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Volumn 1, Issue 2, 2013, Pages 116-124

Peginterferon lambda-1a, a new therapeutic for hepatitis c infection, from bench to clinic

Author keywords

Discovery; HCV; Interferon

Indexed keywords


EID: 84994659407     PISSN: 22250719     EISSN: 23108819     Source Type: Journal    
DOI: 10.14218/JCTH.2013.00014     Document Type: Review
Times cited : (10)

References (45)
  • 1
    • 59149085501 scopus 로고    scopus 로고
    • The global burden of hepatitis C
    • Lavanchy D. The global burden of hepatitis C. Liver Int 2009;29:74–81.
    • (2009) Liver Int , vol.29 , pp. 74-81
    • Lavanchy, D.1
  • 4
    • 80053339008 scopus 로고    scopus 로고
    • An update on treatment of genotype 1 chronic hepatitis C virus infection: 2011 practice guidelines by the American Association for the Study of Liver Diseases
    • Ghany M, Nelson DR, Strader DB, Thomas DL, Seeff LB. An update on treatment of genotype 1 chronic hepatitis C virus infection: 2011 practice guidelines by the American Association for the Study of Liver Diseases. Hepatology 2011;54:1433–1444.
    • (2011) Hepatology , vol.54 , pp. 1433-1444
    • Ghany, M1    Nelson, DR2    Strader, DB3    Thomas, DL4    Seeff, LB.5
  • 5
    • 84865454706 scopus 로고    scopus 로고
    • Safety of telaprevir for chronic hepatitis C virus infection: a meta-analysis of randomized controlled trials
    • Qin H, Li H, Zhou X, Feng F, Shen Y, Tan H, et al. Safety of telaprevir for chronic hepatitis C virus infection: a meta-analysis of randomized controlled trials. Clin Drug Investig 2012;32:665–672.
    • (2012) Clin Drug Investig , vol.32 , pp. 665-672
    • Qin, H1    Li, H2    Zhou, X3    Feng, F4    Shen, Y5    Tan, H6
  • 6
    • 84873275651 scopus 로고    scopus 로고
    • Eligibility and safety of triple therapy for hepatitis C: lessons learned from the first experience in a real world setting
    • Maasoumy B, Port K, Markova AA, Serrano BC, Rogalska-Taranta M, Sollik L, et al. Eligibility and safety of triple therapy for hepatitis C: lessons learned from the first experience in a real world setting. PLoS One 2013;8:e55285.
    • (2013) PLoS One , vol.8 , pp. e55285
    • Maasoumy, B1    Port, K2    Markova, AA3    Serrano, BC4    Rogalska-Taranta, M5    Sollik, L6
  • 7
    • 84876738261 scopus 로고    scopus 로고
    • Safety aspects of protease inhibitors for chronic hepatitis C: adverse events and drug-to-drug interactions
    • Teixeira R, Nascimento Yde A, Crespo D. Safety aspects of protease inhibitors for chronic hepatitis C: adverse events and drug-to-drug interactions. Braz J Infect Dis 2013;17:194–204.
    • (2013) Braz J Infect Dis , vol.17 , pp. 194-204
    • Teixeira, R1    Nascimento Yde, A2    Crespo, D.3
  • 9
    • 0037243222 scopus 로고    scopus 로고
    • IFN-ls mediate antiviral protection through a distinct class II cytokine receptor complex
    • Kotenko SV, Gallagher G, Baurin VV, Lewis-Antes A, Shen M, Shah NK, et al. IFN-ls mediate antiviral protection through a distinct class II cytokine receptor complex. Nat Immunol 2003;4:69–77.
    • (2003) Nat Immunol , vol.4 , pp. 69-77
    • Kotenko, SV1    Gallagher, G2    Baurin, VV3    Lewis-Antes, A4    Shen, M5    Shah, NK6
  • 10
    • 77955880854 scopus 로고    scopus 로고
    • Interferon-lambda: a new addition to an old family
    • Donnelly RP, Kotenko SV. Interferon-lambda: a new addition to an old family. J Interferon Cytokine Res 2010;30:555–564.
    • (2010) J Interferon Cytokine Res , vol.30 , pp. 555-564
    • Donnelly, RP1    Kotenko, SV.2
  • 12
    • 80051949114 scopus 로고    scopus 로고
    • Interferon-lambda and therapy for chronic hepatitis C virus infection
    • Donnelly RP, Dickensheets H, O’Brien TR. Interferon-lambda and therapy for chronic hepatitis C virus infection. Trends Immunol 2011;32:443–450.
    • (2011) Trends Immunol , vol.32 , pp. 443-450
    • Donnelly, RP1    Dickensheets, H2    O’Brien, TR.3
  • 13
    • 33750631014 scopus 로고    scopus 로고
    • Interleukin-29 uses a type 1 interferon-like program to promote antiviral responses in human hepatocytes
    • Doyle SE, Schreckhise H, Khuu-Duong K, Henderson K, Rosler R, Storey H, et al. Interleukin-29 uses a type 1 interferon-like program to promote antiviral responses in human hepatocytes. Hepatology 2006;44:896–906.
    • (2006) Hepatology , vol.44 , pp. 896-906
    • Doyle, SE1    Schreckhise, H2    Khuu-Duong, K3    Henderson, K4    Rosler, R5    Storey, H6
  • 14
    • 73849130903 scopus 로고    scopus 로고
    • Despite IFN-l receptor expression, blood immune cells, but not keratinocytes or melanocytes, have an impaired response to type III interferons: implications for therapeutic applications of these cytokines
    • Witte K, Gruetz G, Volk HD, Looman AC, Asadullah K, Sterry W, et al. Despite IFN-l receptor expression, blood immune cells, but not keratinocytes or melanocytes, have an impaired response to type III interferons: implications for therapeutic applications of these cytokines. Genes Immun 2009;10:702– 714.
    • (2009) Genes Immun , vol.10 , pp. 702-714
    • Witte, K1    Gruetz, G2    Volk, HD3    Looman, AC4    Asadullah, K5    Sterry, W6
  • 15
    • 42949160129 scopus 로고    scopus 로고
    • IFN-lambda (IFN-l) is expressed in a tissue-dependent fashion and primarily acts on epithelial cells in vivo
    • Sommereyns C, Paul S, Staeheli P, Michiels T. IFN-lambda (IFN-l) is expressed in a tissue-dependent fashion and primarily acts on epithelial cells in vivo. PLoS Pathog 2008;4:e1000017.
    • (2008) PLoS Pathog , vol.4 , pp. e1000017
    • Sommereyns, C1    Paul, S2    Staeheli, P3    Michiels, T.4
  • 16
    • 33845605155 scopus 로고    scopus 로고
    • Interferons a and l inhibit hepatitis C virus replication with distinct signal transduction and gene regulation kinetics
    • Marcello T, Grakoui A, Barba-Spaeth G, Machlin ES, Kotenko SV, MacDonald MR, et al. Interferons a and l inhibit hepatitis C virus replication with distinct signal transduction and gene regulation kinetics. Gastroenterology 2006; 131:1887–898.
    • (2006) Gastroenterology , vol.131 , pp. 1887-1898
    • Marcello, T1    Grakoui, A2    Barba-Spaeth, G3    Machlin, ES4    Kotenko, SV5    MacDonald, MR6
  • 17
    • 84866163478 scopus 로고    scopus 로고
    • Type III IFNs are produced by and stimulate human plasmacytoid dendritic cells
    • Yin Z, Dai J, Deng J, Sheikh F, Natalia M, Shih T, et al. Type III IFNs are produced by and stimulate human plasmacytoid dendritic cells. J Immunol 2012;189:2735–2745.
    • (2012) J Immunol , vol.189 , pp. 2735-2745
    • Yin, Z1    Dai, J2    Deng, J3    Sheikh, F4    Natalia, M5    Shih, T6
  • 19
    • 14744276042 scopus 로고    scopus 로고
    • Lambda interferon inhibits hepatitis B and C virus replication
    • Robek MD, Boyd BS, Chisari FV. Lambda interferon inhibits hepatitis B and C virus replication. J Virol 2005;79:3851–3854.
    • (2005) J Virol , vol.79 , pp. 3851-3854
    • Robek, MD1    Boyd, BS2    Chisari, FV.3
  • 20
    • 33646265745 scopus 로고    scopus 로고
    • Novel type I interferon IL-28A suppresses hepatitis C viral RNA replication
    • Zhu H, Butera M, Nelson DR, Liu C. Novel type I interferon IL-28A suppresses hepatitis C viral RNA replication. Virol J 2005;2:80.
    • (2005) Virol J , vol.2 , pp. 80
    • Zhu, H1    Butera, M2    Nelson, DR3    Liu, C.4
  • 22
    • 0034871429 scopus 로고    scopus 로고
    • Development of pegylated interferons for the treatment of chronic hepatitis C
    • Kozlowski A, Charles SA, Harris JM. Development of pegylated interferons for the treatment of chronic hepatitis C. BioDrugs 2001;15:419–429.
    • (2001) BioDrugs , vol.15 , pp. 419-429
    • Kozlowski, A1    Charles, SA2    Harris, JM.3
  • 23
    • 10644244360 scopus 로고    scopus 로고
    • Pegylating IFNs at his-34 improves the in vitro antiviral activity through the JAK/STAT pathway
    • Grace MJ, Cutler D. Pegylating IFNs at his-34 improves the in vitro antiviral activity through the JAK/STAT pathway. Antivir Chem Chemother 2004;15: 287–297.
    • (2004) Antivir Chem Chemother , vol.15 , pp. 287-297
    • Grace, MJ1    Cutler, D.2
  • 24
    • 18244377180 scopus 로고    scopus 로고
    • Structural and biologic characterization of pegylated recombinant IFN-alpha2b
    • Grace M, Youngster S, Gitlin G, Sydor W, Xie L, Westreich L, et al. Structural and biologic characterization of pegylated recombinant IFN-alpha2b. J Interferon Cytokine Res 2001;21:1103–1115.
    • (2001) J Interferon Cytokine Res , vol.21 , pp. 1103-1115
    • Grace, M1    Youngster, S2    Gitlin, G3    Sydor, W4    Xie, L5    Westreich, L6
  • 25
    • 0038010128 scopus 로고    scopus 로고
    • Isolation, structural characterization, and antiviral activity of positional isomers of monopegylated interferon alpha-2a (PEGASYS)
    • Foser S, Schacher A, Weyer KA, Brugger D, Dietel E, Marti S, et al. Isolation, structural characterization, and antiviral activity of positional isomers of monopegylated interferon alpha-2a (PEGASYS). Protein Expr Purif 2003;30: 78–87.
    • (2003) Protein Expr Purif , vol.30 , pp. 78-87
    • Foser, S1    Schacher, A2    Weyer, KA3    Brugger, D4    Dietel, E5    Marti, S6
  • 27
    • 84919717568 scopus 로고    scopus 로고
    • Pharmacokinetics of peg-interferon lambda (pegIFNl) following fixed dosing in treatment-naive hepatitis C subjects (single-dose interim data from a dose-ranging Phase 2a study)
    • Byrnes-Blake KA, Freeman JA, Rapalus L, Pederson S, Fontana D, LopezTalavera JC, et al. Pharmacokinetics of peg-interferon lambda (pegIFNl) following fixed dosing in treatment-naive hepatitis C subjects (single-dose interim data from a dose-ranging Phase 2a study). Hepatology 2010;52: 720A–721A.
    • (2010) Hepatology , vol.52 , pp. 720A-721A
    • Byrnes-Blake, KA1    Freeman, JA2    Rapalus, L3    Pederson, S4    Fontana, D5    LopezTalavera, JC6
  • 28
    • 77955873433 scopus 로고    scopus 로고
    • Phase 1b study of pegylated interferon lambda 1 with or without ribavirin in patients with chronic genotype 1 hepatitis C virus infection
    • Muir AJ, Shiffman ML, Zaman A, Yoffe B, de la Torre A, Flamm S, et al. Phase 1b study of pegylated interferon lambda 1 with or without ribavirin in patients with chronic genotype 1 hepatitis C virus infection. Hepatology 2010;52: 822–832.
    • (2010) Hepatology , vol.52 , pp. 822-832
    • Muir, AJ1    Shiffman, ML2    Zaman, A3    Yoffe, B4    de la Torre, A5    Flamm, S6
  • 29
    • 73849090283 scopus 로고    scopus 로고
    • A Phase 1, randomized, blinded, placebo-controlled, single-dose, dose-escalation study of PEG-interferon lambda (PEG-rIL-29) in healthy subjects
    • (Suppl 2)
    • Hausman DF, Freeman JA, Souza SM, Nesterov IA, Zhang T. A Phase 1, randomized, blinded, placebo-controlled, single-dose, dose-escalation study of PEG-interferon lambda (PEG-rIL-29) in healthy subjects. Global Antiviral J 2007;3(Suppl 2):71–72.
    • (2007) Global Antiviral J , vol.3 , pp. 71-72
    • Hausman, DF1    Freeman, JA2    Souza, SM3    Nesterov, IA4    Zhang, T.5
  • 30
    • 47949127385 scopus 로고    scopus 로고
    • IFN-a and IFN-l differ in their antiproliferative effects and duration of JAK/STAT signaling activity
    • Maher SG, Sheikh F, Scarzello AJ, Romero-Weaver AL, Baker DP, Donnelly RP, et al. IFN-a and IFN-l differ in their antiproliferative effects and duration of JAK/STAT signaling activity. Cancer Biol Ther 2008;7:1109–1115.
    • (2008) Cancer Biol Ther , vol.7 , pp. 1109-1115
    • Maher, SG1    Sheikh, F2    Scarzello, AJ3    Romero-Weaver, AL4    Baker, DP5    Donnelly, RP6
  • 31
    • 77956906274 scopus 로고    scopus 로고
    • PEG-interferon lambda (PEG-rIL-29): translation of in vitro preclinical data to clinical results
    • (Suppl 2)
    • Freeman JA, Zhang T, Holdren MS, Hausman DF. PEG-interferon lambda (PEG-rIL-29): translation of in vitro preclinical data to clinical results. J Hepatol 2008;48(Suppl 2):S294.
    • (2008) J Hepatol , vol.48 , pp. S294
    • Freeman, JA1    Zhang, T2    Holdren, MS3    Hausman, DF.4
  • 32
    • 0022185762 scopus 로고
    • Pharmacokinetic study of a human recombinant interferon (Re-IFN-alpha A) in cynomolgus monkeys by 29–59 oligoadenylate synthetase assay
    • Bannai H, Tatsumi M, Kohase M, Onishi E, Yamazaki S. Pharmacokinetic study of a human recombinant interferon (Re-IFN-alpha A) in cynomolgus monkeys by 29–59 oligoadenylate synthetase assay. Jpn J Med Sci Biol 1985; 38:113–124.
    • (1985) Jpn J Med Sci Biol , vol.38 , pp. 113-124
    • Bannai, H1    Tatsumi, M2    Kohase, M3    Onishi, E4    Yamazaki, S.5
  • 33
    • 0022870025 scopus 로고
    • Comparison of pharmacokinetic behaviors of two human interferons (Lb-IFN-alpha and Re-IFN-alpha A) in cynomolgus monkeys by 29–59 oligoadenylate synthetase assay
    • Bannai H. Comparison of pharmacokinetic behaviors of two human interferons (Lb-IFN-alpha and Re-IFN-alpha A) in cynomolgus monkeys by 29–59 oligoadenylate synthetase assay. Jpn J Med Sci Biol 1986;39:185–198.
    • (1986) Jpn J Med Sci Biol , vol.39 , pp. 185-198
    • Bannai, H.1
  • 35
    • 79958783385 scopus 로고    scopus 로고
    • Pegylated interferon lambda (PEG-IFN l) Phase 2 dose-ranging, active-controlled study in combination with ribavirin (RBV) for treatment-naïve HCV patients (genotypes 1, 2, 3 or 4): safety, viral response, and impact of IL-28B host genotype through week 12
    • Muir AJ, Lawitz E, Ghalib RH, Sussman NL, Anderson F, Everson GT, et al. Pegylated interferon lambda (PEG-IFN l) Phase 2 dose-ranging, active-controlled study in combination with ribavirin (RBV) for treatment-naïve HCV patients (genotypes 1, 2, 3 or 4): safety, viral response, and impact of IL-28B host genotype through week 12. Hepatology 2010;52:715A.
    • (2010) Hepatology , vol.52 , pp. 715A
    • Muir, AJ1    Lawitz, E2    Ghalib, RH3    Sussman, NL4    Anderson, F5    Everson, GT6
  • 36
    • 84863710462 scopus 로고    scopus 로고
    • Peginterferon lambda-1a compared to peginterferon alfa-2a in treatment-naive patients with HCV genotype 2 or 3: first SVR24 results from EMERGE Phase IIB
    • (Suppl 2)
    • Zeuzem S, Arora S, Bacon B, Box T, Charlton M, Diago M, et al. Peginterferon lambda-1a compared to peginterferon alfa-2a in treatment-naive patients with HCV genotype 2 or 3: first SVR24 results from EMERGE Phase IIB. J Hepatol 2012;56(Suppl 2):S5–S6.
    • (2012) J Hepatol , vol.56 , pp. S5-S6
    • Zeuzem, S1    Arora, S2    Bacon, B3    Box, T4    Charlton, M5    Diago, M6
  • 37
    • 84880283111 scopus 로고    scopus 로고
    • Peginterferon lambda-1a (Lambda) compared to peginterferon alfa-2a (alfa) in treatment-treatment-naive patients with HCV genotypes 1 or 4: SVR24 results from EMERGE Phase 2b
    • (Suppl):. naive
    • Muir A, Hillson J, Gray T, Xu D, Ishak L, Freeman J, et al. Peginterferon lambda-1a (Lambda) compared to peginterferon alfa-2a (alfa) in treatment-treatment-naive patients with HCV genotypes 1 or 4: SVR24 results from EMERGE Phase 2b. Hepatology 2012;56(Suppl):299A. naive
    • (2012) Hepatology , vol.56 , pp. 299A
    • Muir, A1    Hillson, J2    Gray, T3    Xu, D4    Ishak, L5    Freeman, J6
  • 38
    • 77951983557 scopus 로고    scopus 로고
    • Lambda interferon renders epithelial cells of the respiratory and gastrointestinal tracts resistant to viral infections
    • Mordstein M, Neugebauer E, Ditt V, Jessen B, Rieger T, Falcone V, et al. Lambda interferon renders epithelial cells of the respiratory and gastrointestinal tracts resistant to viral infections. J Virol 2010;84:5670–5677.
    • (2010) J Virol , vol.84 , pp. 5670-5677
    • Mordstein, M1    Neugebauer, E2    Ditt, V3    Jessen, B4    Rieger, T5    Falcone, V6
  • 39
    • 53049101323 scopus 로고    scopus 로고
    • Interferon-l contributes to innate immunity of mice against influenza A virus but not against hepatotropic viruses
    • Mordstein M, Kochs G, Dumoutier L, Renauld JC, Paludan SR, Klucher K, et al. Interferon-l contributes to innate immunity of mice against influenza A virus but not against hepatotropic viruses. PLoS Pathog 2008;4:e1000151.
    • (2008) PLoS Pathog , vol.4 , pp. e1000151
    • Mordstein, M1    Kochs, G2    Dumoutier, L3    Renauld, JC4    Paludan, SR5    Klucher, K6
  • 40
    • 70349292099 scopus 로고    scopus 로고
    • Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
    • Ge D, Fellay J, Thompson AJ, Simon JS, Shianna KV, Urban TJ, et al. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature 2009;461:399–401.
    • (2009) Nature , vol.461 , pp. 399-401
    • Ge, D1    Fellay, J2    Thompson, AJ3    Simon, JS4    Shianna, KV5    Urban, TJ6
  • 41
    • 70349966196 scopus 로고    scopus 로고
    • Genetic variation in IL28B and spontaneous clearance of hepatitis C virus
    • Thomas DL, Thio CL, Martin MP, Qi Y, Ge D, O’Huigin C, et al. Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature 2009;461: 798–801.
    • (2009) Nature , vol.461 , pp. 798-801
    • Thomas, DL1    Thio, CL2    Martin, MP3    Qi, Y4    Ge, D5    O’Huigin, C6
  • 42
    • 70349533037 scopus 로고    scopus 로고
    • Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C
    • Tanaka Y, Nishida N, Sugiyama M, Kurosaki M, Matsuura K, Sakamoto N, et al. Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C. Nat Genet 2009;41:1105–1109.
    • (2009) Nat Genet , vol.41 , pp. 1105-1109
    • Tanaka, Y1    Nishida, N2    Sugiyama, M3    Kurosaki, M4    Matsuura, K5    Sakamoto, N6
  • 43
    • 70349548852 scopus 로고    scopus 로고
    • IL28B is associated with response to chronic hepatitis C interferon-a and ribavirin therapy
    • Suppiah V, Moldovan M, Ahlenstiel G, Berg T, Weltman M, Abate ML, et al. IL28B is associated with response to chronic hepatitis C interferon-a and ribavirin therapy. Nat Genet 2009;41:1100–1104.
    • (2009) Nat Genet , vol.41 , pp. 1100-1104
    • Suppiah, V1    Moldovan, M2    Ahlenstiel, G3    Berg, T4    Weltman, M5    Abate, ML6
  • 44
    • 77953881002 scopus 로고    scopus 로고
    • Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus
    • Thompson AJ, Muir AJ, Sulkowski MS, Ge D, Fellay J, Shianna KV, et al. Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus. Gastroenterology 2010;139:120–129.
    • (2010) Gastroenterology , vol.139 , pp. 120-129
    • Thompson, AJ1    Muir, AJ2    Sulkowski, MS3    Ge, D4    Fellay, J5    Shianna, KV6
  • 45
    • 84888861102 scopus 로고    scopus 로고
    • Peginterferon lambda-1a is less likely to induce clinically significant neuropsychiatric symptoms during the treatment of chronic hepatitis C virus infection, compared to peginterferon alfa-2a
    • (Suppl)
    • Muir AJ, Srinivasan S, Sapra S, Dimitrova D, Hillson JL, Lopez-Talavera JC. Peginterferon lambda-1a is less likely to induce clinically significant neuropsychiatric symptoms during the treatment of chronic hepatitis C virus infection, compared to peginterferon alfa-2a. Hepatology 2012;56(Suppl): 578A–579A.
    • (2012) Hepatology , vol.56 , pp. 578A-579A
    • Muir, AJ1    Srinivasan, S2    Sapra, S3    Dimitrova, D4    Hillson, JL5    Lopez-Talavera, JC.6


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