A Guardian Angel Phosphatase for Mainline Carbon Metabolism

Trends in Biochemical Sciences

Volumn 41, Issue 11, 2016, Pages 893-894

  Beaudoin, Guillaume A ^a   Hanson, Andrew D ^a  

^a UNIVERSITY OF FLORIDA   (United States)

Author keywords

glycolysis; metabolite damage; metabolite repair; phosphatase; side reaction

Indexed keywords

2 PHOSPHOLACTIC ACID; AMINO ACID; FRUCTOSE 2,6 BISPHOSPHATE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; PHOSPHATASE; PHOSPHOGLUCONATE DEHYDROGENASE; PHOSPHOGLYCOLATE PHOSPHATASE; PYRUVATE KINASE; UNCLASSIFIED DRUG; 2-PHOSPHOLACTIC ACID; 4-PHOSPHOERYTHRONATE; 6-PHOSPHOGLUCONIC ACID; FRUCTOSE 2,6-DIPHOSPHATE; FRUCTOSE BISPHOSPHATE; GLUCONIC ACID; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE (NADP); LACTIC ACID DERIVATIVE; PHO13 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN; SMALL INTERFERING RNA; SUGAR ACID;

CARBON METABOLISM; CELL DAMAGE; CHEMICAL REACTION; DNA DAMAGE; DNA REPAIR; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; GLYCOLYSIS; HUMAN; HYDROLYSIS; NONHUMAN; PRIORITY JOURNAL; SHORT SURVEY; SIGNAL TRANSDUCTION; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; GENETICS; METABOLISM; SACCHAROMYCES CEREVISIAE; SECONDARY METABOLISM;

FRUCTOSEDIPHOSPHATES; GLUCONATES; GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE (NADP+); GLYCOLYSIS; HUMANS; HYDROLYSIS; LACTATES; PHOSPHORIC MONOESTER HYDROLASES; PYRUVATE KINASE; RNA, SMALL INTERFERING; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SECONDARY METABOLISM; SUGAR ACIDS;

EID: 84994772022     PISSN: 09680004     EISSN: 13624326     Source Type: Journal    
DOI: 10.1016/j.tibs.2016.08.005     Document Type: Short Survey

References (10)

1. 1 Bar-Even, A., et al. Rethinking glycolysis: on the biochemical logic of metabolic pathways. Nat. Chem. Biol. 8 (2012), 509–517.
2. 2 Collard, F., et al. A conserved phosphatase destroys toxic glycolytic side products in mammals and yeast. Nat. Chem. Biol. 12 (2016), 601–607.
3. 3 Badwey, J.A., Phosphoglycolate phosphatase in human erythrocytes. J. Biol. Chem. 252 (1977), 2441–2443.
4. 4 Linster, C.L., et al. Metabolite damage and its repair or pre-emption. Nat. Chem. Biol. 9 (2013), 72–80.
5. 5 Hanson, A.D., et al. Metabolite damage and metabolite damage control in plants. Annu. Rev. Plant Biol. 67 (2016), 131–152.
6. 6 Bracher, A., et al. Degradation of potent Rubisco inhibitor by selective sugar phosphatase. Nat. Plants, 1, 2015, 14002.
7. 7 Andralojc, P.J., et al. 2-Carboxy-D-arabinitol 1-phosphate (CA1P) phosphatase: evidence for a wider role in plant Rubisco regulation. Biochem. J. 442 (2012), 733–742.
8. 8 Huang, L., et al. A family of metal-dependent phosphatases implicated in metabolite damage-control. Nat. Chem. Biol. 12 (2016), 621–627.
9. 9 Schwarte, S., Bauwe, H., Identification of the photorespiratory 2-phosphoglycolate phosphatase, PGLP1, in Arabidopsis. Plant Physiol. 144 (2007), 1580–1586.
10. 10 Pellicer, M.T., et al. Role of 2-phosphoglycolate phosphatase of Escherichia coli in metabolism of the 2-phosphoglycolate formed in DNA repair. J. Bacteriol. 185 (2003), 5815–5821.