Persisting neurobehavioral effects of developmental copper exposure in wildtype and metallothionein 1 and 2 knockout mice

BMC Pharmacology and Toxicology

Volumn 17, Issue 1, 2016, Pages

  Petro, Ann ^a   Sexton, Hannah G ^a   Miranda, Caroline ^b   Rastogi, Anit ^c   Freedman, Jonathan H ^d   Levin, Edward D ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^d University of Louisville School of Medicine   (United States)

Author keywords

Copper; Developmental; Dopamine; Memory; Metallothionein; Mouse; Norepinephrine; Radial arm maze; Serotonin

Indexed keywords

COPPER; DOPAMINE; METALLOTHIONEIN I; METALLOTHIONEIN II; NORADRENALIN; SEROTONIN; METALLOTHIONEIN;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN LEVEL; BRAIN STEM; COGNITION; CONTROLLED STUDY; CORPUS STRIATUM; DEVELOPMENT; ENVIRONMENTAL EXPOSURE; EXPERIMENTAL COGNITIVE TEST; FEMALE; FRONTAL CORTEX; GENOTYPE; HIPPOCAMPUS; MALE; MESENCEPHALON; MOUSE; NEUROCHEMISTRY; NONHUMAN; POSTERIOR CORTEX; RADIAL ARM MAZE TEST; SEX DIFFERENCE; SPATIAL LEARNING; SPATIAL MEMORY; WILD TYPE; WORKING MEMORY; YOUNG ADULT; 129 MOUSE; ANIMAL; BRAIN; DEFICIENCY; DOSE RESPONSE; DRUG EFFECTS; GROWTH, DEVELOPMENT AND AGING; KNOCKOUT MOUSE; MAZE TEST; METABOLISM; PHYSIOLOGY;

ANIMALS; BRAIN; COPPER; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; MAZE LEARNING; METALLOTHIONEIN; MICE; MICE, 129 STRAIN; MICE, KNOCKOUT;

EID: 84994032287     PISSN: None     EISSN: 20506511     Source Type: Journal    
DOI: 10.1186/s40360-016-0096-3     Document Type: Article

References (29)

1. Hoogenraad TU. Paradigm shift in treatment of Wilson's disease: zinc therapy now treatment of choice. Brain Dev. 2006;28:141-6.
2. Eddins D, Petro A, Pollard N, Freedman JH, Levin ED. Mercury-induced cognitive impairment in metallothionein knockout mice. Neurotoxicol Teratol. 2008;30:88-95.
3. Levin ED, Perraut C, Pollard N, Freedman JH. Metallothionein expression and neurocognitive function in mice. Physiol Behav. 2006;87:513-8.
4. Danks DM. Copper deficiency in humans. Annu Rev Nutr. 1988;8:235-57.
5. Cloez I, Bourre JM. Copper, manganese and zinc in the developing brain of control and quaking mice. Neurosci Lett. 1987;83:118-22.
6. Hunt DM. Copper and neurological function. Ciba Found Symp. 1980;79:247-66.
7. Aaseth J, Norseth T. Copper. In: Friberg L, Nordberg GF, Vouk V, editors. Handbook on the Toxicology of Metals. New York: Elsevier; 1986. p. 233-54.
8. Bauerly KA, Kelleher SL, Lönnerdal B. Effects of copper supplementation on copper absorption, tissue distribution, and copper transporter expression in an infant rat model. Am J Physiol Gastrointest Liver Physiol. 2005;288:G1007-14.
9. Kodama H, Murata Y. Molecular genetics and pathophysiology of Menke's disease. Pediatr Int. 1999;41:430-5.
10. Das SK, Ray K. Wilson's disease: An update. Nat Clin Pract. 2006;2:482-93.
11. Macreadie IG. Copper transport and Alzheimer's disease. Eur Biophys J. 2007;37:295-300.
12. Prohaska JR. Long-term functional consequences of malnutrition during brain development: copper. Nutrition. 2000;16:502-4.
13. Prohaska JR, Bailey WR. Persistent regional changes in brain copper, cuproenzymes and catecholamines following perinatal copper deficiency in mice. J Nutr. 1993;123:1226-34.
14. Kodama H, Meguro Y, Abe T, Rayner MH, Suzuki KT, Kobayashi S, Nishimura M. Genetic expression of Menke's disease in cultured astrocytes of the macular mouse. J Inherit Metab Dis. 1991;14:896-901.
15. Lau JC, Joseph MG, Cherian MG. Role of placental metallothionein in maternal to fetal transfer of cadmium in genetically altered mice. Toxicology. 1998;127:167-78.
16. Goyer RA, Cherian MG. Role of metallothionein in human placenta and rats exposed to cadmium. In: Nordberg GF, Herber RFM, Alessio L, editors. Cadmium in the Human Environment: Toxicity and Carcinogenicity. New York: IARC; 1992. p. 239-47.
17. Hidalgo J, Aschner M, Zatta P, Vasák M. Roles of the metallothionein family of proteins in the central nervous system. Brain Res Bull. 2001;55:133-45.
18. Carrasco J, Penkowa M, Hadberg H, Molinero A, Hidalgo J. Enhanced seizures and hippocampal neurodegeneration following kainic acid-induced seizures in metallothionein-I + II-deficient mice. Eur J Neurosci. 2000;12:2311-22.
19. Giralt M, Penkowa M, Lago N, Molinero A, Hidalgo J. Metallothionein-1 + 2 protect the CNS after a focal brain injury. Exp Neurol. 2002;173:114-28.
20. Penkowa M, Giralt M, Camats J, Hidalgo J. Metallothionein 1 + 2 protect the CNS during neuroglial degeneration induced by 6-aminonicotinamide. J Comp Neurol. 2002;444:174-89.
21. Yoshida M, Watanabe C, Horie K, Satoh M, Sawada M, Shimada A. Neurobehavioral changes in metallothionein-null mice prenatally exposed to mercury vapor. Toxicol Lett. 2005;155:361-8.
22. Masters BA, Kelly EJ, Quaife CJ, Brinster RL, Palmiter RD. Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium. Proc Natl Acad Sci U S A. 1994;91:584-8.
23. Kelly EJ, Quaife CJ, Froelick GJ, Palmiter RD. Metallothionein I and II protect against zinc deficiency and zinc toxicity in mice. J Nutr. 1996;126:1782-90.
24. Rofe AM, Philcox JC, Coyle P. Trace metal, acute phase and metabolic response to endotoxin in metallothionein-null mice. Biochem J. 1996;314(Pt 3):793-7.
25. Park JD, Liu Y, Klaassen CD. Protective effect of metallothionein against the toxicity of cadmium and other metals(1). Toxicology. 2001;163:93-100.
26. Wilkerson A, Levin ED. Ventral hippocampal dopamine D1 and D2 systems and spatial working memory in rats. Neuroscience. 1999;89:743-9.
27. Aldridge JE, Levin ED, Seidler FJ, Slotkin TA. Developmental exposure of rats to chlorpyrifos leads to behavioral alterations in adulthood, involving serotonergic mechanisms and resembling animal models of depression. Environ Health Perspect. 2005;113:527-31.
28. Levin ED, Pizarro K, Pang WG, Harrison J, Ramsdell JS. Persisting behavioral consequences of prenatal domoic acid exposure in rats. Neurotoxicol Teratol. 2005;27:719-25.
29. Phillips A, Ahn S, Floresco S. Magnitude of dopamine release in medial prefrontal cortex predicts accuracy of memory on a delayed response task. J Neurosci. 2004;24:547-53.