Both transmural dispersion of repolarization and of refractoriness are poor predictors of arrhythmogenicity: A role for iCEB (QT/QRS)?

Journal of Geriatric Cardiology

Volumn 13, Issue 9, 2016, Pages 813-814

  Tse, Gary ^a  

^a and Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics   (Hong Kong)

Author keywords

Depolarization; Excitation wavelength; QT dispersion; QT QRS; Transmural dispersion of refractoriness; Transmural dispersion of repolarization

Indexed keywords

ACTION POTENTIAL DURATION; AORTA STENOSIS; ARRHYTHMOGENESIS; CARDIOVASCULAR PARAMETERS; HEART MUSCLE REFRACTORY PERIOD; HEART REPOLARIZATION; HUMAN; HYPERKALEMIA; INDEX OF OF CARDIAC ELECTROPHYSIOLOGICAL BALANCE; LETTER; LONG QT SYNDROME; QRS INTERVAL; QT DISPERSION; QT INTERVAL; SHORT QT SYNDROME; T WAVE; TRANSCATHETER AORTIC VALVE IMPLANTATION; TRANSMURAL DISPERSION OF REPOLARIZATION;

EID: 84994634412     PISSN: 16715411     EISSN: None     Source Type: Journal    
DOI: 10.11909/j.issn.1671-5411.2016.09.007     Document Type: Letter

References (20)

1. Nuis RJ, Turgut G, van der Boon RM, et al. Defective recovery of QT dispersion following transcatheter aortic valve implantation: frequency, predictors and prognosis. J Geriatr Cardiol 2015; 12: 482-488.
2. Dogan M, Yiginer O, Degirmencioglu G, et al. Transmural dispersion of repolarization: a complementary index for cardiac inhomogeneity. J Geriatr Cardiol 2016; 13: 99-100.
3. Gupta P, Patel C, Patel H, et al. T(p-e)/QT ratio as an index of arrhythmogenesis. J Electrocardiol 2008; 41: 567-574.
4. Maury P, Sacher F, Gourraud JB, et al. Increased Tpeak-Tend interval is highly and independently related to arrhythmic events in Brugada syndrome. Heart Rhythm 2015; 12: 2469-2476.
5. Tatlisu MA, Ozcan KS, Gungor B, et al. Can the T-peak to T-end interval be a predictor of mortality in patients with ST-elevation myocardial infarction? Coron Artery Dis 2014; 25: 399-404.
6. Tse G, Lai ET, Yeo JM, et al. Electrophysiological mechanisms of Bayés syndrome: insights from clinical and mouse studies. Front Physiol 2016; 7: 188.
7. Tse G, Lai ET, Chan YW, et al. What is the arrhythmic substrate in viral myocarditis? Insights from clinical and animal studies. Front Physiol 2016; 7: 308.
8. Tse G, Yan BP, Chan YW, et al. Reactive oxygen species, endoplasmic reticulum stress and mitochondrial dysfunction: the link with cardiac arrhythmogenesis. Front Physiol 2016; 7: 313.
9. Tse G, Lai TH, Yeo JM, et al. Mechanisms of electrical activation and conduction in the gastrointestinal system: lessons from cardiac electrophysiology. Front Physiol 2016; 7: 182.
10. Tse G, Lai ET, Lee AP, et al. Electrophysiological mechanisms of gastrointestinal arrhythmogenesis: lessons from the heart. Front Physiol 2016; 7: 230.
11. Tse G, Lai ET, Tse V, et al. Molecular and electrophysiological mechanisms underlying cardiac arrhythmogenesis in diabetes mellitus. J Diabetes Res. Published Online First: 2016. http://dx.doi.org/10.1155/2016/2848759.
12. Chen Z, Sun B, Tse G, et al. Reversibility of both sinus node dysfunction and reduced HCN4 mRNA expression level in an atrial tachycardia pacing model of tachycardia-bradycardia syndrome in rabbit hearts. Int J Clin Exp Pathol 2016; 9: 8526-8531.
13. Tse G, Tse V, Yeo JM. Ventricular anti-arrhythmic effects of heptanol in hypokalaemic, Langendorff-perfused mouse hearts. Biomedical Reports 2016; 4: 313-324.
14. Tse G, Wong ST, Tse V, Yeo JM. Depolarization vs. repolarization: what is the mechanism of ventricular arrhythmogenesis underlying sodium channel haploinsufficiency in mouse hearts? Acta Physiol (Oxf). Published Online First: 16 Apr 2016. doi: 10.1111/apha.12694.
15. Wilde AA, Postema PG, Di Diego JM, et al. The pathophysiological mechanism underlying Brugada syndrome: depolarization versus repolarization. J Mol Cell Cardiol 2010; 49: 543-553.
16. Lu HR, Yan G-X, Gallacher DJ. A new biomarker - index of Cardiac Electrophysiological Balance (iCEB) - plays an important role in drug-induced cardiac arrhythmias: beyond QT-prolongation and Torsades de Pointes (TdPs). J Pharmacol Toxicol Methods 2013; 68: 250-259.
17. Tse G, Ali A, Prasad SK, et al. Atypical case of post-partum cardiomyopathy: an overlap syndrome with arrhythmogenic right ventricular cardiomyopathy? BJR Case Rep 2015; 1: 201500182.
18. Tse G, Ali A, Alpendurada F, et al. Tuberculous constrictive pericarditis. Res Cardiovasc Med 2015; 4: e29614.
19. Vassiliou V, Chin C, Perperoglou A, et al. Ejection fraction by cardiovascular magnetic resonance predicts adverse outcomes post aortic valve replacement. Heart 2014; 100 (Suppl. 3): A53-A54.
20. Choy L, Yeo JM, Tse V, et al. Cardiac disease and arrhythmogenesis: mechanistic insights from mouse models. Int J Cardiol Heart Vasc 2016; 12: 1-10.