Acute alloxan toxicity causes granulomatous tubulointerstitial nephritis with severe mineralization

Journal of Toxicologic Pathology

Volumn 29, Issue 4, 2016, Pages 261-264

  Zhang, Lianshan ^a   Terayama, Yui ^b   Nishimoto, Taiki ^c   Kodama, Yasushi ^c   Ozaki, Kiyokazu ^b  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b SETSUNAN UNIVERSITY   (Japan)

^c HIROSHIMA INTERNATIONAL UNIVERSITY   (Japan)

Author keywords

Alloxan; Granuloma; Mineralization; Rat; Tubular necrosis

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ALLOXAN; AQUAPORIN 1; GLUCOSE TRANSPORTER 2;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; GLOMERULONEPHRITIS; INTERSTITIAL NEPHRITIS; KIDNEY CALCIFICATION; MACROPHAGE; MALE; MULTINUCLEAR CELL; NEPHROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT;

EID: 84994106545     PISSN: 09149198     EISSN: None     Source Type: Journal    
DOI: 10.1293/tox.2016-0017     Document Type: Article

References (12)

1. Evan AP, Mong SA, Connors BA, Aronoff GR, and Luft FC. The effect of alloxan, and alloxan-induced diabetes on the kidney. Anat Rec. 208: 33–47. 1984.
2. Vargas L, Friederici HH, and Maibenco HC. Cortical sponge kidneys induced in rats by alloxan. Diabetes. 19: 33–44. 1970.
3. Bruckmann G, and Wertheimer E. Alloxan studies; the action of alloxan homologues and related compounds. J Biol Chem. 168: 241–256. 1947.
4. de Water R, Noordermeer C, Houtsmuller AB, Nigg AL, Stijnen T, Schröder FH, and Kok DJ. Role of macrophages in nephrolithiasis in rats: an analysis of the renal interstitium. Am J Kidney Dis. 36: 615–625. 2000.
5. Boevé ER, Ketelaars GA, Vermeij M, Cao LC, Schröder FH, and De Bruijn WC. An ultrastructural study of experimentally induced microliths in rat proximal and distal tubules. J Urol. 149: 893–899. 1993.
6. de Bruijn WC, Boevé ER, van Run PR, van Miert PP, Romi-jn JC, Verkoelen CF, Cao LC, and Schröder FH. Etiology of experimental calcium oxalate monohydrate nephrolithiasis in rats. Scanning Microsc. 8: 541–549, discussion 549–550. 1994.
7. Lieske JC, Spargo BH, and Toback FG. Endocytosis of calcium oxalate crystals and proliferation of renal tubular epithelial cells in a patient with type 1 primary hyperoxaluria. J Urol. 148: 1517–1519. 1992.
8. Khan SR. Calcium oxalate crystal interaction with renal tubular epithelium, mechanism of crystal adhesion and its impact on stone development. Urol Res. 23: 71–79. 1995.
9. Mann PC, Vahle J, Keenan CM, Baker JF, Bradley AE, Goodman DG, Harada T, Herbert R, Kaufmann W, Kellner R, Nolte T, Rittinghausen S, and Tanaka T. International harmonization of toxicologic pathology nomenclature: an overview and review of basic principles. Toxicol Pathol. 40(Suppl): 7S–13S. 2012.
10. Elsner M, Tiedge M, Guldbakke B, Munday R, and Lenzen S. Importance of the GLUT2 glucose transporter for pancreatic beta cell toxicity of alloxan. Diabetologia. 45: 1542–1549. 2002.
11. Weaver DC, McDaniel ML, and Lacy PE. Alloxan uptake by isolated rat islets of Langerhans. Endocrinology. 102: 1847–1855. 1978.
12. Lenzen S. The mechanisms of alloxan- and streptozotocin-induced diabetes. Diabetologia. 51: 216–226. 2008.