Early bactericidal activity of AZD5847 in patients with pulmonary tuberculosis

Antimicrobial Agents and Chemotherapy

Volumn 60, Issue 11, 2016, Pages 6591-6599

  Furin, Jennifer J ^a   Du Bois, Jeannine ^b   Van Brakel, Elana ^b   Chheng, Phalkun ^a   Venter, Amour ^c   Peloquin, Charles A ^d   Alsultan, Abdullah ^d,e   Thiel, Bonnie A ^a   Debanne, Sara M ^a   Boom, W Henry ^a   Diacon, Andreas H ^b,c   Johnson, John L ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TASK APPLIED SCIENCE   (South Africa)

^c STELLENBOSCH UNIVERSITY   (South Africa)

^d UNIVERSITY OF FLORIDA HEALTH   (United States)

^e KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CREATINE KINASE; ETHAMBUTOL PLUS ISONIAZID PLUS PYRAZINAMIDE PLUS RIFAMPICIN; HEMOGLOBIN; POSIZOLID; DRUG COMBINATION; ETHAMBUTOL; ISONIAZID; OXAZOLIDINONE DERIVATIVE; PYRAZINAMIDE; RIFAMPICIN; TUBERCULOSTATIC AGENT;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANEMIA; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; ASYMPTOMATIC DISEASE; BACTERICIDAL ACTIVITY; BACTERIUM CULTURE; BILIRUBIN BLOOD LEVEL; CHRONIC HEPATITIS B; CLINICAL ARTICLE; COLONY FORMING UNIT; CONTROLLED STUDY; CREATINE KINASE BLOOD LEVEL; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG FATALITY; DRUG MEGADOSE; DRUG SAFETY; DRUG WITHDRAWAL; EPISTAXIS; ERYTHROCYTE CONCENTRATE; FEMALE; HEMOGLOBIN DETERMINATION; HOSPITALIZATION; HUMAN; HYPERBILIRUBINEMIA; LEUKOCYTE COUNT; LIQUID CULTURE; LIVER TOXICITY; LUNG TUBERCULOSIS; MALE; MAXIMUM PLASMA CONCENTRATION; MINIMUM INHIBITORY CONCENTRATION; MINIMUM PLASMA CONCENTRATION; MORNING DOSAGE; MYCOBACTERIUM TUBERCULOSIS; OPEN STUDY; OPTIC NERVE DISEASE; PERIPHERAL NEUROPATHY; PHASE 2 CLINICAL TRIAL; PLASMA CONCENTRATION-TIME CURVE; PLATE COUNT; PRIORITY JOURNAL; QT PROLONGATION; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SPUTUM SMEAR; THROMBOCYTE COUNT; THROMBOCYTOPENIA; TIME TO MAXIMUM PLASMA CONCENTRATION; VOLUME OF DISTRIBUTION; BACTERIAL COUNT; BIOASSAY; BLOOD; CHEMICALLY INDUCED; DRUG ADMINISTRATION; DRUG COMBINATION; DRUG EFFECTS; GROWTH, DEVELOPMENT AND AGING; MICROBIOLOGY; MIDDLE AGED; PATHOLOGY; SPUTUM; TIME FACTOR; TUBERCULOSIS, PULMONARY;

ADULT; ANTITUBERCULAR AGENTS; COLONY COUNT, MICROBIAL; DRUG ADMINISTRATION SCHEDULE; DRUG COMBINATIONS; ENDPOINT DETERMINATION; ETHAMBUTOL; FEMALE; HUMANS; HYPERBILIRUBINEMIA; ISONIAZID; MALE; MIDDLE AGED; MYCOBACTERIUM TUBERCULOSIS; OXAZOLIDINONES; PYRAZINAMIDE; RIFAMPIN; SPUTUM; THROMBOCYTOPENIA; TIME FACTORS; TUBERCULOSIS, PULMONARY;

EID: 84994481763     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01163-16     Document Type: Article

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