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Volumn 110, Issue , 2017, Pages 31-38

Determination of nanostructures and drug distribution in lipid nanoparticles by single molecule microscopy

Author keywords

Drug delivery systems; Drug loading; Fluorescence superresolution microscopy; Lipid nanoparticles; Nanostructured lipid carriers; Single particle tracking; TIRF microscopy

Indexed keywords

DRUG CARRIER; FLUORESCENT DYE; MIGLYOL; NANOMATERIAL; SOLID LIPID NANOPARTICLE; LIPID; NANOPARTICLE; OIL;

EID: 84994908915     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2016.10.020     Document Type: Article
Times cited : (24)

References (43)
  • 1
    • 79956102907 scopus 로고    scopus 로고
    • 20 years of lipid nanoparticles (SLN and NLC): present state of development and industrial applications
    • [1] Müller, R.H., Shegokar, R., Keck, C.M., 20 years of lipid nanoparticles (SLN and NLC): present state of development and industrial applications. Curr. Drug. Discov. Technol. 8 (2011), 207-227.
    • (2011) Curr. Drug. Discov. Technol. , vol.8 , pp. 207-227
    • Müller, R.H.1    Shegokar, R.2    Keck, C.M.3
  • 2
    • 85051905091 scopus 로고    scopus 로고
    • Partikelgrößenanalytik für Nanopartikel - Ein Kinderspiel oder doch eine verflixte Kiste?
    • [2] Keck, C.M., Partikelgrößenanalytik für Nanopartikel - Ein Kinderspiel oder doch eine verflixte Kiste?. TechnoPharm 4 (2012), 279-287.
    • (2012) TechnoPharm , vol.4 , pp. 279-287
    • Keck, C.M.1
  • 3
    • 33646106067 scopus 로고    scopus 로고
    • Structural investigations on nanoemulsions, solid lipid nanoparticles and nanostructured lipid carriers by cryo-field emission scanning electron microscopy and Raman spectroscopy
    • [3] Saupe, A., Gordon, K.C., Rades, T., Structural investigations on nanoemulsions, solid lipid nanoparticles and nanostructured lipid carriers by cryo-field emission scanning electron microscopy and Raman spectroscopy. Int. J. Pharm. 314 (2006), 56-62.
    • (2006) Int. J. Pharm. , vol.314 , pp. 56-62
    • Saupe, A.1    Gordon, K.C.2    Rades, T.3
  • 4
    • 1242338847 scopus 로고    scopus 로고
    • Investigations on the structure of solid lipid nanoparticles (SLN) and oil-loaded solid lipid nanoparticles by photon correlation spectroscopy, field-flow fractionation and transmission electron microscopy
    • [4] Jores, K., Mehnert, W., Drechsler, M., Bunjes, H., Johann, C., Mader, K., Investigations on the structure of solid lipid nanoparticles (SLN) and oil-loaded solid lipid nanoparticles by photon correlation spectroscopy, field-flow fractionation and transmission electron microscopy. J. Control. Release 95 (2004), 217-227.
    • (2004) J. Control. Release , vol.95 , pp. 217-227
    • Jores, K.1    Mehnert, W.2    Drechsler, M.3    Bunjes, H.4    Johann, C.5    Mader, K.6
  • 5
    • 0037723990 scopus 로고    scopus 로고
    • Scanning electron microscopy and atomic force microscopy imaging of solid lipid nanoparticles derived from amphiphilic cyclodextrins
    • [5] Dubes, A., Parrot-Lopez, H., Abdelwahed, W., Degobert, G., Fessi, H., Shahgaldian, P., Coleman, A.W., Scanning electron microscopy and atomic force microscopy imaging of solid lipid nanoparticles derived from amphiphilic cyclodextrins. Eur. J. Pharm. Biopharm. 55 (2003), 279-282.
    • (2003) Eur. J. Pharm. Biopharm. , vol.55 , pp. 279-282
    • Dubes, A.1    Parrot-Lopez, H.2    Abdelwahed, W.3    Degobert, G.4    Fessi, H.5    Shahgaldian, P.6    Coleman, A.W.7
  • 6
    • 0034950251 scopus 로고    scopus 로고
    • Incorporation of the model drug ubidecarenone into solid lipid nanoparticles
    • [6] Bunjes, H., Drechsler, M., Koch, M.H.J., Westesen, K., Incorporation of the model drug ubidecarenone into solid lipid nanoparticles. Pharm. Res. 18 (2001), 287-293.
    • (2001) Pharm. Res. , vol.18 , pp. 287-293
    • Bunjes, H.1    Drechsler, M.2    Koch, M.H.J.3    Westesen, K.4
  • 8
    • 77953356716 scopus 로고    scopus 로고
    • Optimization and physicochemical characterization of a triamcinolone acetonide-loaded NLC for ocular antiangiogenic applications
    • [8] Araujo, J., Gonzalez-Mira, E., Egea, M.A., Garcia, M.L., Souto, E.B., Optimization and physicochemical characterization of a triamcinolone acetonide-loaded NLC for ocular antiangiogenic applications. Int. J. Pharm. 393 (2010), 167-175.
    • (2010) Int. J. Pharm. , vol.393 , pp. 167-175
    • Araujo, J.1    Gonzalez-Mira, E.2    Egea, M.A.3    Garcia, M.L.4    Souto, E.B.5
  • 9
    • 77955053464 scopus 로고    scopus 로고
    • Nanostructured lipid carriers for parenteral delivery of silybin: Biodistribution and pharmacokinetic studies
    • [9] Jia, L.J., Zhang, D.R., Li, Z.Y., Duan, C.X., Wang, Y.C., Feng, F.F., Wang, F.H., Liu, Y., Zhang, Q.A., Nanostructured lipid carriers for parenteral delivery of silybin: Biodistribution and pharmacokinetic studies. Colloids Surf., B 80 (2010), 213-218.
    • (2010) Colloids Surf., B , vol.80 , pp. 213-218
    • Jia, L.J.1    Zhang, D.R.2    Li, Z.Y.3    Duan, C.X.4    Wang, Y.C.5    Feng, F.F.6    Wang, F.H.7    Liu, Y.8    Zhang, Q.A.9
  • 12
    • 0037151496 scopus 로고    scopus 로고
    • Nanostructured lipid matrices for improved microencapsulation of drugs
    • [12] Müller, R.H., Radtke, M., Wissing, S.A., Nanostructured lipid matrices for improved microencapsulation of drugs. Int. J. Pharm. 242 (2002), 121-128.
    • (2002) Int. J. Pharm. , vol.242 , pp. 121-128
    • Müller, R.H.1    Radtke, M.2    Wissing, S.A.3
  • 13
    • 84869159030 scopus 로고    scopus 로고
    • Nanostructured Lipid Carriers: a potential drug carrier for cancer chemotherapy
    • [13] Selvamuthukumar, S., Velmurugan, R., Nanostructured Lipid Carriers: a potential drug carrier for cancer chemotherapy. Lipids Health Dis., 11, 2012.
    • (2012) Lipids Health Dis. , vol.11
    • Selvamuthukumar, S.1    Velmurugan, R.2
  • 17
    • 84894288569 scopus 로고    scopus 로고
    • Nanodynamics of dendritic core-multishell nanocarriers
    • [17] Boreham, A., Pfaff, M., Fleige, E., Haag, R., Alexiev, U., Nanodynamics of dendritic core-multishell nanocarriers. Langmuir 30 (2014), 1686-1695.
    • (2014) Langmuir , vol.30 , pp. 1686-1695
    • Boreham, A.1    Pfaff, M.2    Fleige, E.3    Haag, R.4    Alexiev, U.5
  • 18
    • 85000717981 scopus 로고    scopus 로고
    • Detecting and quantifying biomolecular interactions of a dendritic polyglycerol sulfate nanoparticle using fluorescence lifetime measurements
    • [18] Boreham, A., Pikkemaat, J., Volz, P., Brodwolf, R., Kuehne, C., Licha, K., Haag, R., Dernedde, J., Alexiev, U., Detecting and quantifying biomolecular interactions of a dendritic polyglycerol sulfate nanoparticle using fluorescence lifetime measurements. Molecules, 21, 2016.
    • (2016) Molecules , vol.21
    • Boreham, A.1    Pikkemaat, J.2    Volz, P.3    Brodwolf, R.4    Kuehne, C.5    Licha, K.6    Haag, R.7    Dernedde, J.8    Alexiev, U.9
  • 19
    • 84876666769 scopus 로고    scopus 로고
    • Spatially resolved two-color diffusion measurements in human skin applied to transdermal liposome penetration
    • [19] Brewer, J., Bloksgaard, M., Kubiak, J., Sorensen, J.A., Bagatolli, L.A., Spatially resolved two-color diffusion measurements in human skin applied to transdermal liposome penetration. J. Invest. Dermatol. 133 (2013), 1260-1268.
    • (2013) J. Invest. Dermatol. , vol.133 , pp. 1260-1268
    • Brewer, J.1    Bloksgaard, M.2    Kubiak, J.3    Sorensen, J.A.4    Bagatolli, L.A.5
  • 20
  • 21
    • 84872034254 scopus 로고    scopus 로고
    • Studying the protein corona on nanoparticles by FCS
    • [21] Nienhaus, G.U., Maffre, P., Nienhaus, K., Studying the protein corona on nanoparticles by FCS. Methods Enzymol. 519 (2013), 115-137.
    • (2013) Methods Enzymol. , vol.519 , pp. 115-137
    • Nienhaus, G.U.1    Maffre, P.2    Nienhaus, K.3
  • 22
    • 0026528045 scopus 로고
    • Tracking of cell-surface receptors by fluorescence digital imaging microscopy using a charge-coupled device camera - low-density-lipoprotein and influenza-virus receptor mobility at 4-degrees-C
    • [22] Anderson, C.M., Georgiou, G.N., Morrison, I.E.G., Stevenson, G.V.W., Cherry, R.J., Tracking of cell-surface receptors by fluorescence digital imaging microscopy using a charge-coupled device camera - low-density-lipoprotein and influenza-virus receptor mobility at 4-degrees-C. J. Cell Sci. 101 (1992), 415-425.
    • (1992) J. Cell Sci. , vol.101 , pp. 415-425
    • Anderson, C.M.1    Georgiou, G.N.2    Morrison, I.E.G.3    Stevenson, G.V.W.4    Cherry, R.J.5
  • 24
    • 0025997180 scopus 로고
    • Single-particle tracking - analysis of diffusion and flow in 2-dimensional systems
    • [24] Qian, H., Sheetz, M.P., Elson, E.L., Single-particle tracking - analysis of diffusion and flow in 2-dimensional systems. Biophys. J. 60 (1991), 910-921.
    • (1991) Biophys. J. , vol.60 , pp. 910-921
    • Qian, H.1    Sheetz, M.P.2    Elson, E.L.3
  • 27
    • 33749026335 scopus 로고    scopus 로고
    • Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM)
    • [27] Rust, M.J., Bates, M., Zhuang, X.W., Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM). Nat. Methods 3 (2006), 793-795.
    • (2006) Nat. Methods , vol.3 , pp. 793-795
    • Rust, M.J.1    Bates, M.2    Zhuang, X.W.3
  • 28
    • 81755166179 scopus 로고    scopus 로고
    • Activation and molecular recognition of the GPCR rhodopsin - insights from time-resolved fluorescence depolarisation and single molecule experiments
    • [28] Kim, T.Y., Schlieter, T., Haase, S., Alexiev, U., Activation and molecular recognition of the GPCR rhodopsin - insights from time-resolved fluorescence depolarisation and single molecule experiments. Eur. J. Cell Biol. 91 (2012), 300-310.
    • (2012) Eur. J. Cell Biol. , vol.91 , pp. 300-310
    • Kim, T.Y.1    Schlieter, T.2    Haase, S.3    Alexiev, U.4
  • 29
    • 76249091631 scopus 로고    scopus 로고
    • Functional interaction structures of the photochromic retinal protein rhodopsin
    • [29] Kirchberg, K., Kim, T.Y., Haase, S., Alexiev, U., Functional interaction structures of the photochromic retinal protein rhodopsin. Photochem. Photobiol. Sci. 9 (2010), 226-233.
    • (2010) Photochem. Photobiol. Sci. , vol.9 , pp. 226-233
    • Kirchberg, K.1    Kim, T.Y.2    Haase, S.3    Alexiev, U.4
  • 30
    • 67650762824 scopus 로고    scopus 로고
    • Super-resolution fluorescence microscopy
    • [30] Huang, B., Bates, M., Zhuang, X.W., Super-resolution fluorescence microscopy. Annu. Rev. Biochem. 78 (2009), 993-1016.
    • (2009) Annu. Rev. Biochem. , vol.78 , pp. 993-1016
    • Huang, B.1    Bates, M.2    Zhuang, X.W.3
  • 31
    • 84866509897 scopus 로고    scopus 로고
    • Nanostructured Lipid Carriers (NLC)-based gel for the topical delivery of aceclofenac: preparation, characterization, and in vivo evaluation
    • [31] Patel, D., Dasgupta, S., Dey, S., Ramani, Y.R., Ray, S., Mazumder, B., Nanostructured Lipid Carriers (NLC)-based gel for the topical delivery of aceclofenac: preparation, characterization, and in vivo evaluation. Sci. Pharm. 80 (2012), 749-764.
    • (2012) Sci. Pharm. , vol.80 , pp. 749-764
    • Patel, D.1    Dasgupta, S.2    Dey, S.3    Ramani, Y.R.4    Ray, S.5    Mazumder, B.6
  • 32
    • 84897116696 scopus 로고
    • Fluorescence spectroscopy of rhodopsins: insights and approaches
    • [32] Alexiev, U., Farrens, D.L., Fluorescence spectroscopy of rhodopsins: insights and approaches. Biochim. Biophys. Acta, Bioenerg. 2014 (1837), 694-709.
    • (1837) Biochim. Biophys. Acta, Bioenerg. , vol.2014 , pp. 694-709
    • Alexiev, U.1    Farrens, D.L.2
  • 33
    • 66149122990 scopus 로고    scopus 로고
    • Monitoring the interaction of a single G-protein key binding site with rhodopsin disk membranes upon light activation
    • [33] Kim, T.Y., Uji-i, H., Moller, M., Muls, B., Hofkens, J., Alexiev, U., Monitoring the interaction of a single G-protein key binding site with rhodopsin disk membranes upon light activation. Biochemistry 48 (2009), 3801-3803.
    • (2009) Biochemistry , vol.48 , pp. 3801-3803
    • Kim, T.Y.1    Uji-i, H.2    Moller, M.3    Muls, B.4    Hofkens, J.5    Alexiev, U.6
  • 34
    • 84982225677 scopus 로고    scopus 로고
    • Application of single molecule fluorescence microscopy to characterize the penetration of a large amphiphilic molecule in the stratum corneum of human skin
    • [34] Volz, P., Boreham, A., Wolf, A., Kim, T.Y., Balke, J., Frombach, J., Hadam, S., Afraz, Z., Rancan, F., Blume-Peytavi, U., Vogt, A., Alexiev, U., Application of single molecule fluorescence microscopy to characterize the penetration of a large amphiphilic molecule in the stratum corneum of human skin. Int. J. Mol. Sci. 16 (2015), 6960-6977.
    • (2015) Int. J. Mol. Sci. , vol.16 , pp. 6960-6977
    • Volz, P.1    Boreham, A.2    Wolf, A.3    Kim, T.Y.4    Balke, J.5    Frombach, J.6    Hadam, S.7    Afraz, Z.8    Rancan, F.9    Blume-Peytavi, U.10    Vogt, A.11    Alexiev, U.12
  • 35
    • 0035834064 scopus 로고    scopus 로고
    • High intranuclear mobility and dynamic clustering of the splicing factor U1 snRNP observed by single particle tracking
    • [35] Kues, T., Dickmanns, A., Luhrmann, R., Peters, R., Kubitscheck, U., High intranuclear mobility and dynamic clustering of the splicing factor U1 snRNP observed by single particle tracking. Proc. Natl. Acad. Sci. USA 98 (2001), 12021-12026.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 12021-12026
    • Kues, T.1    Dickmanns, A.2    Luhrmann, R.3    Peters, R.4    Kubitscheck, U.5
  • 36
    • 84994834671 scopus 로고
    • 6. Random Chords in the Circle and the Sphere
    • Society for Industrial and Applied Mathematics
    • [36] Solomon, H., 6. Random Chords in the Circle and the Sphere. Geometric Probability, 1978, Society for Industrial and Applied Mathematics, 127-172.
    • (1978) Geometric Probability , pp. 127-172
    • Solomon, H.1
  • 37
    • 0027197103 scopus 로고
    • Lateral diffusion in an archipelago. Single-particle diffusion
    • [37] Saxton, M.J., Lateral diffusion in an archipelago. Single-particle diffusion. Biophys. J. 64 (1993), 1766-1780.
    • (1993) Biophys. J. , vol.64 , pp. 1766-1780
    • Saxton, M.J.1
  • 40
    • 28244474457 scopus 로고    scopus 로고
    • Lipid nanoparticles for skin penetration enhancement-correlation to drug localization within the particle matrix as determined by fluorescence and parelectric spectroscopy
    • [40] Borgia, S.L., Regehly, M., Sivaramakrishnan, R., Mehnert, W., Korting, H.C., Danker, K., Roder, B., Kramer, K.D., Schafer-Korting, M., Lipid nanoparticles for skin penetration enhancement-correlation to drug localization within the particle matrix as determined by fluorescence and parelectric spectroscopy. J. Control. Release 110 (2005), 151-163.
    • (2005) J. Control. Release , vol.110 , pp. 151-163
    • Borgia, S.L.1    Regehly, M.2    Sivaramakrishnan, R.3    Mehnert, W.4    Korting, H.C.5    Danker, K.6    Roder, B.7    Kramer, K.D.8    Schafer-Korting, M.9
  • 41
    • 27144481028 scopus 로고    scopus 로고
    • Solid lipid nanoparticles (SLN) and oil-loaded SLN studied by spectrofluorometry and Raman spectroscopy
    • [41] Jores, K., Haberland, A., Wartewig, S., Mader, K., Mehnert, W., Solid lipid nanoparticles (SLN) and oil-loaded SLN studied by spectrofluorometry and Raman spectroscopy. Pharm. Res. 22 (2005), 1887-1897.
    • (2005) Pharm. Res. , vol.22 , pp. 1887-1897
    • Jores, K.1    Haberland, A.2    Wartewig, S.3    Mader, K.4    Mehnert, W.5
  • 42
    • 84908542101 scopus 로고    scopus 로고
    • Oil-enriched, ultra-small nanostructured lipid carriers (usNLC): a novel delivery system based on flip-flop structure
    • [42] Keck, C.M., Baisaeng, N., Durand, P., Prost, M., Meinke, M.C., Muller, R.H., Oil-enriched, ultra-small nanostructured lipid carriers (usNLC): a novel delivery system based on flip-flop structure. Int. J. Pharm. 477 (2014), 227-235.
    • (2014) Int. J. Pharm. , vol.477 , pp. 227-235
    • Keck, C.M.1    Baisaeng, N.2    Durand, P.3    Prost, M.4    Meinke, M.C.5    Muller, R.H.6
  • 43
    • 85038880785 scopus 로고    scopus 로고
    • smartLipids - the next generation of lipid nanoparticles by optimized design of particle matrix
    • 24-26. September, Frankfurt a.M./Germany, po.
    • [43] R.H. Müller, R. Ruick, C.M. Keck, smartLipids - the next generation of lipid nanoparticles by optimized design of particle matrix, in: DPhG-Jahrestagung, 24-26. September, Frankfurt a.M./Germany, po. 27 2014, pp. 27.
    • (2014) DPhG-Jahrestagung , vol.27 , pp. 27
    • Müller, R.H.1    Ruick, R.2    Keck, C.M.3


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