Effects of honey use on the management of radio/chemotherapy-induced mucositis: a meta-analysis of randomized controlled trials

International Journal of Oral and Maxillofacial Surgery

Volumn 45, Issue 12, 2016, Pages 1618-1625

  Xu, J L ^a   Xia, R ^a   Sun, Z H ^a   Sun, L ^a   Min, X ^a,b   Liu, C ^a   Zhang, H ^a   Zhu, Y M ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

^b Anhui Medical College   (China)

Author keywords

honey; meta analysis; mucositis; radio chemotherapy

Indexed keywords

ANTINEOPLASTIC AGENT; LIDOCAINE; NATURAL PRODUCT;

COCHRANE LIBRARY; HEAD AND NECK CANCER; HONEY; HUMAN; INFORMATION RETRIEVAL; MEDLINE; META ANALYSIS; ORAL MUCOSITIS; PROPHYLAXIS; PUBLISHING; QUALITY CONTROL; RADIO CHEMOTHERAPY INDUCED MUCOSITIS; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SENSITIVITY ANALYSIS; APITHERAPY; CHEMORADIOTHERAPY; CHINA; HEAD AND NECK TUMOR; MUCOSA INFLAMMATION; PROCEDURES; STOMATITIS;

APITHERAPY; CHEMORADIOTHERAPY; CHINA; HEAD AND NECK NEOPLASMS; HONEY; HUMANS; MUCOSITIS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; STOMATITIS;

EID: 84994403330     PISSN: 09015027     EISSN: 13990020     Source Type: Journal    
DOI: 10.1016/j.ijom.2016.04.023     Document Type: Review

References (37)

1. 1 Hollander, D.D., Kampman, E., van Herpen, C.M., Pretreatment body mass index and head and neck cancer outcome: a review of the literature. Crit Rev Oncol Hematol 96 (2015), 328–338.
2. 2 Islam, M., Datta, J., Lang, J.C., Teknos, T.N., Down regulation of RhoC by microRNA-138 results in de-activation of FAK, Src and Erk signaling pathway in head and neck squamous cell carcinoma. Oral Oncol 50 (2014), 448–456.
3. 3 Kim, L., King, T., Agulnik, M., Head and neck cancer: changing epidemiology and public health implications. Oncology (Williston Park) 24 (2010), 915–919 924.
4. 4 Siegel, R.L., Miller, K.D., Jemal, A., Cancer statistics, 2015. CA Cancer J Clin 65 (2015), 5–29.
5. 5 Keren, S., Shoude, Z., Lu, Z., Beibei, Y., Role of EGFR as a prognostic factor for survival in head and neck cancer: a meta-analysis. Tumour Biol 35 (2014), 2285–2295.
6. 6 Bernier, J., Bentzen, S.M., Altered fractionation and combined radio-chemotherapy approaches: pioneering new opportunities in head and neck oncology. Eur J Cancer 39 (2003), 560–571.
7. 7 Lee, D.J., Cosmatos, D., Marcial, V.A., Fu, K.K., Rotman, M., Cooper, J.S., et al. Results of an RTOG phase III trial (RTOG 85-27) comparing radiotherapy plus etanidazole with radiotherapy alone for locally advanced head and neck carcinomas. Int J Radiat Oncol Biol Phys 32 (1995), 567–576.
8. 8 Sprinzl, G.M., Galvan, O., de Vries, A., Ulmer, H., Gunkel, A.R., Lukas, P., Local application of granulocyte-macrophage colony stimulating factor (GM-CSF) for the treatment of oral mucositis. Eur J Cancer 37 (2001), 2003–2009.
9. 9 Hanson, W.R., Marks, J.E., Reddy, S.P., Simon, S., Mihalo, W.E., Tova, Y., Protection from radiation-induced oral mucositis by a mouth rinse containing the prostaglandin E1 analog, misoprostol: a placebo controlled double blind clinical trial. Adv Exp Med Biol 400B (1997), 811–818.
10. 10 Leborgne, J.H., Leborgne, F., Zubizarreta, E., Ortega, B., Mezzera, J., Corticosteroids and radiation mucositis in head and neck cancer. A double-blind placebo-controlled randomized trial. Radiother Oncol 47 (1998), 145–148.
11. 11 Tannehill, S.P., Mehta, M.P., Amifostine and radiation therapy: past, present, and future. Semin Oncol 23:4 Suppl. 8 (1996), 69–77.
12. 12 Keefe, D.M., Schubert, M.M., Elting, L.S., Sonis, S.T., Epstein, J.B., Raber-Durlacher, J.E., et al. Updated clinical practice guidelines for the prevention and treatment of mucositis. Cancer 109 (2007), 820–831.
13. 13 Symonds, R.P., Treatment-induced mucositis: an old problem with new remedies. Br J Cancer 77 (1998), 1689–1695.
14. 14 Wasserman, T., Mackowiak, J.I., Brizel, D.M., Oster, W., Zhang, J., Peeples, P.J., et al. Effect of amifostine on patient assessed clinical benefit in irradiated head and neck cancer. Int J Radiat Oncol Biol Phys 48 (2000), 1035–1039.
15. 15 Bardy, J., Molassiotis, A., Ryder, W.D., Mais, K., Sykes, A., Yap, B., et al. A double-blind, placebo-controlled, randomised trial of active manuka honey and standard oral care for radiation-induced oral mucositis. Br J Oral Maxillofac Surg 50 (2012), 221–226.
16. 16 Biswal, B.M., Zakaria, A., Ahmad, N.M., Topical application of honey in the management of radiation mucositis: a preliminary study. Support Care Cancer 11 (2003), 242–248.
17. 17 Khanal, B., Baliga, M., Uppal, N., Effect of topical honey on limitation of radiation-induced oral mucositis: an intervention study. Int J Oral Maxillofac Surg 39 (2010), 1181–1185.
18. 18 Rashad, U.M., Al-Gezawy, S.M., El-Gezawy, E., Azzaz, A.N., Honey as topical prophylaxis against radiochemotherapy-induced mucositis in head and neck cancer. J Laryngol Otol 123 (2009), 223–228.
19. 19 Maddocks-Jennings, W., Wilkinson, J.M., Cavanagh, H.M., Shillington, D., Evaluating the effects of the essential oils Leptospermum scoparium (manuka) and Kunzea ericoides (kanuka) on radiotherapy induced mucositis: a randomized, placebo controlled feasibility study. Eur J Oncol Nurs 13 (2009), 87–93.
20. 20 Motallebnejad, M., Akram, S., Moghadamnia, A., Moulana, Z., Omidi, S., The effect of topical application of pure honey on radiation-induced mucositis: a randomized clinical trial. J Contemp Dent Pract 9 (2008), 40–47.
21. 21 Hawley, P., Hovan, A., McGahan, C.E., Saunder, D., A randomized placebo-controlled trial of manuka honey for radiation-induced oral mucositis. Support Care Cancer 22 (2014), 751–761.
22. 22 World Health Organization, WHO handbook for reporting the results of cancer treatment. 1979, WHO Offset Publications, Geneva.
23. 23 Cox, J.D., Stetz, J., Pajak, T.F., Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC). Int J Radiat Oncol Biol Phys 31 (1995), 1341–1346.
24. 24 Sonis, S.T., Eilers, J.P., Epstein, J.B., Leveque, F.G., Liggett, W.J., Mulagha, M.T., et al. Validation of a new scoring system for the assessment of clinical trial research of oral mucositis induced by radiation or chemotherapy. Mucositis Study Group. Cancer 85 (1999), 2103–2113.
25. 25 Yang, Y., Qian, J., Chen, Y., Pan, Y., Prognostic role of circulating microRNA-21 in cancers: evidence from a meta-analysis. Tumour Biol 35 (2014), 6365–6371.
26. 26 Bae, J.H., Kim, Y.K., Myung, S.K., Effects of platelet-rich plasma on sinus bone graft: meta-analysis. J Periodontol 82 (2011), 660–667.
27. 27 Peterson, D.E., Bensadoun, R.J., Roila, F., Management of oral and gastrointestinal mucositis: ESMO Clinical Practice Guidelines. Ann Oncol 22:Suppl. 6 (2011), vi78–vi84.
28. 28 Bergman, A., Yanai, J., Weiss, J., Bell, D., David, M.P., Acceleration of wound healing by topical application of honey. An animal model. Am J Surg 145 (1983), 374–376.
29. 29 Khalil, A.T., Khan, I., Ahmad, K., Khan, Y.A., Khan, J., Shinwari, Z.K., Antibacterial activity of honey in north-west Pakistan against select human pathogens. J Tradit Chin Med 34 (2014), 86–89.
30. 30 Efem, S.E., Clinical observations on the wound healing properties of honey. Br J Surg 75 (1988), 679–681.
31. 31 Subrahmanyam, M., Honey impregnated gauze versus polyurethane film (OpSite) in the treatment of burns—a prospective randomised study. Br J Plast Surg 46 (1993), 322–323.
32. 32 Molan, P.C., Re-introducing honey in the management of wounds and ulcers—theory and practice. Ostomy Wound Manage 48 (2002), 28–40.
33. 33 Subrahmanyam, M., Topical application of honey in treatment of burns. Br J Surg 78 (1991), 497–498.
34. 34 Subrahmanyam, M., A prospective randomised clinical and histological study of superficial burn wound healing with honey and silver sulfadiazine. Burns 24 (1998), 157–161.
35. 35 Chiba, M., Idobata, K., Kobayashi, N., Sato, Y., Muramatsu, Y., Use of honey to ease the pain of stomatitis during radiotherapy. Kangogaku Zasshi 49 (1985), 171–176.
36. 36 Song, J.J., Twumasi-Ankrah, P., Salcido, R., Systematic review and meta-analysis on the use of honey to protect from the effects of radiation-induced oral mucositis. Adv Skin Wound Care 25 (2012), 23–28.
37. 37 Cho, H.K., Jeong, Y.M., Lee, H.S., Lee, Y.J., Hwang, S.H., Effects of honey on oral mucositis in patients with head and neck cancer: a meta-analysis. Laryngoscope 125 (2015), 2085–2092.