Outbreaks of colistin-resistant and colistin-susceptible KPC-producing Klebsiella pneumoniae in a Brazilian intensive care unit

Journal of Hospital Infection

Volumn 94, Issue 4, 2016, Pages 322-329

  Rossi Goncalves I ^a   Ferreira, M L ^a   Araujo, B F ^a   Campos, P A ^a   Royer, S ^a   Batistao D W F ^a   Souza, L P ^a   Brito, C S ^a   Urzedo, J E ^a   Gontijo Filho, P P ^a   Ribas, R M ^a  

^a FEDERAL UNIVERSITY OF UBERLÂNDIA   (Brazil)

Author keywords

Antimicrobial resistance; Carbapenem; Colistin; Intensive care unit; Klebsiella pneumoniae; Outbreak

Indexed keywords

ALCOHOL; AMIKACIN; CARBAPENEM; CARBAPENEM DERIVATIVE; CARBAPENEMASE; CEFAZOLIN; CEFEPIME; CEFTRIAXONE; COLISTIN; DISINFECTANT AGENT; ERTAPENEM; IMIPENEM; INCIDIN; LEVOFLOXACIN; MEROPENEM; PIPERACILLIN PLUS TAZOBACTAM; SULFAMETHOXAZOLE; TEICOPLANIN; UNCLASSIFIED DRUG; VANCOMYCIN; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; BETA LACTAMASE;

ADULT; AGED; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIAL TRANSMISSION; BACTERIUM ISOLATE; BLAKPC GENE; BRAZIL; BRAZILIAN; BROTH DILUTION; CLONAL VARIATION; CONTACT PRECAUTION; CONTROLLED STUDY; DISEASE SURVEILLANCE; DISINFECTION; DRUG USE; ENZYME SYNTHESIS; HAND WASHING; HEALTH CARE PERSONNEL; HOSPITAL ADMISSION; HOSPITAL HYGIENE; HUMAN; INFECTION CONTROL; INFECTION RISK; INTENSIVE CARE UNIT; KLEBSIELLA PNEUMONIAE; KLEBSIELLA PNEUMONIAE INFECTION; MAJOR CLINICAL STUDY; MICROBIOLOGICAL EXAMINATION; MIDDLE AGED; MORTALITY; NONHUMAN; PULSED FIELD GEL ELECTROPHORESIS; RECTAL SWAB; SURGICAL INFECTION; UNIVERSITY HOSPITAL; YOUNG ADULT; ADOLESCENT; CLASSIFICATION; DRUG EFFECTS; ENZYMOLOGY; EPIDEMIC; FEMALE; INFANT; ISOLATION AND PURIFICATION; KLEBSIELLA INFECTIONS; MALE; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; MOLECULAR TYPING; SECRETION (PROCESS); VERY ELDERLY;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAMASES; BRAZIL; COLISTIN; DISEASE OUTBREAKS; ELECTROPHORESIS, GEL, PULSED-FIELD; FEMALE; HOSPITALS, UNIVERSITY; HUMANS; INFANT; INTENSIVE CARE UNITS; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MALE; MICROBIAL SENSITIVITY TESTS; MIDDLE AGED; MOLECULAR TYPING; YOUNG ADULT;

EID: 84994713373     PISSN: 01956701     EISSN: 15322939     Source Type: Journal    
DOI: 10.1016/j.jhin.2016.08.019     Document Type: Article

References (21)

1. 1 Yamamoto, M., Pop-Vicas, A., Treatment for infections with carbapenem-resistant Enterobacteriaceae: what options do we still have?. Crit Care, 18, 2014, 229.
2. 2 Van Duin, D., Doi, Y., Outbreak of colistin-resistant, carbapenemase-producing Klebsiella pneumoniae: are we at the end of the road?. J Clin Microbiol 53 (2015), 3116–3117.
3. 3 Giani, T., Arena, F., Vaggelli, G., et al. Large nosocomial outbreak of colistin-resistant, carbapenemase-producing Klebsiella pneumoniae traced to clonal expansion of an mgrB deletion mutant. J Clin Microbiol 53 (2015), 3341–3344.
4. 4 Bogdanovich, T., Adams-Haduch, J.M., Tian, G.B., et al. Colistin-resistant, Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae belonging to the international epidemic clone ST258. Clin Infect Dis 53 (2011), 373–376.
5. 5 Capone, A., Giannella, M., Fortini, D., et al. High rate of colistin resistance among patients with carbapenem-resistant Klebsiella pneumoniae infection accounts for an excess of mortality. Clin Microbiol Infect 19 (2013), E23–E30.
6. 6 Monteiro, J., Santos, A.F., Asensi, M.D., Peirano, G., Gales, A.C., First report of KPC-2-producing Klebsiella pneumoniae strains in Brazil. Antimicrob Agents Chemother 53 (2009), 333–334.
7. 7 Pereira, P.S., de Araujo, C.F.M., Seki, L.M., Zahner, V., Carvalho-Assef, A.P.D.A., Asensi, M.D., Update of the molecular epidemiology of KPC-2-producing Klebsiella pneumoniae in Brazil: spread of clonal complex 11 (ST11, ST437 and ST340). J Antimicrob Chemother 68 (2013), 312–316.
8. 8 Gaspar, G.G., Bellissimo-Rodrigues, F., Andrade, L.N.D., Darini, A.L., Martinez, R., Induction and nosocomial dissemination of carbapenem and polymyxin-resistant Klebsiella pneumoniae. Rev Soc Bras Med Trop 48 (2015), 483–487.
9. 9 Agência Nacional de Vigilância Sanitária (ANVISA), Nota técnica No 1/2010. Medidas para identificação, prevenção e controle de infecções relacionadas à assistência à saúde por microrganismos multirresistentes. 2010 Available at: http://www.saude.rs.gov.br/upload/1365195295_NOTA%20TECNICA%2001%202010%20ANVISA.pdf [last accessed September 2015].
10. 10 Arantes, A., Carvalho, E.S., Medeiros, E.A., Farhat, C.K., Mantese, O.C., Use of statistical process control charts in the epidemiological surveillance of nosocomial infections. Rev Saude Pública 37 (2003), 768–774.
11. 11 World Health Organization, Guidelines for ATC classification and DDD assigment. 2015 Available at: http://www.whocc.no/atc_ddd_publications/guidelines/ [last accessed September 2015].
12. 12 Clinical and Laboratory Standards Institute, Performance standards for antimicrobial susceptibility testing. 2015 Available at: http://shop.clsi.org/site/Sample_pdf/M100S25_sample.pdf [last accessed September 2015].
13. 13 Sader, H.S., Rhomberg, P.R., Farrell, D.J., Jones, R.N., Differences in potency and categorical agreement between colistin and polymyxin B when testing 15,377 clinical strains collected worldwide. Diagn Microbiol Infect Dis 83 (2015), 379–381.
14. 14 European Committee on Antimicrobial Susceptibility Testing (EUCAST), Breakpoint tables for interpretation of MICs and zone diameters. 2015 Available at: http://www.eucast.org/clinical_breakpoints/ [last accessed September 2015].
15. 15 Galetti R. Estudo de Pseudomonas aeruginosa produtoras de metalo-beta-lactamase e de genes envolvidos na resistência aos carbapenêmicos. 2010. Doctoral dissertation, Universidade de São Paulo.
16. 16 Gales, A.C., Castanheira, M., Jones, R.N., Sader, H.S., Antimicrobial resistance among Gram-negative bacilli isolated from Latin America: results from SENTRY Antimicrobial Surveillance Program (Latin America, 2008–2010). Diagn Microbiol Infect Dis 73 (2012), 354–360.
17. 17 Arend, L.N., Toledo, P., Pilonetto, M., Tuon, F.F., Molecular epidemiology of Klebsiella pneumoniae carbapenemase-producing Enterobacteriaceae in different facilities in Southern Brazil. Am J Infect Control 43 (2015), 137–140.
18. 18 Moreira, M.R., Guimarães, M.P., Rodrigues, A.A.D.A., Gontijo Filho, P.P., Antimicrobial use, incidence, etiology and resistance patterns in bacteria causing ventilator-associated pneumonia in a clinical–surgical intensive care unit. Rev Soc Bras Med Trop 46 (2013), 39–44.
19. 19 Pruden, A., Larsson, D.J., Amézquita, A., Management options for reducing the release of antibiotics and antibiotic resistance genes to the environment. Environ Health Perspect 121 (2013), 878–885.
20. 20 Mammina, C., Bonura, C., Di Bernardo, F., et al. Ongoing spread of colistin-resistant Klebsiella pneumoniae in different wards of an acute general hospital, Italy, June to December 2011. Euro Surveill 17 (2012), 1–4.
21. 21 Weterings, V., Zhou, K., Rossen, J.W., et al. An outbreak of colistin-resistant Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae in the Netherlands (July to December 2013), with inter-institutional spread. Eur J Clin Microbiol Infect Dis 34 (2015), 1647–1655.