메뉴 건너뛰기




Volumn 5, Issue 11, 2016, Pages

Reprogramming of TLR7 signaling enhances antitumor NK and cytotoxic T cell responses

Author keywords

Cancer immunotherapy; dendritic cells; poly(I:C); RIG I like receptors agonists; Toll like receptors

Indexed keywords

CD40 ANTIGEN; CD69 ANTIGEN; CHEMOKINE RECEPTOR CCR7; CHEMOKINE RECEPTOR CXCR4; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12P40; INTERLEUKIN 12P70; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MITOGEN ACTIVATED PROTEIN KINASE; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR 7; TUMOR NECROSIS FACTOR;

EID: 84994158598     PISSN: 21624011     EISSN: 2162402X     Source Type: Journal    
DOI: 10.1080/2162402X.2016.1232219     Document Type: Article
Times cited : (29)

References (45)
  • 1
    • 84920545991 scopus 로고    scopus 로고
    • Cancer immunotherapy and breaking immune tolerance: new approaches to an old challenge
    • 25524899
    • Makkouk A, Weiner GJ. Cancer immunotherapy and breaking immune tolerance:new approaches to an old challenge. Cancer Res 2015; 75:5-10; PMID:25524899; doi:10.1158/0008-5472.CAN-14-2538
    • (2015) Cancer Res , vol.75 , pp. 5-10
    • Makkouk, A.1    Weiner, G.J.2
  • 2
    • 33750934617 scopus 로고    scopus 로고
    • Dendritic cells: translating innate to adaptive immunity
    • 17048704
    • Steinman RM, Hemmi H. Dendritic cells:translating innate to adaptive immunity. Curr Top Microbiol Immunol 2006; 311:17-58; PMID:17048704; doi:10.1007/3-540-32636-7_2
    • (2006) Curr Top Microbiol Immunol , vol.311 , pp. 17-58
    • Steinman, R.M.1    Hemmi, H.2
  • 3
    • 34247100277 scopus 로고    scopus 로고
    • Dendritic cells prime natural killer cells by trans-presenting interleukin 15
    • 17398124
    • Lucas M, Schachterle W, Oberle K, Aichele P, Diefenbach A. Dendritic cells prime natural killer cells by trans-presenting interleukin 15. Immunity 2007; 26:503-17; PMID:17398124; doi:10.1016/j.immuni.2007.03.006
    • (2007) Immunity , vol.26 , pp. 503-517
    • Lucas, M.1    Schachterle, W.2    Oberle, K.3    Aichele, P.4    Diefenbach, A.5
  • 4
    • 84940451580 scopus 로고    scopus 로고
    • Translating nucleic acid-sensing pathways into therapies
    • 26292638
    • Junt T, Barchet W. Translating nucleic acid-sensing pathways into therapies. Nat Rev Immunol 2015; 15:529-44; PMID:26292638; doi:10.1038/nri3875
    • (2015) Nat Rev Immunol , vol.15 , pp. 529-544
    • Junt, T.1    Barchet, W.2
  • 6
    • 0036886426 scopus 로고    scopus 로고
    • Imiquimod 5% cream for the treatment of superficial and nodular basal cell carcinoma: randomized studies comparing low-frequency dosing with and without occlusion
    • 12452875
    • Sterry W, Ruzicka T, Herrera E, Takwale A, Bichel J, Andres K, Ding L, Thissen MRTM. Imiquimod 5% cream for the treatment of superficial and nodular basal cell carcinoma:randomized studies comparing low-frequency dosing with and without occlusion. Br J Dermatol 2002; 147:1227-36; PMID:12452875; doi:10.1046/j.1365-2133.2002.05069.x
    • (2002) Br J Dermatol , vol.147 , pp. 1227-1236
    • Sterry, W.1    Ruzicka, T.2    Herrera, E.3    Takwale, A.4    Bichel, J.5    Andres, K.6    Ding, L.7    Thissen, M.R.T.M.8
  • 10
    • 79956314622 scopus 로고    scopus 로고
    • Immune signaling by RIG-I-like receptors
    • 21616437
    • Loo Y-M, Gale M. Immune signaling by RIG-I-like receptors. Immunity 2011; 34:680-92; PMID:21616437; doi:10.1016/j.immuni.2011.05.003
    • (2011) Immunity , vol.34 , pp. 680-692
    • Loo, Y.-M.1    Gale, M.2
  • 11
    • 77949940198 scopus 로고    scopus 로고
    • Intracellular toll-like receptors
    • 20346772
    • Blasius AL, Beutler B. Intracellular toll-like receptors. Immunity 2010; 32:305-15; PMID:20346772; doi:10.1016/j.immuni.2010.03.012
    • (2010) Immunity , vol.32 , pp. 305-315
    • Blasius, A.L.1    Beutler, B.2
  • 12
    • 79956300649 scopus 로고    scopus 로고
    • Toll-like receptors and their crosstalk with other innate receptors in infection and immunity
    • 21616434
    • Kawai T, Akira S. Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity 2011; 34:637-50; PMID:21616434; doi:10.1016/j.immuni.2011.05.006
    • (2011) Immunity , vol.34 , pp. 637-650
    • Kawai, T.1    Akira, S.2
  • 13
    • 0035909372 scopus 로고    scopus 로고
    • Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
    • 11607032
    • Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 2001; 413:732-8; PMID:11607032; doi:10.1038/35099560
    • (2001) Nature , vol.413 , pp. 732-738
    • Alexopoulou, L.1    Holt, A.C.2    Medzhitov, R.3    Flavell, R.A.4
  • 14
    • 77649221014 scopus 로고    scopus 로고
    • Melanoma differentiation-associated gene 5 (MDA5) is involved in the innate immune response to Paramyxoviridae infection in vivo
    • 20107606
    • Gitlin L, Benoit L, Song C, Cella M, Gilfillan S, Holtzman MJ, Colonna M. Melanoma differentiation-associated gene 5 (MDA5) is involved in the innate immune response to Paramyxoviridae infection in vivo. PLoS Pathog 2010; 6:e1000734; PMID:20107606; doi:10.1371/journal.ppat.1000734
    • (2010) PLoS Pathog , vol.6 , pp. e1000734
    • Gitlin, L.1    Benoit, L.2    Song, C.3    Cella, M.4    Gilfillan, S.5    Holtzman, M.J.6    Colonna, M.7
  • 15
    • 23944489407 scopus 로고    scopus 로고
    • Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1–polarizing program in dendritic cells
    • 15995707
    • Napolitani G, Rinaldi A, Bertoni F, Sallusto F, Lanzavecchia A. Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1–polarizing program in dendritic cells. Nat Immunol 2005; 6:769-76; PMID:15995707; doi:10.1038/ni1223
    • (2005) Nat Immunol , vol.6 , pp. 769-776
    • Napolitani, G.1    Rinaldi, A.2    Bertoni, F.3    Sallusto, F.4    Lanzavecchia, A.5
  • 18
    • 79960956913 scopus 로고    scopus 로고
    • Systemic cancer therapy with a small molecule agonist of toll-like receptor 7 can be improved by circumventing TLR tolerance
    • 21697281
    • Bourquin C, Hotz C, Noerenberg D, Voelkl A, Heidegger S, Roetzer LC, Storch B, Sandholzer N, Wurzenberger C, Anz D, et al. Systemic cancer therapy with a small molecule agonist of toll-like receptor 7 can be improved by circumventing TLR tolerance. Cancer Res 2011; 71:5123-33; PMID:21697281; doi:10.1158/0008-5472.CAN-10-3903
    • (2011) Cancer Res , vol.71 , pp. 5123-5133
    • Bourquin, C.1    Hotz, C.2    Noerenberg, D.3    Voelkl, A.4    Heidegger, S.5    Roetzer, L.C.6    Storch, B.7    Sandholzer, N.8    Wurzenberger, C.9    Anz, D.10
  • 19
    • 0037313578 scopus 로고    scopus 로고
    • Interleukin-12 and the regulation of innate resistance and adaptive immunity
    • 12563297
    • Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol 2003; 3:133-46; PMID:12563297; doi:10.1038/nri1001
    • (2003) Nat Rev Immunol , vol.3 , pp. 133-146
    • Trinchieri, G.1
  • 20
    • 50949121439 scopus 로고    scopus 로고
    • IL-6, in synergy with IL-7 or IL-15, stimulates TCR-independent proliferation and functional differentiation of CD8+ T lymphocytes
    • 18523259
    • Gagnon J, Ramanathan S, Leblanc C, Cloutier A, McDonald PP, Ilangumaran S. IL-6, in synergy with IL-7 or IL-15, stimulates TCR-independent proliferation and functional differentiation of CD8+ T lymphocytes. J Immunol Baltim Md 1950 2008; 180:7958-68; PMID:18523259; doi:10.4049/jimmunol.180.12.7958
    • (2008) J Immunol Baltim Md 1950 , vol.180 , pp. 7958-7968
    • Gagnon, J.1    Ramanathan, S.2    Leblanc, C.3    Cloutier, A.4    McDonald, P.P.5    Ilangumaran, S.6
  • 22
    • 0022549790 scopus 로고
    • Dissociation of therapeutic and toxic effects of polyinosinic-polycytidylic acid admixed with poly-L-lysine and solubilized with carboxymethyl cellulose in tumor-bearing mice
    • 3484679
    • Hartmann D, Adams JS, Meeker AK, Schneider MA, Lenz BF, Talmadge JE. Dissociation of therapeutic and toxic effects of polyinosinic-polycytidylic acid admixed with poly-L-lysine and solubilized with carboxymethyl cellulose in tumor-bearing mice. Cancer Res 1986; 46:1331-8; PMID:3484679
    • (1986) Cancer Res , vol.46 , pp. 1331-1338
    • Hartmann, D.1    Adams, J.S.2    Meeker, A.K.3    Schneider, M.A.4    Lenz, B.F.5    Talmadge, J.E.6
  • 23
    • 34248162935 scopus 로고    scopus 로고
    • Generation of clinical grade dendritic cells with capacity to produce biologically active IL-12p70
    • 17430585
    • Zobywalski A, Javorovic M, Frankenberger B, Pohla H, Kremmer E, Bigalke I, Schendel DJ. Generation of clinical grade dendritic cells with capacity to produce biologically active IL-12p70. J Transl Med 2007; 5:18; PMID:17430585; doi:10.1186/1479-5876-5-18
    • (2007) J Transl Med , vol.5 , pp. 18
    • Zobywalski, A.1    Javorovic, M.2    Frankenberger, B.3    Pohla, H.4    Kremmer, E.5    Bigalke, I.6    Schendel, D.J.7
  • 24
    • 79955488983 scopus 로고    scopus 로고
    • Adjuvant combination and antigen targeting as a strategy to induce polyfunctional and high-avidity T-cell responses against poorly immunogenic tumors
    • 21402711
    • Aranda F, Llopiz D, Díaz-Valdés N, Riezu-Boj JI, Bezunartea J, Ruiz M, Martínez M, Durantez M, Mansilla C, Prieto J, et al. Adjuvant combination and antigen targeting as a strategy to induce polyfunctional and high-avidity T-cell responses against poorly immunogenic tumors. Cancer Res 2011; 71:3214-24; PMID:21402711; doi:10.1158/0008-5472.CAN-10-3259
    • (2011) Cancer Res , vol.71 , pp. 3214-3224
    • Aranda, F.1    Llopiz, D.2    Díaz-Valdés, N.3    Riezu-Boj, J.I.4    Bezunartea, J.5    Ruiz, M.6    Martínez, M.7    Durantez, M.8    Mansilla, C.9    Prieto, J.10
  • 26
    • 4143131229 scopus 로고    scopus 로고
    • Synergistic activation of innate immunity by double-stranded RNA and CpG DNA promotes enhanced antitumor activity
    • 15313929
    • Whitmore MM, DeVeer MJ, Edling A, Oates RK, Simons B, Lindner D, Williams BRG. Synergistic activation of innate immunity by double-stranded RNA and CpG DNA promotes enhanced antitumor activity. Cancer Res 2004; 64:5850-60; PMID:15313929; doi:10.1158/0008-5472.CAN-04-0063
    • (2004) Cancer Res , vol.64 , pp. 5850-5860
    • Whitmore, M.M.1    DeVeer, M.J.2    Edling, A.3    Oates, R.K.4    Simons, B.5    Lindner, D.6    Williams, B.R.G.7
  • 27
    • 79958746242 scopus 로고    scopus 로고
    • Viral infection augments Nod1/2 signaling to potentiate lethality associated with secondary bacterial infections
    • 21669398
    • Kim Y-G, Park J-H, Reimer T, Baker DP, Kawai T, Kumar H, Akira S, Wobus C, Núñez G. Viral infection augments Nod1/2 signaling to potentiate lethality associated with secondary bacterial infections. Cell Host Microbe 2011; 9:496-507; PMID:21669398; doi:10.1016/j.chom.2011.05.006
    • (2011) Cell Host Microbe , vol.9 , pp. 496-507
    • Kim, Y.-G.1    Park, J.-H.2    Reimer, T.3    Baker, D.P.4    Kawai, T.5    Kumar, H.6    Akira, S.7    Wobus, C.8    Núñez, G.9
  • 28
    • 77954679956 scopus 로고    scopus 로고
    • Release of IL-12 by dendritic cells activated by TLR ligation is dependent on MyD88 signaling, whereas TRIF signaling is indispensable for TLR synergy
    • 20360404
    • Krummen M, Balkow S, Shen L, Heinz S, Loquai C, Probst H-C, Grabbe S. Release of IL-12 by dendritic cells activated by TLR ligation is dependent on MyD88 signaling, whereas TRIF signaling is indispensable for TLR synergy. J Leukoc Biol 2010; 88:189-99; PMID:20360404; doi:10.1189/jlb.0408228
    • (2010) J Leukoc Biol , vol.88 , pp. 189-199
    • Krummen, M.1    Balkow, S.2    Shen, L.3    Heinz, S.4    Loquai, C.5    Probst, H.-C.6    Grabbe, S.7
  • 29
    • 0023505325 scopus 로고
    • Toxicity of polyinosinic-polycytidylic acid admixed with poly-L-lysine and solubilized with carboxymethylcellulose in mice
    • 3447151
    • Hartmann D, Schneider MA, Lenz BF, Talmadge JE. Toxicity of polyinosinic-polycytidylic acid admixed with poly-L-lysine and solubilized with carboxymethylcellulose in mice. Pathol Immunopathol Res 1987; 6:37-50; PMID:3447151; doi:10.1159/000157040
    • (1987) Pathol Immunopathol Res , vol.6 , pp. 37-50
    • Hartmann, D.1    Schneider, M.A.2    Lenz, B.F.3    Talmadge, J.E.4
  • 31
    • 0022350787 scopus 로고
    • Phase II trial of poly(I,C)-LC, an interferon inducer, in the treatment of children with acute leukemia and neuroblastoma: a report from the Children's Cancer Study Group
    • 2416884
    • Lampkin BC, Levine AS, Levy H, Krivit W, Hammond D. Phase II trial of poly(I,C)-LC, an interferon inducer, in the treatment of children with acute leukemia and neuroblastoma:a report from the Children's Cancer Study Group. J Biol Response Mod 1985; 4:531-7; PMID:2416884
    • (1985) J Biol Response Mod , vol.4 , pp. 531-537
    • Lampkin, B.C.1    Levine, A.S.2    Levy, H.3    Krivit, W.4    Hammond, D.5
  • 35
    • 33645755382 scopus 로고    scopus 로고
    • TLR3 can directly trigger apoptosis in human cancer cells
    • 16585585
    • Salaun B, Coste I, Rissoan M-C, Lebecque SJ, Renno T. TLR3 can directly trigger apoptosis in human cancer cells. J Immunol Baltim Md 1950 2006; 176:4894-901; PMID:16585585; doi:10.4049/jimmunol.176.8.4894
    • (2006) J Immunol Baltim Md 1950 , vol.176 , pp. 4894-4901
    • Salaun, B.1    Coste, I.2    Rissoan, M.-C.3    Lebecque, S.J.4    Renno, T.5
  • 37
    • 84868297666 scopus 로고    scopus 로고
    • Poly I:C-induced tumor cell apoptosis mediated by pattern-recognition receptors
    • 23062195
    • Zhao X, Ai M, Guo Y, Zhou X, Wang L, Li X, Yao C. Poly I:C-induced tumor cell apoptosis mediated by pattern-recognition receptors. Cancer Biother Radiopharm 2012; 27:530-4; PMID:23062195; doi:10.1089/cbr.2012.1226
    • (2012) Cancer Biother Radiopharm , vol.27 , pp. 530-534
    • Zhao, X.1    Ai, M.2    Guo, Y.3    Zhou, X.4    Wang, L.5    Li, X.6    Yao, C.7
  • 40
    • 22544473593 scopus 로고    scopus 로고
    • TLR7/8-mediated activation of human NK cells results in accessory cell-dependent IFN-gamma production
    • 16034103
    • Hart OM, Athie-Morales V, O'Connor GM, Gardiner CM. TLR7/8-mediated activation of human NK cells results in accessory cell-dependent IFN-gamma production. J Immunol Baltim Md 1950 2005; 175:1636-42; PMID:16034103; doi:10.4049/jimmunol.175.3.1636
    • (2005) J Immunol Baltim Md 1950 , vol.175 , pp. 1636-1642
    • Hart, O.M.1    Athie-Morales, V.2    O'Connor, G.M.3    Gardiner, C.M.4
  • 41
    • 77953435969 scopus 로고    scopus 로고
    • Antitumor activity and immune response induction of a dual agonist of Toll-like receptors 7 and 8
    • 20515950
    • Wang D, Precopio M, Lan T, Yu D, Tang JX, Kandimalla ER, Agrawal S. Antitumor activity and immune response induction of a dual agonist of Toll-like receptors 7 and 8. Mol Cancer Ther 2010; 9:1788-97; PMID:20515950; doi:10.1158/1535-7163.MCT-09-1198
    • (2010) Mol Cancer Ther , vol.9 , pp. 1788-1797
    • Wang, D.1    Precopio, M.2    Lan, T.3    Yu, D.4    Tang, J.X.5    Kandimalla, E.R.6    Agrawal, S.7
  • 44
    • 43649107405 scopus 로고    scopus 로고
    • B16 as a mouse model for human melanoma
    • Chapter 20:Unit 20.1, 18432774
    • Overwijk WW, Restifo NP. B16 as a mouse model for human melanoma. Curr Protoc Immunol Ed John E Coligan Al 2001; Chapter 20:Unit 20.1; PMID:18432774; doi:10.1002/0471142735.im2001s39
    • (2001) Curr Protoc Immunol Ed John E Coligan Al
    • Overwijk, W.W.1    Restifo, N.P.2
  • 45
    • 84928770388 scopus 로고    scopus 로고
    • Neoantigens in cancer immunotherapy
    • 25838375
    • Schumacher TN, Schreiber RD. Neoantigens in cancer immunotherapy. Science 2015; 348:69-74; PMID:25838375; doi:10.1126/science.aaa4971
    • (2015) Science , vol.348 , pp. 69-74
    • Schumacher, T.N.1    Schreiber, R.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.