-
2
-
-
79953781233
-
Prognostic factors for survival inmelanoma patients with brain metastases
-
Davies MA, Liu P, McIntyre S, Kim KB, Papadopoulos N, Hwu WJ, et al. Prognostic factors for survival inmelanoma patients with brain metastases. Cancer 2011;117:1687-96.
-
(2011)
Cancer
, vol.117
, pp. 1687-1696
-
-
Davies, M.A.1
Liu, P.2
McIntyre, S.3
Kim, K.B.4
Papadopoulos, N.5
Hwu, W.J.6
-
3
-
-
84868120907
-
Dabrafenib in patients with Val600Glu or Val600Lys BRAF-mutant melanoma metastatic to the brain (BREAK-MB): A multicentre, open-label, phase 2 trial
-
Long GV, Trefzer U, Davies MA, Kefford RF, Ascierto PA, Chapman PB, et al. Dabrafenib in patients with Val600Glu or Val600Lys BRAF-mutant melanoma metastatic to the brain (BREAK-MB): a multicentre, open-label, phase 2 trial. Lancet Oncol 2012;13:1087-95.
-
(2012)
Lancet Oncol
, vol.13
, pp. 1087-1095
-
-
Long, G.V.1
Trefzer, U.2
Davies, M.A.3
Kefford, R.F.4
Ascierto, P.A.5
Chapman, P.B.6
-
4
-
-
84898967738
-
Vemurafenib in metastatic melanoma patients with brain metastases: An open-label, single-arm, phase 2, multicenter study
-
Kefford RF, Maio M, Arance A, Nathan P, Blank C, Avril MF, et al. Vemurafenib in metastatic melanoma patients with brain metastases: an open-label, single-arm, phase 2, multicenter study. Pigment Cell Melanoma Res 2013;26:965.
-
(2013)
Pigment Cell Melanoma Res
, vol.26
, pp. 965
-
-
Kefford, R.F.1
Maio, M.2
Arance, A.3
Nathan, P.4
Blank, C.5
Avril, M.F.6
-
5
-
-
84860446616
-
Ipilimumab in patients with melanoma and brain metastases: An open-label, phase 2 trial
-
Margolin K, Ernstoff MS, Hamid O, Lawrence D, McDermott D, Puzanov I, et al. Ipilimumab in patients with melanoma and brain metastases: an open-label, phase 2 trial. Lancet Oncol 2012;13:459-65.
-
(2012)
Lancet Oncol
, vol.13
, pp. 459-465
-
-
Margolin, K.1
Ernstoff, M.S.2
Hamid, O.3
Lawrence, D.4
McDermott, D.5
Puzanov, I.6
-
6
-
-
84875227164
-
Targeting hyperactivation of the AKT survival pathway to overcome therapy resistance of melanoma brain metastases
-
Niessner H, Forschner A, Klumpp B, Honegger JB, Witte M, Bornemann A, et al. Targeting hyperactivation of the AKT survival pathway to overcome therapy resistance of melanoma brain metastases. Cancer Med 2013;2: 76-85.
-
(2013)
Cancer Med
, vol.2
, pp. 76-85
-
-
Niessner, H.1
Forschner, A.2
Klumpp, B.3
Honegger, J.B.4
Witte, M.5
Bornemann, A.6
-
7
-
-
84910119049
-
Incidence and characteristics of melanoma brain metastases developing during treatment with vemurafenib
-
Peuvrel L, Saint-Jean M, QuereuxG, Brocard A, Khammari A, Knol AC, et al. Incidence and characteristics of melanoma brain metastases developing during treatment with vemurafenib. J Neurooncol 2014;120:147-54.
-
(2014)
J Neurooncol
, vol.120
, pp. 147-154
-
-
Peuvrel, L.1
Saint-Jean, M.2
Quereux, G.3
Brocard, A.4
Khammari, A.5
Knol, A.C.6
-
8
-
-
84855451538
-
Antitumor activity of NVP-BKM120-a selective pan class i PI3 kinase inhibitor showed differential forms of cell death based on p53 status of glioma cells
-
Koul D, Fu J, Shen R, LaFortune TA, Wang S, Tiao N, et al. Antitumor activity of NVP-BKM120-a selective pan class I PI3 kinase inhibitor showed differential forms of cell death based on p53 status of glioma cells. Clin Cancer Res 2012;18:184-95.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 184-195
-
-
Koul, D.1
Fu, J.2
Shen, R.3
LaFortune, T.A.4
Wang, S.5
Tiao, N.6
-
9
-
-
84856826293
-
Identification and characterization of NVP-BKM120, an orally available pan-class i PI3-kinase inhibitor
-
Maira SM, Pecchi S, Huang A, Burger M, Knapp M, Sterker D, et al. Identification and characterization of NVP-BKM120, an orally available pan-class I PI3-kinase inhibitor. Mol Cancer Ther 2012;11:317-28.
-
(2012)
Mol Cancer Ther
, vol.11
, pp. 317-328
-
-
Maira, S.M.1
Pecchi, S.2
Huang, A.3
Burger, M.4
Knapp, M.5
Sterker, D.6
-
10
-
-
84862895654
-
Current clinical development of PI3K pathway inhibitors in glioblastoma
-
Wen PY, Lee EQ, Reardon DA, Ligon KL, Alfred Yung WK. Current clinical development of PI3K pathway inhibitors in glioblastoma. Neuro-oncol 2012;14:819-29.
-
(2012)
Neuro-oncol
, vol.14
, pp. 819-829
-
-
Wen, P.Y.1
Lee, E.Q.2
Reardon, D.A.3
Ligon, K.L.4
Alfred Yung, W.K.5
-
11
-
-
84957540973
-
BKM-120 (Buparlisib): A phosphatidyl-inositol-3 kinase inhibitor with anti-invasive properties in glioblastoma
-
Speranza MC, Nowicki MO, Behera P, Cho CF, Chiocca EA, Lawler SE. BKM-120 (Buparlisib): a phosphatidyl-inositol-3 kinase inhibitor with anti-invasive properties in glioblastoma. Sci Rep 2016;6:20189.
-
(2016)
Sci Rep
, vol.6
, pp. 20189
-
-
Speranza, M.C.1
Nowicki, M.O.2
Behera, P.3
Cho, C.F.4
Chiocca, E.A.5
Lawler, S.E.6
-
12
-
-
84856071447
-
Phase I, dose-escalation study of BKM120, an oral pan-Class i PI3K inhibitor, in patients with advanced solid tumors
-
Bendell JC, Rodon J, Burris HA, de JongeM, Verweij J, Birle D, et al. Phase I, dose-escalation study of BKM120, an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors. J Clin Oncol 2012;30:282-90.
-
(2012)
J Clin Oncol
, vol.30
, pp. 282-290
-
-
Bendell, J.C.1
Rodon, J.2
Burris, H.A.3
De Jongem Verweij, J.4
Birle, D.5
-
13
-
-
84895517907
-
Phase i dose-escalation study of buparlisib (BKM120), an oral pan-class i PI3K inhibitor, in Japanese patients with advanced solid tumors
-
Ando Y, Inada-Inoue M, Mitsuma A, Yoshino T, Ohtsu A, Suenaga N, et al. Phase I dose-escalation study of buparlisib (BKM120), an oral pan-class I PI3K inhibitor, in Japanese patients with advanced solid tumors. Cancer Sci 2014;105:347-53.
-
(2014)
Cancer Sci
, vol.105
, pp. 347-353
-
-
Ando, Y.1
Inada-Inoue, M.2
Mitsuma, A.3
Yoshino, T.4
Ohtsu, A.5
Suenaga, N.6
-
14
-
-
84975753526
-
PIK3CA status in circulating tumor DNA (ctDNA) predicts efficacy of buparlisib (BUP) plus fulvestrant (FULV) in postmenopausal women with endocrine-resistant HR+/HER2-advanced breast cancer (BC): First results from the randomized phase III BELLE-2 trial [abstract]
-
Dec 8-12; San Antonio TX. Philadelphia (PA): AACR; 2015. Abstract nr S6-01.V
-
Baselga J, Im S-A, Iwata H, ClemonsM, Ito Y, Awada A, et al. PIK3CA status in circulating tumor DNA (ctDNA) predicts efficacy of buparlisib (BUP) plus fulvestrant (FULV) in postmenopausal women with endocrine-resistant HR+/HER2-advanced breast cancer (BC): first results from the randomized, phase III BELLE-2 trial [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium; 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; 2015. Abstract nr S6-01.V
-
(2015)
Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium
-
-
Baselga, J.1
Im, S.-A.2
Iwata, H.3
Clemons, M.4
Ito, Y.5
Awada, A.6
-
15
-
-
0033883797
-
Human melanoma progression in skin reconstructs: Biological significance of bFGF
-
Meier F, Nesbit M, Hsu MY, Martin B, Van Belle P, Elder DE, et al. Human melanoma progression in skin reconstructs: biological significance of bFGF. Am J Pathol 2000;156:193-200.
-
(2000)
Am J Pathol
, vol.156
, pp. 193-200
-
-
Meier, F.1
Nesbit, M.2
Hsu, M.Y.3
Martin, B.4
Van Belle, P.5
Elder, D.E.6
-
16
-
-
84909578490
-
Molecular profiling of patient-matched brain and extracranial melanoma metastases implicates the PI3K pathway as a therapeutic target
-
Chen G, Chakravarti N, Aardalen K, Lazar AJ, Tetzlaff MT, Wubbenhorst B, et al. Molecular profiling of patient-matched brain and extracranial melanoma metastases implicates the PI3K pathway as a therapeutic target. Clin Cancer Res 2014;20:5537-46.
-
(2014)
Clin Cancer Res
, vol.20
, pp. 5537-5546
-
-
Chen, G.1
Chakravarti, N.2
Aardalen, K.3
Lazar, A.J.4
Tetzlaff, M.T.5
Wubbenhorst, B.6
-
17
-
-
84964341362
-
Personalized preclinical trials in BRAF inhibitor-resistant patient-derived xenograft models identify second-line combination therapies
-
Krepler C, Xiao M, Sproesser K, Brafford PA, Shannan B, Beqiri M, et al. Personalized preclinical trials in BRAF inhibitor-resistant patient-derived xenograft models identify second-line combination therapies. Clin Cancer Res 2016;22:1592-602.
-
(2016)
Clin Cancer Res
, vol.22
, pp. 1592-1602
-
-
Krepler, C.1
Xiao, M.2
Sproesser, K.3
Brafford, P.A.4
Shannan, B.5
Beqiri, M.6
-
18
-
-
84962490153
-
Enhancing the evaluation of PI3K inhibitors through 3D melanoma models
-
Shannan B, Chen Q, Watters A, Perego M, Krepler C, Thombre R, et al. Enhancing the evaluation of PI3K inhibitors through 3D melanoma models. Pigment Cell Melanoma Res 2016;29:317-28.
-
(2016)
Pigment Cell Melanoma Res
, vol.29
, pp. 317-328
-
-
Shannan, B.1
Chen, Q.2
Watters, A.3
Perego, M.4
Krepler, C.5
Thombre, R.6
-
19
-
-
84902811306
-
A phase i trial of BKM120 combined with vemurafenib in BRAFV600E/K mutant advanced melanoma
-
abstr 9101
-
Algazi AP, Posch C, Ortiz-Urda S, Cockerill A, Munster PN, Daud A. A phase I trial of BKM120 combined with vemurafenib in BRAFV600E/K mutant advanced melanoma. J Clin Oncol 32:5s, 2014 (suppl; abstr 9101).
-
(2014)
J Clin Oncol
, vol.32
, Issue.5
-
-
Algazi, A.P.1
Posch, C.2
Ortiz-Urda, S.3
Cockerill, A.4
Munster, P.N.5
Daud, A.6
-
20
-
-
84909634322
-
Complete loss of PTEN protein expression correlates with shorter time to brain metastasis and survival in stage IIIB/C melanoma patients with BRAFV600 mutations
-
Bucheit AD, Chen G, Siroy A, Tetzlaff M, Broaddus R, Milton D, et al. Complete loss of PTEN protein expression correlates with shorter time to brain metastasis and survival in stage IIIB/C melanoma patients with BRAFV600 mutations. Clin Cancer Res 2014;20:5527-36.
-
(2014)
Clin Cancer Res
, vol.20
, pp. 5527-5536
-
-
Bucheit, A.D.1
Chen, G.2
Siroy, A.3
Tetzlaff, M.4
Broaddus, R.5
Milton, D.6
-
21
-
-
84941979044
-
PLEKHA5 as a biomarker and potential mediator of melanoma brain metastasis
-
Jilaveanu LB, Parisi F, Barr ML, Zito CR, Cruz-Munoz W, Kerbel RS, et al. PLEKHA5 as a biomarker and potential mediator of melanoma brain metastasis. Clin Cancer Res 2015;21:2138-47.
-
(2015)
Clin Cancer Res
, vol.21
, pp. 2138-2147
-
-
Jilaveanu, L.B.1
Parisi, F.2
Barr, M.L.3
Zito, C.R.4
Cruz-Munoz, W.5
Kerbel, R.S.6
-
22
-
-
84908050244
-
A likely role for a novel PH-domain containing protein, PEPP2, in connecting membrane and cytoskeleton
-
Zou Y, Zhong W. A likely role for a novel PH-domain containing protein, PEPP2, in connecting membrane and cytoskeleton. Biocell 2012;36: 127-32.
-
(2012)
Biocell
, vol.36
, pp. 127-132
-
-
Zou, Y.1
Zhong, W.2
-
23
-
-
79952371255
-
Astrocytes upregulate survival genes in tumor cells and induce protection from chemotherapy
-
Kim SJ, Kim JS, Park ES, Lee JS, Lin Q, Langley RR, et al. Astrocytes upregulate survival genes in tumor cells and induce protection from chemotherapy. Neoplasia 2011;13:286-98.
-
(2011)
Neoplasia
, vol.13
, pp. 286-298
-
-
Kim, S.J.1
Kim, J.S.2
Park, E.S.3
Lee, J.S.4
Lin, Q.5
Langley, R.R.6
-
24
-
-
84946559154
-
Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth
-
Zhang L, Zhang S, Yao J, Lowery FJ, Zhang Q, Huang WC, et al. Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth. Nature 2015;527:100-4.
-
(2015)
Nature
, vol.527
, pp. 100-104
-
-
Zhang, L.1
Zhang, S.2
Yao, J.3
Lowery, F.J.4
Zhang, Q.5
Huang, W.C.6
-
25
-
-
84933515262
-
Melanoma brain colonization involves the emergence of a brain-adaptive phenotype
-
Nygaard V, Prasmickaite L, Vasiliauskaite K, Clancy T, Hovig E. Melanoma brain colonization involves the emergence of a brain-adaptive phenotype. Oncoscience 2014;1:82-94.
-
(2014)
Oncoscience
, vol.1
, pp. 82-94
-
-
Nygaard, V.1
Prasmickaite, L.2
Vasiliauskaite, K.3
Clancy, T.4
Hovig, E.5
-
26
-
-
80054793877
-
Cross-species hybridization of microarrays for studying tumor transcriptome of brain metastasis
-
Park ES, Kim SJ, Kim SW, Yoon SL, Leem SH, Kim SB, et al. Cross-species hybridization of microarrays for studying tumor transcriptome of brain metastasis. Proc Natl Acad Sci U S A 2011;108:17456-61.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 17456-17461
-
-
Park, E.S.1
Kim, S.J.2
Kim, S.W.3
Yoon, S.L.4
Leem, S.H.5
Kim, S.B.6
-
27
-
-
84927689875
-
Astrocytes facilitate melanoma brain metastasis via secretion of IL-23
-
Klein A, Schwartz H, Sagi-Assif O, Meshel T, Izraely S, Ben Menachem S, et al. Astrocytes facilitate melanoma brain metastasis via secretion of IL-23. J Pathol 2015;236:116-27.
-
(2015)
J Pathol
, vol.236
, pp. 116-127
-
-
Klein, A.1
Schwartz, H.2
Sagi-Assif, O.3
Meshel, T.4
Izraely, S.5
Ben Menachem, S.6
|