Approach to the Treatment of Diabetic Ketoacidosis

American Journal of Kidney Diseases

Volumn 68, Issue 6, 2016, Pages 967-972

  Kamel, Kamel S ^a,b   Schreiber, Martin ^a   Carlotti, Ana P C P ^c   Halperin, Mitchell L ^a,b  

^a ST MICHAEL'S HOSPITAL   (Canada)

^b ST MICHAEL'S HOSPITAL   (Canada)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

acidemia; cerebral edema; Diabetic ketoacidosis (DKA); hypokalemia; metabolic acidosis; type 1 diabetes mellitus (T1DM)

Indexed keywords

BICARBONATE; INSULIN; POTASSIUM; POTASSIUM CHLORIDE; SODIUM CHLORIDE;

ACIDEMIA; ADOLESCENT; ARTICLE; BICARBONATE BLOOD LEVEL; BRAIN EDEMA; CARBON DIOXIDE TENSION; CASE REPORT; DIABETIC KETOACIDOSIS; FLUID THERAPY; HEART ARRHYTHMIA; HUMAN; HYPOKALEMIA; MALE; PATHOPHYSIOLOGY; PLASMA OSMOLALITY; POTASSIUM BLOOD LEVEL; TREATMENT INDICATION;

ADOLESCENT; DIABETIC KETOACIDOSIS; HUMANS; MALE; POTASSIUM CHLORIDE; SODIUM BICARBONATE;

EID: 84995467396     PISSN: 02726386     EISSN: 15236838     Source Type: Journal    
DOI: 10.1053/j.ajkd.2016.05.034     Document Type: Article

References (31)

1. 1 Kitabchi, A.E., Umpierrez, G.E., Miles, J.M., Fisher, J.N., Hyperglycemic crises in adult patients with diabetes. Diabetes Care 32:7 (2009), 1335–1343.
2. 2 Foster, D.W., Banting lecture 1984. From glycogen to ketones–and back. Diabetes 33:12 (1984), 1188–1199.
3. 3 Sperling, M.A., Cerebral edema in diabetic ketoacidosis: an underestimated complication?. Pediatr Diabetes 7:2 (2006), 73–74.
4. 4 Glaser, N., Barnett, P., McCaslin, I., et al. Risk factors for cerebral edema in children with diabetic ketoacidosis. The Pediatric Emergency Medicine Collaborative Research Committee of the American Academy of Pediatrics. N Engl J Med 344:4 (2001), 264–269.
5. 5 Brown, T.B., Cerebral oedema in childhood diabetic ketoacidosis: is treatment a factor?. Emerg Med J 21:2 (2004), 141–144.
6. 6 Halperin, M.L., Maccari, C., Kamel, K.S., Carlotti, A.P., Bohn, D., Strategies to diminish the danger of cerebral edema in a pediatric patient presenting with diabetic ketoacidosis. Pediatr Diabetes 7:4 (2006), 191–195.
7. 7 Van der Meulen, J.A., Klip, A., Grinstein, S., Possible mechanism for cerebral oedema in diabetic ketoacidosis. Lancet 2:8554 (1987), 306–308.
8. 8 Wu, D., Kraut, J.A., Role of NHE1 in the cellular dysfunction of acute metabolic acidosis. Am J Nephrol 40:1 (2014), 36–42.
9. 9 MacGregor, I.L., Gueller, R., Watts, H.D., Meyer, J.H., The effect of acute hyperglycemia on gastric emptying in man. Gastroenterology 70:2 (1976), 190–196.
10. 10 Carlotti, A.P., St George-Hyslop, C., Guerguerian, A.M., Bohn, D., Kamel, K.S., Halperin, M., Occult risk factor for the development of cerebral edema in children with diabetic ketoacidosis: possible role for stomach emptying. Pediatr Diabetes 10:8 (2009), 522–533.
11. 11 Shafiee, M.A., Charest, A.F., Cheema-Dhadli, S., et al. Defining conditions that lead to the retention of water: the importance of the arterial sodium concentration. Kidney Int 67:2 (2005), 613–621.
12. 12 Beigelman, P.M., Potassium in severe diabetic ketoacidosis. Am J Med 54:4 (1973), 419–420.
13. 13 Adrogue, H.J., Lederer, E.D., Suki, W.N., Eknoyan, G., Determinants of plasma potassium levels in diabetic ketoacidosis. Medicine 65:3 (1986), 163–172.
14. 14 Canadian Diabetes Association Clinical Practice Guidelines Expert Committee, Goguen, J., Gilbert, J., Hyperglycemic emergencies in adults. Can J Diabetes 37:suppl 1 (2013), S72–S76.
15. 15 Clausen, T., Everts, M.E., Regulation of the Na,K-pump in skeletal muscle. Kidney Int 35:1 (1989), 1–13.
16. 16 Gowrishankar, M., Kamel, K.S., Halperin, M.L., A brain protein centered view of H+ buffering. J Am Soc Nephrol 18:8 (2007), 2278–2280.
17. 17 Hoorn, E.J., Carlotti, A.P., Costa, L.A., et al. Preventing a drop in effective plasma osmolality to minimize the likelihood of cerebral edema during treatment of children with diabetic ketoacidosis. J Pediatr 150:5 (2007), 467–473.
18. 18 Katz, M.A., Hyperglycemia-induced hyponatremia–calculation of expected serum sodium depression. N Engl J Med 289:16 (1973), 843–844.
19. 19 Hillier, T.A., Abbott, R.D., Barrett, E.J., Hyponatremia: evaluating the correction factor for hyperglycemia. Am J Med 106:4 (1999), 399–403.
20. 20 Napolova, O., Urbach, S., Davids, M.R., Halperin, M.L., Assessing the degree of extracellular fluid volume contraction in a patient with a severe degree of hyperglycaemia. Nephrol Dial Transplant 18:12 (2003), 2674–2677.
21. 21 Wolfsdorf, J., Craig, M.E., Daneman, D., et al. Diabetic ketoacidosis in children and adolescents with diabetes. Pediatr Diabetes 10:suppl 12 (2009), 118–133.
22. 22 Dunger, D.B., Sperling, M.A., Acerini, C.L., et al. European Society for Paediatric Endocrinology/Lawson Wilkins Pediatric Endocrine Society consensus statement on diabetic ketoacidosis in children and adolescents. Pediatrics 113:2 (2004), e133–e140.
23. 23 Savage, M.W., Dhatariya, K.K., Kilvert, A., et al. Joint British Diabetes Societies guideline for the management of diabetic ketoacidosis. Diabet Med 28:5 (2011), 508–515.
24. 24 Gamba, G., Oseguera, J., Castrejon, M., Gomez-Perez, F.J., Bicarbonate therapy in severe diabetic ketoacidosis. A double blind, randomized, placebo controlled trial. Rev Invest Clin 43:3 (1991), 234–238.
25. 25 Hale, P.J., Crase, J., Nattrass, M., Metabolic effects of bicarbonate in the treatment of diabetic ketoacidosis. Br Med J 289:6451 (1984), 1035–1038.
26. 26 Morris, L.R., Murphy, M.B., Kitabchi, A.E., Bicarbonate therapy in severe diabetic ketoacidosis. Ann Intern Med 105:6 (1986), 836–840.
27. 27 Balaban, R.S., Mandel, L.J., Coupling of aerobic metabolism to active ion transport in the kidney. J Physiol 304 (1980), 331–348.
28. 28 Owen, O.E., Felig, P., Morgan, A.P., Wahren, J., Cahill, G.F. Jr., Liver and kidney metabolism during prolonged starvation. J Clin Invest 48:3 (1969), 574–583.
29. 29 Kamel, S.K., Lin, S.H., Cheema-Dhadli, S., Marliss, E.B., Halperin, M.L., Prolonged total fasting: a feast for the integrative physiologist. Kidney Int 53:3 (1998), 531–539.
30. 30 Kamel, K.S., Halperin, M.L., Acid-base problems in diabetic ketoacidosis. N Engl J Med 372:6 (2015), 546–554.
31. 31 Zipf, W.B., Bacon, G.E., Spencer, M.L., Kelch, R.P., Hopwood, N.J., Hawker, C.D., Hypocalcemia, hypomagnesemia, and transient hypoparathyroidism during therapy with potassium phosphate in diabetic ketoacidosis. Diabetes Care 2:3 (1979), 265–268.