PPAR-γ regulates pharmacological but not physiological or pathological osteoclast formation

Nature Medicine

Volumn 22, Issue 11, 2016, Pages 1203-1205

  Zou, Wei ^a   Rohatgi, Nidhi ^a   Chen, Timothy Hung Po ^a   Schilling, Joel ^a   Abu Amer, Yousef ^a   Teitelbaum, Steven L ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN K; COLONY STIMULATING FACTOR 1; CRE RECOMBINASE; OSTEOCLAST DIFFERENTIATION FACTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; 2,4 THIAZOLIDINEDIONE DERIVATIVE;

BONE MASS; CELL LINEAGE; GENE DELETION; GENE EXPRESSION; GENETIC CODE; LETTER; MICRO-COMPUTED TOMOGRAPHY; MUSCULOSKELETAL FUNCTION; NONHUMAN; OSTEOCLAST; OSTEOCLASTOGENESIS; OSTEOLYSIS; PATHOGENESIS; PHARMACOLOGICAL PARAMETERS; PHENOTYPE; PRIORITY JOURNAL; TRABECULAR BONE; AGONISTS; ANIMAL; BONE DEVELOPMENT; DRUG EFFECTS; FLOW CYTOMETRY; FRACTURE; GENE KNOCKDOWN; GENETICS; HUMAN; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS;

ANIMALS; DIABETES MELLITUS, TYPE 2; FLOW CYTOMETRY; FRACTURES, BONE; GENE KNOCKDOWN TECHNIQUES; HUMANS; MACROPHAGE COLONY-STIMULATING FACTOR; MICE; OSTEOCLASTS; OSTEOGENESIS; PPAR GAMMA; RANK LIGAND; THIAZOLIDINEDIONES;

EID: 84994853932     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.4208     Document Type: Letter

References (12)

1. Grey, A. Diabetes Obes. Metab. 11, 275-284 (2009).
2. Wan, Y., Chong, L.W. & Evans, R.M. Nat. Med. 13, 1496-1503 (2007).
3. Fukunaga, T., Zou, W., Rohatgi, N., Colca, J.R. & Teitelbaum, S.L. J. Bone Miner. Res. 30, 481-488 (2015).
4. Korganow, A.S. et al. Immunity 10, 451-461 (1999).
5. Clausen, B.E., Burkhardt, C., Reith, W., Renkawitz, R. & Förster, I. Transgenic Res. 8, 265-277 (1999).
6. Maeda, K. et al. Nat. Med. 18, 405-412 (2012).
7. de Boer, J. et al. Eur. J. Immunol. 33, 314-325 (2003).
8. McCommis, K.S. et al. Cell Metab. 22, 682-694 (2015).
9. Chen, Z. et al. J. Biol. Chem. 287, 23537-23548 (2012).
10. Wei, W. et al. Mol. Cell. Biol. 31, 4692-4705 (2011).
11. Izawa, T. et al. Cell Rep. 11, 1625-1637 (2015).
12. Lam, J. et al. J. Clin. Invest. 106, 1481-1488 (2000).