-
1
-
-
33744527833
-
Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock
-
Kumar A, Roberts D, Wood KE et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 2006; 34: 1589-96.
-
(2006)
Crit Care Med
, vol.34
, pp. 1589-1596
-
-
Kumar, A1
Roberts, D2
Wood, KE3
-
2
-
-
84901006498
-
Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions
-
Roberts JA, Abdul-Aziz MH, Lipman J et al. Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions. Lancet Infect Dis 2014; 14: 498-509.
-
(2014)
Lancet Infect Dis
, vol.14
, pp. 498-509
-
-
Roberts, JA1
Abdul-Aziz, MH2
Lipman, J3
-
3
-
-
84897414453
-
DALI: defining antibiotic levels in intensive care unit patients: are current b-lactam antibiotic doses sufficient for critically ill patients?
-
Roberts JA, Paul SK, Akova M et al. DALI: defining antibiotic levels in intensive care unit patients: are current b-lactam antibiotic doses sufficient for critically ill patients? Clin Infect Dis 2014; 58: 1072-83.
-
(2014)
Clin Infect Dis
, vol.58
, pp. 1072-1083
-
-
Roberts, JA1
Paul, SK2
Akova, M3
-
4
-
-
84954287957
-
The ADMIN-ICU survey: a survey on antimicrobial dosing and monitoring in ICUs
-
Tabah A, DeWaele J, Lipman J et al. The ADMIN-ICU survey: a survey on antimicrobial dosing and monitoring in ICUs. J Antimicrob Chemother 2015; 70: 2671-7.
-
(2015)
J Antimicrob Chemother
, vol.70
, pp. 2671-2677
-
-
Tabah, A1
DeWaele, J2
Lipman, J3
-
5
-
-
84857059758
-
Comparative Activity of Carbapenem Testing (COMPACT) study in Germany
-
Valenza G, Seifert H, Decker-Burgard S et al. Comparative Activity of Carbapenem Testing (COMPACT) study in Germany. Int J Antimicrob Agents 2012; 39: 255-8.
-
(2012)
Int J Antimicrob Agents
, vol.39
, pp. 255-258
-
-
Valenza, G1
Seifert, H2
Decker-Burgard, S3
-
6
-
-
84858772073
-
Pseudomonas aeruginosa is not just in the intensive care unit any more: implications for empirical therapy
-
Eagye KJ, Banevicius MA, Nicolau DP. Pseudomonas aeruginosa is not just in the intensive care unit any more: implications for empirical therapy. Crit Care Med 2012; 40: 1329-32.
-
(2012)
Crit Care Med
, vol.40
, pp. 1329-1332
-
-
Eagye, KJ1
Banevicius, MA2
Nicolau, DP.3
-
7
-
-
84879197061
-
Pharmacokinetics of meropenem and piperacillin in critically ill patients with indwelling surgical drains
-
Adnan S, Li JX, Wallis SC et al. Pharmacokinetics of meropenem and piperacillin in critically ill patients with indwelling surgical drains. Int J Antimicrob Agents 2013; 42: 90-3.
-
(2013)
Int J Antimicrob Agents
, vol.42
, pp. 90-93
-
-
Adnan, S1
Li, JX2
Wallis, SC3
-
8
-
-
72449120921
-
First-dose and steady-state population pharmacokinetics and pharmacodynamics of piperacillin by continuous or intermittent dosing in critically ill patients with sepsis
-
Roberts JA, Kirkpatrick CM, Roberts MS et al. First-dose and steady-state population pharmacokinetics and pharmacodynamics of piperacillin by continuous or intermittent dosing in critically ill patients with sepsis. Int J Antimicrob Agents 2010; 35: 156-63.
-
(2010)
Int J Antimicrob Agents
, vol.35
, pp. 156-163
-
-
Roberts, JA1
Kirkpatrick, CM2
Roberts, MS3
-
9
-
-
0023594977
-
Development of resistance during antibiotic therapy
-
Milatovic D, Braveny I. Development of resistance during antibiotic therapy. Eur J Clin Microbiol 1987; 6: 234-44.
-
(1987)
Eur J Clin Microbiol
, vol.6
, pp. 234-244
-
-
Milatovic, D1
Braveny, I.2
-
10
-
-
33947197663
-
The epidemiology, pathogenesis and treatment of Pseudomonas aeruginosa infections
-
Driscoll JA, Brody SL, Kollef MH. The epidemiology, pathogenesis and treatment of Pseudomonas aeruginosa infections. Drugs 2007; 67: 351-68.
-
(2007)
Drugs
, vol.67
, pp. 351-368
-
-
Driscoll, JA1
Brody, SL2
Kollef, MH.3
-
11
-
-
84924271420
-
Are standard doses of piperacillin sufficient for critically ill patients with augmented creatinine clearance?
-
Udy AA, Lipman J, Jarrett P et al. Are standard doses of piperacillin sufficient for critically ill patients with augmented creatinine clearance? Crit Care 2015; 19: 28.
-
(2015)
Crit Care
, vol.19
, pp. 28
-
-
Udy, AA1
Lipman, J2
Jarrett, P3
-
12
-
-
49949099257
-
Antibiotic resistance-what's dosing got to do with it?
-
Roberts JA, Kruger P, Paterson DL et al. Antibiotic resistance-what's dosing got to do with it? Crit Care Med 2008; 36: 2433-40.
-
(2008)
Crit Care Med
, vol.36
, pp. 2433-2440
-
-
Roberts, JA1
Kruger, P2
Paterson, DL3
-
13
-
-
84887460013
-
Impact of bolus dosing versus continuous infusion of piperacillin and tazobactam on the development of antimicrobial resistance in Pseudomonas aeruginosa
-
Felton TW, Goodwin J, O'Connor L et al. Impact of bolus dosing versus continuous infusion of piperacillin and tazobactam on the development of antimicrobial resistance in Pseudomonas aeruginosa. Antimicrob Agents Chemother 2013; 57: 5811-9.
-
(2013)
Antimicrob Agents Chemother
, vol.57
, pp. 5811-5819
-
-
Felton, TW1
Goodwin, J2
O'Connor, L3
-
14
-
-
0021809096
-
Two compartment kinetic model with multiple artificial capillary units
-
Suppl A
-
Blaser J, Stone BB, Zinner SH. Two compartment kinetic model with multiple artificial capillary units. J Antimicrob Chemother 1985; 15 Suppl A: 131-7.
-
(1985)
J Antimicrob Chemother
, vol.15
, pp. 131-137
-
-
Blaser, J1
Stone, BB2
Zinner, SH.3
-
17
-
-
84948148424
-
Implications of augmented renal clearance on drug dosing in critically ill patients: a focus on antibiotics
-
Hobbs AL, Shea KM, Roberts KM et al. Implications of augmented renal clearance on drug dosing in critically ill patients: a focus on antibiotics. Pharmacotherapy 2015; 35: 1063-75.
-
(2015)
Pharmacotherapy
, vol.35
, pp. 1063-1075
-
-
Hobbs, AL1
Shea, KM2
Roberts, KM3
-
18
-
-
84930454984
-
Update in sepsis and acute kidney injury 2014
-
Schortgen F, Asfar P. Update in sepsis and acute kidney injury 2014.Am J Respir Crit Care Med 2015; 191: 1226-31.
-
(2015)
Am J Respir Crit Care Med
, vol.191
, pp. 1226-1231
-
-
Schortgen, F1
Asfar, P.2
-
21
-
-
84887622845
-
The hollow fibre infection model for antimicrobial pharmacodynamics and pharmacokinetics
-
Cadwell JJS. The hollow fibre infection model for antimicrobial pharmacodynamics and pharmacokinetics. Adv Pharmacoepidem Drug Safety 2012; doi:10.4172/2167-1052.S1-007.
-
(2012)
Adv Pharmacoepidem Drug Safety
-
-
Cadwell, JJS.1
-
22
-
-
84455161611
-
Pharmacodynamics of b-lactamase inhibition by NXL104 in combination with ceftaroline: examining organisms with multiple types of b-lactamases
-
Louie A, CastanheiraM, LiuWet al. Pharmacodynamics of b-lactamase inhibition by NXL104 in combination with ceftaroline: examining organisms with multiple types of b-lactamases. Antimicrob Agents Chemother 2012; 56: 258-70.
-
(2012)
Antimicrob Agents Chemother
, vol.56
, pp. 258-270
-
-
Louie, A1
Castanheira, M2
LiuWet, al.3
-
23
-
-
77954849218
-
Therapeutic drug monitoring of b-lactams in critically ill patients: proof of concept
-
Roberts JA, Ulldemolins M, Roberts MS et al. Therapeutic drug monitoring of b-lactams in critically ill patients: proof of concept. Int J Antimicrob Agents 2010; 36: 332-9.
-
(2010)
Int J Antimicrob Agents
, vol.36
, pp. 332-339
-
-
Roberts, JA1
Ulldemolins, M2
Roberts, MS3
-
24
-
-
0003484310
-
-
US Department of Health and Human Services, FDA, Center for Drug Evaluation and Research (CDER), Center for Veterinary Medicine (CVM). Rockville, MD, USA
-
US Department of Health and Human Services, FDA, Center for Drug Evaluation and Research (CDER), Center for Veterinary Medicine (CVM). Guidance for Industry. Bioanalytical Method Validation. Rockville, MD, USA, 2001. www.fda.gov/downloads/Drugs/Guidances/ucm070107.pdf.
-
(2001)
Guidance for Industry. Bioanalytical Method Validation
-
-
-
25
-
-
81055146012
-
-
EMA. London, UK
-
EMA. Guideline on Bioanalytical Method Validation. London, UK, 2011. www.ema.europa.eu/docs/en-GB/document-library/Scientific-guideline/2011/08/WC500109686.pdf.
-
(2011)
Guideline on Bioanalytical Method Validation
-
-
-
26
-
-
34247887681
-
A survey of population analysis methods and software for complex pharmacokinetic and pharmacodynamic models with examples
-
Bauer RJ, Guzy S, Ng C. A survey of population analysis methods and software for complex pharmacokinetic and pharmacodynamic models with examples. AAPS J 2007; 9: E60-83.
-
(2007)
AAPS J
, vol.9
, pp. E60-E83
-
-
Bauer, RJ1
Guzy, S2
Ng, C.3
-
27
-
-
79957468849
-
Performance and robustness of the Monte Carlo importance sampling algorithm using parallelized S-ADAPT for basic and complex mechanistic models
-
Bulitta JB, Landersdorfer CB. Performance and robustness of the Monte Carlo importance sampling algorithm using parallelized S-ADAPT for basic and complex mechanistic models. AAPS J 2011; 13: 212-26.
-
(2011)
AAPS J
, vol.13
, pp. 212-226
-
-
Bulitta, JB1
Landersdorfer, CB.2
-
28
-
-
79956327970
-
Development of a new pre- and post-processing tool (SADAPT-TRAN) for nonlinear mixed-effects modeling in S-ADAPT
-
Bulitta JB, Bingolbali A, Shin BS et al. Development of a new pre- and post-processing tool (SADAPT-TRAN) for nonlinear mixed-effects modeling in S-ADAPT. AAPS J 2011; 13: 201-11.
-
(2011)
AAPS J
, vol.13
, pp. 201-211
-
-
Bulitta, JB1
Bingolbali, A2
Shin, BS3
-
29
-
-
84930520421
-
Extracorporeal clearance of colistin methanesulphonate and formed colistin in end-stage renal disease patients receiving intermittent haemodialysis: implications for dosing
-
Jitmuang A, Nation RL, Koomanachai P et al. Extracorporeal clearance of colistin methanesulphonate and formed colistin in end-stage renal disease patients receiving intermittent haemodialysis: implications for dosing. J Antimicrob Chemother 2015; 70: 1804-11.
-
(2015)
J Antimicrob Chemother
, vol.70
, pp. 1804-1811
-
-
Jitmuang, A1
Nation, RL2
Koomanachai, P3
-
30
-
-
84876217985
-
Quantifying subpopulation synergy for antibiotic combinations via mechanism-based modeling and a sequential dosing design
-
Landersdorfer CB, Ly NS, Xu H et al. Quantifying subpopulation synergy for antibiotic combinations via mechanism-based modeling and a sequential dosing design. Antimicrob Agents Chemother 2013; 57: 2343-51.
-
(2013)
Antimicrob Agents Chemother
, vol.57
, pp. 2343-2351
-
-
Landersdorfer, CB1
Ly, NS2
Xu, H3
-
31
-
-
59749102442
-
Development and qualification of a pharmacodynamic model for the pronounced inoculum effect of ceftazidime against Pseudomonas aeruginosa
-
Bulitta JB, Ly NS, Yang JC et al. Development and qualification of a pharmacodynamic model for the pronounced inoculum effect of ceftazidime against Pseudomonas aeruginosa. Antimicrob Agents Chemother 2009; 53: 46-56.
-
(2009)
Antimicrob Agents Chemother
, vol.53
, pp. 46-56
-
-
Bulitta, JB1
Ly, NS2
Yang, JC3
-
32
-
-
84909992516
-
Interaction of drug- and granulocytemediated killing of Pseudomonas aeruginosa in a murine pneumonia model
-
Drusano GL, Liu W, Fikes S et al. Interaction of drug- and granulocytemediated killing of Pseudomonas aeruginosa in a murine pneumonia model. J Infect Dis 2014; 210: 1319-24.
-
(2014)
J Infect Dis
, vol.210
, pp. 1319-1324
-
-
Drusano, GL1
Liu, W2
Fikes, S3
-
33
-
-
0031952586
-
Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men
-
quiz 11-12
-
Craig WA. Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men. Clin Infect Dis 1998; 26: 1-10; quiz 11-12.
-
(1998)
Clin Infect Dis
, vol.26
, pp. 1-10
-
-
Craig, WA.1
-
34
-
-
0028279310
-
Killing of Pseudomonas aeruginosa during continuous and intermittent infusion of ceftazidime in an in vitro pharmacokinetic model
-
Mouton JW, den Hollander JG. Killing of Pseudomonas aeruginosa during continuous and intermittent infusion of ceftazidime in an in vitro pharmacokinetic model. Antimicrob Agents Chemother 1994; 38: 931-6.
-
(1994)
Antimicrob Agents Chemother
, vol.38
, pp. 931-936
-
-
Mouton, JW1
den Hollander, JG.2
-
35
-
-
2142760947
-
Antimicrobial pharmacodynamics: critical interactions of 'bug and drug'
-
Drusano GL. Antimicrobial pharmacodynamics: critical interactions of 'bug and drug'. Nat Rev Microbiol 2004; 2: 289-300.
-
(2004)
Nat Rev Microbiol
, vol.2
, pp. 289-300
-
-
Drusano, GL.1
-
36
-
-
34248328649
-
Clinical pharmacodynamics of meropenem in patients with lower respiratory tract infections
-
Li C, Du X, Kuti JL et al. Clinical pharmacodynamics of meropenem in patients with lower respiratory tract infections. Antimicrob Agents Chemother 2007; 51: 1725-30.
-
(2007)
Antimicrob Agents Chemother
, vol.51
, pp. 1725-1730
-
-
Li, C1
Du, X2
Kuti, JL3
-
37
-
-
40849085072
-
Evaluation of area under the inhibitory curve (AUIC) and time above the minimum inhibitory concentration (T.MIC) as predictors of outcome for cefepime and ceftazidime in serious bacterial infections
-
McKinnon PS, Paladino JA, Schentag JJ. Evaluation of area under the inhibitory curve (AUIC) and time above the minimum inhibitory concentration (T.MIC) as predictors of outcome for cefepime and ceftazidime in serious bacterial infections. Int J Antimicrob Agents 2008; 31: 345-51.
-
(2008)
Int J Antimicrob Agents
, vol.31
, pp. 345-351
-
-
McKinnon, PS1
Paladino, JA2
Schentag, JJ.3
-
38
-
-
84873390207
-
Optimal doripenem dosing simulations in critically ill nosocomial pneumonia patients with obesity, augmented renal clearance, and decreased bacterial susceptibility
-
Roberts JA, Lipman J. Optimal doripenem dosing simulations in critically ill nosocomial pneumonia patients with obesity, augmented renal clearance, and decreased bacterial susceptibility. Crit Care Med 2013; 41: 489-95.
-
(2013)
Crit Care Med
, vol.41
, pp. 489-495
-
-
Roberts, JA1
Lipman, J.2
-
39
-
-
84863807810
-
Subtherapeutic initial b-lactam concentrations in select critically ill patients: association between augmented renal clearance and low trough drug concentrations
-
Udy AA, Varghese JM, Altukroni M et al. Subtherapeutic initial b-lactam concentrations in select critically ill patients: association between augmented renal clearance and low trough drug concentrations. Chest 2012; 142: 30-9.
-
(2012)
Chest
, vol.142
, pp. 30-39
-
-
Udy, AA1
Varghese, JM2
Altukroni, M3
-
40
-
-
84907445421
-
Relationship between ceftolozane-tazobactam exposure and selection for Pseudomonas aeruginosa resistance in a hollow-fiber infection model
-
VanScoy BD, Mendes RE, Castanheira M et al. Relationship between ceftolozane-tazobactam exposure and selection for Pseudomonas aeruginosa resistance in a hollow-fiber infection model. Antimicrob Agents Chemother 2014; 58: 6024-31.
-
(2014)
Antimicrob Agents Chemother
, vol.58
, pp. 6024-6031
-
-
VanScoy, BD1
Mendes, RE2
Castanheira, M3
-
41
-
-
84928891833
-
Novel approach to optimize synergistic carbapenem-aminoglycoside combinations against carbapenem-resistant Acinetobacter baumannii
-
Yadav R, Landersdorfer CB, Nation RL et al. Novel approach to optimize synergistic carbapenem-aminoglycoside combinations against carbapenem-resistant Acinetobacter baumannii. Antimicrob Agents Chemother 2015; 59: 2286-98.
-
(2015)
Antimicrob Agents Chemother
, vol.59
, pp. 2286-2298
-
-
Yadav, R1
Landersdorfer, CB2
Nation, RL3
-
42
-
-
79955768964
-
Application of pharmacokineticpharmacodynamic modeling and the justification of a novel fusidic acid dosing regimen: raising Lazarus from the dead
-
Suppl 7
-
Tsuji BT, Okusanya OO, Bulitta JB et al. Application of pharmacokineticpharmacodynamic modeling and the justification of a novel fusidic acid dosing regimen: raising Lazarus from the dead. Clin Infect Dis 2011; 52 Suppl 7: S513-9.
-
(2011)
Clin Infect Dis
, vol.52
, pp. S513-S519
-
-
Tsuji, BT1
Okusanya, OO2
Bulitta, JB3
-
43
-
-
84926642966
-
Combination treatment with meropenem plus levofloxacin is synergistic against Pseudomonas aeruginosa infection in a murine model of pneumonia
-
Louie A, Liu W, VanGuilder M et al. Combination treatment with meropenem plus levofloxacin is synergistic against Pseudomonas aeruginosa infection in a murine model of pneumonia. J Infect Dis 2015; 211: 1326-33.
-
(2015)
J Infect Dis
, vol.211
, pp. 1326-1333
-
-
Louie, A1
Liu, W2
VanGuilder, M3
-
44
-
-
84455192457
-
Resistance emergence mechanism and mechanism of resistance suppression by tobramycin for cefepime for Pseudomonas aeruginosa
-
Drusano GL, Bonomo RA, Bahniuk N et al. Resistance emergence mechanism and mechanism of resistance suppression by tobramycin for cefepime for Pseudomonas aeruginosa. Antimicrob Agents Chemother 2012; 56: 231-42.
-
(2012)
Antimicrob Agents Chemother
, vol.56
, pp. 231-242
-
-
Drusano, GL1
Bonomo, RA2
Bahniuk, N3
-
45
-
-
77952650628
-
Impact of different carbapenems and regimens of administration on resistance emergence for three isogenic Pseudomonas aeruginosa strains with differing mechanisms of resistance
-
Louie A, Bied A, Fregeau C et al. Impact of different carbapenems and regimens of administration on resistance emergence for three isogenic Pseudomonas aeruginosa strains with differing mechanisms of resistance. Antimicrob Agents Chemother 2010; 54: 2638-45.
-
(2010)
Antimicrob Agents Chemother
, vol.54
, pp. 2638-2645
-
-
Louie, A1
Bied, A2
Fregeau, C3
-
46
-
-
22544468795
-
Bacterial-population responses to drug-selective pressure: examination of garenoxacin's effect on Pseudomonas aeruginosa
-
Tam VH, Louie A, Deziel MR et al. Bacterial-population responses to drug-selective pressure: examination of garenoxacin's effect on Pseudomonas aeruginosa. J Infect Dis 2005; 192: 420-8.
-
(2005)
J Infect Dis
, vol.192
, pp. 420-428
-
-
Tam, VH1
Louie, A2
Deziel, MR3
|