Maternal melatonin or N-acetylcysteine therapy regulates hydrogen sulfide-generating pathway and renal transcriptome to prevent prenatal NG-Nitro-L-arginine-methyl ester (L-NAME)-induced fetal programming of hypertension in adult male offspring

American Journal of Obstetrics and Gynecology

Volumn 215, Issue 5, 2016, Pages 636.e1-636.e72

  Tain, You Lin ^a   Lee, Chien Te ^a   Chan, Julie Y H ^a   Hsu, Chien Ning ^a,b  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

hydrogen sulfide; hypertension; melatonin; N acetylcysteine; nitric oxide; oxidative stress

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 2; 6 N,N' DIMETHYLARGININE; 8 ISOPROSTANE; ACETYLCYSTEINE; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 1B RECEPTOR; ANGIOTENSIN I; ANGIOTENSIN[1-7]; ARACHIDONIC ACID; ARGININE; CITRULLINE; CYSTEINE; CYTOCHROME P450 4A; CYTOCHROME P450 4A2; DIPEPTIDYL CARBOXYPEPTIDASE; GLUTATHIONE; HYDROGEN SULFIDE; MELATONIN; MESSENGER RNA; N(G) NITROARGININE METHYL ESTER; N(G),N(G) DIMETHYLARGININE; RENIN; RNA 18S; TRANSCRIPTOME; UNCLASSIFIED DRUG; ANTIOXIDANT; BIOLOGICAL MARKER;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; ANTIHYPERTENSIVE THERAPY; ARACHIDONIC ACID METABOLISM; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DRD2 GENE; DRUG SYNTHESIS; EPHX2 GENE; FEMALE; GENE EXPRESSION; HEART PROTECTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HPGDS GENE; HYPERTENSION; KIDNEY MASS; MALE; MEAN ARTERIAL PRESSURE; MORTALITY RATE; NEXT GENERATION SEQUENCING; NONHUMAN; ONCOGENE RAS; PREGNANCY; PRIORITY JOURNAL; PROGENY; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PTGDS GENE; PTGS1 GENE; PTGS2 GENE; RAT; REAL TIME POLYMERASE CHAIN REACTION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; RNA SEQUENCE; SPRAGUE DAWLEY RAT; SYSTOLIC BLOOD PRESSURE; ANIMAL; CHEMICALLY INDUCED; DRUG EFFECTS; FETUS DEVELOPMENT; KIDNEY; METABOLISM; ORAL DRUG ADMINISTRATION; OXIDATIVE STRESS; PHYSIOLOGY; PRENATAL EXPOSURE; PREVENTION AND CONTROL;

ACETYLCYSTEINE; ADMINISTRATION, ORAL; ANIMALS; ANTIOXIDANTS; BIOMARKERS; FEMALE; FETAL DEVELOPMENT; HYDROGEN SULFIDE; HYPERTENSION; KIDNEY; MALE; MELATONIN; NG-NITROARGININE METHYL ESTER; OXIDATIVE STRESS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, SPRAGUE-DAWLEY; TRANSCRIPTOME;

EID: 84994389366     PISSN: 00029378     EISSN: 10976868     Source Type: Journal    
DOI: 10.1016/j.ajog.2016.07.036     Document Type: Article

References (29)

1. 1 Baylis, C., Beinder, E., Sütö, T., August, P., Recent insights into the roles of nitric oxide and renin-angiotensin in the pathophysiology of preeclamptic pregnancy. Semin Nephrol 18 (1998), 208–230.
2. 2 Tain, Y.L., Joles, J.A., Reprogramming: a preventive strategy in hypertension focusing on the kidney. Int J Mol Sci, 17, 2015, E23.
3. 3 Ghulmiyyah, L.M., Costantine, M.M., Yin, H., et al. The role of oxidative stress in the developmental origin of adult hypertension. Am J Obstet Gynecol 205 (2011), 155.e7–155.e11.
4. 4 Dennery, P.A., Oxidative stress in development: nature or nurture?. Free Radic Biol Med 49 (2010), 1147–1151.
5. 5 Paixão, A.D., Alexander, B.T., How the kidney is impacted by the perinatal maternal environment to develop hypertension. Biol Reprod, 89, 2013, 144.
6. 6 Tain, Y.L., Huang, L.T., Hsu, C.N., Lee, C.T., Melatonin therapy prevents programmed hypertension and nitric oxide deficiency in offspring exposed to maternal caloric restriction. Oxid Med Cell Longev, 2014, 2014, 283180.
7. 7 Tain, Y.L., Lee, W.C., Hsu, C.N., et al. Asymmetric dimethylarginine is associated with developmental programming of adult kidney disease and hypertension in offspring of streptozotocin-treated mothers. PLoS One, 8, 2013, e55420.
8. 8 Tain, Y.L., Sheen, J.M., Chen, C.C., et al. Maternal citrulline supplementation prevents prenatal dexamethasone-induced programmed hypertension. Free Radic Res 48 (2014), 580–586.
9. 9 Tain, Y.L., Huang, L.T., Lee, C.T., Chan, J.Y., Hsu, C.N., Maternal citrulline supplementation prevents prenatal N(G)-nitro-L-arginine-methyl ester (L-NAME)-induced programmed hypertension in rats. Biol Reprod, 92, 2015, 7.
10. 10 Galano, A., Tan, D.X., Reiter, R.J., On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK. J Pineal Res 54 (2013), 245–257.
11. 11 Chen, Y.C., Sheen, J.M., Tiao, M.M., Tain, Y.L., Huang, L.T., Roles of melatonin in fetal programming in compromised pregnancies. Int J Mol Sci 14 (2013), 5380–5401.
12. 12 Santus, P., Corsico, A., Solidoro, P., Braido, F., Di Marco, F., Scichilone, N., Oxidative stress and respiratory system: pharmacological and clinical reappraisal of N-acetylcysteine. COPD 11 (2014), 705–717.
13. 13 Kolluru, G.K., Shen, X., Kevil, C.G., A tale of two gases: NO and H2S, foes or friends for life?. Redox Biol 1 (2013), 313–318.
14. 14 Tai, I.H., Sheen, J.M., Lin, Y.J., et al. Maternal N-acetylcysteine therapy regulates hydrogen sulfide-generating pathway and prevents programmed hypertension in male offspring exposed to prenatal dexamethasone and postnatal high-fat diet. Nitric Oxide 53 (2016), 6–12.
15. 15 Grigore, D., Ojeda, N.B., Alexander, B.T., Sex differences in the fetal programming of hypertension. Gend Med 5 (2008), S121–S132.
16. 16 Tain, Y.L., Hsieh, C.S., Lin, I.C., et al. Effects of maternal L-citrulline supplementation on renal function and blood pressure in offspring exposed to maternal caloric restriction: the impact of nitric oxide pathway. Nitric Oxide 23 (2010), 34–41.
17. 17 Tain, Y.L., Hsu, C.N., Chan, J.Y., Huang, L.T., Renal transcriptome analysis of programmed hypertension induced by maternal nutritional insults. Int J Mol Sci 16 (2015), 17826–17837.
18. 18 Dennis, G. Jr., Sherman, B.T., Hosack, D.A., et al. DAVID: database for annotation, visualization, and integrated discovery. Genome Biol, 4, 2003, P3.
19. 19 Huang, L.T., Hsieh, C.S., Chang, K.A., Tain, Y.L., Roles of nitric oxide and asymmetric dimethylarginine in pregnancy and fetal programming. Int J Mol Sci 13 (2012), 14606–14622.
20. 20 Huang, H., Zhou, Y., Raju, V.T., et al. Renal 20-HETE inhibition attenuates changes in renal hemodynamics induced by L-NAME treatment in pregnant rats. Am J Physiol Renal Physiol 289 (2005), F1116–F1122.
21. 21 Racasan, S., Braam, B., Koomans, H.A., Joles, J.A., Programming blood pressure in adult SHR by shifting perinatal balance of NO and reactive oxygen species toward NO: the inverted Barker phenomenon. Am J Physiol Renal Physiol 288 (2005), F626–F636.
22. 22 Zhong, G., Chen, F., Cheng, Y., Tang, C., Du, J., The role of hydrogen sulfide generation in the pathogenesis of hypertension in rats induced by inhibition of nitric oxide synthase. J Hypertens 21 (2003), 1879–1885.
23. 23 Wesseling, S., Fledderus, J.O., Verhaar, M.C., Joles, J.A., Beneficial effects of diminished production of hydrogen sulfide or carbon monoxide on hypertension and renal injury induced by NO withdrawal. Br J Pharmacol 172 (2015), 1607–1619.
24. 24 Koning, A.M., Frenay, A.R., Leuvenink, H.G., Van Goor, H., Hydrogen sulfide in renal physiology, disease and transplantation: the smell of renal protection. Nitric Oxide 46 (2015), 37–49.
25. 25 Feng, Y., Xia, H., Santos, R.A., Speth, R., Lazartigues, E., Angiotensin-converting enzyme 2: a new target for neurogenic hypertension. Exp Physiol 95 (2010), 601–606.
26. 26 Tain, Y.L., Leu, S., Wu, K.L., Lee, W.C., Chan, J.Y., Melatonin prevents maternal fructose intake-induced programmed hypertension in the offspring: roles of nitric oxide and arachidonic acid metabolites. J Pineal Res 57 (2014), 80–89.
27. 27 Chen, Y.C., Tain, Y.L., Sheen, J.M., Huang, L.T., Melatonin utility in neonates and children. J Formos Med Assoc 111 (2012), 57–66.
28. 28 Tain, Y.L., Huang, L.T., Chan, J.Y., Transcriptional regulation of programmed hypertension by melatonin: an epigenetic perspective. Int J Mol Sci 15 (2014), 18484–18495.
29. 29 Krege, J.H., Hodgin, J.B., Hagaman, J.R., Smithies, O., A noninvasive computerized tail-cuff system for measuring blood pressure in mice. Hypertension 25 (1995), 1111–1115.