent vasodilation in patients with metabolic syndrome and type 2 diabetes mellitus. Diabetes Res Clinic Pract 2012; 95(2): 237-45.
14. Ribeiro JP, Silva CA, Serafim M, Canto J, Silva RE. Improvement in endothelial function with high-intensity exercise training in patients with type 2 diabetes mellitus or metabolic syndrome. Euro Heart J. 2007; 28: 743-43.
15. Green DJ, Walsh JH, Maiorana A, Best MJ, Taylor RR. Exerciseinduced improvement in endothelial dysfunction is not mediated by changes in CV risk factors: pooled analysis of diverse patient populations. Am J Physiol Heart Circ Physiol. 2003; 285(6): H2679-H87.
16. Montero D, Walther G, Benamo E, Perez-Martin A, Vinet As. Effects of Exercise Training on Arterial Function in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis. Sports Med. 2013; 43(11): 1191-9.
17. Mourot L, Boussuges A, Campo P, Maunier S, Debussche X. Cardiovascular rehabilitation increase arterial compliance in type 2 diabetic patients with coronary artery disease. Diabetes Res Clinic Pract. 2009; 84(2): 138-44.
18. Monahan KD, Tanaka H, Dinenno FA, Seals DR. Central arterial compliance is associated with age-and habitual exercise‚ ÄìRelated differences in cardiovagal baroreflex sensitivity. Circulation. 2001; 104(14): 1627-32.
19. Madden KM, Lockhart C, Cuff D, Potter TF, Meneilly GS. Shortterm aerobic exercise reduces arterial stiffness in older adults with type 2 diabetes, hypertension, and hypercholesterolemia. Diabetes Care. 2009; 32(8): 1531-5.
20. Green DJ, Walsh JH, Maiorana A, Burke V, Taylor RR. Comparison of resistance and conduit vessel nitric oxide-mediated vascular function in vivo: effects of exercise training. J Appl Physiol. 2004; 97(2): 749-55; discussion 48.
21. Maiorana A, O'Driscoll G, Cheetham C, Dembo L, Stanton K. The effect of combined aerobic and resistance exercise training on vascular function in type 2 diabetes. J Am Coll Cardiol. 2001; 38(3): 860-6.
22. London GM, Pannier B. Arterial functions: how to interpret the complex physiology. Nephrol Dial Transplant. 2010; 25(12): 3815-23.
23. Katakami N, Osonoi T, Takahara M, Saitou M, Matsuoka T-a. Clinical utility of brachial-ankle pulse wave velocity in the prediction of cardiovascular events in diabetic patients. Cardiovasc Diabetol. 2014; 13.
24. Sharman JE, Davies JE, Jenkins C, Marwick TH. Augmentation Index, Left Ventricular Contractility, and Wave Reflection. [Article]. Hypertension. 2009; 54(5): 1099-105.
25. Ashor AW, Lara J, Siervo M, Celis-Morales C, Mathers JC. Effects of exercise modalities on arterial stiffness and wave reflection: A systematic review and meta-analysis of randomized controlled trials. PLoS One. 2014; 9(10).
26. Laurent S, Cockcroft J, Van Bortel L, Boutouyrie P, Giannattasio C et al. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Euro Heart J 2006; 27(21): 2588-605.
27. Deanfield JE, Halcox JP, Rabelink TJ. Endothelial function and dysfunction: testing and clinical relevance. Circulation. 2007; 115(10): 1285.
28. Hwang M-H, Kim S. Type 2 Diabetes: Endothelial dysfunction and Exercise. J. Exerc. Nutrition Biochem. 2014; 6(1): 239-47.
29. Naka KK, Papathanassiou K, Bechlioulis A, Kazakos N, Pappas K. Determinants of vascular function in patients with type 2 diabetes. Cardiovasc Diabetol. 2012; 11(1): 127-27.
30. Downs SH, Black N. The Feasibility of Creating a Checklist for the Assessment of the Methodological Quality Both of Randomised and Non-Randomised Studies of Health Care Interventions. J Epidemiol Community Health (1979-). 1998; 52(6): 377-84.
31. Choi KM, Han KA, Ahn HJ, Hwang SY, Hong HC. Effects of exercise on sRAGE levels and cardiometabolic risk factors in patients with type 2 diabetes: a randomized controlled trial. J Clin Endocrinol Metab. 2012; 97(10): 3751-8.
32. Kwon HR, Min KW, Ahn HJ, Seok HG, Lee JH. Effects of Aerobic Exercise vs. Resistance Training on Endothelial Function in Women with Type 2 Diabetes Mellitus. Diabetes Metab. J. 2011; 35(4): 364-73.
33. McGavock J, Mandic S, Lewanczuk R, Koller M, Muhll IV. Cardiovascular adaptations to exercise training in postmenopausal women with type 2 diabetes mellitus. Cardiovasc Diabetol. 2004; 3.
34. Jung JY, Min KW, Ahn HJ, Kwon HR, Lee JH. Arterial stiffness by aerobic exercise is related with aerobic capacity, physical activity energy expenditure and total fat but not with insulin sensitivity in obese female patients with type 2 diabetes. Diabetes Metab. J. 2014; 38(6): 439-48.
35. Loimaala A, Groundstroem K, Rinne M, Nenonen A, Huhtala H. Effect of long-term endurance and strength training on metabolic control and arterial elasticity in patients with type 2 diabetes mellitus. Am. J. Cardiol. 2009; 103(7): 972-7.
36. Loimaala A, Huikuri HV, Koobi T, Rinne M, Nenonen A. Exercise training improves baroreflex sensitivity in type 2 diabetes. Diabetes. 2003; 52(7): 1837-42.
37. Schmidt JF, Andersen TR, Horton J, Brix J, Tarnow L. Soccer Training Improves Cardiac Function in Men with Type 2 Diabetes. Med Sci Sports Exerc. 2013; 45(12): 2223-33.
38. Bronas UG, Weber ML, Treat-Jacobson D, Duprez D, Rosenberg M. Exercise improves vascular endothelial function in patients with early diabetic kidney disease. Vasc Med. 2013; 18(3): 154-54.
39. Dobrosielski DA, Gibbs BB, Ouyang P, Bonekamp S, Clark JM. Effect of exercise on blood pressure in type 2 diabetes: a randomized controlled trial. J Gen Intern Med. 2012; 27(11): 1453-9.
40. Madden KM, Lockhart C, Cuff D, Potter TF, Meneilly GS. Aerobic training-induced improvements in arterial stiffness are not sustained in older adults with multiple cardiovascular risk factors. J Human Hypertension. 2013; 27(5): 335-39.
41. Sanudo B, Alfonso-Rosa R, del Pozo-Cruz B, del Pozo-Cruz J, Galiano D. Whole body vibration training improves leg blood flow and adiposity in patients with type 2 diabetes mellitus. Euro J Appl Physiol. 2013; 113(9): 2245-52.
42. Wycherley TP, Brinkworth GD, Noakes M, Buckley JD, Clifton PM. Effect of caloric restriction with and without exercise training on oxidative stress and endothelial function in obese subjects with type 2 diabetes. Diabetes Obes Metab. 2008; 10(11): 1062-73.
43. Mitranun W, Deerochanawong C, Tanaka H, Suksom D. Continuous vs interval training on glycemic control and macro-and microvascular reactivity in type 2 diabetic patients. Scand J Med Sci Sports. 2014; 24(2): e69-76.
44. Barone Gibbs B, Dobrosielski DA, Bonekamp S, Stewart KJ, Clark JM. A randomized trial of exercise for blood pressure reduction in type 2 diabetes: effect on flow-mediated dilation and circulating biomarkers of endothelial function. Atherosclerosis. 2012; 224(2): 446-53.
45. Seidell JC, Flegal KM. Assessing obesity: classification and epidemiology. British medical bulletin. 1997; 53(2): 238.
46. Marwick TH, Hordern MD, Miller T, Chyun DA, Bertoni AG. Exercise training for type 2 diabetes mellitus: impact on cardiovascular risk: a scientific statement from the American Heart Association. Circulation. 2009; 119(25): 3244.
47. Verma S, Buchanan MR, Anderson TJ. Endothelial function testing as a biomarker of vascular disease. Circulation. 2003; 108(17): 2054-59.
48. Beckman JA, Creager MA, Libby P. Diabetes and Atherosclerosis: Epidemiology, Pathophysiology, and Management. JAMA. 2002; 287(19): 2570-81.
49. Ando J, Yamamoto K. Effects of Shear Stress and Stretch on Endothelial Function. Antioxid Redox Signal. 2011; 15(5): 1389-403.
50. Meigs JB, Hu FB, Rifai N, Manson JE. Biomarkers of Endothelial Dysfunction and Risk of Type 2 Diabetes Mellitus. JAMA. 2004; 291(16): 1978-86.
51. Huebschmann AG, Kohrt WM, Regensteiner JG. Exercise attenuates the premature cardiovascular aging effects of type 2 diabetes mellitus. Vasc Med. 2011; 16(5): 378-90.
52. Aronson D. Cross-linking of glycated collagen in the pathogenesis of arterial and myocardial stiffening of aging and diabetes. J. Hypertension. 2003; 21(1): 3-12.
53. Francescomarino SD, Sciartilli A, Valerio VD, Baldassarre AD, Gallina S. The Effect of Physical Exercise on Endothelial Function. Sports Med. 2009; 39(10): 797-812.
54. Weston KS, Wisoff U, Coombes JS. High-intensity interval training in patients with lifestyle-induced cardiometabolic disease: a systematic review and meta-analysis. Br J Sports Med. 2014; 48(16): 1227.