The Efficacy of Combined Use of Rivaroxaban and Tranexamic Acid on Blood Conservation in Minimally Invasive Total Knee Arthroplasty a Double-Blind Randomized, Controlled Trial

Journal of Arthroplasty

Volumn 32, Issue 3, 2017, Pages 801-806

  Wang, Jun Wen ^a   Chen, Bradley ^b   Lin, Po Chun ^a   Yen, Shih Hsiang ^a   Huang, Chung Cheng ^a   Kuo, Feng Chih ^a  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

rivaroxaban; total blood loss; total knee arthroplasty; tranexamic acid; venous thromboembolism; wound complications

Indexed keywords

HEMOGLOBIN; RIVAROXABAN; TRANEXAMIC ACID; ANTIFIBRINOLYTIC AGENT; BLOOD CLOTTING FACTOR 10A INHIBITOR; MORPHOLINE DERIVATIVE; THIOPHENE DERIVATIVE;

AGED; ARTICLE; BLOOD CONSERVATION; BLOOD TRANSFUSION; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; ECCHYMOSIS; FEMALE; HEMATOMA; HEMOGLOBIN BLOOD LEVEL; HUMAN; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; MINIMALLY INVASIVE SURGERY; PHLEBOGRAPHY; POSTOPERATIVE CARE; POSTOPERATIVE HEMORRHAGE; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; TOTAL KNEE ARTHROPLASTY; TREATMENT DURATION; WOUND COMPLICATION; BLOOD LOSS, SURGICAL; COMBINATION DRUG THERAPY; KNEE REPLACEMENT; MIDDLE AGED; POSTOPERATIVE PERIOD; PULMONARY EMBOLISM; STATISTICS AND NUMERICAL DATA; VENOUS THROMBOSIS;

AGED; ANTIFIBRINOLYTIC AGENTS; ARTHROPLASTY, REPLACEMENT, KNEE; BLOOD LOSS, SURGICAL; BLOOD TRANSFUSION; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FACTOR XA INHIBITORS; FEMALE; HEMATOMA; HUMANS; MALE; MIDDLE AGED; MORPHOLINES; POSTOPERATIVE HEMORRHAGE; POSTOPERATIVE PERIOD; PROSPECTIVE STUDIES; PULMONARY EMBOLISM; RIVAROXABAN; THIOPHENES; TRANEXAMIC ACID; VENOUS THROMBOSIS;

EID: 84994495851     PISSN: 08835403     EISSN: 15328406     Source Type: Journal    
DOI: 10.1016/j.arth.2016.08.020     Document Type: Article

References (49)

1. 1 Clutier, J.M., Results of total knee arthroplasty with a non-constrained prosthesis. J Bone Joint Surg Am, 65, 1983, 906.
2. 2 Ewald, F.C., Jacobs, M.A., Miegel, R.E., et al. Kinematic total knee replacement. J Bone Joint Surg Am, 66(7), 1984, 1032.
3. 3 Salido, J.A., Marín, L.A., Gómez, L.A., et al. Preoperative hemoglobin levels and the need for transfusion after prosthetic hip and knee surgery: analysis of predictive factors. J Bone Joint Surg Am, 84-A(2), 2002, 216.
4. 4 Fahmy, N.R., Patel, D.G., Hemostatic changes and postoperative deep-vein thrombosis associated with use of a pneumatic tourniquet. J Bone Joint Surg Am, 63(3), 1981, 461.
5. 5 Murphy, W.G., Davies, M.J., Eduardo, A., The haemostatic responses to surgery and trauma. Br J Anaesth, 70(2), 1993, 205.
6. 6 Petäjä, J., Myllynen, P., Myllylä, G., et al. Fibrinolysis after application of a pneumatic tourniquet. Acta Chir Scand, 153(11-12), 1976, 647.
7. 7 Dunn, C.J., Goa, K.L., Tranexamic acid: a review of its use in surgery and indications. Drug, 57, 1999, 1005.
8. 8 Mannucci, P.M., Hemostatic drugs. N Engl J Med, 339, 1988, 245.
9. 9 Prentice, C.R., Basis of antifibrinolytic therapy. J Clin Pathol Suppl (R Coll Pathol), 14, 1980, 35.
10. 10 Benoni, G., Fredin, H., Fibrinolytic inhibition with tranexamic acid reduces blood loss and blood transfusion after knee arthroplasty: a prospective, randomised, double-blind study of 86 patients. J Bone Joint Surg Br, 78(3), 1996, 434.
11. 11 Ekbäck, G., Axelsson, K., Ryttberg, L., et al. Tranexamic acid reduces blood loss in total hip replacement surgery. Anesth Analg, 91(5), 2000, 1124.
12. 12 Hiippala, S., Strid, L., Wennerstrand, M., et al. Tranexamic acid (Cyklokapron) reduces perioperative blood loss associated with total knee arthroplasty. Br J Anaesth, 74(5), 1995, 534.
13. 13 Lin, P.C., Hsu, C.H., Chen, W.S., et al. Does tranexamic acid save blood in minimally invasive total knee arthroplasty?. Clin Orthop Relat Res, 469, 2011, 1995.
14. 14 Alshryda, S., Sarda, P., Sukeik, M., et al. Tranexamic acid in total knee replacement: a systematic review and meta-analysis. J Bone Joint Surg Br, 93(12), 2011, 1577.
15. 15 Cid, J., Lozano, M., Tranexamic acid reduces allogeneic red cell transfusions in patients undergoing total knee arthroplasty: results of a meta-analysis of randomized control trials. Transfusion, 45, 2005, 1302.
16. 16 Ho, K.M., Insmail, H., Use of intravenous tranexamic acid to reduce allogeneic blood transfusion in total hip and knee arthroplasty: a meta-analysis. Anaesth Intensive Care, 31, 2003, 529.
17. 17 Yang, Z.G., Chen, W.P., Wu, L.D., Effective and safety of tranexamic acid in reducing blood loss in total knee arthroplasty: a meta-analysis. J Bone Joint Surg Am, 94, 2012, 1153.
18. 18 Perzborn, E., Strassburger, J., Wilmen, A., et al. In vitro and in vivo studies of the novel antithrombotic agent BAY 59-7939–an oral, direct factor Xa inhibitor. J Thromb Haemost, 3(3), 2005, 514.
19. 19 Lassen, M.R., Ageno, W., Borris, L.C., et al., RECORD3 Investigators. Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty. N Engl J Med, 358(26), 2008, 2776.
20. 20 Turpie, A.G., Lassen, M.R., Davidson, B.L., et al., RECORD4 Investigators. Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty (RECORD4): a randomised trial. Lancet, 373(9676), 2009, 1673.
21. 21 Jameson, S.S., Rymaszewska, M., Hui, A.C., et al. Wound complications following rivaroxaban administration: a multicenter comparison with low-molecular-weight heparins for thromboprophylaxis in lower limb arthroplasty. J Bone Joint Surg Am, 94(17), 2012, 1554.
22. 22 Jensen, C.D., Steval, A., Partington, P.F., et al. Return to theatre following total hip and knee replacement, before and after the introduction of rivaroxaban: a retrospective cohort study. J Bone Joint Surg Br, 93(1), 2011, 91.
23. 23 Lotke, P.A., Rivaroxaban for thromboprophylaxis. N Engl J Med, 359, 2008, 2174.
24. 24 Brimmo, O., Glenn, M., Klika, A.K., et al. Rivaroxaban use for thrombosis prophylaxis is associated with early periprosthetic joint infection. J Arthroplasty, 31, 2016, 1295.
25. 25 Rath, N.K., Goodson, M.W., White, S.P., et al. The use of rivaroxaban for chemical thromboprephylaxis following total knee replacement. Knee, 20, 2013, 397.
26. 26 Sindali, K., Rose, B., Soueid, H., et al. Elective hip and knee arthroplasty and the effect of rivaroxaban and enoxaparin thromboprophylaxis on wound healing. Eur J Orthop Surg Traumatol, 23, 2013, 481.
27. 27 Arnljots, B., Wieslander, J.B., Dongan, P., et al. Importance of fibrinolysis in limiting thrombus formation following severe microarterial trauma: an experimental study in the rabbit. Microsurgery, 12, 1991, 332.
28. 28 Astedt, B., Liedholm, P., Wingerup, L., The effect of tranexamic acid on the fibrinolytic activity of vein walls. Ann Chir Gynaecol, 67, 1978, 203.
29. 29 Wong, J., Abrishami, A., El Beheiry, H., et al. Topical application of tranexamic acid reduces postoperative blood loss in total knee arthroplasty: a randomized, controlled trial. J Bone Joint Surg Am, 92(15), 2010, 2503.
30. 30 Camarasa, M.A., Ollé, G., Serra-Prat, M., et al. Efficacy of aminocaproic, tranexamic acids in the control of bleeding during total knee replacement: a randomized clinical trial. Br J Anaesth, 96(5), 2006, 576.
31. 31 Tria, A.J. Jr., Advancement in minimally invasive total knee arthroplasty. Orthopedics, 26(8 Suppl), 2003, S859.
32. 32 Haas, S.B., Cook, S., Beksac, B., Minimally invasive total knee replacement through a mini midvastus approach: a comparative study. Clin Orthop Relat Res, 428, 2004, 68.
33. 33 Bonutti, P.M., Mont, M.A., McMahon, M., et al. Minimally invasive total knee arthroplasty. J Bone Joint surg Am, 86(Supple 2), 2004, 26.
34. 34 Owens, W.D., Felts, J.A., Spitznagel, E.L. Jr., ASA physical status classification: a study of consistency of ratings. Anesthesiology, 49, 1978, 239.
35. 35 Nadler, S.B., Hidalgo, J.U., Bloch, T., Prediction of blood volume in normal human adults. Surgery, 51, 1962, 224.
36. 36 Rosencher, N., Kerkkamp, H.E., Macheras, G., et al. Orthopedic Surgery Transfusion Hemoglobin European Overview (OSTHEO) study: blood management in elective knee and hip arthroplasty in Europe. Transfusion, 43(4), 2003, 459.
37. 37 Well, P.S., Anderson, D.R., Bormanis, J., et al. Value of assessment of pretest probability of deep-vein thrombosis in clinical management. Lancet, 350, 1997, 1795.
38. 38 Rabinov, K., Paulin, S., Roentgen diagnosis of venous thrombosis in the leg. Arch Surg, 104(2), 1972, 134.
39. 39 Lin, P.C., Hsu, C.H., Huang, C.C., et al. The blood-saving effect of tranexamic acid in minimally invasive total knee replacement: is an additional pre-operative injection effective?. J Bone Joint Surg Br, 94(7), 2012, 932.
40. 40 Levine, M.N., Raskob, G., Beyth, R.J., et al. Hemorrhagic complications of anticoagulant treatment: the seventh ACCP conference on antithrombotic and thrombolytic therapy. Chest, 126(3 Suppl), 2004, 287S.
41. 41 Shaieb, M.D., Watson, B.N., Atkinsom, R.E., Bleeding complications with enoxaparin for deep venous thrombosis prophylaxis. J Arthroplasty, 14, 1999, 432.
42. 42 Ricket, A.C., Stewart, D.W., Wood, R.C., et al. Comparison of postoperative bleeding in total hip and knee arthroplasty patients receiving rivaroxaban or enoxaparin. Ann Phyarmcother, 50, 2016, 270.
43. 43 Trkulja, V., Kolundzic, R., Rivaroxaban vs dabigatran for thromboprophylaxis after joint-replacement surgery: exploratory indirect comparison based on meta-analysis of pivotal clinical trials. Croat Med J, 51(2), 2010, 113.
44. 44 Galat, D.D., McGovern, S.C., Hanssen, A.D., et al. Early return to surgery for evacuation of a postoperative hematoma after primary total knee arthroplasty. J Bone Joint Surg Am, 90(11), 2008, 2331.
45. 45 Patel, V.P., Walsh, M., Sehgal, B., et al. Factors associated with prolonged wound drainage after primary total hip and knee arthroplasty. J Bone Joint Surg Am, 89(1), 2007, 33.
46. 46 Yen, S.H., Lin, P.C., Kuo, F.C., et al. Thromboprophylaxis after minimally invasive total knee arthroplasty: a comparison of rivaroxaban and enoxaparin. Biomed J, 37, 2014, 199.
47. 47 Charters, M.A., Firsch, N.B., Wessel, N.M., et al. Rivaroxaban versus enoxaparin for venous thromboembolism prophylaxis after hip and knee arthroplasty. J Arthroplasty, 30, 2015, 1277.
48. 48 Clavé, A., Fuzilleau, F., Dumser, D., et al. Efficacy of tranexamic acid on blood loss after primary cementless total hip replacement with rivaroxaban thromboprophylaxis: a case-control study in 70 patients. Orthop Traumatol Surg Res, 98(5), 2012, 484.
49. 49 Wood, A.M., Smith, R., Keenan, A., et al. Using a combination of tranexamic acid and rivaroxaban in total knee replacements reduces transfusion requirements: a prospective cohort study. J Arthrosc Joint Surg, 1(2), 2014, 76.